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81. 发明申请

US20140370614A1 HILIC / ANION-EXCHANGE / CATION-EXCHANGE MULTIMODAL MEDIA 有权
公开(公告)号：US20140370614A1
公开(公告)日：2014-12-18
申请号：US13918481
申请日：2013-06-14
申请人： Xiaodong LIU , Christopher A. POHL , Jinhua CHEN
发明人： Xiaodong LIU , Christopher A. POHL , Jinhua CHEN
IPC分类号： B01J20/281
CPC分类号： G01N30/482 , B01D15/305 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/288 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J43/00
摘要： The present invention provides an agglomerated multimodal chromatographic medium. the medium of the invention includes groups active in anion exchange, cation exchange and hydrophilic interaction chromatographic modalities. The invention provides methods of making these media and using them in separations of analytes. Also provided are separations devices incorporating the medium and systems incorporating these separations devices.
摘要翻译：本发明提供了聚集的多峰色谱介质。本发明的介质包括在阴离子交换，阳离子交换和亲水相互作用层析方式中有活性的基团。本发明提供了制备这些介质并将其用于分析物分离的方法。还提供了并入介质的分离装置和并入这些分离装置的系统。

82. 发明申请

US20140124445A1 TEMPERATURE-RESPONSIVE MONOLITHIC POROUS BODY, METHOD FOR PRODUCING SAME, AND TEMPERATURE-RESPONSIVE CHROMATOGRAPHY METHOD USING SAME 审中-公开
标题翻译：温度响应的单体多孔体，其制造方法和使用相同的温度响应色谱法
公开(公告)号：US20140124445A1
公开(公告)日：2014-05-08
申请号：US14003366
申请日：2012-03-12
申请人： Kenichi Nagase , Jun Kobayashi , Akihiko Kikuchi , Yoshikatsu Akiyama , Hideko Kanazawa , Teruo Okano
发明人： Kenichi Nagase , Jun Kobayashi , Akihiko Kikuchi , Yoshikatsu Akiyama , Hideko Kanazawa , Teruo Okano
IPC分类号： B01J20/288 , B01D15/42
CPC分类号： G01N30/54 , B01D15/22 , B01D15/3876 , B01D15/42 , B01J20/267 , B01J20/28042 , B01J20/283 , B01J20/288 , B01J20/3204 , B01J20/3219 , B01J20/327 , B01J2220/825 , C07J1/00 , C07J7/009 , G01N30/50 , G01N2030/528
摘要： A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° C. and being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° C., from the initiator using an atom transfer radical process under a presence of a catalyst.
摘要翻译：得到一种温度响应整体多孔材料，其包含具有在0至80℃的温度范围内变化的水合能力的聚合物，并通过结合原子转移自由基聚合以高密度固定在多孔材料的表面上引发剂到多孔材料的表面，并且使用原子转移自由基法在具有0至80℃的温度范围内变化的水合能力的聚合物的生长反应下，在催化剂。

83. 发明授权

US08702988B2 Polar-modified bonded phase materials for chromatographic separations 有权
标题翻译：用于色谱分离的极性改性的键合相材料
公开(公告)号：US08702988B2
公开(公告)日：2014-04-22
申请号：US11438562
申请日：2006-05-22
申请人： Guang Q. Li
发明人： Guang Q. Li
IPC分类号： B01J20/288 , B01J20/32
CPC分类号： B01J20/288 , B01J20/3227
摘要： Novel compositions are disclosed for use as a stationary phase in chromatography comprising an inorganic substrate that is modified with at least one silane having the formula R1δ-Qα-(CH2)βSiR2γX3-γ. In a preferred embodiment, the inorganic substrate is silica gel and is modified with at least two silanes. Methods of preparation and use in chromatographic applications are disclosed. The novel compositions provide superior chromatographic performance, reduced silanol activity, enhanced stability, and reproducibility in preparation and performance.
摘要翻译：公开了用于色谱法中的固定相的新型组合物，其包含用至少一种具有式R 1-Qα-（CH 2）bgr; SiR 2γX3-γ的硅烷改性的无机基质。在优选的实施方案中，无机底物是硅胶，并用至少两种硅烷改性。公开了在色谱应用中的制备和使用方法。该新型组合物提供优异的色谱性能，降低的硅烷醇活性，增强的稳定性和制备和性能的重现性。

84. 发明授权

US08476335B2 Method of manufacturing monolithic stationary phase and monolithic stationary phase produced thereby 有权
标题翻译：制造由此产生的单片固定相和整体固定相的方法
公开(公告)号：US08476335B2
公开(公告)日：2013-07-02
申请号：US13235681
申请日：2011-09-19
申请人： Hsi-Ya Huang , Yung-Han Shih , Chao-Hsiang Hsu , Wan-Ling Liu , Singco Brenda
发明人： Hsi-Ya Huang , Yung-Han Shih , Chao-Hsiang Hsu , Wan-Ling Liu , Singco Brenda
IPC分类号： C08F20/22 , C08F2/46 , B29D11/00 , H05B6/68 , C08J3/28
CPC分类号： C08F2/46 , B01J20/28042 , B01J20/286 , B01J20/288 , B01J2220/86 , C08F292/00 , C08F230/08 , C08F220/10 , C08F212/08 , C08F212/36
摘要： The present invention relates to a method of manufacturing a polymer-based monolithic stationary phase in an ionic liquid reaction medium via microwave-assisted vinylization and polymerization. The invention is time-effective and environmental friendly for not using volatile organic compounds.
摘要翻译：本发明涉及通过微波辅助乙烯化和聚合在离子液体反应介质中制造基于聚合物的整体固定相的方法。本发明对于不使用挥发性有机化合物是时效且环保的。

85. 发明授权

US08425778B2 Organosilanes and substrate bonded with same 有权
标题翻译：有机硅烷和与其粘合的底物
公开(公告)号：US08425778B2
公开(公告)日：2013-04-23
申请号：US13464644
申请日：2012-05-04
申请人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供了新颖的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在底物上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

86. 发明申请

US20130067991A1 Hydrocarbon Separation and Analysis Apparatus and Methods 有权
标题翻译：烃分离与分析装置及方法
公开(公告)号：US20130067991A1
公开(公告)日：2013-03-21
申请号：US13237568
申请日：2011-09-20
申请人： John F. Schabron , Ryan B. Boysen , Eric W. Kalberer , Joseph F. Rovani, JR.
发明人： John F. Schabron , Ryan B. Boysen , Eric W. Kalberer , Joseph F. Rovani, JR.
IPC分类号： C10L1/00 , G01N30/02 , G06Q90/00 , C10C3/00 , C10C3/08
CPC分类号： C10G53/08 , B01D15/00 , B01D15/08 , B01D15/265 , B01J20/103 , B01J20/281 , B01J20/283 , B01J20/284 , B01J20/286 , B01J20/287 , B01J20/288 , B01J2220/603 , C10G25/00 , C10G25/003 , C10G25/12 , C10G2300/206 , C10G2400/30 , G01N30/14 , G01N30/461 , G01N30/468 , G01N33/2823 , G01N33/2835 , G01N2030/027 , G01N2030/085 , G01N2030/143 , G01N2030/8854
摘要： The inventive technology may involve, in particular embodiments, novel use of a non-porous, high surface energy stationary phase to adsorb, in reversible fashion, the most polar component of a resins fraction of an input hydrocarbon when a mobile phase is passed over the stationary phase. Such reversible adsorption prevents irreversibly adsorption of such components on active stationary phase(s) downflow of the non-porous, high surface energy stationary phase, thereby conserving stationary phase costs and increasing resolution of resins elutions, and accuracy of hydrocarbon component results. Aspects of the inventive technology may also involve a novel combination of a solubility based asphaltene component fractionating and analysis method and an adsorption chromatography method for separating and/or analyzing saturate, aromatics and resins components of an input hydrocarbon.
摘要翻译：在具体实施方案中，本发明的技术可以涉及无孔高表面能固定相的新用途，以可逆的方式吸附输入烃的树脂级分的最极性组分，当流动相通过固定相。这种可逆吸附防止这些组分在无孔，高表面能固定相的活性固定相向下流动中的不可逆吸附，从而保持固定相成本和提高树脂洗脱液的分离度以及烃组分结果的准确性。本发明技术的方面还可以涉及一种基于溶解度的沥青质组分分馏和分析方法的新型组合以及用于分离和/或分析输入烃的饱和物，芳族化合物和树脂组分的吸附层析方法。

87. 发明申请

US20130026099A1 ORGANOSILANES AND SUBSTRATE BONDED WITH SAME 有权
标题翻译：有机硅和底物与其结合
公开(公告)号：US20130026099A1
公开(公告)日：2013-01-31
申请号：US13464644
申请日：2012-05-04
申请人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
发明人： Xiadong Liu , Christopher A. Pohl , Andrei V. Bordunov , Nebojsa Avdalovic
IPC分类号： B01D15/08 , G01N30/00
CPC分类号： B01J20/288 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3285 , C07F7/1804
摘要： The present invention provides novel silicon compounds, methods for making these novel silicon compounds, compositions comprising these novel silicon compounds attached to substrates, methods for attaching the novel silicon compounds to substrates and methods for using the compositions in a variety of chromatographic applications.
摘要翻译：本发明提供了新颖的硅化合物，制备这些新型硅化合物的方法，包含这些新型硅化合物附着在底物上的组合物，将新型硅化合物附着于底物的方法以及在各种色谱应用中使用该组合物的方法。

88. 发明申请

US20110100915A1 Packing Material For Hydrophilic Interaction Chromatography 审中-公开
标题翻译：亲水相互作用色谱的包装材料
公开(公告)号：US20110100915A1
公开(公告)日：2011-05-05
申请号：US13001653
申请日：2009-06-04
申请人： Taketoshi Kanda , Yasuo Igarashi , Kenichi Sakuma , Yousuke Toujo
发明人： Taketoshi Kanda , Yasuo Igarashi , Kenichi Sakuma , Yousuke Toujo
IPC分类号： B01D15/08 , C07F9/09 , B01D15/32 , B01J20/286
CPC分类号： B01D15/305 , B01D15/322 , B01D15/364 , B01J20/261 , B01J20/28016 , B01J20/28019 , B01J20/288 , B01J20/289 , B01J20/3204 , B01J20/3219 , B01J20/3259 , B01J20/3285 , Y10T428/2982
摘要： The object of the present invention is to provide a packing material and a separation method that manifest excellent hydrophilic interactions.The present invention provides a packing material for hydrophilic interaction chromatography consisting of a modified support treated with the surface modifier represented by the following formula (6) or (7).(In this formula, m denotes 2-6 and n denotes 1-4. X1, X2, and X3, independent of each other, denote a methoxy group, ethoxy group, or halogen. Up to two of X1, X2, and X3 can be any of the following groups: a methyl group, ethyl group, propyl group, isopropyl group, butyl group, or isobutyl group.)
摘要翻译：本发明的目的是提供一种表现出优异的亲水相互作用的包装材料和分离方法。本发明提供一种用于亲水相互作用色谱的包装材料，其由用下式（6）或（7）表示的表面改性剂处理的改性载体组成。（在该式中，m表示2-6，n表示1-4，X1，X2，X3彼此独立地表示甲氧基，乙氧基或卤素，直至2个X 1，X 2，X 3 可以是甲基，乙基，丙基，异丙基，丁基或异丁基中的任一个。）

89. 发明申请

US20100016536A1 Process for Analyzing, for Separating, and for Isolating Individual Polar Protic Monomers and/or Oligomers 审中-公开
标题翻译：用于分离，分离和分离单个极性促进单体和/或低聚物的方法
公开(公告)号：US20100016536A1
公开(公告)日：2010-01-21
申请号：US12487243
申请日：2009-06-18
申请人： Mark A. Kelm , Christopher J. Johnson , Rebecca J. Robbins
发明人： Mark A. Kelm , Christopher J. Johnson , Rebecca J. Robbins
IPC分类号： B01D15/08 , C07H1/06 , C07K1/16 , C07C231/24 , C07C41/34
CPC分类号： B01D15/32 , B01J20/286 , B01J20/288 , B01J2220/54
摘要： An improved process for separating and isolating individual polar protic monomer(s) and/or oligomer(s) on the basis of degree of polymerization. A liquid sample containing polar protic monomer(s) and/or oligomer(s) is introduced into a liquid chromatography (LC) column packed with a polar bonded stationary chromatographic phase. The individual polar protic monomer(s) and/or oligomer(s) are separated via a binary mobile phase elution. One or more individual fractions containing the monomer(s) and/or oligomer(s) are eluted. The polar protic monomer(s) and/or oligomer(s) may be proanthocyanidins, hydrolyzable tannins, oligosaccharides, oligonucleotides, peptides, acrylamides, polysorbates, polyketides, poloxarners, polyethylene glycols, polyoxyethylene alcohols or polyvinyl alcohols. The binary mobile phase comprises an A phase consisting essentially of a polar aprotic solvent and a B phase consisting essentially of a polar protic solvent.A process for separating and isolating xanthine(s) (e.g., caffeine and theobromine) from polar protic monomer(s) and/or oligomer(s). A liquid sample containing xanthine(s) and polar protic monomer(s) and/or oligomer(s) is introduced into an LC column packed with a polar bonded stationary chromatographic phase. The xanthines are separated via an isocratic mobile phase elution, and one or more individual fractions containing the xanthines are eluted.
摘要翻译：基于聚合度分离和分离各极性质子单体和/或低聚物的改进方法。将含有极性质子单体和/或低聚物的液体样品引入填充有极性键合静止色谱相的液相色谱（LC）柱中。单独的极性质子单体和/或低聚物通过二元流动相洗脱分离。洗脱含有单体和/或低聚物的一种或多种单独级分。极性质子单体和/或低聚物可以是原花青素，可水解单宁，寡糖，寡核苷酸，肽，丙烯酰胺，聚山梨醇酯，聚酮化合物，聚硅氧烷，聚乙二醇，聚氧乙烯醇或聚乙烯醇。二元流动相包含基本上由极性非质子溶剂和基本上由极性质子溶剂组成的B相组成的A相。从极性质子单体和/或低聚物分离和分离黄嘌呤（例如咖啡因和可可碱）的方法。将含有黄嘌呤和极性质子单体和/或低聚物的液体样品引入填充有极性键合的静止色谱相的LC柱中。黄嘌呤通过等度流动相洗脱分离，并且洗脱含有黄嘌呤的一个或多个单独级分。

90. 发明申请

US20090281288A1 MATRIX FOR SEPARATION OF POLYETHERS AND METHOD OF SEPARATION 有权
标题翻译：用于分离聚合物的基质和分离方法
公开(公告)号：US20090281288A1
公开(公告)日：2009-11-12
申请号：US12506445
申请日：2009-07-21
申请人： JAMES VAN ALSTINE , Jan Bergstrom , Henrik Ihre , Tobias Soderman
发明人： JAMES VAN ALSTINE , Jan Bergstrom , Henrik Ihre , Tobias Soderman
IPC分类号： C07K1/14 , C07C29/74
CPC分类号： B01J20/3278 , B01D15/32 , B01D15/362 , B01D15/38 , B01D15/424 , B01J20/286 , B01J20/288 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/328
摘要： The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.
摘要翻译：本发明涉及一种分离基质，其由其上已经连接有聚合物链的表面的载体组成，其中每个聚合物链呈现重复的质子供体基团，并且载体的至少表面基本上是亲水的。在最有利的实施方案中，载体是多孔交联琼脂糖，聚合物是聚（丙烯酸），质子供体基团是羧基。该矩阵是有用的。以从液体中的聚乙二醇化和/或天然化合物中除去PEG。因此，本发明还包括诸如色谱方法的方法，其中使用根据本发明的分离基质，例如作为包含未反应的PEG，聚乙二醇化蛋白质和天然蛋白质的反应混合物的预处理。

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