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81. 发明授权

US3903283A 2-Aminoalkyl tetrahydroquinolines as anti-schistosomal agents 失效
标题翻译： 2-氨基烷基四氢喹啉作为抗血吸虫药
公开(公告)号：US3903283A
公开(公告)日：1975-09-02
申请号：US46221174
申请日：1974-04-19
申请人： PFIZER LTD
发明人： RICHARDS HUGH COLIN
IPC分类号： C07D215/06 , C07D215/12 , C07D215/18 , C07D215/38 , C07D215/48 , C07D215/60 , C12P17/12 , A61K31/47
CPC分类号： C12P17/12 , C07D215/06 , C07D215/12 , C07D215/18 , C07D215/38 , C07D215/48 , C07D215/60 , Y10S435/913
摘要： Novel 2-aminoalkyl-7-substituted-1,2,3,4,-tetrahydroquinoline compounds, useful as effective anti-schistosomal agents, are disclosed and suitable modes of preparation are described. These compounds all possess either nitro, cyano or halogen substituted at the 7-position of the molecule, in addition to having a methyl, hydroxymethyl, alkoxymethyl or formyl group located at the adjacent 6-position.

82. 发明授权

US3438860A Process for the preparation of pyridoxal-5'-phosphate 失效
标题翻译：制备吡咯烷-5'-磷酸酯的方法
公开(公告)号：US3438860A
公开(公告)日：1969-04-15
申请号：US3438860D
申请日：1967-02-24
申请人： DAINIPPON PHARMACEUTICAL CO
发明人： SHOJI OSAMU , YOKOGAWA KANAE , SUNAHARA NORIYUKI , OGATA KOICHI
IPC分类号： C07F9/58 , C12P17/12 , C12B1/00
CPC分类号： C07F9/582 , C12P17/12 , Y10S435/829 , Y10S435/831 , Y10S435/859 , Y10S435/874 , Y10S435/875
摘要： 1,178,550. Pyridoxal-5 1 -phosphate. DAINIPPON PHARMACEUTICAL CO. Ltd. 2 March, 1967 [4 March, 1966; 29 Oct., 1966], No. 9944/67. Heading C2V. Pyridoxal-5 1 -phosphate is obtained by oxidation of pyridoxine-5 1 -phosphate or pyridoxamine-51-phosphate with enzymes of certain micro-organisms in the presence of 1 to 20 mol parts of an α-amino acid which can form a Schiff's base with pyridoxal-5 1 -phosphate, or a salt of such an α-amino acid, and 0À5 to 4 mol parts of a salt of zinc, nickel, magnesium, iron, copper, aluminium, vanadium, mercury or arsenic, per mol part of the starting phosphate. In examples pyridoxine-5 1 -phosphate is reacted with extracts obtained from cells produced by growing Alcaligenes faecalis in aqueous media, the reactions being carried out in the presence of lysine monohydrochloride, sodium glutamate, zinc sulphate, magnesium chloride and nickel chloride.
摘要翻译： 1,178,550。吡哆醛-5磷酸酯。大ON药业有限公司1967年3月2日[1966年3月4日] 1966年10月29日]，第9944/67号。标题C2V。吡哆醛-5磷酸酯是通过在1〜1的存在下用某些微生物的酶氧化吡哆醇-5β-磷酸酯或吡哆胺-5-磷酸而得到的可以形成具有吡哆醛-5β-磷酸盐的席夫碱或这样的α-氨基酸的盐的20摩尔份的α-氨基酸和0〜5〜4摩尔的盐的锌，镍，镁，铁，铜，铝，钒，汞或砷。在实施例中，吡哆素-5磷酸酯与从水溶液中生长的产碱杆菌产生的细胞获得的提取物反应，反应在赖氨酸单盐酸盐，谷氨酸钠，硫酸锌，镁氯化物和氯化镍。

83. 发明授权

US3086917A Method for producing orotic acid by fermentation process 失效
标题翻译：通过发酵工艺生产乳清酸的方法
公开(公告)号：US3086917A
公开(公告)日：1963-04-23
申请号：US11694361
申请日：1961-06-14
申请人： KYOWA HAKKO KOGYO KK
发明人： SHUKUO KINOSHITA , KATSUNOBU TANAKA , KAZUO KIMURA
IPC分类号： C12P17/12
CPC分类号： C12P17/12 , Y10S435/861

84. 发明申请

US20180273917A1 HEME PROTEIN CATALYSTS FOR CARBON-BORON BOND FORMATION IN VITRO AND IN VIVO 审中-公开
公开(公告)号：US20180273917A1
公开(公告)日：2018-09-27
申请号：US15914788
申请日：2018-03-07
申请人： California Institute of Technology
发明人： S.B. Jennifer Kan , Xiongyi Huang , Kai Chen
IPC分类号： C12N9/02 , C12P17/10 , C12P17/12
CPC分类号： C12N9/0053 , C07K14/195 , C12P17/10 , C12P17/12 , C12Y109/03001
摘要： Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.

85. 发明申请

US20180208955A1 Microbiological Process 审中-公开
公开(公告)号：US20180208955A1
公开(公告)日：2018-07-26
申请号：US15915194
申请日：2018-03-08
申请人： GlaxoSmithKline Intellectual Property Development Limited
发明人： Emilio ALVAREZ-RUIZ , Andrew John COLLIS , Alison Sarah DANN , Andrew Peter FOSBERRY , Sarah Jane READY , Maria Jesus VAZQUEZ MUNIZ
IPC分类号： C12P17/12 , C12N1/20 , C12P19/26 , C12R1/465 , C07D211/46 , A61K31/445
CPC分类号： C12P17/12 , A61K31/445 , C07D211/46 , C12N1/20 , C12P19/26 , C12R1/465 , Y02A50/481
摘要： A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.

86. 发明授权

US09738915B2 Biocatalytic transamination process 有权
公开(公告)号：US09738915B2
公开(公告)日：2017-08-22
申请号：US14649308
申请日：2013-12-03
申请人： Merck Sharp & Dohme Corp.
发明人： Paul Gerard Bulger , Birgit Kosjek , Nelo Rivera
IPC分类号： C12P17/12 , C12P13/00 , C12N9/10 , C07D211/02
CPC分类号： C12P17/12 , C07D211/02 , C12N9/1096 , C12P13/001 , C12Y206/01
摘要： A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: employing dynamic kinetic resolution (DKR). The DKR process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors which may be useful for the treatment of cancer.

87. 发明申请

US20170218414A1 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF ADIPATE, HEXAMETHYLENEDIAMINE AND 6-AMINOCAPROIC ACID 审中-公开
公开(公告)号：US20170218414A1
公开(公告)日：2017-08-03
申请号：US15263149
申请日：2016-09-12
申请人： Genomatica, Inc.
发明人： Mark J. BURK , Anthony P. BURGARD , Robin E. OSTERHOUT , Priti PHARKYA
IPC分类号： C12P17/10 , C12P13/00 , C12N15/52
CPC分类号： C12P17/10 , C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P13/02 , C12P17/12
摘要： The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

88. 发明授权

US09630923B2 Biocatalyzed synthesis of the optically pure (R) and (S) 3-methyl-1,2,3,4-tetrahydroquinoline and their use as chiral synthons for the preparation of the antithrombic (21R)- and (21S)-argatroban 有权
公开(公告)号：US09630923B2
公开(公告)日：2017-04-25
申请号：US14992226
申请日：2016-01-11
申请人： Euticals S.P.A.
发明人： Paride Grisenti
IPC分类号： C07D215/06 , C12P41/00 , C12P17/12 , C12P17/16
CPC分类号： C07D215/06 , C12P17/12 , C12P17/165 , C12P41/004
摘要： The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3R) and (3S)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in particular, for the preparation of diastereomerically pure (21R) and (21S)-agratroban and its analogs. New compounds used as intermediates in the process of the invention are also disclosed.

89. 发明申请

US20170009264A1 PROCESSES AND METHODS OF MANUFACTURE OF ARECOLINE 有权
标题翻译：方法制备方法及方法
公开(公告)号：US20170009264A1
公开(公告)日：2017-01-12
申请号：US15272211
申请日：2016-09-21
申请人： Vapor Corp
发明人： Edwin Balder
IPC分类号： C12P17/12 , A24B15/30 , A24B15/16 , A61K31/455 , A61K36/889
CPC分类号： C12P17/12 , A23L25/30 , A24B15/16 , A24B15/167 , A61K31/455 , A61K36/889 , A61K2236/13 , A61K2236/15 , A61K2236/19 , A61K2236/51
摘要： Processes and methods of manufacturing an areca fruit product. One process may include the steps of providing a plurality of areca fruits, drying the plurality of areca fruits, dehusking the plurality of areca fruits to obtain a plurality of areca nuts, chopping, shredding or grinding the plurality of areca nuts into a multiplicity of areca nut particles, introducing the multiplicity of areca nut particles into a tank containing water, agitating the multiplicity of areca nut particles to create a slurry, determining an amount of arecoline in the slurry and pumping the water having the predetermined amount of arecoline through a filter and into a holding tank and evaporating the arecoline from the water. Additional steps include fermentation, distillation, pasteurization, and cold pressing of the arecoline to produce a synthetic nicotine and/or botanical pesticide.
摘要翻译：槟榔果制品的制作方法和方法。一个过程可以包括以下步骤：提供多个果实果实，干燥多个果实果实，去掉多个果实果实以获得多个芥末果实，切碎，切碎或将多个槟榔粉碎成多个芥末螺母颗粒，将多种槟榔螺母颗粒引入含有水的罐中，搅拌多个槟榔螺母颗粒以产生浆料，确定浆料中的槟榔碱量并通过过滤器泵送具有预定量的槟榔碱的水，进入储罐并从水中蒸发槟榔碱。另外的步骤包括发酵，蒸馏，巴氏消毒和槟榔碱的冷压以产生合成的尼古丁和/或植物性农药。

90. 发明申请

US20160355856A1 MICROBIOLOGICAL PROCESS 审中-公开
标题翻译：微生物学过程
公开(公告)号：US20160355856A1
公开(公告)日：2016-12-08
申请号：US15118924
申请日：2015-02-17
申请人： GlaxoSmithKline Intellectual Property Development Limited
发明人： Emilio ALVAREZ-RUIZ , Andrew John COLLIS , Alison Sarah DANN , Andrew Peter FOSBERRY , Sarah Jane READY , Maria Jesus VAZQUEZ MUNIZ
IPC分类号： C12P17/12 , C12R1/465 , C12N1/20 , A61K31/445 , C07D211/46
CPC分类号： C12P17/12 , A61K31/445 , C07D211/46 , C12N1/20 , C12P19/26 , C12R1/465 , Y02A50/481
摘要： A process for the microbial synthesis of migalastat, specifically a process for the production of migalastat comprising culturing a microorganism under conditions such that at least one imino sugar is produced and detecting and/or isolating an imino sugar produced by said microorganism, and the microorganisms used in this process. The invention also comprises migalastat produced according to the above method and pharmaceutical compositions and uses thereof.
摘要翻译：用于微生物合成migalastat的方法，特别是一种生产migalastat的方法，包括在产生至少一种亚氨基糖并检测和/或分离由所述微生物产生的亚氨基糖的条件下培养微生物，所用微生物在这个过程中。本发明还包括根据上述方法制备的migastastat及其药物组合物及其用途。

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