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    • 82. 发明授权
    • Recombinant mycobacterial methionyl-tRNA synthetase genes and methods of
use therefore
    • 重组分枝杆菌甲硫氨酰-tRNA合成酶基因及其使用方法
    • US5798240A
    • 1998-08-25
    • US584226
    • 1996-01-11
    • Susan A. MartinisMandana SassanfarSunghoon KimSang Ho LeePaul R. Schimmel
    • Susan A. MartinisMandana SassanfarSunghoon KimSang Ho LeePaul R. Schimmel
    • A61K38/00C12N9/00C07H21/04C12N1/20C12N15/00
    • C12N9/93A61K38/00Y10S435/863
    • Isolated and/or recombinant nucleic acids encoding mycobacterial methionyl-tRNA synthetase have been characterized. Recombinant DNA constructs and vectors having a sequence which encodes mycobacterial methionyl-tRNA synthetase have been made, and can be used for the construction of tester strains as well as for the production of isolated and/or recombinant methionyl-tRNA synthetases. These enzymes or portions thereof are useful in the biochemical separation of methionine and quantification of methionine or ATP, and for producing antibodies useful in the purification and study of the enzyme, for example. Host cells and methods useful for producing recombinant mycobacterial methionyl-tRNA synthetases are described, as are tester strains, which are cells engineered to rely on the function of the tRNA synthetase encoded by an introduced cloned gene. Tester strains can be used to identify inhibitors of the essential tRNA synthetase enzyme encoded by the introduced cloned gene, and thus provide a means to assess the antimicrobial effect and specificity of the inhibitor without employing slow-growing, pathogenic strains of mycobacteria, such as Mycobacterium tuberculosis.
    • 已经表征了编码分枝杆菌甲硫氨酰-tRNA合成酶的分离和/或重组核酸。 已经制备了具有编码分枝杆菌甲硫氨酰-tRNA合成酶的序列的重组DNA构建体和载体,并且可用于构建测试菌株以及用于分离和/或重组甲硫氨酰-tRNA合成酶的产生。 这些酶或其部分可用于甲硫氨酸的生物化学分离和甲硫氨酸或ATP的定量,以及用于产生用于纯化和研究酶的抗体。 描述了可用于产生重组分枝杆菌甲硫氨酰-tRNA合成酶的宿主细胞和方法,试验菌株是被依赖于引入的克隆基因编码的tRNA合成酶的功能而被工程化的细胞。 测试菌株可以用于鉴定由引入的克隆基因编码的必需tRNA合成酶的抑制剂,并且因此提供了评估抑制剂的抗微生物效果和特异性的方法,而不使用分枝杆菌的缓慢生长的致病菌株,例如分枝杆菌 结核。
    • 83. 发明授权
    • Column repair circuit for integrated circuits
    • 集成电路列修复电路
    • US5689464A
    • 1997-11-18
    • US600599
    • 1994-04-19
    • Jong Seuk LeeSeung Min KimJae Hyeoung KimSang Ho Lee
    • Jong Seuk LeeSeung Min KimJae Hyeoung KimSang Ho Lee
    • G11C11/413G11C29/00G11C29/04G11C7/00
    • G11C29/812G11C29/846
    • A column repair circuit for a semiconductor memory having an input/output selection circuit for inputting a control signal, selecting a bit line and a bit bar line corresponding to a faulty memory cell and replacing the selected bit line and bit bar line with a spare bit line and a spare bit bar line. The input/output selection circuit includes an input stage for inputting the control signal, a spare bit line and a spare bit bar line, and a plurality of fuses each having one side connected to the input stage and other side connected to a plurality of resistors. The other side of the resistors are connected to ground for outputting the output signals. The input/output selection circuit further has a plurality of n-channel MOSFETs each including a gate connected to each of the other stages of the plurality of fuses via the resistors in a 2 to 1 manner for inputting the output signals. The drains of the MOSFETS are connected to the spare bit line and spare bit bar line and their sources are connected to each of the plurality of data bit lines and the plurality of data bit bar lines for functioning as a switch. Therefore, the present invention can provide the column repair circuit for a semiconductor memory which is capable of increasing its repair yield by adding the input/output selecting circuit enabling input/output selecting.
    • 一种用于半导体存储器的列修复电路,具有用于输入控制信号的输入/输出选择电路,选择与故障存储器单元相对应的位线和位线,并用备用位替换所选位线和位线 线和备用位线。 输入/输出选择电路包括用于输入控制信号的输入级,备用位线和备用位线条,以及多个熔丝,每个熔丝具有连接到输入级的一侧和连接到多个电阻器的另一侧 。 电阻的另一侧连接到地,用于输出输出信号。 所述输入/输出选择电路还具有多个n沟道MOSFET,每个n沟道MOSFET包括通过所述电阻器以多个熔丝连接到所述多个熔丝中的每一个的栅极,以2:1的方式输入所述输出信号。 MOSFETS的漏极连接到备用位线和备用位线,并且它们的源极连接到用作开关的多个数据位线和多个数据位线中的每一个。 因此,本发明可以提供半导体存储器的列修复电路,该半导体存储器能够通过添加能够进行输入/输出选择的输入/输出选择电路来提高其修复产率。
    • 89. 发明授权
    • Power control system for LCD monitor
    • 液晶显示器电源控制系统
    • US08373641B2
    • 2013-02-12
    • US12038429
    • 2008-02-27
    • Sang Ho Lee
    • Sang Ho Lee
    • G09G3/36G09G5/00G06F3/038
    • H05B41/2855Y02B20/186
    • A power control system for an LCD monitor having an LCD panel includes a light source unit providing light to the LCD panel, a power supply unit generating a standard low DC current, and a high-voltage generator for converting the lower DC voltage to a relatively high voltage and supplying the high voltage to the light source. The power control system further includes a feedback control unit coupled to the power supply unit for interrupting the operation of the power supply unit when the converted high voltage is determined to be abnormal. The feedback control unit includes a cable, through which a voltage can be induced due to high voltage generated by the high-voltage generator, and a power supply control circuit capable of interrupting the operation of the power supply unit when the converted high voltage is determined to be abnormal by analyzing the induced current.
    • 一种具有LCD面板的LCD监视器的电源控制系统,包括:向LCD面板提供光的光源单元,产生标准低DC电流的电源单元;以及用于将较低DC电压转换成相对较低的DC电压的高压发生器 高电压并向光源提供高电压。 功率控制系统还包括耦合到电源单元的反馈控制单元,用于在转换的高电压被确定为异常时中断电源单元的操作。 反馈控制单元包括电缆,由于高电压发生器产生的高电压,可以感应电压;以及电源控制电路,当确定转换高电压时能够中断供电单元的动作 通过分析感应电流异常。