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81. 发明授权

US09636424B2 Composition, method, system and kit for optical electrophysiology 有权
公开(公告)号：US09636424B2
公开(公告)日：2017-05-02
申请号：US15159376
申请日：2016-05-19
申请人： The Research Foundation of State University of New York , The University of Connecticut
发明人： Arkady M. Pertsov , Arvydas Matiukas , Leslie M. Loew , Joseph P. Wuskell
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , C09B23/01 , G01N21/47 , G01N21/64 , A61K47/10 , C09B23/10 , A61B5/04
CPC分类号： A61K49/0032 , A61B5/0059 , A61B5/0071 , A61B5/04 , A61B2503/40 , A61K47/10 , A61K49/0017 , A61K49/0019 , A61K49/006 , C09B23/0075 , C09B23/107 , G01N21/4795 , G01N21/6428
摘要： The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.

82. 发明申请

US20170065729A1 PSMA-TARGETED NIR DYES AND THEIR USES 有权
标题翻译： PSMA靶向近红外及其用途
公开(公告)号：US20170065729A1
公开(公告)日：2017-03-09
申请号：US14937169
申请日：2015-11-10
申请人： On Target Laboratories, LLC
发明人： Sumith A. Kularatne , Philip S. Low , Pravin Gagare , Carrie Myers
IPC分类号： A61K49/00 , G01N33/58 , C07K5/083 , C07D209/20 , C07K5/062
CPC分类号： A61K49/0052 , A61K49/0017 , A61K49/0032 , A61K49/0056 , A61K49/16 , C07D209/20 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06095 , C07K5/06121 , C07K5/06147 , C07K5/06156 , C07K5/0806 , C07K5/0812 , C07K5/0817 , C07K5/1019 , C07K7/02 , C07K7/06 , C12Y304/17021 , G01N21/6428 , G01N33/57434 , G01N33/57492 , G01N2021/6439 , G01N2333/948
摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
摘要翻译：本公开涉及与近红外（NIR）染料缀合的前列腺特异性膜抗原（PSMA）靶向化合物及其治疗和诊断用途的方法。更具体地，本公开提供了用于诊断和治疗与表达前列腺特异性膜抗原（PSMA）的细胞和/或血管系统相关的疾病的化合物和方法，例如前列腺癌和相关疾病。本公开进一步描述了制备和使用化合物的方法和组合物，并入化合物的方法，以及并入化合物的试剂盒。

83. 发明授权

US09585972B2 Method for imaging a site of arthritis in an animal 有权
标题翻译：用于成像动物中关节炎部位的方法
公开(公告)号：US09585972B2
公开(公告)日：2017-03-07
申请号：US14116711
申请日：2012-05-09
申请人： Sherry L. Thornton , Xiaoyang Qi , Matthew J. Flick
发明人： Sherry L. Thornton , Xiaoyang Qi , Matthew J. Flick
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , A61K9/51
CPC分类号： A61K49/0056 , A61B5/004 , A61B5/0071 , A61B5/4528 , A61B2503/40 , A61K9/5146 , A61K49/0017
摘要： The present disclosure demonstrates that a nanovesicle comprising a membrane-associated lysosomal protein (saposin C; “SapC”) incorporated into a phospholipid has a high fusogenic affinity for phosphatidylserine-rich domains on the surfaces of target cell membranes. It is believed that the nanovesicles target surface exposed phosphatidylserine on the membranes of cells associated with arthritis, allowing for detection of local tissue damage associated with arthritis. In plasma membranes, phosphatidylserine is normally present only on the inner leaflet but is “flipped” to the outer leaflet upon the presence of cell damage. Incorporation of the fluorophore in the nanovesicles allows for the in vivo visualization of the fluorophore in targeted tissue and provides a technique to detect and evaluate the onset and progression of arthritic disease in an animal. Furthermore, the use of the nanovesicle in optical imaging methods provides great promise for analyzing events occurring early in the pathogenesis of arthritis and arthritic disease.
摘要翻译：本公开内容表明包含掺入磷脂的膜相关溶酶体蛋白（saposin C;“SapC”）的纳米囊体对靶细胞膜表面上的磷脂酰丝氨酸富集结构域具有高融合亲和力。据信纳米囊体将表面暴露的磷脂酰丝氨酸靶向与关节炎相关的细胞膜，允许检测与关节炎相关的局部组织损伤。在质膜中，磷脂酰丝氨酸通常仅存在于内部小叶上，但是在存在细胞损伤时被“翻转”到外部小叶上。荧光团在纳米囊中的引入允许目标组织中的荧光团的体内可视化，并且提供了检测和评价动物中关节炎疾病发病和进展的技术。此外，纳米囊在光学成像方法中的应用为分析关节炎和关节炎疾病发病早期发生的事件提供了巨大的前景。

84. 发明授权

US09579402B2 Heterocycle-substituted xanthene dyes 有权
标题翻译：杂环取代的呫吨染料
公开(公告)号：US09579402B2
公开(公告)日：2017-02-28
申请号：US12850578
申请日：2010-08-04
申请人： Fei Mao , Wai-Yee Leung , Ching-Ying Cheung , Hye Eun Hoover
发明人： Fei Mao , Wai-Yee Leung , Ching-Ying Cheung , Hye Eun Hoover
IPC分类号： C07D233/64 , A61K49/00 , C07D311/88 , C07D405/04 , C07D491/147 , C07K1/13 , C07K16/28 , C07K16/32 , C07D491/22
CPC分类号： C07H15/26 , A61K49/0017 , C07D311/88 , C07D405/04 , C07D405/14 , C07D491/147 , C07D491/22 , C07F9/65586 , C07K1/13 , C07K16/00 , C07K16/2809 , C07K16/32 , Y10T436/25
摘要： The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
摘要翻译：本发明一般涉及荧光染料。本发明提供了广泛的荧光染料和含有该荧光染料的试剂盒，其可用于标记各种生物分子，细胞和微生物。本发明还提供使用荧光染料进行研究，开发鉴定，环境研究，诊断，预后和/或治疗疾病的各种方法。

85. 发明申请

US20170049380A1 Diagnostic System for the Detection of Skin Cancer 审中-公开
标题翻译：诊断系统检测皮肤癌
公开(公告)号：US20170049380A1
公开(公告)日：2017-02-23
申请号：US15345378
申请日：2016-11-07
申请人： Catherine M. Shachaf , Amit Shachaf
发明人： Catherine M. Shachaf , Amit Shachaf
IPC分类号： A61B5/00 , A61K49/00
CPC分类号： A61B5/444 , A61B5/0071 , A61B5/0077 , A61B5/416 , A61B5/445 , A61B2090/306 , A61B2560/0431 , A61B2562/0233 , A61B2562/046 , A61B2562/164 , A61B2562/166 , A61B2576/02 , A61K49/0004 , A61K49/0006 , A61K49/0017 , A61K51/00
摘要： Methods and compositions are provided for the analysis of skin surfaces to determine the presence of neoplastic tissue. In the methods of the invention, a composition comprising a florescent probe that binds to a specific neoplasia associated marker is applied topically to the area of interest. After topical administration, the probe preferentially binds to markers associated in neoplastic lesions in situ, which binding is detected with a compact illumination unit that provides illumination at a wavelength appropriate for image acquisition. The illumination unit comprises a light source and fiber optic bundle to direct the light towards the area of examination. A detection unit is used to capture and record an image of the area of investigation. The detection unit may be a digital camera, film camera, etc. A mapping module may also be provided to catalogue the site of examination.
摘要翻译：提供方法和组合物用于分析皮肤表面以确定肿瘤组织的存在。在本发明的方法中，将包含结合特定瘤形成相关标志的荧光探针的组合物局部施用于感兴趣区域。局部给药后，探针优先与原位肿瘤病变相关的标志物结合，用紧凑的照明单元检测结合，该照明单元以适合于图像采集的波长提供照明。照明单元包括光源和光纤束，以将光引向检查区域。检测单元用于捕获和记录调查区域的图像。检测单元可以是数码相机，胶卷相机等。还可以提供映射模块以对检查地点进行编目。

86. 发明授权

US09561183B2 Prussian blue-inspired constructs for multimodal imaging and therapy 有权
标题翻译：普鲁士蓝色启发的多模式成像和治疗结构
公开(公告)号：US09561183B2
公开(公告)日：2017-02-07
申请号：US14213380
申请日：2014-03-14
申请人： Children's National Medical Center
发明人： Rohan Fernandes , Matthieu F. Dumont , Raymond W. Sze , Laurie S. Conklin , Hilary A. Hoffman , Jyoti K. Jaiswal
IPC分类号： A61B5/00 , A61B8/10 , A61B10/00 , A61K9/14 , A61K41/00 , A61K47/48 , A61K49/00
CPC分类号： A61K49/0032 , A61K9/143 , A61K41/0052 , A61K47/6923 , A61K49/0017 , C01C3/12 , C01P2004/04
摘要： The invention describes a coordination polymer construct for multimodal imaging and therapy. The construct consists of a core particle made of a novel coordination polymer. The core is coated with a biocompatible coating that stabilizes the particles in a physiological environment. The biocompatible coating can contain attached targeting agents, imaging agents and therapeutic agents or combinations one or more of the targeting, imaging and therapeutic agents. When administered to a subject or a subject-derived specimen, the resulting coordination polymer core-shell construct enables multimodal imaging and therapy, which improves the diagnostic and treatment outcomes of the conditions or diseases where it is administered. The invention describes the novel material, base for the construct, methods for the preparation of the said construct and its use as a multimodal imaging and therapy agent.
摘要翻译：本发明描述了用于多模式成像和治疗的配位聚合物构建体。该构造体由由新的配位聚合物制成的核心颗粒组成。核心涂有生物相容性涂层，使生物环境中的颗粒稳定。生物相容性涂层可以含有附着的靶向剂，成像剂和治疗剂或一种或多种靶向，成像和治疗剂的组合。当施用于受试者或受试者衍生的标本时，得到的配位聚合物核 - 壳结构可实现多模式成像和治疗，其改善其施用条件或疾病的诊断和治疗结果。本发明描述了新型材料，构建体的基础，制备所述构建体的方法及其作为多峰成像和治疗剂的用途。

87. 发明申请

US20160256576A1 COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY 有权
标题翻译：光学电子学的组成，方法，系统和工具包
公开(公告)号：US20160256576A1
公开(公告)日：2016-09-08
申请号：US15159376
申请日：2016-05-19
申请人： The Research Foundation of State University of New York , The University of Connecticut
发明人： Arkady M. Pertsov , Arvydas Matiukas , Leslie M. Loew , Joseph P. Wuskell
IPC分类号： A61K49/00 , C09B23/10 , A61K47/10 , A61B5/00
CPC分类号： A61K49/0032 , A61B5/0059 , A61B5/0071 , A61B5/04 , A61B2503/40 , A61K47/10 , A61K49/0017 , A61K49/0019 , A61K49/006 , C09B23/0075 , C09B23/107 , G01N21/4795 , G01N21/6428
摘要： The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.
摘要翻译：本发明提供一种光学电生理学探测方法，包括：提供荧光化学探针; 使组织的厚部分与荧光化学探针接触以产生经处理组织的厚部分; 将电磁辐射的第一波长范围应用于组织的处理部分; 以及检测从经处理的组织的较厚部分发射的多个深度特异性发射波长。

88. 发明授权

US09107948B2 Compounds for diagnosing diseases associated with the expression of MUC5AC 有权
标题翻译：用于诊断与MUC5AC表达相关的疾病的化合物
公开(公告)号：US09107948B2
公开(公告)日：2015-08-18
申请号：US13993975
申请日：2011-11-30
申请人： Sébastien Ballet , Walter Gonzalez , Yannick Rossez
发明人： Sébastien Ballet , Walter Gonzalez , Yannick Rossez
IPC分类号： A61K49/00 , A61K47/48 , A61K49/04 , A61K49/14 , A61K49/18 , A61K51/04 , A61K51/08 , B82Y5/00
CPC分类号： A61K49/14 , A61K47/548 , A61K49/0017 , A61K49/049 , A61K49/1842 , A61K49/186 , A61K49/1866 , A61K51/0478 , A61K51/048 , A61K51/0482 , A61K51/08 , A61K51/088 , B82Y5/00
摘要： The application relates to a compound of general formula (I) below: Signal-Linker-Peptide (I) and to the uses thereof for medical imaging or diagnosis or the preparation of a composition for diagnosis of an MUC5AC pathological condition.
摘要翻译：本申请涉及以下通式（I）的化合物：信号连接子 - 肽（I）及其用于医学成像或诊断或用于诊断MUC5AC病理状况的组合物的制备。

89. 发明申请

US20150225692A1 PROGRAMMABLE DRUG DELIVERY PROFILES OF TUMOR-TARGETED BACTERIA 有权
标题翻译：肿瘤靶向细菌的可编程药物递送概况
公开(公告)号：US20150225692A1
公开(公告)日：2015-08-13
申请号：US14428341
申请日：2013-09-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Sangeeta N. Bhatia , Tal Danino
IPC分类号： C12N1/20 , A23L1/30 , A61K49/00 , A61K38/02 , A61K35/74 , A61K45/06
CPC分类号： C12N1/20 , A23L33/135 , A23V2002/00 , A23Y2220/00 , A23Y2300/00 , A61K35/74 , A61K38/00 , A61K38/02 , A61K45/06 , A61K49/0017 , C07K2319/55 , C12N15/74
摘要： The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.
摘要翻译：本发明涉及包含至少一种非致病性细菌细胞的组合物，其中所述非致病性细菌细胞至少包含第一和第二核酸序列，所述第一核酸序列包含至少一种非组成型启动子，其可操作地连接涉及编码治疗剂的第二核酸序列，其中所述非组成型启动子是对至少一种刺激物有响应的诱导型启动子，并且所述至少一种刺激物包含一定密度或一定数量的细菌细胞的存在，所述细菌细胞包含第一和第二核酸序列。

90. 发明申请

US20150152390A1 Compounds With Modifying Activity Enhanced Under Hypoxic Conditions 有权
标题翻译：低氧条件下改性活性增强的化合物
公开(公告)号：US20150152390A1
公开(公告)日：2015-06-04
申请号：US14531774
申请日：2014-11-03
申请人： Board of Regents, The University of Texas System
发明人： Frederick M. MacDonnell , Thamara K. Janaratne , Sanjay Awashti
IPC分类号： C12N5/09
CPC分类号： C12N5/0693 , A61K31/435 , A61K49/0017 , C07F15/0046 , C07F15/0053 , C12N2500/10
摘要： Compositions and methods for modifying one or more biologic targets are provided. Suitable targets include cells, DNA, proteins, enzymes, and/or a subject in need thereof. The compositions may exist as a monomer or multimer and are active in a biologic environment with enhanced activity in hypoxic environments and, thus, exhibit improved specificity for hypoxic biologic targets (e.g., tumorigenic cells and those undergoing uncontrolled cell growth). A composition typically comprises a complex with an overall charge of 2+ or greater having at least one ruthenium atom attached to a redox active ligand. The redox active ligand helps maintain separation of more than one ruthenium atom. Suitable compositions may further include a terminal ligand comprising a heterocyclic aromatic compound. When provided to a biologic target, the composition modifies the biologic target and no additional compounds need be provided. Suitable compositions are typically catalytic and regenerative in the presence of a reducing agent.
摘要翻译：提供了修改一个或多个生物靶标的组合物和方法。合适的靶标包括细胞，DNA，蛋白质，酶和/或有需要的受试者。组合物可以作为单体或多聚体存在，并且在缺氧环境中具有增强活性的生物环境中具有活性，因此对缺氧生物靶标（例如致瘤细胞和经受不受控制的细胞生长的那些）表现出改善的特异性。组合物通常包含具有2+或更大的总电荷的复合物，其具有连接到氧化还原活性配体的至少一个钌原子。氧化还原活性配体有助于保持多于一个钌原子的分离。合适的组合物还可以包括包含杂环芳族化合物的末端配体。当提供给生物靶标时，组合物修饰生物靶标，不需要提供其他化合物。合适的组合物通常在还原剂存在下是催化和再生的。

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