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81. 发明授权

US07567836B2 ECG signal power vector detection of ischemia or infarction 有权
标题翻译：心电信号功率矢量检测缺血或梗塞
公开(公告)号：US07567836B2
公开(公告)日：2009-07-28
申请号：US11275800
申请日：2006-01-30
申请人： Yi Zhang
发明人： Yi Zhang
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/04011 , A61B5/7207 , A61B5/7285
摘要： A system comprising a processor that includes a cardiac signal vector module and an ischemia detection module. The cardiac signal vector module is configured to measure a first dominant vector corresponding to a direction and magnitude of maximum signal power of a first segment of at least one cardiac cycle of a subject and at least a second dominant vector corresponding to a direction and magnitude of maximum signal power of a second segment of the cardiac cycle from an electrical cardiac signal. The ischemia detection module is configured to measure a change in the first dominant vector, to form a difference by subtracting a measured change in the second dominant vector from a measured change in the first dominant vector, and to declare whether an ischemic event occurred using the difference.
摘要翻译：一种系统，包括包括心脏信号矢量模块和缺血检测模块的处理器。心脏信号矢量模块被配置为测量对应于受试者的至少一个心动周期的第一段的最大信号功率的方向和幅度的第一显性矢量，以及对应于对象的方向和幅度的至少第二显性矢量来自心电信号的心动周期的第二段的最大信号功率。局部缺血检测模块被配置为测量第一显性矢量的变化，以通过从第一显性矢量的测量变化中减去第二显性矢量的测量变化来形成差异，并且声明是否使用区别。

82. 发明申请

US20090155805A1 COPY NUMBER ALTERATIONS THAT PREDICT METASTATIC CAPABILITY OF HUMAN BREAST CANCER 审中-公开
标题翻译：预测人乳腺癌的分类能力的复制编号
公开(公告)号：US20090155805A1
公开(公告)日：2009-06-18
申请号：US12335162
申请日：2008-12-15
申请人： Yi Zhang , Jack X. Yu , Yuqui Jiang , Yixin Wang
发明人： Yi Zhang , Jack X. Yu , Yuqui Jiang , Yixin Wang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827
摘要： Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.
摘要翻译：在本说明书中公开的是通过总结染色体预定部分中所有SNP（单核苷酸多态性）的意义来定义预后价值的染色体区域来定义预后价值的染色体区域的方法。基于特定基因的SNP，可以提供更准确的乳腺癌预后。

83. 发明授权

US07530956B2 Daytime/nighttime respiration rate monitoring 有权
标题翻译：白天/夜间呼吸率监测
公开(公告)号：US07530956B2
公开(公告)日：2009-05-12
申请号：US11820002
申请日：2007-06-15
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/00
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
摘要翻译：一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

84. 发明申请

US20090042737A1 Methods and Devices for Correlated, Multi-Parameter Single Cell Measurements and Recovery of Remnant Biological Material 审中-公开
标题翻译：用于相关多参数单细胞测量和残留生物材料回收的方法和装置
公开(公告)号：US20090042737A1
公开(公告)日：2009-02-12
申请号：US12188999
申请日：2008-08-08
申请人： Andrew S. Katz , Haichuan Zhang , Keunho Ahn , Yi Zhang
发明人： Andrew S. Katz , Haichuan Zhang , Keunho Ahn , Yi Zhang
IPC分类号： C40B30/06 , C40B60/12
CPC分类号： B01L3/502761 , B01L7/525 , B01L2200/027 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0663 , B01L2300/087 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , G01N15/1484 , G01N2015/149
摘要： Methods and apparatus are provided for analysis and correlation of phenotypic and genotypic information for a high throughput sample on a cell by cell basis. Cells are isolated and sequentially analyzed for phenotypic information and genotypic information which is then correlated. Methods for correlating the phenotype-genotype information of a sample population can be performed on a continuous flow sample within a microfluidic channel network or alternatively on a sample preloaded into a nano-well array chip. The methods for performing the phenotype-genotype analysis and correlation are scalable for samples numbering in the hundreds of cells to thousands of cells up to the tens and hundreds of thousand cells.
摘要翻译：提供了方法和装置，用于基于细胞的高通量样品的表型和基因型信息的分析和相关性。分离细胞并依次分析表型信息和基因型信息，然后相关。可以在微流体通道网络内的连续流动样品上或者预先加载到纳米阵列芯片中的样品上进行将样品群体的表型 - 基因型信息相关联的方法。用于进行表型 - 基因型分析和相关性的方法可扩展到数百个细胞中的样品编号到数千个细胞直到数十万个细胞。

85. 发明申请

US20090013091A1 CUSTOMER BASED MESSAGE ROUTING 审中-公开
标题翻译：基于客户的消息路由
公开(公告)号：US20090013091A1
公开(公告)日：2009-01-08
申请号：US11773102
申请日：2007-07-03
申请人： Yi Zhang , Chi H. Tang
发明人： Yi Zhang , Chi H. Tang
IPC分类号： G06F15/173
CPC分类号： H04L51/28
摘要： A method and system for messaging, and more particularly archiving of messages in a distributed network of archiver nodes, by routing and grouping of the messages by customer, utilizing traditional recipient email addresses in SMTP is disclosed.
摘要翻译：公开了一种通过利用SMTP中的传统接收方电子邮件地址通过客户路由和分组消息来消息传送的方法和系统，并且更具体地归档归档节点的分布式网络中的消息。

86. 发明授权

US07457664B2 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US07457664B2
公开(公告)日：2008-11-25
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋向闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

87. 发明申请

US20080281367A1 SYSTEM AND METHOD TO DETERMINE HEMODYNAMIC TOLERABILITY 有权
标题翻译：确定血液动力学耐受性的系统和方法
公开(公告)号：US20080281367A1
公开(公告)日：2008-11-13
申请号：US11745016
申请日：2007-05-07
申请人： Yi Zhang , Allan C. Shuros , Dan Li
发明人： Yi Zhang , Allan C. Shuros , Dan Li
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61B5/02028 , A61B5/0464 , A61B5/0535 , A61B5/0538 , A61B5/7264
摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.
摘要翻译：可植入医疗装置检测心脏的快速性心律失常。在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。灌注信息也可用于改变快速性心律失常检测或分类。

88. 发明申请

US20080262360A1 USING RESPIRATION DISTRESS MANIFESTATIONS FOR HEART FAILURE DETECTION 有权
标题翻译：使用呼吸部分心理失调检测
公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
申请人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
发明人： Yousufali Dalal , John D. Hatlestad , Yi Zhang , Aaron Lewicke , Jeffrey E. Stahmann
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译：讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。

89. 发明申请

US20080248458A1 Purification, Characterization and Reconstitution of a Ubiquitin E3 Ligase 有权
标题翻译：泛素E3连接酶的纯化，表征和重构
公开(公告)号：US20080248458A1
公开(公告)日：2008-10-09
申请号：US11915610
申请日：2006-06-01
申请人： Ru Cao , Hengbin Wang , Yi Zhang
发明人： Ru Cao , Hengbin Wang , Yi Zhang
IPC分类号： C12Q1/00 , C12N9/00 , C12P21/04 , C12N5/06
CPC分类号： C12Q1/25 , C12N9/93 , G01N2333/9015 , G01N2500/02
摘要： The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further comprises HPH2 and/or HPC3. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that modulate the ubiquitin E3 ligase activity of the native or reconstituted complex, and methods of identifying candidate compounds for treating cancer. Kits for determining modulation of protein ubiquitination and/or for ubiquitinating a target substrate are further provided.
摘要翻译：本发明提供了包含Bmi1和/或Ring1和/或Ring2的天然或重构的复合物，其中所述复合物具有泛素E3连接酶活性。任选地，复合物还包含HPH 2和/或HPC 3。还公开了产生重构复合物的方法，鉴定调节天然或重构复合物的泛素E3连接酶活性的化合物的方法以及鉴定用于治疗癌症的候选化合物的方法。还提供了用于确定蛋白质泛素化和/或用于泛素化靶基质的调节的试剂盒。

90. 发明申请

US20080177156A1 ISCHEMIA DETECTION USING PRESSURE SENSOR 审中-公开
标题翻译：使用压力传感器进行ISCHEMIA检测
公开(公告)号：US20080177156A1
公开(公告)日：2008-07-24
申请号：US11624974
申请日：2007-01-19
申请人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
发明人： Yi Zhang , Krzysztof Z. Siejko , Richard Fogoros , Abhilash Patangay
IPC分类号： A61B5/0205 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure (“PAP”) signal of a pulmonary artery (“PA”) and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译：本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算将血液供应减少到至少一部分心脏使用来自PAP信号的信息。使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

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