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81. 发明授权

US08987367B2 Energy absorbing composition and impact and sound absorbing applications thereof 有权
标题翻译：能量吸收组合物及其吸收和吸音应用
公开(公告)号：US08987367B2
公开(公告)日：2015-03-24
申请号：US13826978
申请日：2013-03-14
申请人： Joel L. Sereboff
发明人： Joel L. Sereboff
IPC分类号： C09B67/00 , C08J9/16
CPC分类号： C09K5/00 , C08L83/04 , C08L89/00 , C08L99/00 , F23M20/005 , F24V99/00 , G10K11/165 , Y10T428/13
摘要： A substantially non-elastic incompressible composition, which substantially does not quickly self-level under standard operating conditions, includes: a suspending agent which reacts substantially as a solid when subjected to forces below a critical force, and which becomes substantially flowable when subjected to forces above said critical force. Aspects include compositions comprising one or more of ceramic microparticulates, flexible-walled microparticulates, celled macroparticulates, and fibers dispersed within the suspending agent, and energy absorbing applications thereof. Another aspect comprises thin-walled macrospheres containing a substantially non-elastic incompressible composition.
摘要翻译：基本上不弹性的不可压缩组合物在标准操作条件下基本上不能快速自我水平，包括：当受到临界力以下的作用时基本上作为固体反应的悬浮剂，并且当受到力时变得基本上可流动高于上述临界力。方面包括包含一种或多种陶瓷微粒，柔性壁微粒，细胞大颗粒和分散在悬浮剂中的纤维的组合物及其能量吸收应用。另一方面包括含有基本上非弹性的不可压缩组合物的薄壁大球。

82. 发明授权

US08980295B2 Multifunctional in situ polymerized network via thiol-ene and thiol-maleimide chemistry 有权
标题翻译：多功能原位聚合网络通过硫醇 - 烯和硫醇 - 马来酰亚胺化学
公开(公告)号：US08980295B2
公开(公告)日：2015-03-17
申请号：US13411387
申请日：2012-03-02
申请人： Weiyuan J. Kao , Yao Fu
发明人： Weiyuan J. Kao , Yao Fu
IPC分类号： A61K31/7088 , A61K35/00 , A61K38/22 , A61K38/43 , A61K47/36 , C08J3/24 , A61L15/26 , A61L15/44 , A61L15/58 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/54 , C08H1/06 , C08L1/04 , C08L1/28 , C08L5/04 , C08L5/08 , C08L89/00 , A61K38/00
CPC分类号： C08J3/246 , A61K38/00 , A61L15/26 , A61L15/44 , A61L15/585 , A61L27/18 , A61L27/26 , A61L27/52 , A61L27/54 , C08H1/06 , C08J2371/02 , C08J2389/00 , C08L1/04 , C08L1/286 , C08L5/04 , C08L5/08 , C08L89/00 , C08L71/02
摘要： Biomaterials that support cell attachment and growth are provided. In one aspect, biomaterials are provided comprising a first polymer matrix comprising reactive amino moieties and a second polymer matrix that interpenetrates with the first polymer matrix, where the second polymer matrix comprises a poly(alkylene oxide) comprising two or more alkylene oxide oligomers joined by gamma-thioether carbonyl linkages. In another aspect, biomaterials are provided comprising at least one biopolymer comprising amino groups, thiol groups, and bifunctional modifiers connecting at least some of the amino groups to at least some of the thiol groups; and at least one poly(alkylene oxide) cross-linked to at least two thiol groups of the biopolymer. The biomaterials may further comprise a pharmacologically active agent or cells. Methods of administering such biomaterials to a patient in need thereof are also provided.
摘要翻译：提供了支持细胞附着和生长的生物材料。在一个方面，提供生物材料，其包含包含反应性氨基部分的第一聚合物基质和与第一聚合物基质相互渗透的第二聚合物基质，其中第二聚合物基质包含包含两个或多个环氧烷低聚物的聚（环氧烷） γ-硫醚羰基键。在另一方面，提供生物材料，其包含至少一种包含氨基，硫醇基和至少部分氨基连接至至少一些巯基的双官能改性剂的生物聚合物; 和至少一种与生物聚合物的至少两个硫醇基交联的聚（环氧烷）。生物材料还可以包含药理活性剂或细胞。还提供了向有需要的患者施用这种生物材料的方法。

83. 发明授权

US08974778B2 Method for drying biomaterials 有权
公开(公告)号：US08974778B2
公开(公告)日：2015-03-10
申请号：US13326558
申请日：2011-12-15
申请人： Sarjit Johal
发明人： Sarjit Johal
IPC分类号： A61K45/00 , C08L97/02 , A23K1/14 , A23K1/16 , A23L1/03 , A23L1/054 , A23L1/172 , C08L5/00 , C08L89/00 , C08L99/00
CPC分类号： A23K1/009 , A23K10/18 , A23K10/37 , A23K20/163 , A23L7/152 , A23L29/065 , A23L29/269 , A23Y2220/00 , A23Y2260/00 , A23Y2280/00 , A23Y2300/00 , A23Y2320/00 , C08L5/00 , C08L89/00 , C08L97/02 , C08L99/00 , Y02P60/877 , Y10S426/805 , C08L2666/26 , C08L2666/02
摘要： The present invention provides a means to concentrate, dry and formulate biomaterials such as polysaccharides, gums and related biopolymers, and microorganisms such as cells, spores, and the like from dilute solutions using spent germ and other oil bearing residues. In addition, the spent germ can serve as a carrier for such biomaterials. The sorbed materials are useful in animal feeds.

84. 发明授权

US08951505B2 Methods and systems for mineralization of demineralized tissue 有权
标题翻译：软化组织矿化的方法和系统
公开(公告)号：US08951505B2
公开(公告)日：2015-02-10
申请号：US12576058
申请日：2009-10-08
申请人： David Henry Pashley , Franklin Chi-Meng Tay
发明人： David Henry Pashley , Franklin Chi-Meng Tay
IPC分类号： A61Q11/00 , A61K8/02 , A61K8/24 , A61K33/06 , A61K6/033
CPC分类号： A61K6/033 , A61K6/087 , C08L89/00
摘要： Disclosed are systems, methods, compositions and kits for mineralizing tissue, particularly dental tissue. The methods, compositions and kits may be used to strengthen and prevent weakening of the tissue. For example, the methods, compositions and kits may be used for treating and filling cavities in teeth caused by tooth decay.
摘要翻译：公开了用于矿化组织，特别是牙科组织的系统，方法，组合物和试剂盒。方法，组合物和试剂盒可用于加强和防止组织的变弱。例如，方法，组合物和试剂盒可用于治疗和填充由牙齿蛀牙引起的牙齿空洞。

85. 发明申请

US20150038043A1 CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF 有权
公开(公告)号：US20150038043A1
公开(公告)日：2015-02-05
申请号：US14293308
申请日：2014-06-02
申请人： Trustees of Tufts College
发明人： David L. KAPLAN , Ung-Jin KIM , Jaehyung PARK , Hyoung-Joon JIN
IPC分类号： A61L27/22 , B29D7/01 , B29C39/20 , B29C39/00 , B29C55/00
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

86. 发明申请

US20150031863A1 CONJUGATING AMINES 有权
标题翻译：混合氨基酸
公开(公告)号：US20150031863A1
公开(公告)日：2015-01-29
申请号：US14128958
申请日：2012-07-11
申请人： Edward T. Ryan , Pavol Kovac , Firdausi Qadri , Peng Xu , Stephen B. Calderwood , Willie Frank Vann , Dwight Christopher Peterson
发明人： Edward T. Ryan , Pavol Kovac , Firdausi Qadri , Peng Xu , Stephen B. Calderwood , Willie Frank Vann , Dwight Christopher Peterson
IPC分类号： A61K47/48 , A61K39/02 , A61K39/08
CPC分类号： A61K47/4833 , A61K9/0019 , A61K39/08 , A61K39/107 , A61K47/646 , A61K2039/55544 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C08B37/00 , C08H1/00 , C08L89/00 , Y02A50/472 , Y02A50/478 , Y02A50/484
摘要： The disclosure provides directly conjugated polysaccharide vaccine molecules and methods related thereto.
摘要翻译：本公开内容提供直接缀合的多糖疫苗分子及其相关方法。

87. 发明申请

US20150031259A1 FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDER COMPOSITIONS 有权
标题翻译：无甲醛无蛋白含量的组合物
公开(公告)号：US20150031259A1
公开(公告)日：2015-01-29
申请号：US14168458
申请日：2014-01-30
申请人： JOHNS MANVILLE
发明人： Mingfu Zhang , Kiarash Alavi Shooshtari , Jawed Asrar
IPC分类号： C08L35/06 , C08J5/24
CPC分类号： C08L35/06 , C08H99/00 , C08J5/24 , C08J2389/00 , C08K5/0025 , C08K7/02 , C08K7/14 , C08L33/00 , C08L33/02 , C08L89/00 , C08L2205/16 , C08L2666/02 , C09J133/02 , C09J189/00 , D04H1/587 , Y10T428/253 , Y10T428/2933 , Y10T442/20 , Y10T442/2992
摘要： One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.
摘要翻译：描述了可以包括蛋白质和交联组合的单组分粘合剂组合物。交联组合可以包括至少第一交联化合物和第二交联化合物。第一和第二交联化合物可以彼此和蛋白质单独交联。蛋白质的实例包括大豆蛋白。还描述了制造纤维产品的纤维产品和方法。在基于一部分粘合剂组合物的溶液的固化的热固性粘合剂中，纤维产品可以包括有机纤维，无机纤维或两者。

88. 发明申请

US20150030656A1 Composition and Method for Delivery of BMP-2 Amplifier/Co-Activator for Enhancement of Osteogenesis 审中-公开
标题翻译：用于增强骨形成的BMP-2放大器/辅助活化剂的组合物和方法
公开(公告)号：US20150030656A1
公开(公告)日：2015-01-29
申请号：US14452304
申请日：2014-08-05
申请人： BioSurface Engineering Technologies, Inc.
发明人： Paul Zamora , Brent Lee Atkinson , Xinhua Lin , Louis A. Pena
IPC分类号： C07K14/47 , A61L27/12 , A61L27/24 , A61L27/22
CPC分类号： C07K14/4705 , A61K38/1875 , A61L27/12 , A61L27/16 , A61L27/22 , A61L27/227 , A61L27/24 , A61L27/34 , A61L27/507 , A61L2430/02 , C07K14/51 , C08L27/18 , C08L89/00
摘要： A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
摘要翻译：包含合成生长因子类似物的组合物，其包含非生长因子肝素结合区，接头和与细胞表面受体特异性结合的序列和骨传导性材料，其中所述合成生长因子类似物与所述合成生长因子类似物连接并可从骨传导材料是骨诱导的放大器/辅助激活物。

89. 发明授权

US08937025B2 Formaldehyde-free protein-containing binders for spunbond products 有权
标题翻译：用于纺粘产品的不含甲醛的含蛋白质的粘合剂
公开(公告)号：US08937025B2
公开(公告)日：2015-01-20
申请号：US13296768
申请日：2011-11-15
申请人： Mingfu Zhang , Jawed Asrar , Zhihua Guo
发明人： Mingfu Zhang , Jawed Asrar , Zhihua Guo
IPC分类号： C09J189/00 , C08H99/00 , C08L33/02 , C08L89/00 , C08J5/24 , C08J3/24 , C08K5/00 , C08K7/02 , C08K7/14
CPC分类号： C08J5/24 , C08H99/00 , C08J3/243 , C08J3/246 , C08J2325/08 , C08J2325/18 , C08J2389/00 , C08K5/0025 , C08K7/02 , C08K7/14 , C08L33/00 , C08L33/02 , C08L89/00 , C08L101/00 , C08L2205/16 , C09J189/00 , D04H3/12 , Y10T442/60 , Y10T442/681
摘要： One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions.
摘要翻译：描述了可以包括蛋白质和交联组合的单组分粘合剂组合物。交联组合可以包括至少第一交联化合物和第二交联化合物。第一和第二交联化合物可以彼此和蛋白质单独交联。蛋白质的实例包括大豆蛋白。还描述了制造纤维产品的纤维产品和方法。在基于一部分粘合剂组合物的溶液的固化的热固性粘合剂中，纤维产品可以包括有机纤维，无机纤维或两者。

90. 发明授权

US08906444B2 Diazonium salt modification of silk polymer 有权
标题翻译：丝绸聚合物的重氮盐改性
公开(公告)号：US08906444B2
公开(公告)日：2014-12-09
申请号：US13479709
申请日：2012-05-24
申请人： David L. Kaplan , Amanda Murphy
发明人： David L. Kaplan , Amanda Murphy
IPC分类号： B05D3/00 , C12N5/02 , A61K38/17 , C08L89/00 , C08H1/00
CPC分类号： C09D189/00 , C08H1/00 , C08L89/00
摘要： A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.
摘要翻译：本文描述了通过将化学部分偶联到丝聚合物的酪氨酸残基来修饰丝聚合物的方法，用于改变丝蛋白的物理性质。因此，可以通过本文所述的方法制备具有所需物理性质的丝蛋白。当需要向哺乳动物引入细胞时，这些方法特别有用，因为对丝蛋白的修饰会影响所需细胞的物理性质，因此影响粘附，代谢活性和细胞形态。可以修饰丝蛋白以产生或修饰为所需细胞提供最佳环境的结构。

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