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81. 发明申请

US20010044617A1 Methods for extracting substances using alternating current 失效
标题翻译：使用交流电提取物质的方法
公开(公告)号：US20010044617A1
公开(公告)日：2001-11-22
申请号：US09783696
申请日：2001-02-13
发明人： S. Kevin Li , William I. Higuchi , Honggang Zhu , Yang Song
IPC分类号： A61N001/30 , A61M031/00
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/325
摘要： A variety of methods for extracting different substances such as endogenous substances, pharmaceutical substances, markers of disease, and their metabolites across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which extraction occurs, thereby allowing substances to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be utilized to assist in promoting extraction of the substance. The methods have utility in a variety of different clinical settings and applications.
摘要翻译：提供了各种用于提取不同物质的方法，例如内源性物质，药物物质，疾病标志物及其跨组织的代谢物。该方法利用AC信号在组织的区域中保持基本上恒定的电状态，通过该区域进行提取，从而允许以受控和可预测的方式将物质运送到组织上。某些方法包括可选的AC或DC预脉冲信号，以初始实现目标电状态。也可以使用可选的DC偏移信号来辅助促进物质的提取。该方法在各种不同的临床设置和应用中具有实用性。

82. 发明授权

US06259946B1 Iontophoresis device structure 有权
标题翻译：离子电渗装置结构
公开(公告)号：US06259946B1
公开(公告)日：2001-07-10
申请号：US09331766
申请日：1999-09-27
申请人： Naruhito Higo , Kazutaka Inoue , Kenji Mori
发明人： Naruhito Higo , Kazutaka Inoue , Kenji Mori
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0436
摘要： It is the object of the present invention to provide an iontophoresis device structure which has excellent contouring ability at its site of attachment, has very high safety, is of high quality with high product yields, and can be produced with fewer production steps to improve working efficiency and increase productivity to allow mass production at low cost. The iontophoresis device structure of the present invention has a construction provided with a cup-shaped support including a concave part, at least one electrification hole formed in the concave part, an electrode layer laid on the flat part of the rim of the concave part, and an electrolyte layer or drug-holding layer fitted into the concave part.
摘要翻译：本发明的目的是提供一种离子电渗装置结构，其在其附着部位具有优异的轮廓能力，具有非常高的安全性，具有高质量和高产率的离子电渗装置结构，并且可以用较少的生产步骤生产以改善工作提高效率并提高生产率，以便以低成本批量生产。本发明的离子电渗装置结构具有设置有杯状支撑体的结构，所述杯状支撑体包括凹部，在所述凹部中形成的至少一个带电孔，设置在所述凹部的边缘的平坦部分上的电极层，以及装配到凹部中的电解质层或药物保持层。

83. 发明授权

US6119037A Electrode system in iontophoretic treatment devices 失效
公开(公告)号：US6119037A
公开(公告)日：2000-09-12
申请号：US826706
申请日：1997-04-07
申请人： Dean L. Kellogg , Wojciech A. Kosiba
发明人： Dean L. Kellogg , Wojciech A. Kosiba
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/044
摘要： This invention relates to the field of medical devices employing electrophoresis to combat bacterial colonization. More particularly, it relates to an apparatus and method of providing an electrophoresis-type medical device that mitigates the burning of surrounding biological tissue. This invention uses grooves in the contact surface of the medical device for containing the electrodes which cause the electrophoresis to occur. The grooves allow the electrodes to contact biological fluid without contacting and hence burning the surrounding biological tissue. Through the use of this invention it is possible to provide an electrophoresis-type medical device while minimizing the burning of surrounding tissue.

84. 发明授权

US06094594A Hair removal system 失效
公开(公告)号：US06094594A
公开(公告)日：2000-07-25
申请号：US696721
申请日：1996-08-14
申请人： Robert Tapper
发明人： Robert Tapper
IPC分类号： A45D26/00 , A61B17/00 , A61K8/00 , A61K8/46 , A61N1/30 , A61N1/32 , A61Q9/04
CPC分类号： A61N1/044 , A61N1/325 , A61B2017/00752 , A61N1/0436 , A61N1/0448
摘要： A method and apparatus for selective long term and/or permanent hair removal from a biological subject by iontophoretic delivery of a chemical depilatory agent deeply into a hair removal site for effecting varying degrees of damage to hair roots.

85. 发明授权

US5983131A Apparatus and method for electroporation of tissue 失效
标题翻译：用于组织电穿孔的装置和方法
公开(公告)号：US5983131A
公开(公告)日：1999-11-09
申请号：US695032
申请日：1996-08-09
申请人： James C. Weaver , Uwe Pliquett , Timothy Vaughan
发明人： James C. Weaver , Uwe Pliquett , Timothy Vaughan
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0424 , A61N1/327 , A61N1/044
摘要： The present invention relates to an apparatus and method for localized electroporation of tissue. An apparatus includes a perforate electrically insulating layer, a first electrode at a first side of the perforate electrically insulating layer and a second electrode at a second side of the perforate electrically insulating layer. An electric field extending between the first and second electrodes will preferentially extend through perforations of the electrically insulating layer. The electric field thereby causes electroporation of tissue that is proximate to the first electrode and is partitioned from the electrically insulating layer and the second electrode by the first electrode. The apparatus controllably limits the depth of the electric field within a tissue, such as skin, thereby electroporating a surface layer, such as a stratum corneum layer of the skin, without stimulating submerged nerve endings within the skin. Sensation of the applied voltage and especially pain sensation can thereby be controlled by the invention.
摘要翻译：本发明涉及组织局部电穿孔的装置和方法。一种装置包括穿孔电绝缘层，在穿孔电绝缘层的第一侧的第一电极和在穿孔电绝缘层的第二侧的第二电极。在第一和第二电极之间延伸的电场将优先延伸穿过电绝缘层的穿孔。电场因此导致组织的电穿孔，其接近第一电极，并且通过第一电极与电绝缘层和第二电极分隔开。该装置可控制地限制组织（例如皮肤）内的电场的深度，由此电穿孔皮肤的表层，例如皮肤角质层，而不刺激皮肤内的淹没的神经末梢。因此，本发明可以控制施加电压的感觉，特别是疼痛感。

86. 发明授权

US5954684A Iontophoretic drug delivery system and method for using same 失效
标题翻译：离子电渗药物输送系统及其使用方法
公开(公告)号：US5954684A
公开(公告)日：1999-09-21
申请号：US541058
申请日：1995-10-11
申请人： Ronald J. Flower , Burton H. Sage, Jr.
发明人： Ronald J. Flower , Burton H. Sage, Jr.
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An iontophoretic drug delivery device of the present invention includes a power source and an electrode assembly containing at least two electrodes, in electrical contact with a first reservoir and a second reservoir. The present invention also includes at least three electrodes in a three electrode embodiment, with the third electrode in electrical contact with a third reservoir. In either embodiment, the first reservoir and the second reservoir contain an active agent to be delivered to an applied area of a patient. The present invention also includes in its two electrode embodiment a switch for reversing the flow of current or in its three electrode embodiment a switch for switching the flow of current, so as to reduce sensation. The devices also include a timer for controlling the amount of time the electrical current flows in each direction. In this way, the devices are suitable for use to deliver an active agent to the applied area approximate the first reservoir when the electrical current flows in one direction for a first period of time and to deliver an active agent to the applied area approximate the second reservoir when the electrical current flows in the other direction during a second period of time. Thus, reversing polarity or switching the flow of current between electrodes, and iontophoresing thereunder below the sensation threshold results in sensation anesthesia so that the current can be raised to deliver the drug without sensation.
摘要翻译：本发明的离子电渗药物输送装置包括电源和包含至少两个与第一储存器和第二储存器电接触的电极的电极组件。本发明还包括三电极实施例中的至少三个电极，其中第三电极与第三储存器电接触。在任一实施方案中，第一储存器和第二储存器包含待递送至患者的施用区域的活性剂。本发明在其两个电极实施例中还包括用于使电流流动或在其三电极实施例中用于切换电流的开关的开关，以便减少感觉。这些装置还包括用于控制电流在每个方向上流动的时间量的计时器。以这种方式，当电流在一个方向上流动第一时间段时，这些装置适用于将活性剂递送到施加的区域近似第一储存器，并将活性剂递送到施加的区域，接近第二储存器当电流在第二时间段期间在另一个方向上流动时，存储器。因此，反转极性或切换电极之间的电流流动以及低于感觉阈值的离子电导导致感觉麻醉，使得电流可以升高以递送药物而没有感觉。

87. 发明授权

US5899875A Device for percutaneous administration of medicaments for treating male impotence 失效
标题翻译：用于经皮给药的用于治疗男性阳of的药物的装置
公开(公告)号：US5899875A
公开(公告)日：1999-05-04
申请号：US836350
申请日：1997-05-12
申请人： Philippe Millot , Michel Lamoise
发明人： Philippe Millot , Michel Lamoise
IPC分类号： A61N1/30 , A61F5/37 , A61N1/05
CPC分类号： A61N1/0448 , A61N1/044
摘要： A device for the percutaneous administration of a medicament for treating male impotence comprises two reservoirs (1,2) hydratable with a medicament solution and intended to be applied to the skin of the penis. The reservoirs are mounted on substantially cylindrical bracelet-shaped means (8) with an elastically expansible diameter to support and press the reservoirs (1,2) against said skin during the treatment. The device includes a sensor which is fixed on the bracelet and is sensitive to the expansion of the bracelet in order to deliver a signal to the user.
摘要翻译： PCT No.PCT / FR95 / 01510 Sec。 371日期：1997年5月12日 102（e）日期1997年5月12日PCT提交1995年11月16日PCT公布。公开号WO96 / 14897 日期1996年5月23日用于经皮给药用于治疗男性阳a的药物的装置包括可与药物溶液水合并旨在施用于阴茎皮肤的两个储存器（1,2）。储存器安装在具有弹性可膨胀直径的基本上圆柱形的手镯形装置（8）上，以在处理期间支撑并压紧储存器（1,2）抵靠所述皮肤。该装置包括固定在手镯上的传感器，并且对手镯的扩张敏感，以向用户传递信号。

88. 发明授权

US5622530A Method and apparatus for controlled environment electrotransport 失效
公开(公告)号：US5622530A
公开(公告)日：1997-04-22
申请号：US451119
申请日：1995-05-26
申请人： Joseph B. Phipps
发明人： Joseph B. Phipps
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： Methods for conducting controlled environment electrotransport are described. The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected control over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for controlled environment electrotransport are also described. In general the apparatus comprises an electrotransport system including an active electrode reservoir having therein both a primary electrode arrangement and a secondary electrode arrangement, with a control arrangement for selected operation of both. The secondary electrode arrangement, being operated different from the primary electrode arrangement, is selected for operation to selectively enhance or otherwise modify ion presence in the active electrode reservoir, to achieve application of the general methods described. The apparatus may include a sensor means therein, for use as feedback to a control system during operation. Methods and systems involving diffusion type delivery are also described.

89. 发明授权

US5591123A Programmable control mounting system for transdermal drug applicator 失效
标题翻译：用于透皮药物涂抹器的可编程控制安装系统
公开(公告)号：US5591123A
公开(公告)日：1997-01-07
申请号：US381141
申请日：1995-01-30
申请人： Dan Sibalis , Sanford Rosen
发明人： Dan Sibalis , Sanford Rosen
IPC分类号： A61M37/00 , A61N1/30
CPC分类号： A61N1/044 , A61M37/00 , A61N1/0448 , A61N1/303 , A61M2037/0007 , A61N1/0444
摘要： A transdermal drug applicator (100) for application to a living body for the delivery of at least one drug through the skin (144) into the bloodstream comprising an applicator (100) including at least one drug reservoir (182A,182B) containing the drug for delivering same through the skin (144) by physico/chemical mass transfer. A mounting structure (138, 140) is removably mounted to the body for holding the applicator (100) to the skin (144), with the applicator (100) removably connected to the mounting structure (138,140). A power supply (166) for the applicator (100) and a circuit transmitting electrical power from the power supply (166) to the applicator (100) is disclosed, wherein an electric circuit is created between the applicator (100) and the skin (144). The device includes a computer (158) with the mounting structure (138,140) for receiving programmed instructions relative to the drug, and transmitting signals relative to the drug and the programmed instructions to the power supply (166) for regulating the generation of power and delivery of drug through the skin (144).
摘要翻译：一种用于施用于生物体以将至少一种药物通过皮肤（144）输送到血流中的透皮药物施用器（100），其包括施用器（100），所述施用器（100）包括至少一个含有药物的药物储存器（182A，182B）用于通过物理/化学传质通过皮肤（144）输送它。安装结构（138,140）可移除地安装到主体上，用于将涂敷器（100）保持在皮肤（144）上，涂抹器（100）可移除地连接到安装结构（138,140）。公开了一种用于涂敷器（100）的电源（166）和从电源（166）向施加器（100）传输电力的电路，其中在施加器（100）和皮肤（100）之间产生电路 144）。该装置包括具有安装结构（138,140）的计算机（158），用于接收关于药物的编程指令，以及将相对于药物的信号和编程指令传送到电源（166），用于调节功率和输送的产生的药物通过皮肤（144）。

90. 发明授权

US5356632A Transdermal drug delivery device 失效
标题翻译：透皮给药装置
公开(公告)号：US5356632A
公开(公告)日：1994-10-18
申请号：US759006
申请日：1991-09-12
申请人： Joseph Gross , Shlomo Zucker
发明人： Joseph Gross , Shlomo Zucker
IPC分类号： A61N1/30 , A61F13/00
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/303
摘要： A transdermal drug delivery device includes anode and cathode electrodes supported on a base member in spaced relation to each other to define a gap therebetween, a gel containing a liquid drug to be delivered covering the gap and in contact with both of the electrodes, and a liquid permeable sheet covering the gel containing the liquid to be delivered.
摘要翻译：透皮药物递送装置包括阳极和阴极电极，所述阳极和阴极电极彼此间隔开地支撑在基底构件上以在它们之间形成间隙，所述凝胶含有待传送的液体药物覆盖所述间隙并与两个电极接触，透液片覆盖含有待输送液体的凝胶。

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