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81. 发明申请

US20120232064A1 ASPARTYL PROTEASE INHIBITORS 有权
标题翻译： ASPARTYL PROTEASE抑制剂
公开(公告)号：US20120232064A1
公开(公告)日：2012-09-13
申请号：US13421396
申请日：2012-03-15
申请人： Yusheng Wu , Ulrich Iserloh , Jared N. Cumming , Xiaoxiang Liu , Robert D. Mazzola , Zhong-Yue Sun , Ying Huang , Andrew Stamford , Brian McKittrick , Zhaoning Zhu
发明人： Yusheng Wu , Ulrich Iserloh , Jared N. Cumming , Xiaoxiang Liu , Robert D. Mazzola , Zhong-Yue Sun , Ying Huang , Andrew Stamford , Brian McKittrick , Zhaoning Zhu
IPC分类号： A61K31/506 , C07D403/04 , A61K31/497 , A61P29/00 , A61K31/551 , A61P9/00 , A61P25/28 , C07D409/14 , C07D401/04
CPC分类号： C07D239/20 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/04 , C07D409/14 , C07D411/04 , C07D417/04 , C07D417/14 , C07D495/20
摘要： Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification.Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，U，W，X，R 1，R 2，R 6，R 7，R 30和R 31如上文在说明书中所述。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

82. 发明授权

US08266431B2 Method and apparatus for performing encryption of data at rest at a port of a network device 有权
标题翻译：用于在网络设备的端口处静止地进行数据的加密的方法和装置
公开(公告)号：US08266431B2
公开(公告)日：2012-09-11
申请号：US11264191
申请日：2005-10-31
申请人： Jonathan M. Parlan , Raymond J. Kloth , Ying Huang , Fabio R. Maino , Pawan Agrawal
发明人： Jonathan M. Parlan , Raymond J. Kloth , Ying Huang , Fabio R. Maino , Pawan Agrawal
IPC分类号： G06F21/00
CPC分类号： H04L9/0897 , H04L9/0891 , H04L9/0894 , H04L9/3247 , H04L63/0428 , H04L63/0485 , H04L2209/56 , H04L2209/80
摘要： Methods and apparatus for performing encryption for data at rest at a port of a network device such as a switch are disclosed. Specifically, when data is received from a host during a write to a storage medium such as a disk, the data is encrypted by the port prior to transmitting the encrypted data to the storage medium. Similarly, when a host attempts to read data from the storage medium, the port of the network device receives the encrypted data from the storage medium, decrypts the data, and transmits the decrypted data to the host. In this manner, encryption and decryption of data at rest are supported by the port of the network device.
摘要翻译：公开了用于在诸如交换机的网络设备的端口处静止的数据执行加密的方法和装置。具体地说，当在向诸如盘的存储介质的写入期间从主机接收到数据时，在将加密数据发送到存储介质之前，数据被端口加密。类似地，当主机尝试从存储介质读取数据时，网络设备的端口从存储介质接收加密的数据，解密数据，并将解密的数据发送到主机。以这种方式，网络设备的端口支持静止数据的加密和解密。

83. 发明申请

US20120171126A1 NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：新型[3,2-c]异烟肼作为葡萄糖激素受体激动剂组合物及其用途
公开(公告)号：US20120171126A1
公开(公告)日：2012-07-05
申请号：US13378893
申请日：2010-06-15
申请人： Biju J. Purakkattle , Michael Y. Berlin , Yeon-Hee Lim , Rema D. Bitar , Kevin D. McCormick , Robert G. Aslanian , Yoon Joo Lee , Junying Zheng , Ying Huang , Walter Won
发明人： Biju J. Purakkattle , Michael Y. Berlin , Yeon-Hee Lim , Rema D. Bitar , Kevin D. McCormick , Robert G. Aslanian , Yoon Joo Lee , Junying Zheng , Ying Huang , Walter Won
IPC分类号： A61K31/58 , A61K9/12 , A61P37/00 , A61P29/00 , A61P17/00 , A61P17/06 , A61P17/04 , A61P11/06 , A61P11/02 , A61P11/08 , A61P11/00 , A61P1/00 , A61P1/04 , A61P25/00 , A61P27/02 , C07J71/00
CPC分类号： C07J71/0047 , C07J71/0063
摘要： The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas (H-A), (II-A1), (II-A2), (II-A2.1), (ll-A-2.2), (ll-A-2.3), (II-A4), (H-B), (H-C), (III), (IV), (V), (VI), as described herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.
摘要翻译：本发明提供具有以下通式结构的式（I）化合物及其药学上可接受的盐，溶剂合物，酯，前体药物，互变异构体或异构体：其中L，R1，R2，R3，R4 R 5和R 6彼此独立地选择并如本文所定义。本发明还提供式（IIa），（Ⅱ-A1），（Ⅱ-A2），（Ⅱ-A2.1），（Ⅱ-A2）的化合物（和盐，溶剂合物，酯，前体药物，互变异构体和异构体）（II-A-2.3），（II-A4），（HB），（HC），（III），（IV），（V），（VI）还提供了药物组合物，制备方法和使用这些化合物在治疗和预防广泛范围的免疫，自身免疫和炎性疾病和病症中的方法。

84. 发明申请

US20110090374A1 SUB-FRAME TAPERED RESET 有权
标题翻译：子框复位
公开(公告)号：US20110090374A1
公开(公告)日：2011-04-21
申请号：US12582316
申请日：2009-10-20
申请人： Ying Huang , Giuseppe Rossi , Lester Joseph Kozlowski , Laurent Blanquart , Qianjiang Mao , Gregory Chow
发明人： Ying Huang , Giuseppe Rossi , Lester Joseph Kozlowski , Laurent Blanquart , Qianjiang Mao , Gregory Chow
IPC分类号： H04N5/217 , H04N5/335
CPC分类号： H04N5/363 , H04N5/343 , H04N5/3532 , H04N5/374 , H04N5/3765
摘要： Systems and methods are provided that facilitate employing a plurality of independent reset buses for a column of pixels in a pixel array of a CMOS sensor imager. Utilization of the plurality of independent reset buses for the column of pixels can enable independent reset to be effectuated when employing sub-frame integration. For example, rows to be read and reset during a given readout time interval can be selected based upon one or more criteria. Further, each of the rows selected during the given readout time interval can be associated with a respective distinct reset bus. By leveraging the plurality of independent reset buses, uniformity in pixel operation can be maintained whether operating in full frame integration mode or sub-frame integration mode. Thus, noise resultant from changing between integration modes can be mitigated by using the plurality of independent reset buses.
摘要翻译：提供了系统和方法，其便于对CMOS传感器成像器的像素阵列中的像素列采用多个独立的复位总线。对于像素列，多个独立复位总线的利用可以使得在采用子帧集成时能够实现独立的复位。例如，可以基于一个或多个标准来选择在给定的读出时间间隔期间要读取和复位的行。此外，在给定读出时间间隔期间选择的每行都可以与相应的不同的复位总线相关联。通过利用多个独立的复位总线，无论是在全帧集成模式还是子帧集成模式下操作，都可以保持像素操作的均匀性。因此，可以通过使用多个独立复位总线来减轻由积分模式之间变化引起的噪声。

85. 发明申请

US20100292203A1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 有权
公开(公告)号：US20100292203A1
公开(公告)日：2010-11-18
申请号：US12693874
申请日：2010-01-26
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan
IPC分类号： A61K31/505 , C07D239/22 , A61K31/55 , A61K31/397
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

86. 发明授权

US07803802B2 Substituted amide beta secretase inhibitors 有权
标题翻译：取代的酰胺β分泌酶抑制剂
公开(公告)号：US07803802B2
公开(公告)日：2010-09-28
申请号：US11185419
申请日：2005-07-20
申请人： Ying Huang , Guoqing Li , Andrew W Stamford
发明人： Ying Huang , Guoqing Li , Andrew W Stamford
IPC分类号： A61K31/497 , C07D241/02
CPC分类号： C07D401/12 , C07D241/04 , C07D241/08 , C07D401/10 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R4 and X are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are methods of treating a cognitive or neurodegenerative disease comprising administering to a patient I need of such treatment a combination of at least one compound of formula I and at least one compound selected from the group consisting of β-secretase inhibitors other than those of formula I, HMG-CoA reductase inhibitors, gamma-secretase inhibitors, non-steroidal anti-inflammatory agents, N-methyl-D-aspartate receptor antagonists, cholinesterase inhibitors and anti-amyloid antibodies.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐或溶剂化物，其中R1，R2，R3，R4和X如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经退行性疾病的方法，包括向需要这种治疗的患者施用至少一种式I化合物和至少一种选自除了那些的那些之外的其他化合物式I，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，非甾体抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂和抗淀粉样蛋白抗体。

87. 发明申请

US20100152138A1 CYCLIC AMINE BACE-1 INHIBITORS HAVING A BENZAMIDE SUBSTITUENT 有权
标题翻译：具有苯甲酸替代物的循环胺BACE-1抑制剂
公开(公告)号：US20100152138A1
公开(公告)日：2010-06-17
申请号：US12641952
申请日：2009-12-18
申请人： Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X.H. Le , Jeffrey F. Lowrie , Kurt W. Saionz , Suresh D. Babu
发明人： Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X.H. Le , Jeffrey F. Lowrie , Kurt W. Saionz , Suresh D. Babu
IPC分类号： A61K31/4015 , C07D207/12 , C07D217/24 , C07D413/12 , C07D243/08 , A61K31/47 , A61K31/675 , A61K31/397 , A61K31/5377 , A61K31/551 , A61P25/28
CPC分类号： C07D243/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/26 , C07D209/52 , C07D211/26 , C07D211/46 , C07D217/18 , C07D233/32 , C07D241/04 , C07D241/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/12 , C07D413/06
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification.Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中R1是R是-C（O）-N（R27）（R28），或其余的变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的药物组合物和方法，其包含式I化合物与除式I以外的分泌抑制剂抑制剂，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，非 - 甾族抗炎药，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂或抗淀粉样蛋白抗体。

88. 发明申请

US20100113033A1 COMMUNICATION SYSTEM, NETWORK HANDOVER PROCESSING METHOD AND APPARATUS 有权
标题翻译：通信系统，网络切换处理方法和设备
公开(公告)号：US20100113033A1
公开(公告)日：2010-05-06
申请号：US12683824
申请日：2010-01-07
申请人： Yong Qiu , Min Huang , Ying Huang , Hongzhuo Zhang
发明人： Yong Qiu , Min Huang , Ying Huang , Hongzhuo Zhang
IPC分类号： H04W36/00 , H04W36/06
CPC分类号： H04W36/0033 , H04W36/0011 , H04W36/0055 , H04W36/0066 , H04W76/18
摘要： A communication system, a network handover processing method and a network handover processing apparatus are disclosed. The method includes the following steps: receiving, by a target evolution NodeB (T-eNB), identity information sent from a user equipment (UE), the identity information being allocated to the UE by a source evolution NodeB (S-eNB); and sending, by the T-eNB, parameters to the UE if identity information, matching the received identity information sent from the UE, is available in the T-eNB, wherein the parameters are allocated to the UE. The apparatus includes a receiving module and a sending module. The communication system, network handover processing method and network handover processing apparatus can reduce the state change times of the UE in the network handover process and save the system resources.
摘要翻译：公开了一种通信系统，网络切换处理方法和网络切换处理装置。该方法包括以下步骤：由目标演进节点B（T-eNB）接收从用户设备（UE）发送的身份信息，身份信息由源演进节点B（S-eNB）分配给UE; 以及如果从所述UE发送的所接收的身份信息的匹配的身份信息在所述T-eNB中可用，则由所述T-eNB向所述UE发送参数，其中，所述参数被分配给所述UE。该装置包括接收模块和发送模块。通信系统，网络切换处理方法和网络切换处理装置可以在网络切换过程中减少UE的状态改变时间并节省系统资源。

89. 发明授权

US07705153B2 Bipiperdine derivatives useful as CCR3 antagonists 失效
标题翻译：双哌啶衍生物可用作CCR3拮抗剂
公开(公告)号：US07705153B2
公开(公告)日：2010-04-27
申请号：US11049460
申请日：2005-02-02
申请人： Pauline C. Ting , Jianhua Cao , Youhao Dong , Eric J. Gilbert , Ying Huang , Joseph M. Kelly , Stuart McCombie , Neng-Yang Shih
发明人： Pauline C. Ting , Jianhua Cao , Youhao Dong , Eric J. Gilbert , Ying Huang , Joseph M. Kelly , Stuart McCombie , Neng-Yang Shih
IPC分类号： A61K31/4709 , A61K31/4725 , C07D215/14
CPC分类号： C07D401/14 , C07D211/18 , C07D211/58 , C07D401/04 , C07D471/04
摘要： The use of CCR3 antagonists of the formula I or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula II, pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.
摘要翻译：公开了使用式I的CCR3拮抗剂或其药学上可接受的盐治疗哮喘，以及式II的新型化合物，包含它们的药物组合物及其在治疗哮喘中的用途，其中R， Ra，X，Xa，R1，R2，R2a，R14，R14a，R16和n如说明书中所定义。

90. 发明申请

US20090312341A1 CYCLIC AMINE BACE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT 有权
标题翻译：具有杂环取代基的循环胺BACE-1抑制剂
公开(公告)号：US20090312341A1
公开(公告)日：2009-12-17
申请号：US12490884
申请日：2009-06-24
申请人： Jared N. Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie
发明人： Jared N. Cumming , Ying Huang , Guoqing Li , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voigt , Yusheng Wu , Jianping Pan , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey F. Lowrie
IPC分类号： A61K31/496 , C12N9/99 , A61P25/28
CPC分类号： C04B35/632 , C07D207/277 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is X is —O—, —C(R14)2— or —N(R)—; Z is —C(R14)2— or —N(R)—; t is 0, 1, 2 or 3; each R and R2 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R14 is H, alkyl, alkenyl, alkynyl, halo, —CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, —OR35, —N(R24) (R25) or —SR35; R41 is alkyl, cycloalkyl, —SO2(alkyl), —C(O)-alkyl, —C(O)-cycloalkyl or -alkyl-NH—C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
摘要翻译：公开了下式的新化合物或其药学上可接受的盐或溶剂合物，其中R 1是X是-O - ， - C（R 14）2 - 或-N（R） - ; Z是-C（R 14）2 - 或-N（R） - ; t为0,1,2或3; 每个R和R 2独立地为H，烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，烯基或炔基; 每个R 14是H，烷基，烯基，炔基，卤素，-CN，卤代烷基，环烷基，环烷基烷基，芳基，杂芳基，杂环烷基，芳基烷基，杂芳基烷基，杂环烷基烷基，-OR 35，-N（R 24）（R 25）或-SR 35; R41是烷基，环烷基，-SO2（烷基），-C（O） - 烷基，-C（O） - 环烷基或 - 烷基-NH-C（O）CH3; 其余变量如本说明书中所定义。还公开了包含式I化合物的药物组合物和用式I化合物治疗认知障碍或神经变性疾病的方法。还公开了药物组合物和治疗方法，其包含式I化合物与用于治疗认知或神经变性的其它药剂疾病

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