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81. 发明授权

US08940333B2 Amphiphilic block copolymers and nanoparticles comprising the same 有权
标题翻译：两亲性嵌段共聚物和包含其的纳米颗粒
公开(公告)号：US08940333B2
公开(公告)日：2015-01-27
申请号：US12053327
申请日：2008-03-21
申请人： Ming-Fa Hsieh , Hsuen-Tseng Cha'ng , Chin-Fu Chen , Yuan-Chia Chang , Pei Kan , Tsai-Yu Lin
发明人： Ming-Fa Hsieh , Hsuen-Tseng Cha'ng , Chin-Fu Chen , Yuan-Chia Chang , Pei Kan , Tsai-Yu Lin
IPC分类号： A61K9/14 , A61K9/51 , A61K31/00 , C08G63/91 , C08G63/48 , A61K8/11 , A61K9/107 , A61K47/34 , C08G63/664 , C08G63/685 , C08G63/688 , C08G63/692 , A61K8/00 , A61K9/12
CPC分类号： A61K9/5153 , A61K9/1075 , A61K31/4745 , A61K47/34 , C08G63/664 , C08G63/6852 , C08G63/6882 , C08G63/6922 , Y10S977/906 , Y10S977/926
摘要： An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.
摘要翻译：公开了两亲嵌段共聚物。两亲性嵌段共聚物包括一种或多种亲水性聚合物，一种或多种疏水性聚合物和一种或多种两性离子。本发明还提供了包含用于递送水不溶性药物，生长因子，基因或水不溶性化妆品物质的两亲嵌段共聚物的纳米颗粒和载体。

82. 发明授权

US08936800B2 Gel composition for treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt 有权
标题翻译：用于治疗常见痤疮的凝胶组合物，其包含过氧化苯甲酰和阿达帕林和/或阿达帕林盐的组合
公开(公告)号：US08936800B2
公开(公告)日：2015-01-20
申请号：US13660831
申请日：2012-10-25
申请人： Galderma Research & Development
发明人： Sandrine Orsoni , Nathalie Willcox
IPC分类号： A61K8/00 , A61K31/07 , A61K31/075 , A61K31/192 , A61K31/327 , A61K47/30 , A61K31/20 , A61K31/19
CPC分类号： A61K31/20 , A61K9/0014 , A61K9/06 , A61K31/07 , A61K31/19 , A61K31/192 , A61K31/327 , A61K47/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° C. and 40° C.
摘要翻译：适于预防或治疗细胞分化和/或增殖和/或角质化疾病（包括预防或治疗常见痤疮）的皮肤病学/化妆品组合物在生理学上可接受的培养基中包含（i）至少一种分散的类视色素，（ii）分散的苯甲酰基过氧化物，游离或包封形式，和（iii）至少一种不依赖于pH的胶凝剂，其选自（a）聚丙烯酰胺胶凝剂，（b）与疏水链偶联的丙烯酸聚合物的胶凝剂，（c ）改性淀粉胶凝剂及其混合物，所述组合物在4℃至40℃的温度下保持良好的（i）和（ii）化学稳定性，而不会随时间降解。

83. 发明授权

US08916180B2 Cosmetic treatment system and methods 有权
标题翻译：化妆品治疗系统及方法
公开(公告)号：US08916180B2
公开(公告)日：2014-12-23
申请号：US14184244
申请日：2014-02-19
申请人： Access Business Group International LLC
发明人： John V. Scimeca , Amy C. Zimmerman , Mark F. Mettler , Akiko Kudo , Yoko Kawasaki
IPC分类号： A61K8/00 , A61K38/43 , A61K36/53 , A61K36/47 , A61K36/28 , A61K8/97
CPC分类号： A61K38/51 , A61K8/0208 , A61K8/66 , A61K8/97 , A61K9/0014 , A61K9/7084 , A61K36/07 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/53 , A61K36/535 , A61K36/62 , A61K36/899 , A61K36/9062 , A61K38/46 , A61K38/47 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： A cosmetic treatment system is provided having ingredients that may prevent signs of aging, improve the aesthetic appearance of skin, and promote recovery from environmental stresses. The composition includes natural ingredients, including at least one ingredient or extract from rosemary; at least one ingredient or extract from Centella, Echinacea, Alpinia or mixtures thereof; a DNA repair enzyme; and at least one pharmaceutically or cosmetically acceptable vehicle. The treatment system may further include a patch for applying the cosmetic ingredients and/or a packaging system for holding the components of the cosmetic treatment system.
摘要翻译：提供了具有可以防止老化迹象，改善皮肤美学外观并促进从环境压力恢复的成分的美容治疗系统。该组合物包括天然成分，包括至少一种来自迷迭香的成分或提取物; 至少一种来自Centella，Echinacea，Alpinia或其混合物的成分或提取物; DNA修复酶; 和至少一种药学或化妆品可接受的载体。治疗系统还可以包括用于施加化妆品成分的贴剂和/或用于保持化妆品处理系统的组分的包装系统。

84. 发明授权

US08906347B2 Oral stannous compositions 有权
标题翻译：口服亚锡组成
公开(公告)号：US08906347B2
公开(公告)日：2014-12-09
申请号：US12266937
申请日：2008-11-07
申请人： Ross Strand , Maurice Joseph Prendergast , Xiaoli Wang
发明人： Ross Strand , Maurice Joseph Prendergast , Xiaoli Wang
IPC分类号： A61Q11/00 , A61K8/00 , A61K8/21 , A61K8/27 , A61K8/25 , A61K8/73 , A61K8/19 , A61K8/55 , A61K8/24
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/27 , A61K8/55 , A61K8/73
摘要： The present invention relates to an aqueous oral composition comprising: a) from 0.2% to 3% divalent metal ions comprising: i. from 0.1% to 1.5% of zinc ions; ii. from 0.1% to 2% of tin (II) ions; and b) a source of fluoride ions; c) a silica dental abrasive; d) one or more chelants having a MW of less than 1000 and capable of forming water-soluble complexes with the zinc ions, wherein the chelants comprise less than 0.2% linear polyphosphates having a chain length of four or more; e) an orally acceptable carrier comprising at least 20% total water; wherein the pH of the composition is from 5 to 6.5, the molar ratio of the chelants to the divalent metal ions is at least 0.70:1 and at least 80% by weight of the total zinc ions are solubilised within the composition. The composition of the invention has been found to give improved antimicrobial activity from the zinc/stannous combination without significant taste, staining or stability problems, compared to compositions having lower levels of chelants.
摘要翻译：本发明涉及含水口服组合物，其包含：a）0.2％至3％的二价金属离子，包括：从0.1％到1.5％的锌离子; ii。 0.1％至2％的锡（II）离子; 和b）氟离子源; c）二氧化硅牙科磨料; d）一种或多种MW小于1000并能够与锌离子形成水溶性络合物的螯合剂，其中螯合剂包含链长为4或更大的少于0.2％的线性多磷酸盐; e）口服可接受的载体，其包含至少20％的总水; 其中组合物的pH为5至6.5，螯合剂与二价金属离子的摩尔比为至少0.70:1，并且总锌离子的至少80重量％溶解在组合物内。与具有较低水平的螯合剂的组合物相比，已发现本发明的组合物从锌/亚锡组合中提供改善的抗微生物活性，而没有显着的味道，染色或稳定性问题。

85. 发明授权

US08894983B2 Conditioner and conditioning shampoo compound containing pentaerythritol ester 有权
标题翻译：含季戊四醇酯的护发素和护发素化合物
公开(公告)号：US08894983B2
公开(公告)日：2014-11-25
申请号：US13635203
申请日：2011-03-05
申请人： Markus Dierker , Hans-Martin Haake , Daniela Prinz , Junko Kano , Kakushi Doki , Tae-Seong Kim , Koichi Masaki , Sybille Cornelsen
发明人： Markus Dierker , Hans-Martin Haake , Daniela Prinz , Junko Kano , Kakushi Doki , Tae-Seong Kim , Koichi Masaki , Sybille Cornelsen
IPC分类号： A61Q5/12 , A61K8/00 , A61K8/37 , A61K8/891 , A61K8/898 , A61Q5/02
CPC分类号： A61K8/375 , A61K8/891 , A61K8/898 , A61Q5/02 , A61Q5/12
摘要： The invention relates to a cosmetic preparation containing (a) esters of fatty acids having 6 to 12 carbon atoms with pentaerythritol and (b) silicones.
摘要翻译：本发明涉及含有（a）具有6至12个碳原子的脂肪酸酯与季戊四醇和（b）硅氧烷的化妆品制剂。

86. 发明授权

US08883129B2 Enhanced efficacy antiperspirant active 有权
标题翻译：增强功效止汗剂活性
公开(公告)号：US08883129B2
公开(公告)日：2014-11-11
申请号：US11034477
申请日：2005-01-13
申请人： David Frederick Swaile , Wayne Edward Beimesch , David Good , Scott Edward Smith
发明人： David Frederick Swaile , Wayne Edward Beimesch , David Good , Scott Edward Smith
IPC分类号： A61K8/00 , A61Q15/00 , A61K8/26
CPC分类号： A61Q15/00 , A61K8/26
摘要： An enhanced efficacy aluminum only salt active. The method for making such active comprises the steps of (a) providing an aqueous solution of an aluminum salt having a Band III polymer concentration of at least about 20%; (b) adding to the aqueous solution of step (a) an aqueous solution of a monomeric aluminum salt to form a mixture; and (c) rapidly drying the mixture to form a product powder. The active comprises an aluminum only salt having a Band III polymer concentration of at least about 20%, an aluminum to anion ratio of from about 1.1:1 to about 1.8:1 and a level of monomeric aluminum of from about 2% to about 20% of the total aluminum.
摘要翻译：增强功效铝只有盐活性。制备这种活性物质的方法包括以下步骤：（a）提供具有至少约20％的Band III聚合物浓度的铝盐水溶液; （b）向步骤（a）的水溶液中加入单体铝盐的水溶液以形成混合物; 和（c）快速干燥混合物以形成产物粉末。该活性物质包括仅具有III族聚合物浓度至少为约20％，铝与阴离子比为约1.1:1至约1.8:1的铝盐，单体铝含量为约2％至约20 占总铝的百分比。

87. 发明授权

US08877165B2 Solid preparation for oral application 有权
标题翻译：用于口服应用的固体制剂
公开(公告)号：US08877165B2
公开(公告)日：2014-11-04
申请号：US12293554
申请日：2007-04-12
申请人： Takahisa Yamashiro , Kazuhiko Kato , Shigeto Kayane , Junji Nakamura
发明人： Takahisa Yamashiro , Kazuhiko Kato , Shigeto Kayane , Junji Nakamura
IPC分类号： A61K8/00 , A61Q11/00 , A61K45/06 , A61K8/24 , A61K31/726 , A61K8/34 , A61K31/715 , A61K33/42 , A61K8/73 , A61K8/55 , A61K9/00 , A61K9/20
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/345 , A61K8/55 , A61K8/73 , A61K9/0056 , A61K9/2018 , A61K31/715 , A61K31/726 , A61K33/42 , A61K45/06 , A61K2300/00
摘要： Provided is a solid preparation for oral application containing (a) gum tragacanth and (b) a polyphosphoric acid or salt thereof and constituted so that the polyphosphoric acid or salt thereof starts to dissolve firstly and the gum tragacanth starts to dissolve subsequently. The solid preparation for oral application according to the present invention has a high plaque formation inhibiting effect.
摘要翻译：提供一种用于口服的固体制剂，其包含（a）黄蓍胶和（b）多磷酸或其盐，并且构成为使得多磷酸或其盐首先开始溶解，随后将黄蓍胶开始溶解。本发明的口服固体制剂具有高的斑块形成抑制作用。

88. 发明授权

US08871183B2 Composition for promoting and maintaining oral health 有权
标题翻译：促进和维持口腔健康的组合
公开(公告)号：US08871183B2
公开(公告)日：2014-10-28
申请号：US11749111
申请日：2007-05-15
申请人： Tim Clarot , Regina Miskewitz
发明人： Tim Clarot , Regina Miskewitz
IPC分类号： A61K8/00 , A61K8/27 , A61K33/30 , A61K31/14 , A61Q11/00 , A61K8/49 , A61K31/44
CPC分类号： A61K8/4926 , A61K8/27 , A61K31/44 , A61Q11/00
摘要： A composition for improving oral health and methods of using and forming the composition are disclosed. The composition includes one or more active ingredients and a carrier. The composition is configured to maintain the active ingredient(s) with a surface of an oral cavity for an extended period of time to promote oral health and hygiene.
摘要翻译：公开了一种用于改善口腔健康的组合物以及使用和形成该组合物的方法。组合物包含一种或多种活性成分和载体。所述组合物被配置成将活性成分与口腔表面保持较长时间以促进口腔健康和卫生。

89. 发明授权

US08865144B2 Personal care compositions comprising responsive particles 有权
标题翻译：包含响应性颗粒的个人护理组合物
公开(公告)号：US08865144B2
公开(公告)日：2014-10-21
申请号：US11705888
申请日：2007-02-14
申请人： Ioannis Constantine Constantinides , Robert J. Willicut , Ellen Schmidt Baker , Howard David Hutton, III , Timothy James Felts , Lee Arnold Schechtman , Sergiy Minko , Mikhail Motornov
发明人： Ioannis Constantine Constantinides , Robert J. Willicut , Ellen Schmidt Baker , Howard David Hutton, III , Timothy James Felts , Lee Arnold Schechtman , Sergiy Minko , Mikhail Motornov
IPC分类号： A61K8/00 , A61K8/81 , A61K8/18 , A61K8/72 , A61K8/19 , A61K8/49 , A61K8/11 , A61Q19/00 , A61Q1/02 , A61K8/29
CPC分类号： A61Q1/02 , A61K8/11 , A61K8/29 , A61K2800/412 , A61Q19/00
摘要： Personal care compositions comprising responsive particles. In one aspect, the responsive particle comprises: (1) a particle core having an interfacial surface, (2) a first polymer having a first property, and (3) a second polymer having a contrasting property. The first polymer and the second polymer are attached at different locations to the interfacial surface of the particle core. In another aspect, the responsive particle comprises: (1) a particle core having an interfacial surface, (2) at least one block co-polymer comprising a first block and a second block, wherein said first block has a first property and said second block has a second property, and (3) optionally, at least one other polymer having a third property. The block co-polymer and the optional other polymer (if present) are attached to the interfacial surface of the particle core, and at least one of the properties contrasts. The personal care compositions also comprise a dermatologically acceptable carrier. Also disclosed are methods of making responsive particles.
摘要翻译：包含响应性颗粒的个人护理组合物。一方面，响应性颗粒包括：（1）具有界面的颗粒芯，（2）具有第一性质的第一聚合物，和（3）具有对比性质的第二聚合物。第一聚合物和第二聚合物在不同的位置连接到颗粒芯的界面。在另一方面，响应颗粒包括：（1）具有界面表面的颗粒芯，（2）至少一个包含第一嵌段和第二嵌段的嵌段共聚物，其中所述第一嵌段具有第一性质，所述第二嵌段嵌段具有第二性质，和（3）任选的至少一种具有第三性质的其它聚合物。嵌段共聚物和任选的其它聚合物（如果存在）连接到颗粒芯的界面表面，并且至少一个性质形成对比。个人护理组合物还包含皮肤病学可接受的载体。还公开了制备响应颗粒的方法。

90. 发明授权

US08865132B2 Compressed gas aerosol compositions 有权
标题翻译：压缩气体气溶胶组合物
公开(公告)号：US08865132B2
公开(公告)日：2014-10-21
申请号：US13973375
申请日：2013-08-22
申请人： Richard S. Valpey, III , Paul A. Clark , Jessica A. Elwell (nee Heiser)
发明人： Richard S. Valpey, III , Paul A. Clark , Jessica A. Elwell (nee Heiser)
IPC分类号： A61K9/12 , A61K8/00 , A01N25/00 , A01N25/02 , C11D3/50 , C11B9/00 , A01N25/06 , C09K3/30 , A01N25/30
CPC分类号： A01N25/06 , A01N25/30 , C09K3/30 , C11B9/00 , Y10S514/919
摘要： Certain surfactants suitable for use alone to dissolve a water-insoluble component in compositions is described for providing VOC-free compressed gas aerosol compositions. The compositions include water-insoluble component(s), a surfactant and water. The water-insoluble component(s) can be active agent(s), such as fragrance(s) and/or an insecticide(s). The surfactant is present as a single surfactant which, in the absence of a solvent, dissolves or disperses the water-insoluble component(s) and provides a homogenous blend in water which provides a stable compressed gas emulsion. The surfactant is an anionic surfactant or a nonionic surfactant, in particular nonionic alkylpolyglycosides; nonionic cocoglucoside; nonionic alkylene oxide extended chain alkylpolyglycosides; anionic sodium lauryl ether sulfate (SLES), nonionic C13-C15 oxoalcohol ethoxylate with 8 ethylene oxides (EO), nonionic C12-C14 secondary alcohol ethoxylate with 7EO or 12EO, polyethylene glycol (PEG) hydrogenated castor oil wherein the PEG is PEG-60 or PEG-40, polyglyceryl-10 laurate and polyglyceryl-6 caprylate.
摘要翻译：描述适用于单独使用以溶解组合物中的水不溶性组分的某些表面活性剂，用于提供无VOC的压缩气体气溶胶组合物。组合物包括水不溶性组分，表面活性剂和水。水不溶性组分可以是活性剂，例如香料和/或杀虫剂。表面活性剂作为单一表面活性剂存在，在不存在溶剂的情况下，溶解或分散水不溶性组分，并在水中提供均匀的共混物，其提供稳定的压缩气体乳液。表面活性剂是阴离子表面活性剂或非离子表面活性剂，特别是非离子烷基多糖苷; 非离子型葡糖苷非离子环氧烷延伸链烷基多糖苷; 阴离子十二烷基醚硫酸钠（SLES），具有8个环氧乙烷（EO）的非离子C 13 -C 15多元醇乙氧基化物，具有7EO或12EO的非离子C 12 -C 14仲醇乙氧基化物，聚乙二醇（PEG）氢化蓖麻油，其中PEG是PEG-60 或PEG-40，聚甘油-10-月桂酸酯和聚甘油-6辛酸酯。

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