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81. 发明授权

US08070768B2 Devices and methods for treatment of obesity 有权
标题翻译：用于治疗肥胖的装置和方法
公开(公告)号：US08070768B2
公开(公告)日：2011-12-06
申请号：US11407701
申请日：2006-04-19
申请人： Steven Kim , Joshua Makower
发明人： Steven Kim , Joshua Makower
IPC分类号： A61M29/00
CPC分类号： A61F5/003 , A61B17/0401 , A61B2017/00557 , A61B2017/0414 , A61B2017/0417 , A61B2017/0441
摘要： Implantable devices, instruments, kits and methods for treatment of obesity. One or more devices can be implanted adjacent to or in contact with the stomach to occupy a space to prevent the stomach from expanding into that space as food is taken into the stomach. Alternatively, one or more devices may be implanted and expanded to displace at least a portion of the wall of the stomach to decrease the internal volume of the stomach that is available to receive food. Devices may be anchored to one or more internal structures at one or more locations without piercing through the wall of the stomach. Devices can be implanted using minimally invasive methods, such as percutaneous or laparoscopic methods. Delivery instruments are also provided. An intra-gastric sizing device is provided to facilitate implantation of an extra-gastric device in some method embodiments.
摘要翻译：用于治疗肥胖的可植入装置，器械，试剂盒和方法。一个或多个装置可以被植入在胃附近或与胃接触以占据一个空间，以防止胃在胃中被引入到该空间中。或者，可以将一个或多个装置植入和扩张以置换胃壁的至少一部分以减小可用于接收食物的胃的内部体积。设备可以在一个或多个位置处锚定到一个或多个内部结构，而不穿透胃的壁。可以使用微创方法植入装置，例如经皮或腹腔镜方法。还提供交货工具。在一些方法实施例中提供胃内施加装置以便于植入胃外装置。

82. 发明授权

US08062207B2 Intra-gastric fastening devices 有权
标题翻译：胃内紧固装置
公开(公告)号：US08062207B2
公开(公告)日：2011-11-22
申请号：US11129626
申请日：2005-05-13
申请人： Jamy Gannoe , Gary Weller , Craig Gerbi , Douglas S. Sutton
发明人： Jamy Gannoe , Gary Weller , Craig Gerbi , Douglas S. Sutton
IPC分类号： A61F2/00
CPC分类号： A61F5/003 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0644 , A61B17/08 , A61B2017/00557 , A61B2017/0441 , A61B2017/06171 , A61B2017/0649 , A61F5/0036
摘要： Intra-gastric fastening devices are disclosed herein. Expandable devices that are inserted into the stomach of the patient are maintained within by anchoring or otherwise fixing the expandable devices to the stomach walls. Such expandable devices, like inflatable balloons, have tethering regions for attachment to the one or more fasteners which can be configured to extend at least partially through one or several folds of the patient's stomach wall. The fasteners are thus affixed to the stomach walls by deploying the fasteners and manipulating the tissue walls entirely from the inside organ. Such fasteners can be formed in a variety of configurations, e.g., helical, elongate, ring, clamp, and they can be configured to be non-piercing. Alternatively, sutures can be used to wrap around or through a tissue fold for tethering the expandable devices. Non-piercing biased clamps can also be used to tether the device within the stomach.
摘要翻译：本文公开了胃内紧固装置。通过锚定或以其他方式将可扩张装置固定在胃壁上，可以将插入到患者胃中的可扩张装置保持在内部。这种可膨胀装置，如可充气气囊，具有用于连接到一个或多个紧固件的束缚区域，所述紧固件可构造成至少部分延伸穿过患者胃壁的一个或多个折叠。因此，紧固件通过展开紧固件并完全从内部器官操纵组织壁而固定在胃壁上。这种紧固件可以以各种构造形成，例如螺旋，细长，环形，夹紧，并且它们可被构造成不穿孔。或者，可以使用缝合线缠绕或穿过组织折叠以将可扩张装置系在一起。非刺穿偏压夹具也可用于将装置系在胃内。

83. 发明申请

US20110276076A1 Implantable Device With A Multi-Layer Envelope, And Corresponding Method Of Production 审中-公开
标题翻译：具有多层包络的可植入装置及相应的生产方法
公开(公告)号：US20110276076A1
公开(公告)日：2011-11-10
申请号：US13133434
申请日：2009-12-09
申请人： Pascal Paganon
发明人： Pascal Paganon
IPC分类号： A61M29/00 , C09J5/02
CPC分类号： A61F5/003
摘要： The invention relates to a medical or surgical device (1) implantable in a human or animal body, said device (1) comprising an envelope (3) consisting of a multi-layer complex, of which at least a first layer (4) is for the most part composed of a first flexible polymer, and of which at least a second layer (5) is for the most part composed of a second flexible polymer, the chemical composition of said first and second flexible polymers preventing the formation of chemical bonds between said first and second flexible polymers, and said envelope (3) being designed to be filled with an inflating fluid. Said device (1) comprises at least a third layer (6), which is designed to form chemical bonds with each of said first and second flexible polymers, in such a way as to join said first and second layers (4, 5) across substantially the entire surface thereof.
摘要翻译：本发明涉及一种可植入人体或动物体内的医疗或手术装置（1），所述装置（1）包括由多层复合体构成的包层（3），其中至少第一层（4）为大部分由第一柔性聚合物组成，并且其中至少第二层（5）大部分由第二柔性聚合物组成，所述第一和第二柔性聚合物的化学组成防止形成化学键在所述第一和第二柔性聚合物之间，并且所述封套（3）被设计成填充有充气流体。所述装置（1）包括至少第三层（6），其被设计成与所述第一和第二柔性聚合物中的每一个形成化学键，以使所述第一和第二层（4,5）跨过基本上整个表面。

84. 发明授权

US08048169B2 Pyloric valve obstructing devices and methods 有权
标题翻译：幽门阀阻塞装置及方法
公开(公告)号：US08048169B2
公开(公告)日：2011-11-01
申请号：US10833950
申请日：2004-04-27
申请人： Daniel R. Burnett , Gregory W. Hall , Roxanne Richman , David A. Gallup , Annette Campbell-White
发明人： Daniel R. Burnett , Gregory W. Hall , Roxanne Richman , David A. Gallup , Annette Campbell-White
IPC分类号： A61F2/04
CPC分类号： A61B17/12022 , A61B5/036 , A61B5/073 , A61B5/14539 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61B17/12172 , A61B17/1219 , A61B2017/00004 , A61B2017/00557 , A61B2017/12054 , A61B2017/12086 , A61F5/003 , A61F5/0036 , A61F5/0079
摘要： Methods, devices and systems facilitate intermittent and/or partial obstruction of a pyloric valve. Devices generally include a support portion for preventing the device from passing through the pyloric valve and a tissue engagement portion for contacting tissue adjacent the pyloric valve to obstruct the valve. Some embodiments also include a positioning member extending from the tissue engagement portion for helping position the device for obstructing the valve. A retaining member may optionally be included on the distal end of the positioning member for further maintaining a position of the device in the stomach. Some embodiments are deliverable into the stomach through the esophagus, either by swallowing or through a delivery tube or catheter. Some embodiments are fully reversible. Some embodiments self-expand within the stomach, while others are inflated or otherwise expanded.
摘要翻译：方法，装置和系统促进幽门阀的间歇性和/或局部阻塞。装置通常包括用于防止装置通过幽门阀的支撑部分和用于接触幽门阀附近的组织以阻塞瓣膜的组织接合部分。一些实施例还包括从组织接合部分延伸的定位构件，用于帮助定位用于阻塞阀的装置。可以可选地将保持构件包括在定位构件的远端上，以进一步保持装置在胃中的位置。一些实施例可通过吞咽或通过输送管或导管通过食道输送到胃中。一些实施例是完全可逆的。一些实施例在胃内自扩张，而另一些实施例被膨胀或以其他方式扩张。

85. 发明申请

US20110213448A1 APPARATUS AND METHODS FOR MINIMALLY INVASIVE OBESITY TREATMENT 有权
标题翻译：装置和方法进行最小的入侵治疗
公开(公告)号：US20110213448A1
公开(公告)日：2011-09-01
申请号：US13055395
申请日：2009-07-13
申请人： Daniel H. Kim
发明人： Daniel H. Kim
IPC分类号： A61N1/00
CPC分类号： A61N1/0517 , A61B17/3468 , A61F5/0003 , A61F5/0026 , A61F5/003 , A61F5/0069 , A61F5/0073 , A61M25/0017 , A61M25/1002 , A61M2025/1072 , A61N1/36007 , A61N1/36114
摘要： Apparatus and methods are provided for the effective and minimally invasive treatment of obesity. In one embodiment, a device for providing therapy to a patient includes an inflatable structure adapted and configured for positioning at least partially within a gastroesophageal (GE) space formed between an inner wall of a phrenoesophageal ligament (POL) and outer walls of the esophagus and cardiac orifice and an electrode structure adapted and configured for positioning at least partially within the GE space. In another embodiment, a method for treating a patient includes introducing an electrode at least partially into a gastroesophageal (GE) space formed between an inner wall of a phrenoesophageal ligament (POL) and outer walls of the esophagus and cardiac orifice and modulating tissue using the electrode.
摘要翻译：提供了用于有效和微创治疗肥胖症的装置和方法。在一个实施例中，用于向患者提供治疗的装置包括适于和构造用于至少部分地定位在食管韧带（POL）的内壁和食管外壁之间形成的胃食管（GE）空间内的充气结构，心脏孔和适于和构造用于至少部分地定位在GE空间内的电极结构。在另一个实施方案中，用于治疗患者的方法包括至少部分地将电极引入形成在食管韧带（POL）的内壁和食管外壁之间的胃食管（GE）空间和心脏孔，并使用电极。

86. 发明授权

US08001974B2 Devices and methods for treatment of obesity 有权
标题翻译：用于治疗肥胖的装置和方法
公开(公告)号：US08001974B2
公开(公告)日：2011-08-23
申请号：US12215014
申请日：2008-06-23
申请人： Joshua Makower , Theodore M. Bender , Brian K. Shiu , Pablo G. Acosta , Shuji Uemura , Josef L. Friedmann , Crystine Lee
发明人： Joshua Makower , Theodore M. Bender , Brian K. Shiu , Pablo G. Acosta , Shuji Uemura , Josef L. Friedmann , Crystine Lee
IPC分类号： A61B19/00
CPC分类号： A61B17/3468 , A61B5/036 , A61B5/04884 , A61B5/416 , A61B5/42 , A61B17/0467 , A61B17/0469 , A61B17/0482 , A61B34/20 , A61B34/30 , A61B90/98 , A61B2017/00221 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/0488 , A61B2017/06176 , A61B2017/2927 , A61B2090/064 , A61B2090/3983 , A61F5/003 , A61F5/0073 , A61N1/36007
摘要： Methods, devices, tools and assemblies for treating a patient to effect weight loss. One method embodiment involves passing a device including an expandable member in a collapsed configuration and a buoyancy member through an opening in the skin of a patient and into the abdominal cavity of the patient, and anchoring at least a portion of the expandable member, relative to at least one structure in the abdominal cavity. Devices including at least one expandable member and at least one buoyancy member are provided.
摘要翻译：用于治疗患者减轻体重的方法，装置，工具和装置。一个方法实施例涉及将包括处于折叠构造的可膨胀构件和浮力构件的装置通过患者皮肤中的开口传递到患者的腹腔中，并且相对于患者的至少一部分锚固可扩张构件腹腔中至少有一个结构。提供包括至少一个可膨胀构件和至少一个浮力构件的装置。

87. 发明申请

US20110112383A1 Devices, systems and methods for treatment of eating disorders 审中-公开
标题翻译：用于治疗进食障碍的装置，系统和方法
公开(公告)号：US20110112383A1
公开(公告)日：2011-05-12
申请号：US12930377
申请日：2011-01-04
申请人： Houston Fredrick Voss , Bernhard B. Sterling
发明人： Houston Fredrick Voss , Bernhard B. Sterling
IPC分类号： A61B5/07
CPC分类号： A61F5/003 , A61B5/073 , A61B5/4238
摘要： An ingestible gastric device comprising a formed body that is adapted to expand upon exposure to a hydration medium and then degrade after a first residence time in the stomach cavity, allowing the device to be passed by the patient's normal digestive process, and monitoring means for monitoring the gastric device. In some embodiments, the monitoring means comprises a biocompatible RFID tag.
摘要翻译：一种可摄入的胃装置，其包括成形体，其适于在暴露于水合介质后膨胀，然后在第一停留时间后在胃腔中降解，允许该装置通过患者的正常消化过程，以及用于监测的监测装置胃装置。在一些实施例中，监测装置包括生物相容性RFID标签。

88. 发明授权

US07892250B2 Use of biosurgical adhesive on inflatable device for gastric restriction 有权
标题翻译：在充气装置上使用生物手术粘合剂进行胃限制
公开(公告)号：US07892250B2
公开(公告)日：2011-02-22
申请号：US11555322
申请日：2006-11-01
申请人： Mark S. Ortiz , Randal T. Byrum , Fredrick E. Shelton, IV
发明人： Mark S. Ortiz , Randal T. Byrum , Fredrick E. Shelton, IV
IPC分类号： A61M29/00
CPC分类号： A61F5/0079 , A61F5/003 , A61F5/0036
摘要： An apparatus for forming a gastric restriction comprises an applier, an expandable member, and an adhesive. The applier comprises an elongate shaft, and is dimensioned to fit in an esophagus. The applier has a conduit configured to communicate a fluid medium. The expandable member is in fluid communication with the conduit of the applier. The adhesive is positioned on at least a portion of the outer surface of the expandable member. The adhesive is configured to adhere the expanded expandable member to the inner wall of a patient's stomach. The expandable member may have a generally toroid configuration with a stoma, such that the expandable member may provide a gastric restriction when expanded and adhered to the inner wall of a patient's stomach. The expandable member may thus provide a treatment for morbid obesity by reducing food intake, by reducing stomach volume, or otherwise.
摘要翻译：用于形成胃限制的装置包括施放器，可膨胀构件和粘合剂。施放器包括细长轴，并且其尺寸适于装配在食道中。施加器具有构造成连通流体介质的导管。可膨胀构件与施加器的导管流体连通。粘合剂定位在可扩张构件的外表面的至少一部分上。粘合剂构造成将膨胀的可扩张构件粘附到患者胃的内壁。可扩张构件可以具有通气孔形状，其具有造口，使得当膨胀并粘附到患者胃的内壁时，可膨胀构件可提供胃限制。因此，可膨胀构件可以通过减少食物摄入，减少胃体积或其它方式提供对病态肥胖症的治疗。

89. 发明申请

US20110040318A1 BIOERODIBLE SELF-DEPLOYABLE INTRAGASTRIC IMPLANTS 有权
标题翻译：生物可分离的自制植入式植入物
公开(公告)号：US20110040318A1
公开(公告)日：2011-02-17
申请号：US12841283
申请日：2010-07-22
申请人： Doron Marco , Shimon Eckhouse
发明人： Doron Marco , Shimon Eckhouse
IPC分类号： A61F2/04 , A61M29/02
CPC分类号： A61F2/02 , A61F5/003 , A61F5/0036 , A61F2002/044 , A61F2210/0004
摘要： Described herein are bioerodible, biodegradable, or digestible self-deploying intragastric implants that may be swallowed. Once swallowed, the implants undergo self-expansion in the stomach and apply a suitable pressure against the stomach wall to provide a feeling of satiety to the individual. The implants then dissolve or are disassembled perhaps using gastric liquids and pass out of the stomach. Methods of using the devices, perhaps for an individual participating in a dietary control regimen, are described.
摘要翻译：本文描述的是可以被吞噬的可生物腐蚀的，可生物降解的或可消化的自身部署的胃内植入物。一旦吞咽，植入物在胃中经历自我扩张，并对胃壁施加合适的压力，以向个体提供饱腹感。然后植入物可能会溶解或分解，可能使用胃液并从胃中传出。描述了可能为参与饮食控制方案的个体使用这些装置的方法。

90. 发明授权

US07883525B2 Intragastric catheter 有权
标题翻译：肠内导管
公开(公告)号：US07883525B2
公开(公告)日：2011-02-08
申请号：US11859472
申请日：2007-09-21
申请人： Rebecca DeLegge
发明人： Rebecca DeLegge
IPC分类号： A61M29/02
CPC分类号： A61F5/003 , A61F5/004
摘要： An intragastric catheter provides satiety due to its presence in the stomach cavity. Efficacy is improved by the tactile sensation provided by a plurality of fingers that extend from the device. Normal peristaltic action upon the device moves the fingers relative to the stomach. The structure of the intragastric catheter reduces the level of precision required in placement of the device, and blockage of conduits to and from the stomach by the device is unlikely.
摘要翻译：胃内导管由于其在胃腔中的存在而提供饱腹感。通过从装置延伸的多根手指提供的触感提高了功效。手指上的正常蠕动作用相对于胃移动手指。胃内导管的结构降低了装置放置所需的精度水平，并且不可能通过该装置阻塞导管和胃的导管。

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