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81. 发明申请

US20110224660A1 Diode Laser Induced Vapor/Plasma Mediated Medical Procedures and Device 有权
标题翻译：二极管激光诱导蒸气/等离子体介导的医疗程序和装置
公开(公告)号：US20110224660A1
公开(公告)日：2011-09-15
申请号：US12629313
申请日：2009-12-02
申请人： Wolfgang Neuberger , Walter Cecchetti
发明人： Wolfgang Neuberger , Walter Cecchetti
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B18/042 , A61B2018/263 , A61N1/44
摘要： An improved method and device for safe and efficient medical applications is provided. In a preferred embodiment, based on using the inherent benefits of laser diodes (such as efficient power generation from a reliable and compact solid state device), plasmas and high energy vapors are produced for medical applications with power levels and power densities sufficient to treat medical indications and avoid the creation of extensive damage zones. Transmissions means in different configurations are used to achieve a high power density, which is able to initiate plasma and high-energy vapor at the tip. Once a sparkless plasma and high energy vapor bubbles are formed, it is often found that it will also absorb other wavelengths in addition to the one that initiated it. As a consequence, other wavelengths more efficiently generated by diodes or diode pumped lasers may be added into the beam in order to improve treatment efficiency. For example, the 1470 nm wavelength can be used to produces sparkler-less plasma bubbles, together with the 980 nm wavelength to produce tissue vaporization and an excellent haemostasis effect. Once plasma and or high-energy vapors are in place, radiation from this zone determine tissue effects. In another embodiment, high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally it can be applied in combination with another wavelength with medium absorption in water such as 980 nm. In another embodiment a concentric double core fiber is used, in which the ignition radiation is guided in near single mode, inner core and the radiation used to maintain and enhance the pulse is guided into the surrounding second outer core.
摘要翻译：提供了一种用于安全有效的医疗应用的改进方法和装置。在优选实施例中，基于使用激光二极管的固有优点（例如来自可靠和紧凑的固态器件的有效发电），为医疗应用产生等离子体和高能蒸气，其功率水平和功率密度足以治疗医疗适应症，避免造成广泛的伤害区。传输意味着不同的配置用于实现高功率密度，其能够启动尖端处的等离子体和高能蒸气。一旦形成了无火花等离子体和高能量蒸汽气泡，经常发现除了引发它之外，它也将吸收其它波长。因此，为了提高处理效率，可以将更多由二极管或二极管泵浦激光器产生的其它波长添加到光束中。例如，1470nm波长可用于产生无闪蒸的等离子体气泡，以及980nm波长以产生组织蒸发和良好的止血效果。一旦等离子体和/或高能量蒸气就位，来自该区域的辐射决定了组织的影响。在另一个实施例中，使用高峰值功率脉冲辐射。优选1470nm，1940nm或1550nm的波长。此外，它可以与另外一种在水中具有介质吸收的波长（例如980nm）结合使用。在另一个实施例中，使用同心双芯纤维，其中点火辐射在近单模模式内引导，并且用于维持和增强脉冲的辐射被引导到周围的第二外核中。

82. 发明申请

US20110082410A1 Method for Reducing Pain during Photodynamic Therapy 审中-公开
标题翻译：光动力治疗期间减轻疼痛的方法
公开(公告)号：US20110082410A1
公开(公告)日：2011-04-07
申请号：US12896551
申请日：2010-10-01
申请人： Albrecht Volker , Wolfgang Neuberger
发明人： Albrecht Volker , Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B18/203 , A61B2017/00172 , A61B2018/00452 , A61B2018/00476
摘要： The present invention provides a method for application of photodynamic therapy which results in a reduction of pain experienced by a patient during treatment. An irradiation pattern of short pulses is applied to a treatment site. The same total energy dosage and light intensity parameters for a specific application, as known in the state of the art is used, but the radiation is applied in a series of short pulses. In a preferred embodiment, radiation is applied with about 350 millisecond pulses, and each pulse is separated by about 100 to 500 millisecond intervals. Application of radiation in pulses rather than continuous wave application reduces pain during treatment without sacrificing the therapeutic effect.
摘要翻译：本发明提供了一种应用光动力疗法的方法，其导致患者在治疗期间经历的疼痛减轻。将短脉冲的照射图案施加到治疗部位。使用如现有技术中已知的具体应用的相同的总能量剂量和光强度参数，但是以一系列短脉冲施加辐射。在优选实施例中，以大约350毫秒的脉冲施加辐射，并且每个脉冲被隔开大约100到500毫秒的间隔。辐射在脉冲而不是连续波应用中的应用减少治疗期间的疼痛而不牺牲治疗效果。

83. 发明申请

US20110060388A1 DEVICE AND METHOD FOR VESSEL TREATMENT 有权
公开(公告)号：US20110060388A1
公开(公告)日：2011-03-10
申请号：US12877721
申请日：2010-09-08
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B90/36 , A61N2005/063 , A61N2005/0659
摘要： A device and method for restoring functionality of blood vessels are disclosed. Laser energy is accurately and precisely applied in order to restore vessel functionality. This is accomplished by a controlled, reliable and specific shrinkage and/or strengthening of the vessel structure. Laser radiation is transported in a controlled manner via an optical fiber to the site where energy is needed. Laser wavelength is chosen according to the required penetration depth in tissue. It has been found that a wavelength that is essentially absorbed within less than a millimeter of the actual dimensions of the vessel walls thickness works best. In a preferred embodiment, wavelength of approximately 1470 nm is used. A mini-endoscope is preferably used to control the process by visual inspection from the inside of the vessel. Other means such as ultrasound, echography, Positron Emission Tomography (PET), Computed Tomography (CT) and Optical Coherence Tomography (OCT), or other imaging means can also be combined to control the procedure. Full 360° radial emission, i.e., delivery of laser radiation perpendicularly or fairly inclined relative to the veins axis, is beneficial, and is accomplished by means of a radial emitting fiber. In another preferred embodiment, a 360 degree radiation pattern can be achieved by using a twister or side-emitting fiber, along with rotational and sweeping movements, to apply energy in an even, more-controlled, and guided manner. Valve function is restored to recover whole vein functionality, avoiding the need of closing it. In a preferred embodiment, energy is applied from the outside of the vessel, by inserting a device through the skin and tissue. In another preferred embodiment, specific radiation absorbers (and/or scattering enhancers) can be located at suitable positions inside the vessel wall or near the tissue to be treated, thus radiation can then selectively target tagged locations. Vessel function is restored preserving its structure, using a minimally invasive treatment. A wide range of vessel diameters are effectively treated. Vessels include veins, arteries and fistulas. Specifically, when treating veins, valvular incompetence is accurately and precisely treated, thus rendering a safe, versatile and fast procedure with reduced recurrence possibilities.

84. 发明申请

US20100179525A1 ENDOLUMINAL LASER ABLATION DEVICE AND METHOD FIR TREATING VEINS 审中-公开
标题翻译：内镜激光治疗装置和方法FIR治疗病毒
公开(公告)号：US20100179525A1
公开(公告)日：2010-07-15
申请号：US12731525
申请日：2010-03-25
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B18/18
CPC分类号： A61B18/245 , A61B17/22012 , A61B18/24 , A61B2018/2272
摘要： An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.
摘要翻译：提供了一种改进的方法和装置，用于安全有效的低功率密度腔内治疗静脉功能不全。一个这样的装置通过具有锥形尖端的光纤端部径向地发射脉冲或连续的能量，用于360°径向发射。在一些实施例中，锥形反射表面与发射尖端相对并面对发射尖端，以通过反射径向方向上任何设计或残余的向前传输的能量来增强径向发射效率。其他设备包括密封在保护性辐射透明盖内的平坦发射面。另外的实施例包括间隔/定中心机构，以使静止壁与径向等距离发射。激光辐射以波长和功率传输，使得其基本上完全被血管壁吸收，以充分损伤血管内皮，从而实现血管闭合。因为能量基本上完全被吸收在血管壁内，所以可以基本上避免沿着血管治疗区域的局部麻醉剂的需要。

85. 发明申请

US20090131499A1 PHOTODYNAMIC THERAPY FOR SKIN RELATED PROBLEMS 审中-公开
标题翻译：皮肤相关问题的光化疗法
公开(公告)号：US20090131499A1
公开(公告)日：2009-05-21
申请号：US12271708
申请日：2008-11-14
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61K31/407
CPC分类号： A61K41/0071
摘要： PhotoDynamic Therapy method is used to treat problems associated with pilosebaceous units including acne and other skin conditions. At least one liposomal-formulated, hydrophobic photosensitizer, such as a dihydro- or tetrahydro-porphyrin, is topically applied to acne affected regions, and is allowed to penetrate the hair follicle before being irradiated with a suitable wavelength of light energy overlapping the absorption spectrum of the selected photosensitizer. The photoactivated agent initiates a cytotoxic effect in the sebaceous gland, reducing excess oil production and destroying bacterial growth in the follicle thus subsiding inflammatory action. Scarring of the skin is minimized and the skin heals faster due to collagen cell stimulation.
摘要翻译： PhotoDynamic Therapy方法用于治疗与皮脂腺单位相关的问题，包括痤疮和其他皮肤病症。将至少一种脂质体配制的疏水性光敏剂，例如二氢或四氢卟啉，局部施用于痤疮受影响的区域，并且在用合适的波长的能量与吸收光谱重叠之前，允许穿透毛囊的所选光敏剂。光活化剂在皮脂腺中引发细胞毒性作用，减少多余的油产生并破坏卵泡中的细菌生长，从而消除炎症反应。由于胶原细胞刺激，皮肤的疤痕被最小化，皮肤愈合愈快。

86. 发明申请

US20080275432A1 Photodynamic foam composition and sclerosis treatment 审中-公开
标题翻译：光动力泡沫组合物和硬化症治疗
公开(公告)号：US20080275432A1
公开(公告)日：2008-11-06
申请号：US11800400
申请日：2007-05-04
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A61B6/00 , A61K31/407 , A61K47/26
CPC分类号： A61K31/407 , A61K41/0042 , A61K41/0071 , A61K49/00 , A61N5/062 , A61N2005/0602
摘要： A photodynamic composition and a method for in vivo photonic treatments that is minimally invasive, versatile and precise are described. The invention allows for photonic treatments with only minimal insertions into the area of treatment, often a single one. The invention may be used with a standard insertion component making the system inexpensive and easy for doctors to use. The invention has applications in several areas of treatment. In vivo treatment of aesthetic skin blemishes such as varicose veins can be performed with minimal external effects. A predetermined amount of a photodynamic composition, as a foam, is injected into the vein or structure of concern. The composition is a sclerosis foam including a photosensitizer. By external compression, where applicable, the photodynamic composition is forced to remain in the vein or structure. After a predetermined time, radiation of appropriate wavelength from a light source is delivered directly to the vascular structure. Among the key benefits of the present invention are the elimination of targeted varicose veins, without need for anesthesia along the length of the vein; no edema; no skin reaction; and tactile appreciation.
摘要翻译：描述了光动力学组合物和微创，多功能和精确的体内光子处理方法。本发明允许光子治疗，只有最少的插入到治疗区域，通常是单一治疗。本发明可以与标准的插入部件一起使用，使得该系统便于医生使用。本发明在几个治疗领域都有应用。美容皮肤瑕疵如静脉曲张的体内治疗可以以最小的外部作用进行。将预定量的作为泡沫的光动力学组合物注入到关注的静脉或结构中。该组合物是包含光敏剂的硬化泡沫。通过外部压缩，如果适用，光动力学组合物被迫保持在静脉或结构中。在预定时间之后，从光源的适当波长的辐射直接传送到血管结构。本发明的主要优点之一是消除目标静脉曲张，而不需要沿着静脉的长度麻醉; 无水肿; 无皮肤反应; 和触觉欣赏。

87. 发明申请

US20070129712A1 Benign prostate hyperplasia treatment using photosensitizer and laser ablation 审中-公开
标题翻译：良性前列腺增生治疗使用光敏剂和激光消融
公开(公告)号：US20070129712A1
公开(公告)日：2007-06-07
申请号：US11598401
申请日：2006-11-13
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61N5/06
CPC分类号： A61B18/24 , A61B2017/00274 , A61B2018/00547 , A61B2018/2272 , A61K9/0034 , A61K9/127 , A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/061
摘要： A method and apparatus are disclosed to employ a combination of laser ablation/coagulation and photosensitizers (PS) to treat benign prostate hyperplasia (BPH). According to this method a photosensitizer is administered locally to the prostate zone, which is to be treated, using a suitable device to ensure an adequately uniform distribution of the photosensitizer in the hyperplasic prostate tissue to be treated. In one embodiment enlarged prostate tissue is laser irradiated using an optical fiber inserted through an endoscope to ablate and coagulate tissue nearby and to activate the photosensitizer to destroy tissue deeper into the prostate. In another embodiment a suitable laser wavelength is used to photoactivate the photosensitizer in the presensitized prostate tissue to enhance ablation, photo-coagulation and destruction of diseased prostate tissues. Additional wavelengths may be employed that would target different areas of the prostate. Generally laser ablation is done in pulsed or continuous irradiations where the photosensitizer can be activated before, during, or after this radiation. Multiple wavelength laser sources can also be used to achieve laser ablation, photo-coagulation and absorption by the photosensitizer. The photosensitizer used in the invention may be formulated in a liposomal or other drug carrier system to achieve an enhanced effect of the drug.
摘要翻译：公开了采用激光烧蚀/凝固和光敏剂（PS）的组合来治疗良性前列腺增生（BPH）的方法和装置。根据该方法，使用合适的装置将光敏剂局部施用于待治疗的前列腺区域，以确保光敏剂在待治疗的增生性前列腺组织中的均匀分布。在一个实施方案中，使用插入通过内窥镜的光纤激光照射放大的前列腺组织以消融和凝结附近的组织并激活光敏剂以将组织深入到前列腺中。在另一个实施方案中，使用合适的激光波长来光敏化未化学前列腺组织中的光敏剂，以增强患病前列腺组织的消融，光凝和破坏。可以采用靶向前列腺的不同区域的附加波长。通常在脉冲或连续照射下进行激光烧蚀，其中光敏剂可以在该辐射之前，期间或之后被激活。多波长激光源也可用于实现光敏剂的激光烧蚀，光凝和吸收。本发明中使用的光敏剂可以配制在脂质体或其它药物载体体系中以实现药物的增强作用。

88. 发明申请

US20060217692A1 Power regulated medical underskin irradiation treatment system for manual movement 有权
公开(公告)号：US20060217692A1
公开(公告)日：2006-09-28
申请号：US11443143
申请日：2006-05-30
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61B18/24 , A61B18/20 , A61B2017/00075 , A61B2018/00196 , A61B2018/00636
摘要： A system and method for controllably releasing radiation in percutaneous radiation treatment is provided. In a preferred embodiment, a laser is coupled to an optical fiber that is inserted below the skin or into a vascular lumen to a predetermined point. The fiber is connected to a source of electromagnetic radiation such as a laser, non-coherent radiation source, high power laser diode, LED, and an ultrasonic source. Radiation is then delivered to the treatment site while the fiber is simultaneously drawn out to the entry point. The fiber is manually withdrawn and during this time the radiation is administered in a manner appropriate for the vein being treating in regards to power or energy level. To maintain a constant proper energy density, the speed of withdrawal is measured and sent to a controlling mechanism. The controlling mechanism modifies the power emitted, pulse length or pulse rate to ensure that the vein or tissue receives a consistent dose of energy during manual withdrawal. In one preferred embodiment, an imaging device provides the controlling device with position and time information so that speed information from fiber or catheter surface textural properties or based on one or more bar code like markings. In another preferred embodiment, additional information is collected, such as vein diameter prior to treatment, position of the distal end of the fiber, and/or impact measurements such as vibration or temperature during treatment, and the controlling mechanism adjusts output power or pulse rate in response to measurements to maintain a desired power density at all position during the manual withdrawal.

89. 发明授权

US07005623B2 Autocalibrating medical diode laser system 失效
标题翻译：自动校准医用二极管激光系统
公开(公告)号：US07005623B2
公开(公告)日：2006-02-28
申请号：US10438513
申请日：2003-05-15
申请人： Wolfgang Neuberger , Stefan Spaniol
发明人： Wolfgang Neuberger , Stefan Spaniol
IPC分类号： G01J1/32
CPC分类号： G01J1/08 , G01J1/04 , G01J1/0425 , G01J1/0474 , G01J1/32 , G01J1/42 , G01J2001/4247
摘要： Briefly stated, the present invention discloses a novel device that automatically calibrates and adjusts the intensity, dosage, and other parameters of a radiation delivery system and radiation source based on selected or detected radiation delivery systems. Such radiation delivery systems include optical fiber systems, and any type of diffuser, as well as bare fiber tips. The functions of a radiation source and a calibration device are combined by storing the characteristics of a wide variety of delivery system types and brands and calibrating the radiation based on those stored characteristics. In a preferred embodiment, a calibration sheath is provided that fits over a delivery system, such as a bare fiber tip or a diffuser at the distal end of a fiber, to both protect the system during calibration and direct output radiation to a detector. In another embodiment, one or more detectors are situated on the interior surface of the calibration sheath to directly measure at least a preselected portion of the emitted radiation. Power readings are directed to a calibration subsystem from the detector or detectors, which then adjusts the emitted power to conform to desired treatment parameters. The need for different calibration devices based on the characteristics of the delivery system is alleviated.
摘要翻译：简而言之，本发明公开了一种基于选定或检测的辐射传播系统自动校准和调整辐射传播系统和辐射源的强度，剂量和其它参数的新型装置。这种辐射递送系统包括光纤系统和任何类型的扩散器以及裸光纤尖端。辐射源和校准装置的功能通过存储各种传送系统类型和品牌的特性并基于这些存储的特性来校准辐射来组合。在优选实施例中，提供了一种校准护套，其配合在诸如光纤末端处的裸光纤尖端或扩散器之类的传送系统上，以在校准期间保护系统并且将直接输出辐射传输到检测器。在另一个实施例中，一个或多个检测器位于校准护套的内表面上，以直接测量所发射的辐射的至少预选部分。功率读数从检测器或检测器引导到校准子系统，然后检测器或检测器调整发射功率以符合所需的治疗参数。基于输送系统的特性对不同校准装置的需求得到缓解。

90. 发明授权

US06984229B2 Device and method for minimizing restenosis after angioplasty treatment 失效
公开(公告)号：US06984229B2
公开(公告)日：2006-01-10
申请号：US10103234
申请日：2002-03-21
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B18/245 , A61B2017/22002 , A61B2018/2261 , A61N5/0601
摘要： A novel device and method for preventing restenosis and streamlining the angioplasty procedure. The device and method provide a fiberoptic guidewire, or, alternatively, a light-conducting catheter, to decrease the size of the angioplasty device, decrease the overall time of the procedure, and increase the safety of the procedure. The present invention delivers radiation to a sclerotized area after balloon angioplasty treatment to prevent restenosis Radiation delivered via the catheter or fiberoptic guidewire discourages the cell proliferation and cell growth after angioplasty, thereby improving the chances of avoiding restenosis.

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