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    • 82. 发明授权
    • Method for preparing composite particles
    • 复合颗粒的制备方法
    • US5474803A
    • 1995-12-12
    • US995174
    • 1992-12-24
    • Yuji Kikuchi
    • Yuji Kikuchi
    • B01J2/00B01J2/30B29B9/16C08J3/12C08J3/20C08J7/04B05D1/12
    • B01J2/30B01J2/006B29B9/16C08J3/12C08J3/203
    • The present invention is directed to a method for preparing composite particles by fixing, on the surface of a thermoplastic substance having an average particle diameter of 100 .mu.m to 10 mm, a substance having a smaller size and more excellent heat resistance than the thermoplastic substance, the method being characterized by comprising the steps of heating the substance having a smaller size and more excellent heat resistance than the thermoplastic substance up to a temperature of not less than a softening point of the thermoplastic substance with stirring in an apparatus having a stirring mechanism and a heating mechanism; putting the thermoplastic substance in the apparatus; and then fixing the substance having the excellent heat resistance on the surface of the thermoplastic substance.
    • 本发明涉及一种通过在平均粒径为100〜10mm的热塑性物质的表面上固定具有比热塑性物质更小尺寸和更优异的耐热性的物质来制备复合颗粒的方法 该方法的特征在于包括以下步骤:在具有搅拌机构的装置中将具有比热塑性物质更小的尺寸和更优异的耐热性的物质加热至不低于热塑性物质的软化点的温度,同时搅拌 和加热机构; 将热塑性物质放入设备中; 然后将具有优异耐热性的物质固定在热塑性物质的表面上。
    • 83. 发明授权
    • Production of pellets composed of an ephedrine derivative
    • 生产由麻黄碱衍生物组成的丸粒
    • US5453280A
    • 1995-09-26
    • US117285
    • 1993-09-07
    • Thomas MoestUwe LoefflerHans Waiblinger
    • Thomas MoestUwe LoefflerHans Waiblinger
    • A61K9/16A61K31/135A61K31/137A61K9/54B29B9/08B29B9/16
    • A61K31/135A61K9/1688
    • A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm.sup.3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 .mu.m at 0.degree.-90.degree. C. with stirring in a water-immiscible non solvent with a boiling point in the range from 60.degree. to 160.degree. C., adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25.degree. C. at 5-40K per hour, with the stirring speed being adjusted after the agglomeration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets. A drug which contains the active ingredient in the form of such pellets, with or without slowing of release, is also described.
    • 一种制备显影球形,粒径为0.1〜4mm,表观密度为0.5g / cm 3以上的颗粒的方法,由90-100重量%的麻黄碱衍生物和0〜 10重量%的药物助剂,需要在0〜90℃下搅拌平均粒度为0.5〜50μm的麻黄碱衍生物粉末,在沸点范围内的不溶于水的非溶剂中搅拌 从60℃升至160℃,在连续搅拌的同时加入约5-60重量%的基于麻黄碱衍生物的附聚液,如果先前加热,冷却至-5〜25℃ 以每小时5-40K的速度调整粉末颗粒附聚后的搅拌速度至所需的平均颗粒尺寸所需的值,并除去和干燥所得的颗粒。 还描述了含有这种丸剂形式的活性成分的药物,其具有或没有减缓释放。
    • 85. 发明授权
    • Method of making biodegradable free fill foam packing material
    • 制造可生物降解的自由填充泡沫包装材料的方法
    • US5116550A
    • 1992-05-26
    • US499647
    • 1990-03-27
    • Newton B. Perkins
    • Newton B. Perkins
    • B29B9/06B29B9/16B29C44/02B29C67/24
    • B29C67/24B29B9/16B29C44/3402B29K2003/00B29K2075/00
    • Biodegradable free fill expanded polyurethane foam packing materials are formed by pumping liquid starch or sugar, diisocyanate, polyols and a catalyst into a mixing head. The mixture is released from an exit port in the mixing chamber as a sticky material. At predetermied intervals air blasts chop the sticky material mass from the exit port. The material beings expanding as it drops through a curing chamber against upward warm air currents. When the materials expand to full size and dry to a non-tacky surface, the materials are released from the chamber and collected for use as packing materials. The materials have a bionutrient starch or sugar content of about 40% or more, making them readily biodegradable by microbes. The polyurethane components are broken down into very small sizes and convert to urea, making the products highly suitable for disposal in landfills and as soil amendment and fertilizers.
    • 通过将液体淀粉或糖,二异氰酸酯,多元醇和催化剂泵送到混合头中来形成可生物降解的自由填充发泡聚氨酯泡沫包装材料。 混合物作为粘性材料从混合室中的出口释放。 在预先设定的时间间隔,空气从出口处切断粘性物料。 材料随着固化室下降而向上膨胀,以抵抗向上的暖气流。 当材料膨胀到全尺寸并干燥到非粘性表面时,材料从室中释放并收集用作包装材料。 这些材料具有约40%或更多的生物淀粉或糖含量,使其易于由微生物降解。 聚氨酯组件分解成非常小的尺寸并转化为尿素,使产品非常适合在垃圾填埋场以及土壤修复和肥料中处理。