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81. 发明申请

US20140163644A1 MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM 有权
标题翻译：微型可入侵神经系统
公开(公告)号：US20140163644A1
公开(公告)日：2014-06-12
申请号：US14098672
申请日：2013-12-06
申请人： Medtronic, Inc.
发明人： Erik R. Scott , John E. Kast , Xuan K. Wei , Todd V. Smith , Joel A. Anderson , Forrest C.M. Pape , Duane L. Bourget , Timothy J. Denison , David A. Dinsmoor , Randy S. Roles , Stephen J. Roddy
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61B17/00234 , A61N1/02 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36007 , A61N1/36021 , A61N1/3605 , A61N1/36053 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36139 , A61N1/37205 , A61N1/37211 , A61N1/37223 , A61N1/37235 , A61N1/37247 , A61N1/37252 , A61N1/3727 , A61N1/375 , A61N1/3754 , A61N1/3756 , A61N1/3787 , F04C2270/0421
摘要： An external medical device generates a drive signal inductively coupled to an implantable coil from an external coil. A regulator module coupled to the implantable coil generates an output signal in response to the inductively coupled signal and a feedback signal correlated to an amplitude of the inductively coupled signal. A signal generator receives the output signal for generating a therapeutic electrical stimulation signal. The control module adjusts the drive signal in response to the feedback signal to control the electrical stimulation signal.
摘要翻译：外部医疗装置从外部线圈产生感应耦合到可植入线圈的驱动信号。耦合到可植入线圈的调节器模块响应于电感耦合信号和与电感耦合信号的振幅相关的反馈信号产生输出信号。信号发生器接收用于产生治疗性电刺激信号的输出信号。控制模块响应于反馈信号来调节驱动信号以控制电刺激信号。

82. 发明授权

US08666504B2 Communication and charging circuitry for a single-coil implantable medical device 有权
标题翻译：用于单线圈可植入医疗设备的通信和充电电路
公开(公告)号：US08666504B2
公开(公告)日：2014-03-04
申请号：US13608490
申请日：2012-09-10
申请人： Vasily Dronov , Jordi Parramon , Robert Ozawa , Md. Mizanur Rahman , Emanuel Feldman
发明人： Vasily Dronov , Jordi Parramon , Robert Ozawa , Md. Mizanur Rahman , Emanuel Feldman
IPC分类号： A61N1/05
CPC分类号： H01F38/14 , A61N1/36 , A61N1/37223 , A61N1/3787 , H02J50/12 , H04Q9/12
摘要： Communication and charging circuitry for an implantable medical device is described having a single coil for receiving charging energy and for data telemetry. The circuitry removes from the AC side of the circuit a tuning capacitor and switch traditionally used to tune the tank circuitry to different frequencies for telemetry and charging. As such, the tank circuitry is simplified and contains no switchable components. A switch is serially connected to the storage capacitor on the DC side of the circuit. During telemetry, the switch is opened, thus disconnecting the storage capacitor from the tank circuit, and alleviating concerns that this capacitor will couple to the tank circuit and interfere with telemetry operations. During charging, the switch is closed, which allows the storage capacitor to couple to the tank circuitry through the rectifier during some portions of the tank circuitry's resonance.
摘要翻译：描述了用于可植入医疗装置的通信和充电电路，其具有用于接收充电能量和用于数据遥测的单个线圈。该电路从电路的AC侧消除了调谐电容器和传统上用于将电路调谐到不同频率的开关，用于遥测和充电。因此，容器电路被简化并且不包含可切换的部件。开关串联连接到电路直流侧的存储电容器。在遥测期间，开关打开，从而将存储电容器与储能电路断开，并减轻该电容器将耦合到储能电路并干扰遥测操作的担忧。在充电期间，开关闭合，这允许存储电容器在储罐电路的共振的某些部分期间通过整流器耦合到储能电路。

83. 发明申请

US20140031897A1 DEVICE FOR THE TREATMENT OF SKIN 审中-公开
标题翻译：用于治疗皮肤的装置
公开(公告)号：US20140031897A1
公开(公告)日：2014-01-30
申请号：US13944440
申请日：2013-07-17
申请人： Edelgard Liebl
发明人： Horst LIEBL
IPC分类号： A61N1/36
CPC分类号： A61N1/36 , A61B2018/143 , A61M37/0015 , A61N1/0464 , A61N1/0468 , A61N1/0476 , A61N1/0502 , A61N1/205 , A61N1/326 , A61N1/328
摘要： A skin treatment device includes a roller rotatably mounted about its longitudinal axis and having needles protruding radially outwardly from its peripheral surface, and a device for establishing electrical contact between at least part of the needles and a voltage source having first and second poles, including first and second terminals capable of being electrically connected to the first and second poles, respectively, a first contacting zone electrically connected to first needles, a second contacting zone spaced and electrically insulated from the first contacting zone and electrically connected to second needles, the terminals and the contacting zones being configured such that when the first terminal is connected to the first contacting zone, the second terminal is likewise connected to the second contacting zone. The first and the second needles are each arranged in a row, the rows being separated from each other in a circumferential direction of the roller.
摘要翻译：皮肤治疗装置包括可围绕其纵向轴线可旋转地安装并具有从其外周表面径向向外突出的针的辊，以及用于在至少一部分针之间建立电接触的装置和具有第一和第二极的电压源，包括第一以及第二端子，其能够分别电连接到所述第一和第二极;电连接到第一针的第一接触区，与所述第一接触区间隔并电绝缘并与所述第二接触区电连接的第二接触区，所述端子和所述接触区域构造成使得当所述第一端子连接到所述第一接触区域时，所述第二端子同样连接到所述第二接触区域。第一针和第二针各自排列成一排，这些排在辊的圆周方向上彼此分离。

84. 发明申请

US20140031886A1 VENTRICULAR PACING TO AUGMENT ATRIAL NATRIURETIC HORMONE PRODUCTION 审中-公开
标题翻译：静脉输送至胃肠道胃肠激素生产
公开(公告)号：US20140031886A1
公开(公告)日：2014-01-30
申请号：US14045572
申请日：2013-10-03
申请人： Cardiac Pacemakers, Inc.
发明人： Jeffrey E. Stahmann , Ramesh Wariar , Stephen B. Ruble
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36 , A61N1/362 , A61N1/3627 , A61N1/365
摘要： Intermittent delivery of ventricular pacing pulses synchronized to occur during an atrial diastole time period can be used to provide atrial stretch therapy and augment the production and release of atrial natriuretic hormone.
摘要翻译：间歇性输送心房舒张期同步发生的心室起搏脉冲可用于提供心房伸展疗法，并增加心房钠尿激素的产生和释放。

85. 发明申请

US20140024881A1 Sensor device for treatment and remote monitoring of vital biological parameters 有权
标题翻译：用于治疗和远程监测重要生物参数的传感器装置
公开(公告)号：US20140024881A1
公开(公告)日：2014-01-23
申请号：US13984545
申请日：2012-02-14
申请人： Antonio Alexandre , Alvise Alexandre , Andrea Alexandre
发明人： Antonio Alexandre , Alvise Alexandre , Andrea Alexandre
IPC分类号： A61N2/00 , A61N5/06 , A61N1/36
CPC分类号： A61N2/002 , A61B5/0022 , A61B5/02438 , A61B5/0816 , A61B5/11 , A61B5/14552 , A61B5/6804 , A61B2562/164 , A61N1/36 , A61N5/0625 , G06F19/00 , G16H40/67
摘要： A portable multi-sensor device (1) comprises a substantially sheet-like and at least partially flexible unit support element (2), a garment (W) designed to be worn by a user and to be removably associated with the unit element (2), a plurality of sensors (S), adapted to detect biological and/or vital parameters on the body of a user and transduce them into electric signals, at least one of which is incorporated in the unit support element (2), transceiver means (6) for remote transmission of the electric signals to a remote monitoring center (C), processing and control means (6′) for processing and controlling the associated electric signals, therapeutic treatment means (21) associated with the unit support element (2) and designed to contact one part of the wearer's body. The therapeutic treatment means (21) are electrically connected to the processing and control means (6′) to be controlled thereby and to provide therapeutic and/or thermal therapeutic treatment to the area of the body with which they are in contact.
摘要翻译：便携式多传感器装置（1）包括基本上片状的和至少部分柔性的单元支撑元件（2），设计成由使用者佩戴并且可拆卸地与单元元件（2）相关联的衣服（W）），多个传感器（S），其适于检测用户身体上的生物和/或生命参数，并将其转换成电信号，其中至少一个被并入单元支撑元件（2）中，收发器装置（6），用于将电信号远程传输到远程监控中心（C），用于处理和控制相关电信号的处理和控制装置（6'），与单元支撑元件（2）相关联的治疗处理装置（21）），并设计用于接触穿戴者身体的一部分。治疗处理装置（21）电连接到要被控制的加工和控制装置（6'），并且向与其接触的身体的区域提供治疗和/或热治疗处理。

86. 发明授权

US08594783B2 Systems and methods for stimulating cellular function in tissue 有权
公开(公告)号：US08594783B2
公开(公告)日：2013-11-26
申请号：US13216313
申请日：2011-08-24
申请人： Timothy Andrew Wagner
发明人： Timothy Andrew Wagner
IPC分类号： A61N1/02
CPC分类号： A61N1/36025 , A61B2018/00994 , A61F7/00 , A61N1/205 , A61N1/325 , A61N1/326 , A61N1/327 , A61N1/36 , A61N1/36021 , A61N7/00 , A61N2007/0021 , A61N2007/0026
摘要： The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.

87. 发明申请

US20130288260A1 Compositions and Methods For Enhancing the Biological Response to Chemical Agents and Physical Stimuli 审中-公开
标题翻译：用于增强对化学试剂和物理刺激的生物反应的组合物和方法
公开(公告)号：US20130288260A1
公开(公告)日：2013-10-31
申请号：US13879551
申请日：2011-10-14
申请人： Clinton Rubin , Janet Rubin
发明人： Clinton Rubin , Janet Rubin
IPC分类号： A61N1/05 , A61M5/00 , C12N13/00
CPC分类号： A61N1/05 , A61M5/00 , A61M31/002 , A61N1/326 , A61N1/36 , A61N2/00 , A61N2/02 , A61N5/062 , C12N13/00
摘要： The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.
摘要翻译：本发明涉及构造成将刺激（例如治疗剂或治疗有益的信号）递送至细胞，组织，器官或生物体的组合物和方法。刺激施加至少两次，并且第一和第二应用分开休止期，其中不再进一步刺激。休息时间具有足以引起对第二刺激的增强的响应的持续时间（例如，约1-6小时）。

88. 发明授权

US08548579B2 System and methods for performing surgical procedures and assessments 有权
公开(公告)号：US08548579B2
公开(公告)日：2013-10-01
申请号：US13568236
申请日：2012-08-07
申请人： James Gharib , Allen Farquhar , Norbert Kaula , Eric Finley , Jamil Ebanna , Scot Martinelli , Goretti Medeiros
发明人： James Gharib , Allen Farquhar , Norbert Kaula , Jeffrey Blewett , Eric Finley , Jamil Ebanna , Scot Martinelli
IPC分类号： A61B5/04
CPC分类号： A61F2/4611 , A61B1/32 , A61B5/04001 , A61B5/0492 , A61B5/4893 , A61B5/6828 , A61B5/6831 , A61B17/0218 , A61B17/3417 , A61B17/3421 , A61B17/3423 , A61B34/20 , A61B34/25 , A61B90/36 , A61B90/37 , A61B2017/00039 , A61B2017/00199 , A61B2017/0262 , A61B2034/2053 , A61B2034/2072 , A61F2/4455 , A61F2002/4635 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/36135 , A61N1/36142 , A61N1/36157 , A61N1/37247
摘要： The present invention involves systems and related methods for performing surgical procedures and assessments, including the use of neurophysiology-based monitoring to: (a) determine nerve proximity and nerve direction to surgical instruments employed in accessing a surgical target site; (b) assess the pathology (health or status) of a nerve or nerve root before, during, or after a surgical procedure; and/or (c) assess pedicle integrity before, during or after pedicle screw placement, all in an automated, easy to use, and easy to interpret fashion so as to provide a surgeon-driven system.

89. 发明申请

US20130253628A1 DEVICE AND METHODS FOR RENAL NERVE MODULATION 审中-公开
标题翻译：用于神经调节的装置和方法
公开(公告)号：US20130253628A1
公开(公告)日：2013-09-26
申请号：US13838356
申请日：2013-03-15
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： Scott R. Smith , Mark L. Jenson
IPC分类号： A61N1/36
CPC分类号： A61N1/36 , A61B18/1492 , A61B18/18 , A61B2018/0022 , A61B2018/00232 , A61B2018/00285 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1467 , A61N2007/0043
摘要： Medical devices as well as methods for making and using medical devices are disclosed. An example medical device may include a system for nerve modulation. The system may include an elongate shaft having a proximal end region and a distal end region. A helical inflatable balloon may be coupled to the shaft. The balloon may have a proximal end, a distal end, and an outer surface. The balloon may be disposed adjacent to the distal end region of the elongate shaft. A first nerve modulation element may be attached to the balloon.
摘要翻译：公开了医疗设备以及制造和使用医疗设备的方法。示例性医疗装置可以包括用于神经调节的系统。该系统可以包括具有近端区域和远端区域的细长轴。螺旋状可充气气囊可以联接到轴。球囊可以具有近端，远端和外表面。气囊可以布置成与细长轴的远端区域相邻。第一神经调制元件可以附接到气囊。

90. 发明授权

US08535224B2 Electro diagnostic functional assessment unit (EFA-2) 有权
标题翻译：电诊断功能评估单位（EFA-2）
公开(公告)号：US08535224B2
公开(公告)日：2013-09-17
申请号：US12660075
申请日：2010-02-18
申请人： MaryRose Cusimano Reaston , Phil Reaston
发明人： MaryRose Cusimano Reaston , Phil Reaston
IPC分类号： A61B5/00
CPC分类号： A61B5/00 , A61B5/02055 , A61B5/024 , A61B5/026 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/11 , A61B5/225 , A61N1/36 , A61N7/00
摘要： An electro diagnostic functional assessment unit (EFA-2) that diagnoses age of and treats soft tissue injuries. The EFA-2 utilizes sensor(s) including EMG, Range of Motion, FCE, pinch and grip, and allows for monitoring of muscles and muscle groups to ascertain compliance, pain and function. The EFA-2 also monitors disc pathology and determines whether a person requires surgery or conservative care and, the age of the disc. Additionally, the EFA-2 monitors EEK activity and NCV, as well as invasive EMG that monitors nerve damage. Previously, with NCV the temperature and the position of electrodes would effect readings and produce false positive or false negative readings. The EFA-2 eliminates these problems by incorporating temperature sensor(s) and electrode placement sensor(s). The EFA-2 also provides direct treatment by means of ultrasound and electrical stimulation. Thus, the EFA-2 allows diagnosis any treatment by means of a single unit.
摘要翻译：诊断功能评估单元（EFA-2），用于诊断软组织损伤的年龄和治疗。 EFA-2使用包括EMG，运动范围，FCE，夹紧和抓地力的传感器，并允许监测肌肉和肌肉群以确定顺应性，疼痛和功能。 EFA-2还监测椎间盘病理学，并确定一个人是否需要手术或保守护理，以及椎间盘的年龄。此外，EFA-2监测EEK活动和NCV，以及监测神经损伤的侵入性EMG。以前，使用NCV，电极的温度和位置会影响读数并产生假的正或负的读数。 EFA-2通过并入温度传感器和电极放置传感器来消除这些问题。 EFA-2还通过超声和电刺激提供直接治疗。因此，EFA-2允许通过单个单元诊断任何治疗。

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