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81. 发明授权

US09134300B2 Method for screening a drug in retinal tissue 有权
标题翻译：筛选视网膜组织中药物的方法
公开(公告)号：US09134300B2
公开(公告)日：2015-09-15
申请号：US14306898
申请日：2014-06-17
申请人： Research Foundation of the City University of New York
发明人： Ioannis Danias , Hyungsik Lim
IPC分类号： G01N33/50 , G01J9/00 , G01J4/00 , G01N33/483 , G01N21/63 , G01N21/17 , G01N21/21 , A61B5/00 , A61B3/10 , G02B21/00
CPC分类号： G01N33/5044 , A61B3/10 , A61B5/4848 , G01J4/00 , G01J9/00 , G01J2009/002 , G01J2009/004 , G01N21/1717 , G01N21/21 , G01N21/63 , G01N21/636 , G01N33/4833 , G01N33/5008 , G01N2021/1734 , G02B21/002
摘要： The subject matter disclosed herein pertains to a method for screening drugs using second-harmonic generation microscopy. The tissue is scanned with a pulsed laser light which has an excitation wavelength. At least some of microtubules within the tissue produce generated light with a second-harmonic wavelength that is half the excitation wavelength. A microtubule pattern within the tissue is determined based on an analysis of the generated second-harmonic wavelength.
摘要翻译：本文公开的主题涉及使用二次谐波生成显微术来筛选药物的方法。组织用具有激发波长的脉冲激光扫描。组织内的至少一些微管产生产生的光，其二次谐波波长是激发波长的一半。基于生成的二次谐波波长的分析来确定组织内的微管图案。

82. 发明授权

US08921101B2 Attenuated poliovirus 有权
标题翻译：减毒脊髓灰质炎病毒
公开(公告)号：US08921101B2
公开(公告)日：2014-12-30
申请号：US13269213
申请日：2011-10-07
申请人： Eckard Wimmer , Jeronimo Cello , Aniko Paul , Hidemi Toyoda , Jiang Yin
发明人： Eckard Wimmer , Jeronimo Cello , Aniko Paul , Hidemi Toyoda , Jiang Yin
IPC分类号： A61K39/12 , C12N7/00 , A61K35/76
CPC分类号： C12N7/00 , A61K35/768 , C12N2770/32332 , C12N2770/32361 , C12N2800/30 , C12N2840/203
摘要： A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.
摘要翻译：在神经母细胞瘤细胞中复制的新颖且稳定的减毒脊髓灰质炎病毒通过将本地复制元件（cre）工程化成5'非翻译的基因组区域并使位于2C编码区的天然cre元件失活而产生， crePV）。稳定减毒的脊髓灰质炎病毒在表达CD155（脊髓灰质炎病毒受体）的神经母细胞瘤模型（Neuro-2aCD155肿瘤）中复制，并且对于固体肿瘤如神经母细胞瘤的溶瘤治疗和治愈是有效的。

83. 发明授权

US08680236B2 Altered OspA of borrelia burgdorferi 有权
标题翻译：改变了勃氏疏螺旋体的OspA
公开(公告)号：US08680236B2
公开(公告)日：2014-03-25
申请号：US12313443
申请日：2008-11-19
申请人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
发明人： Benjamin J. Luft , John J. Dunn , Shohei Koide , Catherine L. Lawson
IPC分类号： C07K14/00 , C07K14/20 , C12N15/00 , C12N15/31
CPC分类号： C07K14/20 , A61K39/00 , C07K2319/00 , Y02A50/401
摘要： Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
摘要翻译：本文提供了具有某些改变的来自莱姆病引起的疏螺旋体的OspA多肽。在一个实施方案中，所述改变增加含有所述改变的OspA多肽的构象稳定性，同时保持相应未改变的OspA多肽的至少一些抗原性。在另一个实施方案中，与相应的未改变的OspA多肽相比，改变的OspA多肽具有降低的与hLFA-1的交叉反应性。

84. 发明申请

US20120021130A1 METHOD FOR INHIBITING DECOMPOSITION OF METAL SULFIDE-CONTAINING MATERIAL 审中-公开
标题翻译：用于抑制含金属硫化物材料分解的方法
公开(公告)号：US20120021130A1
公开(公告)日：2012-01-26
申请号：US13255227
申请日：2010-03-04
申请人： Daniel R. Strongin , Martin Schoonen , JUn Hao
发明人： Daniel R. Strongin , Martin Schoonen , JUn Hao
IPC分类号： B05D3/10 , B05D7/00 , B05D5/00 , C09D191/00
CPC分类号： C01G49/12 , C01P2002/82 , C01P2004/04
摘要： This invention provides methods of producing a crosslinked lipid coating on a metal sulfide-containing material using a chemical initiator. The crosslinked lipid coating attached to the surface of the material prevents dissolution or oxidation of the material. The methods may be useful to prevent oxidation and leaking of sulfide-containing material in the environment and may be used in the control of environmental pollution.
摘要翻译：本发明提供使用化学引发剂在含金属硫化物的材料上生产交联脂质涂层的方法。附着在材料表面的交联脂质涂层防止材料的溶解或氧化。该方法可用于防止环境中含硫化物材料的氧化和泄漏，并可用于控制环境污染。

85. 发明授权

US07970476B2 Method and apparatus for guiding movement of a freely roaming animal through brain stimulation 有权
标题翻译：通过脑刺激引导自由漫游动物的运动的方法和装置
公开(公告)号：US07970476B2
公开(公告)日：2011-06-28
申请号：US10361441
申请日：2003-02-10
申请人： John K. Chapin , Sanjiv K. Talwar , Shaohua Xu , Emerson S. Hawley
发明人： John K. Chapin , Sanjiv K. Talwar , Shaohua Xu , Emerson S. Hawley
IPC分类号： A61N1/08
CPC分类号： A01K15/021 , A01K1/031 , A61N1/0529 , A61N1/36017 , G06N3/061
摘要： Movement of a freely roaming animal (190), such as a rat, is guided using electric stimulation of the animal's brain. Cues are provided to the animal to move forward by stimulating a reward center of the brain. Cues are provided to the animal to change its direction by stimulating portions of the animal's brain that control right and left movements, such as a cortical representation of whiskers of the animal. Multi-channel, remotely controlled equipment (140, 145, 150, 350) may be carried by the animal to enable independent energizing of electrodes attached to different regions of the animal's brain. A transmitter carried by the animal may report back data to allow monitoring. A component may be carried by the animal for carrying out a mission, such as for search and rescue or surveillance. Groups of animals may be controlled in real-time by coordinating their movements and tracking their locations.
摘要翻译：使用动物大脑的电刺激来引导诸如大鼠的自由漫游动物（190）的运动。通过刺激大脑的奖励中心向动物提供线索向前移动。通过刺激动物脑部控制左右运动的部分，例如动物的晶须的皮层表示，向动物提供线索来改变其方向。可以由动物携带多通道远程控制的设备（140,145,150,350），以使得能够独立地激励附着在动物脑部的不同区域的电极。由动物携带的发射器可以报告数据以允许监测。动物可以携带组件进行任务，例如搜索和救援或监视。可以通过协调他们的动作和跟踪他们的位置来实时控制一组动物。

86. 发明授权

US07856369B2 Frequency based method for scheduling jobs with hard constraints 有权
标题翻译：用于调度具有硬约束的作业的基于频率的方法
公开(公告)号：US07856369B2
公开(公告)日：2010-12-21
申请号：US10613507
申请日：2003-07-03
申请人： Eugene Feinberg , Michael Curry
发明人： Eugene Feinberg , Michael Curry
IPC分类号： G06F17/50
CPC分类号： G06Q10/04 , G06Q10/06314
摘要： A method is provided for generating a feasible schedule for n jobs given a duration and a revisit time for each job. The method comprises determining whether it is impossible to generate a feasible schedule, determining whether a round robin schedule is possible, calculating theoretical probabilities, calculating actual probabilities, creating a potential schedule based on the theoretical probabilities and the actual probabilities, and searching for a feasible schedule from the potential schedule.
摘要翻译：提供了一种用于为每个作业给出持续时间和重新访问时间的n个作业生成可行的时间表的方法。该方法包括：确定是否不可能产生可行的调度，根据理论概率和实际概率确定循环调度是否可行，计算理论概率，计算实际概率，创建潜在调度，以及搜索可行的从潜在的时间安排。

87. 发明授权

US07829140B1 Method of forming iron oxide core metal shell nanoparticles 有权
标题翻译：形成氧化铁芯金属壳纳米颗粒的方法
公开(公告)号：US07829140B1
公开(公告)日：2010-11-09
申请号：US11391883
申请日：2006-03-29
申请人： Chuan-Jian Zhong , Lingyan Wang , Jin Luo
发明人： Chuan-Jian Zhong , Lingyan Wang , Jin Luo
IPC分类号： B05D7/00
CPC分类号： A61K49/1839 , A61K49/183 , B01J23/8906 , B01J35/0013 , B01J35/008 , B82Y5/00 , B82Y30/00 , C01G49/06 , C01G49/08 , C01P2002/72 , C01P2002/84 , C01P2004/04 , C01P2004/51 , C01P2004/52 , C01P2004/64 , C01P2006/42 , C09C1/24
摘要： A method of forming mono-disperse iron-oxide core metal shell nanoparticles is disclosed. Particle size of the oxide core seeds is controlled and capped seeds are formed. The capping layer is desorbed by a thermally activated process and metal such as gold is chemically deposited on the core seeds in situ. This process can be repeated to produce multi-metal or different metal shells. A second capping layer is applied on the core/shell composite nanoparticles. In another step, the particles are sized by centrifuging to obtain a tightly controlled and narrow particle size distribution. The water-dispersibility of the particles is achieved by a thiol exchange reaction on the gold shell of the core/shell nanoparticles or by deposition of gold on ferritin-derived iron oxide cores in aqueous solution. Mono and multilayer thin films are assembled on different substrates using the core/shell particles and linking molecules.
摘要翻译：公开了形成单分散铁氧化物芯金属壳纳米颗粒的方法。控制氧化核心种子的粒径并形成封盖的种子。封盖层通过热激活过程解吸，并且诸如金的金属原位化学沉积在核心种子上。可以重复该过程以产生多金属或不同的金属壳。在核/壳复合纳米颗粒上施加第二盖层。在另一个步骤中，颗粒通过离心来定尺寸以获得严格控制和窄的粒度分布。颗粒的水分散性通过在核/壳纳米颗粒的金壳上的硫醇交换反应或通过在水溶液中在铁蛋白衍生的氧化铁芯上沉积金来实现。使用核/壳颗粒和连接分子将单层和多层薄膜组装在不同的基底上。

88. 发明授权

US07685540B1 Standard block design: an effective approach for large scale floorplanning 失效
标题翻译：标准块设计：大规模布局规划的有效方法
公开(公告)号：US07685540B1
公开(公告)日：2010-03-23
申请号：US11744208
申请日：2007-05-03
申请人： Patrick H. Madden , Ameya R. Agnihotri
发明人： Patrick H. Madden , Ameya R. Agnihotri
IPC分类号： G06F17/50
CPC分类号： G06F17/5077
摘要： As circuit sizes have increased, designs have become increasingly hierarchical. It is common for designs to have large numbers of macro blocks; many of these blocks are “soft,” and may have variable width and height. The present invention provides an alternate method to handle designs with large numbers of blocks. Rather than approaching them as expanded floorplanning, the problems are re-cast as traditional mixed size placement, and many macro blocks are treated as standard cells. Using existing mixed size placement tools, the superior reported are obtained. First, an effective “standard block design” methodology is provided. Second, new mixed size placement legalization algorithms that are more robust than the widely-used mixed-size Tetris algorithm is presented.
摘要翻译：随着电路尺寸的增加，设计越来越分级。设计通常有大量的宏块; 这些块中的许多是“软的”，并且可以具有可变的宽度和高度。本发明提供了处理具有大量块的设计的替代方法。而不是将它们作为扩展的布局规划，而是将这些问题重新转变为传统的混合大小放置，许多宏块被视为标准单元。使用现有的混合尺寸放置工具，获得了上级报告。首先，提供了一种有效的“标准块设计”方法。第二，提出了比广泛使用的混合大小俄罗斯方块算法更强大的新的混合大小放置合法化算法。

89. 发明授权

US07653608B2 System and method for ranking academic programs 有权
标题翻译：学术课程排名的制度和方法
公开(公告)号：US07653608B2
公开(公告)日：2010-01-26
申请号：US11389815
申请日：2006-03-27
申请人： Lawrence B. Martin , Anthony J. Olejniczak
发明人： Lawrence B. Martin , Anthony J. Olejniczak
IPC分类号： G06N5/00
CPC分类号： G06Q10/10
摘要： A computer-implemented method for ranking a plurality of academic programs includes receiving a plurality of records corresponding to the plurality of academic programs, respectively, combining elements of the plurality of records to determine respective z-scores according to a predetermined metric, and ranking the plurality of academic programs according to the respective z-scores.
摘要翻译：用于对多个学术课程进行排名的计算机实现的方法包括分别接收与多个学术课程相对应的多个记录，组合多个记录的元素以根据预定度量来确定相应的z分数，并且将根据各自的z分数，多个学术课程。

90. 发明授权

US07605248B2 Recombinant constructs of Borrelia burgdorferi 失效
标题翻译：博氏疏螺旋体的重组构建体
公开(公告)号：US07605248B2
公开(公告)日：2009-10-20
申请号：US11527161
申请日：2006-09-26
申请人： Raymond J. Dattwyler , Maria J. C. Gomes-Solecki , Benjamin J. Luft , John J. Dunn
发明人： Raymond J. Dattwyler , Maria J. C. Gomes-Solecki , Benjamin J. Luft , John J. Dunn
IPC分类号： C07H21/04 , C07H21/02 , A61K39/02
CPC分类号： C07K16/1207 , A61K39/00 , A61K2039/53 , C07K14/20 , C07K2319/00 , Y02A50/401
摘要： Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.
摘要翻译：公开了编码包含OspC或其抗原性片段的嵌合型疏螺旋体蛋白和OspA或其抗原性片段的新型嵌合核酸。还公开了由核酸序列编码的嵌合蛋白。嵌合蛋白质可用作针对莱姆硼芽孢杆菌病的疫苗免疫原，以及用于免疫诊断试剂。

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