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81. 发明申请

US20110288160A1 Treatment of Metabolic-Related Disorders Using Hypothalamic Gene Transfer of BDNF and Compositions Therefor 有权
标题翻译：使用BDNF及其组合物的下丘脑基因转移治疗代谢相关性疾病
公开(公告)号：US20110288160A1
公开(公告)日：2011-11-24
申请号：US12934735
申请日：2009-03-27
申请人： Matthew J. During , Lei Cao
发明人： Matthew J. During , Lei Cao
IPC分类号： A61K48/00 , C12N15/85 , C12N15/86 , A61P3/08 , A61P3/00 , A61P3/10 , A61P3/04 , C12N15/63 , C12N15/861
CPC分类号： A61K48/005 , A61K48/0075 , C12N15/1136 , C12N15/86 , C12N2310/14 , C12N2330/51 , C12N2750/14143 , C12N2830/48 , C12N2830/50
摘要： Described herein is a system which uses a gene therapy particle that includes at least one gene, cDNA, fragment or analogue of at least one neurotropin that binds to the trkB receptor or the trkB receptor itself. The gene therapy particle is capable of being delivered to a subject in need thereof for therapy of a metabolic disorder. In a particular aspect, this invention is directed to an inventive method that demonstrates a remarkable efficacy on lowering body weight.
摘要翻译：本文描述的是使用包含至少一种结合trkB受体或trkB受体本身的至少一种神经肌肽的基因，cDNA，片段或类似物的基因治疗颗粒的系统。基因治疗颗粒能够被递送到有需要的受试者用于治疗代谢紊乱。在一个特定方面，本发明涉及一种显示降低体重的显着功效的本发明方法。

82. 发明申请

US20110286902A1 CARBONATION CALCINATION REACTION PROCESS FOR CO2 CAPTURE USING A HIGHLY REGENERABLE SORBENT 有权
标题翻译：使用高可再生能力的二氧化碳捕集的碳酸化计算反应过程
公开(公告)号：US20110286902A1
公开(公告)日：2011-11-24
申请号：US13111794
申请日：2011-05-19
申请人： Liang-Shih Fan , Shwetha Ramkumar , William Wang , Robert Statnick
发明人： Liang-Shih Fan , Shwetha Ramkumar , William Wang , Robert Statnick
IPC分类号： B01D53/62 , B01J8/00
CPC分类号： B01D53/62 , B01D53/508 , B01D53/96 , B01D2251/404 , B01D2257/302 , B01D2257/504 , B01J20/041 , B01J20/043 , B01J20/3433 , B01J20/3483 , B01J20/3491 , C01F11/02 , Y02C10/04 , Y02C10/06 , Y02C10/08 , Y02P20/129 , Y02P20/13 , Y02P20/152
摘要： A process for the efficient capture of CO2 and sulfur from combustion flue gas streams and gasification based fuel gas mixtures using regenerable and recyclable calcium based sorbents. The regeneration of the calcium sorbent is accomplished by hydrating the sorbent at high temperatures of about 600° C. and a pressure higher than 6 bars to lower the parasitic energy consumption.
摘要翻译：使用可再生和可回收的钙基吸附剂从燃烧烟道气和基于气化的燃料气体混合物有效捕获二氧化碳和硫的方法。钙吸附剂的再生通过在约600℃的高温和高于6巴的高温下使吸附剂水合来降低寄生能量消耗来实现。

83. 发明授权

US08053186B2 Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing 有权
标题翻译：用于靶向Drosha介导的microRNA加工的致癌性ALL-1融合蛋白
公开(公告)号：US08053186B2
公开(公告)日：2011-11-08
申请号：US12664531
申请日：2008-06-13
申请人： Carlo M. Croce
发明人： Carlo M. Croce
IPC分类号： C12Q1/68
CPC分类号： C07H19/00 , C07H21/00 , C12N15/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/178 , G01N33/57426
摘要： Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.
摘要翻译：公开了通过与ALL1融合蛋白的靶向相互作用来减少ALL癌细胞增殖的组合物和方法。

84. 发明授权

US08039502B2 Anti-infective agents against intracellular pathogens 有权
标题翻译：针对细胞内病原体的抗感染剂
公开(公告)号：US08039502B2
公开(公告)日：2011-10-18
申请号：US12179134
申请日：2008-07-24
申请人： Ching-Shih Chen , Hao-Chieh Chiu , Dasheng Wang , John S. Gunn , Larry S. Schlesinger
发明人： Ching-Shih Chen , Hao-Chieh Chiu , Dasheng Wang , John S. Gunn , Larry S. Schlesinger
IPC分类号： C07D231/12 , A61K31/415
CPC分类号： C07D231/12 , C07D403/04 , C07D403/10 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C12N2501/06
摘要： A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is —CF3, Ar is selected from and R is selected from where R′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, and R″ is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,
摘要翻译：一类新的式I的磷酸肌醇依赖性激酶-1（PDK-1）抑制剂：其中X为X为-CF 3，Ar为选自R为选自其中R'为L-Lys，D-Lys，bgr ; -Ala，L-Lue，L-Ile，Phe，SO2CH2CH2NH2，SO2NH2，Asn，Glu或Gyl，R“为甲基，乙基，烯丙基，CH2CH2OH，CH2CN，CH2CH2CN，CH2CONH2，

85. 发明授权

US08038907B2 Aligned nanostructured polymers 有权
标题翻译：对齐纳米结构聚合物
公开(公告)号：US08038907B2
公开(公告)日：2011-10-18
申请号：US11731974
申请日：2007-04-02
申请人： Arthur J. Epstein , Nan-Rong Chiou , Ly James Lee , Chunmeng Lu
发明人： Arthur J. Epstein , Nan-Rong Chiou , Ly James Lee , Chunmeng Lu
IPC分类号： H01B1/00 , C08G73/06
CPC分类号： C08G73/0266 , B82Y30/00 , B82Y40/00 , D01D5/38 , D01F6/76 , H01B1/128 , H01L51/5215 , Y10T428/249924
摘要： Novel, simple methods are presented directed to the synthesis of aligned nanofibers of polyaniline and substituted derivatives on a substrate. The production of these fibers is achieved via various methods by controlling the concentration of aniline monomer or substituted aniline derivatives or an oxidant in the reaction medium and maintaining said concentration at a level much lower than conventional polyaniline synthesis methods. Methods are disclosed relating to the use of a permeable membrane to control the release of a monomer and/or oxidant as well as a bulk polymerization method.
摘要翻译：提出了一种简单的方法，用于合成基板上聚苯胺和取代衍生物的取向纳米纤维。这些纤维的生产通过各种方法通过控制苯胺单体或取代的苯胺衍生物或反应介质中的氧化剂的浓度来实现，并将该浓度保持在比常规聚苯胺合成方法低得多的水平。公开了关于使用可渗透膜来控制单体和/或氧化剂的释放以及本体聚合方法的方法。

86. 发明申请

US20110214487A1 ELECTRO-SPUN FIBERS AND APPLICATIONS THEREFORE 有权
标题翻译：电激发纤维及其应用
公开(公告)号：US20110214487A1
公开(公告)日：2011-09-08
申请号：US13046552
申请日：2011-03-11
申请人： Susan V. Olesik , Jonathan E. Clark , Jeremy K. Steach , Joseph W. Zewe
发明人： Susan V. Olesik , Jonathan E. Clark , Jeremy K. Steach , Joseph W. Zewe
IPC分类号： G01N30/90 , B29C47/78 , B82Y40/00
CPC分类号： D01D5/0084 , B01D15/20 , B01J20/28007 , B01J20/28033 , B01J20/28035 , B01J20/286 , B01J20/3293 , B01J20/3295 , B01J2220/54 , B05D5/00 , B82Y30/00 , D01F9/12 , G01N30/06 , G01N30/93 , G01N2030/009 , G01N2030/062
摘要： A supported nanofiber medium useful for segregating chemical species is provided by selecting a polymer, selecting a substrate; and electrospinning the polymer to form a nanofiber medium on the supporting substrate. When the substrate is a planar surface, the nanofiber medium will be a mat suitable for conducting chromatographic separation. When the substrate is a filament, the nanofiber medium is an annular mat suitable for solid phase microextraction. The nanofiber media formed may be selectively cross-linked and at least partially carbonized to carbon nanofibers. The nanofiber medium is supported on the substrate without the use of binder material.
摘要翻译：通过选择聚合物，选择底物提供了可用于分离化学物质的负载型纳米纤维介质; 并静电纺丝聚合物以在支撑基底上形成纳米纤维介质。当基材是平面时，纳米纤维介质将是适于进行色谱分离的垫。当基底是细丝时，纳米纤维介质是适用于固相微萃取的环形垫。形成的纳米纤维介质可以选择性地交联并且至少部分地碳化成碳纳米纤维。纳米纤维介质在不使用粘合剂材料的情况下被支撑在基底上。

87. 发明申请

US20110171646A1 MICRORNA EXPRESSION PROFILE ASSOCIATED WITH PANCREATIC CANCER 审中-公开
标题翻译：与胰腺癌相关的MICRORNA表达谱
公开(公告)号：US20110171646A1
公开(公告)日：2011-07-14
申请号：US12962065
申请日：2010-12-07
申请人： Thomas D. Schmittgen , Daniel J. Brackett
发明人： Thomas D. Schmittgen , Daniel J. Brackett
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6813 , C12Q1/6869 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological sample derived from the subject's pancreas. An alteration in the level of the miR gene product in the biological sample as compared to the level of a corresponding miR gene product in a control sample, is indicative of the subject either having, or being at risk for developing, pancreatic cancer
摘要翻译：提供了用于诊断受试者是否具有或有发展胰腺癌风险的方法。所述方法包括测量源自受试者胰腺的生物样品中至少一种miR基因产物的水平。与对照样品中相应的miR基因产物的水平相比，生物样品中miR基因产物水平的改变指示受试者具有或有发展胰腺癌的风险

88. 发明申请

US20110144747A1 ADJUSTABLE INTRAOCULAR LENS 有权
标题翻译：可调节内窥镜
公开(公告)号：US20110144747A1
公开(公告)日：2011-06-16
申请号：US12936005
申请日：2009-04-03
申请人： Vincent D. McGinniss , Steven M. Risser , Cynthia J. Roberts
发明人： Vincent D. McGinniss , Steven M. Risser , Cynthia J. Roberts
IPC分类号： A61F2/16 , B01J19/08
CPC分类号： A61F2/1627 , A61F2/1635 , A61F2/1659 , A61F2002/16965 , A61L27/50 , A61L2430/16 , G02B1/043
摘要： Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.
摘要翻译：公开了用于改变诸如人工晶状体的透镜的功率的方法和装置。在一种方法中，透镜包含含有可交联侧基的单一聚合物基质，其中当交联时聚合物基体的体积增加。镜头不含有游离单体。当暴露于紫外线辐射时，交联使得透镜的暴露部分体积增加，导致折射率增加。在另一种方法中，透镜包含含有可光漂白的发色团的聚合物基质。在紫外线照射下，光漂白导致曝光部分的折射率降低，透镜厚度没有变化。这些方法避免了等待发生扩散以改变透镜形状的需要，并且避免了第二次暴露于辐射以锁定透镜变化的需要。

89. 发明授权

US07954357B2 Driver plate for electromagnetic forming of sheet metal 有权
标题翻译：钣金电磁成型用驱动板
公开(公告)号：US07954357B2
公开(公告)日：2011-06-07
申请号：US11867734
申请日：2007-10-05
申请人： John R. Bradley , Glenn S. Daehn
发明人： John R. Bradley , Glenn S. Daehn
IPC分类号： B21D26/00
CPC分类号： B21D26/14 , Y10T29/49803
摘要： A multi-layer driver plate is disclosed for use in electromagnetic sheet metal forming operations. In one embodiment, the driver plate comprises a first layer characterized by low electrical resistivity and thickness for inducement and application of a suitable electromagnetic forming force, a second layer comprising an elastomeric material for compressing a sheet metal workpiece against a die surface and then regaining its original pre-forming structure, and a third layer interposed between the first layer and the second layer to protect the EMF force providing layer and to provide overall strength and durability to the EMF driver plate.
摘要翻译：公开了用于电磁钣金成型操作的多层驱动器板。在一个实施例中，驱动器板包括第一层，其特征在于用于诱导和施加合适的电磁成形力的低电阻率和厚度，第二层包括用于将金属板工件压靠在模具表面上的弹性材料，然后重新获得原始预成形结构，以及插入在第一层和第二层之间的第三层，以保护EMF力提供层并为EMF驱动器板提供总体强度和耐久性。

90. 发明授权

US07947251B2 Catalyst for hydrogen production from water gas shift reaction 有权
标题翻译：用于从水煤气变换反应生成氢的催化剂
公开(公告)号：US07947251B2
公开(公告)日：2011-05-24
申请号：US11917509
申请日：2006-06-15
申请人： Umit S. Ozkan , Xueqin Wang , Lingzhi Zhang , Sittichai Natesakhawat
发明人： Umit S. Ozkan , Xueqin Wang , Lingzhi Zhang , Sittichai Natesakhawat
IPC分类号： C01B3/12 , B01J23/00 , B01J21/00 , B01J20/00
CPC分类号： C01B3/16 , B01J23/002 , B01J23/745 , B01J31/2234 , B01J35/002 , B01J37/033 , B01J37/036 , B01J2231/70 , B01J2523/00 , B01J2531/842 , C01B2203/0233 , C01B2203/0283 , C01B2203/066 , C01B2203/1041 , C01B2203/1047 , C01B2203/1076 , Y02P20/52 , B01J2523/17 , B01J2523/31 , B01J2523/842
摘要： Fe—Al—Cu catalysts have numerous industrial applications, for example, as catalysts in a water gas shift reactor. A method of producing a Fe—Al—Cu catalyst comprises the steps of providing an organic iron precursor, dissolving the organic iron precursor in a solvent solution, adding an aqueous solution comprising aluminum nitrate and copper nitrate to the organic iron pre-cursor-solvent solution, precipitating a gel comprising Fe—Al—Cu by adding a base, and drying the gel to form the Fe—Al—Cu catalyst.
摘要翻译： Fe-Al-Cu催化剂具有许多工业应用，例如作为水煤气变换反应器中的催化剂。制备Fe-Al-Cu催化剂的方法包括提供有机铁前体，将有机铁前体溶解在溶剂溶液中，向有机铁前体溶剂中加入包含硝酸铝和硝酸铜的水溶液溶液，通过加入碱沉淀包含Fe-Al-Cu的凝胶，并干燥凝胶以形成Fe-Al-Cu催化剂。

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