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81. 发明申请

US20110091903A1 METHOD OF ANALYZING A SAMPLE FOR A BACTERIUM USING DIACETYLENE-CONTAINING POLYMER SENSOR 审中-公开
标题翻译：使用含有二乙烯基聚合物传感器分析细菌样品的方法
公开(公告)号：US20110091903A1
公开(公告)日：2011-04-21
申请号：US12743518
申请日：2008-11-20
申请人： G. Marco Bommarito , Sridhar V. Dasaratha , Brinda B. Lakshmi , Robert E. Brennan, JR. , Joseph J. Stoffel , Joseph P. Hensler , Triet M. Lu , Patrick A. Mach , Chunmei Guo , Mara S. Reif-Wenner , Heather M. Webb
发明人： G. Marco Bommarito , Sridhar V. Dasaratha , Brinda B. Lakshmi , Robert E. Brennan, JR. , Joseph J. Stoffel , Joseph P. Hensler , Triet M. Lu , Patrick A. Mach , Chunmei Guo , Mara S. Reif-Wenner , Heather M. Webb
IPC分类号： G01N33/53
CPC分类号： C12Q1/04 , G01N33/54326 , G01N33/56911 , G01N33/586 , G01N2333/31
摘要： The invention relates to methods of analyzing a sample for a bacterium of interest. In particular, the methods involve an initial capture process that includes the use of one or more antibodies having antigenic specificities for one or more distinct analytes characteristic of the specific bacterium. After initial capture of a specific bacterium, techniques of analyzing involve colorimetric techniques, particularly using colorimetric sensors that include polydiacetylene (PDA) materials.
摘要翻译：本发明涉及分析感兴趣的细菌的样品的方法。特别地，所述方法包括初始捕获过程，其包括使用一种或多种具有针对特定细菌特征的一种或多种不同分析物具有抗原特异性的抗体。在初步捕获特定细菌后，分析技术涉及比色技术，特别是使用包含聚二乙炔（PDA）材料的比色传感器。

82. 发明申请

US20100291670A1 Method for Detecting Candida on Skin 有权
标题翻译：检测皮肤上假丝酵母的方法
公开(公告)号：US20100291670A1
公开(公告)日：2010-11-18
申请号：US12843922
申请日：2010-07-27
申请人： Stephanie M. Martin , Andrew M. Long , J. Gavin MacDonald , Jason Lye
发明人： Stephanie M. Martin , Andrew M. Long , J. Gavin MacDonald , Jason Lye
IPC分类号： C12M1/34
CPC分类号： A61L15/56 , G01N2333/245 , G01N2333/31 , G01N2333/40
摘要： A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.
摘要翻译：提供了用于快速检测宿主皮肤上的假丝酵母的方法和系统，例如具有尿布疹的婴儿。该方法包括使真皮样品与在假丝酵母存在下显示特定光谱响应（例如颜色变化）的着色剂接触。例如，着色剂可以从第一颜色变为第二颜色，从无色到颜色，或从颜色变为无色。着色剂通常能够区分假丝酵母（例如白色念珠菌）和通常与尿布疹相关的其它微生物，例如金黄色葡萄球菌和大肠杆菌。因此，当真皮样品与着色剂接触时，可以简单地观察颜色变化以确定感染是否由念珠菌引起。如果颜色变化发生一定程度（例如，从黄色到鲜红色），则可以确定测试样品含有念珠菌。同样地，如果在较小程度上发生颜色变化（例如，从黄色到微弱橙色），或根本不发生变色，则可以确定真皮样品含有其他微生物（例如金黄色葡萄球菌或大肠杆菌），无感染存在，或感染仅仅是由于其他原因。无论是否需要对念珠菌的治疗，将变得显而易见。

83. 发明申请

US20100197649A1 Compositions and Methods for Diagnosing and Treating Community-Acquired Methicillin-Resistant Staphylococcus Aureus 有权
标题翻译：用于诊断和治疗社区获得性耐甲氧西林金黄色葡萄球菌的组合物和方法
公开(公告)号：US20100197649A1
公开(公告)日：2010-08-05
申请号：US12670457
申请日：2008-08-07
申请人： Ambrose Cheung , Guido Memmi
发明人： Ambrose Cheung , Guido Memmi
IPC分类号： A61K31/43 , C07H21/04 , C12Q1/68 , A61K31/545 , A61P31/00
CPC分类号： A61K45/06 , A61K31/546 , C12Q1/18 , C12Q1/689 , G01N2333/31 , A61K2300/00
摘要： The present invention includes compositions and methods for diagnosing and treating CA-MRSA infections in patients. The methods are based on the finding that combining cefoxitin and a synthetic penicillin in a treatment regimen results in a synergistic effect of the two drugs, an effect that is related to PBP4 activity in CA-MRSA isolates. Also provided is a CA-MRSA-specific biomarker which can be used to detect the presence of a CA-MRSA infection in a patient.
摘要翻译：本发明包括用于诊断和治疗患者的CA-MRSA感染的组合物和方法。方法基于在治疗方案中结合头孢西丁和合成青霉素的结果，这两种药物的协同效应是与CA-MRSA分离物中PBP4活性相关的作用。还提供了可用于检测患者中CA-MRSA感染的存在的CA-MRSA特异性生物标志物。

84. 发明申请

US20100015138A1 Crystal structure of Staphylococcus aureus clumping factor a in complex with fibrinogen derived peptide and uses thereof 有权
标题翻译：金黄色葡萄球菌凝集因子α与纤维蛋白原衍生肽复合的晶体结构及其用途
公开(公告)号：US20100015138A1
公开(公告)日：2010-01-21
申请号：US12459327
申请日：2009-06-30
申请人： Magnus Hook , Ya-Ping Ko , Emanuel Smeds , Yannakambadi K. Ganesh
发明人： Magnus Hook , Ya-Ping Ko , Emanuel Smeds , Yannakambadi K. Ganesh
IPC分类号： A61K39/395 , C07K14/31 , A61K38/16 , G01N33/566 , A61K39/02 , A61K39/40 , C07K16/12 , A61P31/04
CPC分类号： C07K14/75 , A61K38/00 , A61K38/363 , C07K14/31 , C07K16/1271 , C07K16/18 , C07K16/36 , G01N33/68 , G01N2333/31 , G01N2333/75
摘要： The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the present invention also discloses the use of this structure in the design of ClfA targeted vaccines and therapeutic agents (including monoclonal antibodies). In addition, the present invention discloses isolated and purified engineered Staphylococcus clumping factor A protein (ClfA) with a stabilized, closed conformation and immunogenic compositions thereof including methods of treating a Staphylococcus infection in an individual.
摘要翻译：本发明公开了与纤维蛋白原（Fg）衍生肽复合的金黄色葡萄球菌凝集因子A（ClfA）的晶体结构。此外，本发明还公开了这种结构在设计ClfA靶向疫苗和治疗剂（包括单克隆抗体）中的用途。此外，本发明公开了具有稳定的封闭构象和免疫原性组合物的分离和纯化的工程化葡萄球菌凝聚因子A蛋白（ClfA），其包括在个体中治疗葡萄球菌感染的方法。

85. 发明申请

US20070122416A1 CROSS-REACTIVE DISPLACING ANTIBODIES FROM COLLAGEN-BINDING PROTEINS AND METHOD OF IDENTIFICATION AND USE 有权
标题翻译：来自胶原蛋白结合蛋白的交叉反应位移抗体及其鉴定和使用方法
公开(公告)号：US20070122416A1
公开(公告)日：2007-05-31
申请号：US09810428
申请日：2001-03-19
申请人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph Patti , Pratiksha Patel , Paul Domanski
发明人： Magnus Hook , Yi Xu , Pietro Speziale , Livia Visal , Fabrizia Casolini , Joseph Patti , Pratiksha Patel , Paul Domanski
IPC分类号： A61K39/40 , G01N33/554 , C07K16/12
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/56938 , G01N2333/31 , G01N2333/78 , G01N2500/00
摘要： Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.
摘要翻译：提供了对CNA蛋白和来自胶原结合结构域的其他区域（包括结构域CNA19）的抗体，并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应，因此可以用于预防和治疗由这两种细菌引起的感染。此外，可以使用本发明的抗体治疗医疗器械，以便减少或消除它们被感染或进一步扩散感染的可能性。特别地，蛋白质是有利的，因为它们是交叉反应性的，并且因此可以施用于患者，以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。以这种方式产生的抗体也已显示出显示置换活性，因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法，因为能够从细胞外基质上的结合位点置换细菌蛋白质。最后，还提供了鉴定，分离和利用置换抗体的方法。

86. 发明申请

US20050123552A1 Fibronectin binding protein compositions and methods of use 有权
标题翻译：纤连蛋白结合蛋白组合物和使用方法
公开(公告)号：US20050123552A1
公开(公告)日：2005-06-09
申请号：US10731238
申请日：2003-12-10
申请人： Magnus Hook , Joseph Patti , Karen House-Pompeo , Pietro Speziale , Danny Joh , Martin McGavin
发明人： Magnus Hook , Joseph Patti , Karen House-Pompeo , Pietro Speziale , Danny Joh , Martin McGavin
IPC分类号： A61K38/00 , A61K39/00 , A61K51/08 , C07K14/31 , C07K14/315 , C07K16/12 , G01N33/68 , C07K16/22 , C12P21/04
CPC分类号： A61K39/085 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , C07K14/31 , C07K14/315 , C07K16/1271 , C07K16/1275 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2319/00 , G01N33/6887 , G01N2333/31 , G01N2333/315 , G01N2333/78
摘要： Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus aureus, the fnbA and fnbB genes of Streptococcus dysgalactiae, and the sfb gene of Streptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.
摘要翻译：公开了阻断纤连蛋白与纤连蛋白结合的抗体。还公开了衍生自金黄色葡萄球菌的fnbA和fnbB基因的位点特异性突变和截短的肽表位，失语链球菌的fnbA和fnbB基因，以及化脓性链球菌的sfb基因，以及编码这些肽和表位的核酸片段。产生阻断纤连蛋白结合蛋白与纤连蛋白结合的抗体的抗（纤连蛋白结合位点）抗体，肽和表位，以及编码这些蛋白质的DNA片段，并且可用于各种筛选，诊断和治疗应用，包括活性和被动免疫和预防动物或人类中链球菌和葡萄球菌定居的方法。提出这些DNA片段及其衍生的肽直接用于疫苗的制备，也可用作疫苗制剂中的载体蛋白。

87. 发明申请

US20050025775A1 Capsular polysaccharide adhesin antigen, preparation, purification and use 失效
标题翻译：荚膜多糖粘附素抗原，制备，纯化和使用
公开(公告)号：US20050025775A1
公开(公告)日：2005-02-03
申请号：US10856123
申请日：2004-05-28
申请人： Gerald Pier
发明人： Gerald Pier
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/085 , A61K39/09 , A61P31/04 , C07K14/00 , C07K16/00 , C07K16/12 , C12N5/10 , C12P21/00 , C12P21/08 , C12Q1/06 , C12R1/44 , C12R1/45 , C12R1/91 , A61K39/38
CPC分类号： C12R1/46 , A61K38/00 , A61K39/00 , A61K39/085 , C07K16/1271 , C12Q1/06 , G01N2333/31 , Y10S435/82
摘要： A substantially pure capsular exopolysaccharide adhesin of coagulase-negative staphylococcal strains, and a gonoral method to prepare such adhesins, are described. Vaccines composed of such adhesins, and uses of such adhesins to produce polyclonal and monoclonal antibodies against such adhesins, are also disclosed. The adhesins are useful in coating polymoric medical materials to prevent colonization by coagulase-negative staphylococcal strains, and as a probe in selecting desirable polymeric medical materials. Such adhesin antibodies are useful in vivo to prevent infection by nosocomial coagulase-negative staphylococcal strains, in assays for the detection of such bacteria, in assays for the estimation of such adhesins in complex mixtures, and as an affinity chromatography matrix.
摘要翻译：描述了凝固酶阴性葡萄球菌菌株的基本上纯的荚膜胞外多糖粘附素和制备这种粘附素的道德方法。还公开了由这种粘附素组成的疫苗，以及这些粘附素的用途来产生针对这种粘附素的多克隆和单克隆抗体。粘附素可用于涂覆多形态医学材料以防止凝固酶阴性葡萄球菌菌株的定居，以及作为选择期望的聚合物医疗材料的探针。这样的粘附素抗体在体内可用于预防医院内凝固酶阴性葡萄球菌菌株的感染，用于检测这种细菌的测定中，在复合混合物中估计这种粘附素的测定中，以及作为亲和层析基质。

88. 发明申请

US20040115624A1 Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals 审中-公开
公开(公告)号：US20040115624A1
公开(公告)日：2004-06-17
申请号：US10714691
申请日：2003-11-17
发明人： Wondu Wolde-Mariam
IPC分类号： C12Q001/70 , G01N033/53 , G01N033/569 , G01N033/554
CPC分类号： G01N33/56911 , G01N33/558 , G01N2333/245 , G01N2333/30 , G01N2333/31 , G01N2333/315 , G01N2333/34 , G01N2333/35 , G01N2333/355 , G01N2333/39 , G01N2469/10 , Y10S435/97 , Y10S435/973 , Y10S436/81 , Y10S436/823
摘要： The present invention involves a method and an immuno-analytical device for the rapid and simultaneous detection of multiple micro-organisms in the biological fluids from milk-producing animals suffering from mastitis. This method is based on a lateral flow immuno-assay technique performed to detect antigens specific for multiple infectious agents which are known to cause and/or be encountered in cases of mastitis. Mastitis is an inflammatory condition affecting the udders of milk-producing animals as a result of microbial infections.

89. 发明授权

US06720160B2 Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals 失效
标题翻译：用于同时检测来自乳腺动物的生物标本中的多种微生物抗原的方法
公开(公告)号：US06720160B2
公开(公告)日：2004-04-13
申请号：US09976512
申请日：2001-10-11
申请人： Wondu Wolde-Mariam
发明人： Wondu Wolde-Mariam
IPC分类号： G01N33543
CPC分类号： G01N33/56911 , G01N33/558 , G01N2333/245 , G01N2333/30 , G01N2333/31 , G01N2333/315 , G01N2333/34 , G01N2333/35 , G01N2333/355 , G01N2333/39 , G01N2469/10 , Y10S435/97 , Y10S435/973 , Y10S436/81 , Y10S436/823
摘要： The present invention involves a method and an immuno-analytical device for the rapid and simultaneous detection of multiple micro-organisms in the biological fluids from milk-producing animals suffering from mastitis. This method is based on a lateral flow immuno-assay technique performed to detect antigens specific for multiple infectious agents which are known to cause and/or be encountered in cases of mastitis. Mastitis is an inflammatory condition affecting the udders of milk-producing animals as a result of microbial infections.
摘要翻译：本发明涉及一种用于快速和同时检测来自产生乳腺炎的产奶动物的生物液体中的多种微生物的方法和免疫分析装置。该方法基于进行的侧流免疫分析技术，以检测在乳腺炎病例中已知引起和/或遇到的多种感染因子特异性的抗原。乳腺炎是由于微生物感染而影响产奶动物的乳腺炎的炎性病症。

90. 发明申请

US20030143580A1 Rapid and sensitive detection of molecules 有权
标题翻译：快速灵敏的分子检测
公开(公告)号：US20030143580A1
公开(公告)日：2003-07-31
申请号：US10236105
申请日：2002-09-06
发明人： Don Straus
IPC分类号： C12Q001/68 , C07H021/04 , C07K014/00
CPC分类号： C12Q1/06 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/04 , C12Q1/18 , G01N15/1429 , G01N15/1475 , G01N21/6428 , G01N33/5005 , G01N33/5008 , G01N33/56916 , G01N33/56938 , G01N33/56966 , G01N33/56983 , G01N33/58 , G01N33/582 , G01N2015/1486 , G01N2015/1488 , G01N2021/6439 , G01N2021/6471 , G01N2333/195 , G01N2333/245 , G01N2333/31 , G01N2333/32 , G01N2333/33
摘要： The invention features methods for rapidly and sensitively identifying molecular targets in medical, industrial, and environmental samples. The invention labels target molecules and then images them using large area imaging. Diagnostic tests based on the invention can be rapid, ultrasensitive, quantitative, multiplexed, and automated. A broad range of infectious agents (e.g., bacteria, viruses, fungi, and parasites) and molecules (e.g., proteins, DNA, RNA, hormones, and drugs) can be detected by the methods. The invention enables rapid, ultra-sensitive, cost-effective, and portable assays. The ability of the invention to detect low levels of target molecules rapidly and cost-effectively results from the combination of high intensity labeling, formats that facilitate rapid reaction kinetics, and large area imaging based using either instrumentation made from off-the-shelf commercial components or no instrumentation at all.
摘要翻译：本发明的特征在于快速和敏感地鉴定医学，工业和环境样品中的分子靶标的方法。本发明标记目标分子，然后使用大面积成像对其进行成像。基于本发明的诊断测试可以是快速，超灵敏，定量，多路复用和自动化。可以通过这些方法检测各种感染因子（例如细菌，病毒，真菌和寄生虫）和分子（例如蛋白质，DNA，RNA，激素和药物）。本发明可实现快速，超灵敏，成本效益和便携式测定。本发明通过高强度标记，促进快速反应动力学的方式的组合以及使用由现成的商业部件制成的仪器的大面积成像的组合，快速且经济高效地检测低水平目标分子的能力或根本没有工具。

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