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81. 发明授权

US08772507B2 Imidazole-benzamide anti-cancer agents 有权
标题翻译：咪唑 - 苯甲酰胺抗癌剂
公开(公告)号：US08772507B2
公开(公告)日：2014-07-08
申请号：US13612690
申请日：2012-09-12
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D233/64 , C07D231/12 , A61K31/415 , A61K31/4164
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

82. 发明授权

US08586585B2 Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease 失效
标题翻译：用于治疗淀粉样蛋白病和突触核蛋白病如阿尔茨海默病，2型糖尿病和帕金森病的化合物，组合物和方法
公开(公告)号：US08586585B2
公开(公告)日：2013-11-19
申请号：US13413417
申请日：2012-03-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , Charlotte Coffen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen
IPC分类号： A01N43/58 , A61K31/50 , A61K31/497 , A01N43/40 , A61K31/435
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译：双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，其合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是Aβ淀粉样变性中的用途，例如在阿尔茨海默病，IAPP淀粉样变性在2型糖尿病中观察到，以及突触核蛋白病，例如在帕金森病中观察到的，以及用于这种治疗的药物的制造。

83. 发明申请

US20130245128A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES, AND PARKINSON'S DISEASE 有权
标题翻译：用于治疗阿尔茨海默病，类型2糖尿病和帕金森病的淀粉样变性和合并症的化合物，组合物和方法
公开(公告)号：US20130245128A1
公开(公告)日：2013-09-19
申请号：US13887762
申请日：2013-05-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen
IPC分类号： C07C49/248
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： The use of 3,4,3′,4′-tetrahydroxychalcone in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease.
摘要翻译： 3,4,3'，4'-四羟基查耳酮用于治疗淀粉样蛋白病，特别是Aβ型淀粉样变性，例如阿尔茨海默病，IAPP淀粉样变性，如2型糖尿病观察到的突触核蛋白病，以及突触核蛋白病，如帕金森病

84. 发明申请

US20120225890A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER'S DISEASE, TYPE 2 DIABETES AND PARKINSON'S DISEASE 失效
标题翻译：化合物，组合物和治疗淀粉样变性疾病和合并症的方法，如阿尔茨海默病，2型糖尿病和帕金森病
公开(公告)号：US20120225890A1
公开(公告)日：2012-09-06
申请号：US13413417
申请日：2012-03-06
申请人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
发明人： Alan D. Snow , Beth Nguyen , Gerardo Castillo , Virginia Sanders , Thomas Lake , Lesley Larsen , Rex T. Weavers , Stephen Lorimer , David Larsen , David L. Coffen , Charlotte Coffen
IPC分类号： A61K31/495 , C07D211/44 , A61K31/45 , C07D295/10 , C07D241/04 , A61P25/16 , A61K31/44 , C07D213/69 , A61P25/28 , A61P3/10 , A61P29/00 , A61P35/00 , C07D295/096 , C07D213/30
CPC分类号： C07C49/248 , A61K31/047 , C07C39/15 , C07C39/16 , C07C39/17 , C07C45/62 , C07C45/64 , C07C49/83 , C07C49/835 , C07C69/017 , C07C215/50 , C07C231/02 , C07C235/34 , C07C235/38 , C07C235/48 , C07C235/54 , C07C235/56 , C07C237/22 , C07C275/34 , C07D207/16 , C07D211/74 , C07D213/30 , C07D213/69 , C07D213/85 , C07D221/08 , C07D221/18 , C07D231/06 , C07D241/08 , C07D263/38 , C07D265/38 , C07D295/096 , C07D295/192 , C07D311/60 , C07D317/50 , C07D317/54 , C07D317/58 , C07D317/60 , C07D317/66 , C07D317/68 , C07D333/16 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D451/06 , C07D471/04 , C07D487/08 , C07D491/08
摘要： Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要翻译：双 - 和三 - 二羟基芳基化合物及其亚甲二氧基类似物和药学上可接受的酯，它们的合成，含有它们的药物组合物及其在治疗淀粉样蛋白病，尤其是A＆诸如在阿尔茨海默病中观察到的淀粉样变性，诸如在2型糖尿病中观察到的IAPP淀粉样变性和诸如在帕金森病中观察到的突触核蛋白病，以及用于这种治疗的药物的制造。

86. 发明授权

US08129355B2 Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex 有权
标题翻译：通过蜕皮激素受体复合物调节外源基因表达的酮配体
公开(公告)号：US08129355B2
公开(公告)日：2012-03-06
申请号：US11889988
申请日：2007-08-17
申请人： Colin M. Tice , Enrique L. Michelotti , Robert E. Hormann
发明人： Colin M. Tice , Enrique L. Michelotti , Robert E. Hormann
IPC分类号： A61K48/00 , A01N33/18 , C12N15/00
CPC分类号： C07D487/04 , C07C233/31 , C07C233/76 , C07C235/46 , C07C235/48 , C07C235/50 , C07C235/54 , C07C237/32 , C07C271/20 , C07C275/24 , C07C311/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D211/56 , C07D211/58 , C07D309/14 , C07D317/54 , C07D319/18 , C07D321/08 , C07D335/02 , C07F9/36 , C07K14/70567 , C07K14/721 , C12Q1/6897
摘要： This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.
摘要翻译：本发明涉及一种调节外源基因表达的方法，其中蜕皮激素受体复合物包含：DNA结合域; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。配体包括一类酮。

87. 发明申请

US20110312092A1 DUAL-TERMINAL AMIDE HYDROGELLING AGENT 失效
标题翻译：双端氨基酸加氢剂
公开(公告)号：US20110312092A1
公开(公告)日：2011-12-22
申请号：US13201111
申请日：2010-02-23
申请人： Hitoshi Tamiaki , Keishiro Ogawa , Kazunori Toma
发明人： Hitoshi Tamiaki , Keishiro Ogawa , Kazunori Toma
IPC分类号： C12N5/02 , C12N5/071 , C07C235/48
CPC分类号： C07C235/48 , C12N5/0068 , C12N2533/30
摘要： Disclosed is a benzamide derivative represented by formula (1). In the formula, k1 represents an integer from 0-4, m1 represents an integer from 1-100, and n1 represents an integer from 1-6. In addition, R1 represents a hydrocarbon group with 8-22 carbon atoms bonded via an oxygen atom; R2 represents H or a hydrocarbon group with 1-22 carbon atoms bonded via an oxygen atom; R3 represents H or a hydrocarbon group with 1-22 carbon atoms bonded via an oxygen atom; and R2 and R3 are not H at the same time.
摘要翻译：公开了式（1）表示的苯甲酰胺衍生物。式中k1表示0-4的整数，m1表示1-100的整数，n1表示1-6的整数。另外，R 1表示通过氧原子键合碳原子数为8〜22的烃基， R2表示H或通过氧原子键合有1-22个碳原子的烃基; R3表示H或通过氧原子键合有1-22个碳原子的烃基; R2和R3不同时为H。

88. 发明申请

US20110201817A1 LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF 有权
标题翻译： LEVODOPA PRODRUGS及其组合物及其用途
公开(公告)号：US20110201817A1
公开(公告)日：2011-08-18
申请号：US13095101
申请日：2011-04-27
申请人： Jia-Ning XIANG , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
发明人： Jia-Ning XIANG , Mark A. Gallop , Cindy X. Zhou , Mark Nguyen , Xuedong Dai , Jianhua Li , Kenneth C. Cundy , Nelson L. Jumbe
IPC分类号： C07C229/36 , C07D213/803
CPC分类号： C07C235/60 , C07C229/34 , C07C229/36 , C07C235/48 , C07C2601/14 , C07D213/79 , C07D213/80 , C07D213/803
摘要： Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
摘要翻译：公开了左旋多巴的前药，制备左旋多巴的前药的方法，使用左旋多巴的前药的方法和左旋多巴的前药组合物。

89. 发明授权

US07985879B2 Process for making galantamine 有权
标题翻译：加兰他敏的制备方法
公开(公告)号：US07985879B2
公开(公告)日：2011-07-26
申请号：US12080380
申请日：2008-04-02
申请人： Lunghu Wang , Yung Fa Chen , Julian Paul Henschke
发明人： Lunghu Wang , Yung Fa Chen , Julian Paul Henschke
IPC分类号： C07C231/02
CPC分类号： C07C231/02 , C07D491/20 , C07C235/48
摘要： A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (−)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4-hydroxyphenyl]ethyl) amine.
摘要翻译：制备N-甲基-N-（2- [4-羟基苯基]乙基）-5-羟基-4-甲氧基苯甲酰胺的新方法，其可用作（ - ） - 加兰他敏合成中的中间体，包括5-羟基-4-甲氧基苯甲酸衍生物与N-甲基-N-（2- [4-羟基苯基]乙基）胺的反应。

90. 发明授权

US07956010B2 Amide compound and use thereof for controlling plant diseases 失效
标题翻译：酰胺化合物及其用途，用于防治植物病害
公开(公告)号：US07956010B2
公开(公告)日：2011-06-07
申请号：US12451126
申请日：2008-04-25
申请人： Takashi Komori , Mayumi Kubota , Yuichi Matsuzaki
发明人： Takashi Komori , Mayumi Kubota , Yuichi Matsuzaki
IPC分类号： A01N37/18 , C07C233/00
CPC分类号： C07C235/48 , A01N37/40 , A01N43/44 , C07C235/46 , C07C235/54 , C07C2601/14 , C07C2601/16
摘要： Disclosed is an amide compound represented by the formula (1) below, which has excellent plant disease controlling activity. In the formula, X1 represents a fluorine atom or a methoxy group; X2 represents a hydrogen atom, a halogen atom, a C1-C4 alkyl group or the like; X3 represents a halogen atom, a C1-C4 alkyl group or the like; Z represents an oxygen atom or a sulfur atom; and A represents an A1-CR11R12R13 group, an A2-Cy1 group or an A3-Cy2 group, wherein A1 represents a CH2 group or the like, A2 represents a single bond, a CH2 group or the like, A3 represents a C1-C3 haloalkyl group, a C2-C4 alkenyl group or the like, Cy1 represents a C3-C6 cycloalkyl group substituted with a C1-C6 alkoxy group or the like, Cy2 represents a C3-C6 cycloalkyl group which may be substituted with a halogen atom or the like, R11 and R12 independently represent a C1-C4 alkyl group, and R13 represents a halogen atom, a hydroxyl group or the like.
摘要翻译：公开了下述式（1）表示的酰胺化合物，其具有优异的植物病害防治活性。在该式中，X 1表示氟原子或甲氧基; X2表示氢原子，卤素原子，C1-C4烷基等; X3表示卤素原子，C1-C4烷基等; Z表示氧原子或硫原子; A表示A1-CR11R12R13基团，A2-Cy1基团或A3-Cy2基团，其中A1表示CH2基团等，A2表示单键，CH2基团等，A3表示C1-C3 卤代烷基，C2-C4烯基等，Cy1表示被C1-C6烷氧基等取代的C3-C6环烷基，Cy2表示可被卤素原子取代的C3-C6环烷基或 R11和R12独立地表示C1-C4烷基，R13表示卤素原子，羟基等。

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