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81. 发明授权

US07834238B2 Saspase knockout animal 有权
标题翻译： Saspase敲除动物
公开(公告)号：US07834238B2
公开(公告)日：2010-11-16
申请号：US12088640
申请日：2006-10-04
申请人： Takeshi Matsui , Fumie Kisumi
发明人： Takeshi Matsui , Fumie Kisumi
IPC分类号： A16K15/00
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/6413 , C12N15/8509
摘要： Knockout animals in which a gene encoding a SASPase has been deleted (hereinafter, referred to as SASPase KO animals) are provided. The SASPase KO animals deficient in expression of functional SASPase were produced by deleting a gene encoding a stratified epithelium-specific protease, SASPase, through targeted disruption. The SASPase KO animals showed a significant increase in wrinkles on the sides of the body and so on. The SASPase KO animals find utility as animal models of wrinkles.
摘要翻译：提供其中已经缺失了编码SASPase的基因的敲除动物（以下称为SASPase KO动物）。缺乏表达功能性SASPase的SASPase KO动物是通过目标破坏来删除编码分层上皮特异性蛋白酶SASPase的基因而产生的。 SASPase KO动物在身体两侧的皱纹显着增加等等。 SASPase KO动物用作皱纹的动物模型。

82. 发明申请

US20100039464A1 PRINTING APPARATUS, PRINTING METHOD, AND PROGRAM 失效
标题翻译：打印设备，打印方法和程序
公开(公告)号：US20100039464A1
公开(公告)日：2010-02-18
申请号：US12538329
申请日：2009-08-10
申请人： Tatsumi Ito , Yuichiro Ikemoto , Koji Ashizaki , Takeshi Matsui , Masahiro Maikuma , Shintaro Tanaka
发明人： Tatsumi Ito , Yuichiro Ikemoto , Koji Ashizaki , Takeshi Matsui , Masahiro Maikuma , Shintaro Tanaka
IPC分类号： B41J29/38
CPC分类号： G11B23/40 , B41J3/4071
摘要： A print head which includes at least two discharge nozzle lines arranged on at least two lines, out of a base line corresponding to a radial direction of the rotating print object and at least one offset lines parallel to the base line, discharges ink drops of the same color from discharge nozzles of the discharge nozzle lines, moves the print head so as to minutely move the discharge nozzle lines on the base line or the offset lines, and discharges ink drops of the same color from the discharge nozzles passing through second paths moved minutely from the first paths over the rotating print object. In this way, the ink drops are discharged on the area where print defects are caused because the area is not on the paths of the discharge nozzles before the discharge nozzles are minutely moved.
摘要翻译：一种打印头，其包括布置在至少两条线上的至少两个排出喷嘴线，从与旋转的打印对象的径向相对应的基线和平行于基线的至少一个偏移线排出，与排出喷嘴管线的排出喷嘴相同的颜色，移动打印头，以使排出喷嘴线在基线或偏移线上微小地移动，并且从通过第二路径移动的排出喷嘴排出相同颜色的墨滴从旋转的打印对象上的第一路径分钟。以这种方式，在排出喷嘴被微小移动之前，由于区域不在排出喷嘴的路径上，所以墨滴被排出在引起打印缺陷的区域上。

83. 发明申请

US20080238960A1 Print method, print apparatus, and recording medium driving apparatus 失效
标题翻译：打印方法，打印装置和记录介质驱动装置
公开(公告)号：US20080238960A1
公开(公告)日：2008-10-02
申请号：US11986286
申请日：2007-11-20
申请人： Tatsumi Ito , Takeshi Matsui , Yuichiro Ikemoto
发明人： Tatsumi Ito , Takeshi Matsui , Yuichiro Ikemoto
IPC分类号： B41J29/38
CPC分类号： B41J2/175 , B41J3/4071 , B41J29/38
摘要： A print method that prints visible information by ejecting ink droplets from a print head onto a printed object rotated by a rotational driving unit is provided. The print method includes the steps of: carrying out impact position correction that corrects displacements in impact positions of the ink droplets to convert the visible information to impact position-corrected polar coordinate data when converting the visible information from biaxial perpendicular coordinate data to polar coordinate data; generating ink ejection data based on the impact position-corrected polar coordinate data; and printing the visible information by ejecting the ink droplets onto the printed object based on the ink ejection data.
摘要翻译：提供一种打印方法，其通过将墨滴从打印头喷射到由旋转驱动单元旋转的打印对象上来打印可见信息。打印方法包括以下步骤：执行冲击位置校正，其校正墨滴的冲击位置中的位移，以将可见信息转换为将可见信息从双轴垂直坐标数据转换为极坐标数据时冲击位置校正的极坐标数据 ; 基于冲击位置校正的极坐标数据产生喷墨数据; 以及通过基于喷墨数据将墨滴喷射到打印对象上来打印可见信息。

84. 发明申请

US20070259383A1 Novel Genes involved in Epidermal differentiation, and uses thereof 审中-公开
标题翻译：参与表皮分化的新基因及其用途
公开(公告)号：US20070259383A1
公开(公告)日：2007-11-08
申请号：US10591099
申请日：2005-03-02
申请人： Takeshi Matsui , Fumie Kisumi , Yoko Kinoshita
发明人： Takeshi Matsui , Fumie Kisumi , Yoko Kinoshita
IPC分类号： C12P1/04 , C07H21/04 , C07K14/00 , C07K16/18 , G01N33/53 , C12N15/00 , C12N5/06
CPC分类号： G01N33/6881 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , G01N2333/4742 , G01N2800/20
摘要： A high-throughput in situ hybridization system was applied to the mouse foot pad epidermis to identify novel genes involved in epidermal differentiation. As a result, epidermal expression patterns were detected for about 100 unique mRNAs. Of these, two novel secreted proteins, dermokine-α and -β, which are expressed in the suprabasal layer of the differentiated epithelia, were successfully identified. Further, the gene encoding the above proteins was found to constitute a novel gene complex (SSC).
摘要翻译：将高通量原位杂交系统应用于小鼠脚垫表皮以鉴定涉及表皮分化的新基因。结果，检测到约100个独特的mRNA表皮表达模式。其中，成功鉴定了在分化上皮的上基层中表达的两种新型分泌蛋白，皮质激素-α和-β。此外，发现编码上述蛋白质的基因构成新的基因复合物（SSC）。

85. 发明申请

US20060172419A1 Highly efficient gene targeting vectors and methods for gene targeting method forward epithelial cell line 审中-公开
标题翻译：高效的基因靶向载体和基因靶向方法前向上皮细胞系
公开(公告)号：US20060172419A1
公开(公告)日：2006-08-03
申请号：US10539534
申请日：2003-12-24
申请人： Kazuaki Umeda , Takeshi Matsui , Mayumi Nakayama
发明人： Kazuaki Umeda , Takeshi Matsui , Mayumi Nakayama
IPC分类号： A01K67/027 , C12N5/06 , C12N15/87
CPC分类号： C07K14/47 , A01K2217/072 , A01K2217/075 , A01K2227/105 , C12N15/8509 , C12N15/907 , C12N2800/30 , C12N2830/42 , C12N2840/203 , C12N2840/44
摘要： In the process of generating ZO-1 gene knockout mice, the present inventors developed gene targeting vectors that allow homologous recombination to occur at a high probability (90% or more). In addition, the present inventors used the targeting vectors for studying optimal electroporation conditions in epithelial cells, and as a result, successfully determined optimal electroporation conditions that would enable efficient gene targeting in the EpH4 mouse epithelial cell line. Use of the vectors of the present invention enables easy introduction of exogenous genes into the ZO-1 allele of ES cells. Moreover, since effects on the genomic structure need not be considered, the methods of the present invention are expected to solve problems encountered in the conventional methods for generating transgenic mice and stable transformants.
摘要翻译：在产生ZO-1基因敲除小鼠的过程中，本发明人开发了以高概率（90％或更高）发生同源重组的基因靶向载体。此外，本发明人使用靶向载体来研究上皮细胞中的最佳电穿孔条件，结果成功地确定了能够在EpH4小鼠上皮细胞系中实现有效基因靶向的最佳电穿孔条件。使用本发明的载体能够容易地将外源基因引入到ES细胞的ZO-1等位基因中。此外，由于不需要考虑对基因组结构的影响，预期本发明的方法可以解决用于产生转基因小鼠和稳定转化体的常规方法中遇到的问题。

86. 发明授权

US07084853B2 Display unit and drive method therefor 失效
标题翻译：显示单元及其驱动方式
公开(公告)号：US07084853B2
公开(公告)日：2006-08-01
申请号：US10250965
申请日：2002-11-07
申请人： Kenji Shinozaki , Takeshi Matsui , Kenichi Takahashi
发明人： Kenji Shinozaki , Takeshi Matsui , Kenichi Takahashi
IPC分类号： G09G3/38 , G09G3/20
CPC分类号： G02F1/163 , G02F1/1508 , G02F1/155 , G02F2001/1519 , G09G3/3622
摘要： An electrochemical display apparatus in which simple matrix driving is realized, whereby apparatus constitution can be simplified, and the price of the apparatus can be lowered. The electrochemical display apparatus performs display by use of electrochemical deposition/dissolution of a metal. The display apparatus is driven by a simple matrix driving system, in which a deposition overvoltage at the time of deposition of metallic ions as the metal is used as a threshold in the simple matrix driving. A driving voltage is set to be not more than two times the deposition overvoltage. The electrochemical display apparatus includes transparent electrodes and counter electrodes, the display is performed by utilizing deposition/dissolution of the metal on the transparent electrodes, and the potential difference between the metal to be deposited on the transparent electrodes and the counter electrodes is set to be less than the deposition overvoltage. Ideally, the same metal as the metal which is deposited is used for constituting the counter electrodes.
摘要翻译：实现简单矩阵驱动的电化学显示装置，由此能够简化装置结构，并且能够降低装置的价格。电化学显示装置通过使用金属的电化学沉积/溶解来进行显示。显示装置由简单矩阵驱动系统驱动，其中在简单矩阵驱动中使用作为金属沉积金属离子时的沉积过电压作为阈值。驱动电压设定为不超过沉积过电压的两倍。电化学显示装置包括透明电极和对电极，通过利用金属在透明电极上的沉积/溶解进行显示，并且将要沉积在透明电极和对置电极上的金属之间的电位差设定为小于沉积过电压。理想地，与沉积的金属相同的金属用于构成对电极。

87. 发明授权

US06259565B1 Display apparatus 失效
标题翻译：显示装置
公开(公告)号：US06259565B1
公开(公告)日：2001-07-10
申请号：US09117050
申请日：1998-07-17
申请人： Akira Kawamura , Takeshi Matsui , Shunichi Hashimoto , Yoshinori Tanaka , Takeshiro Nakatsue
发明人： Akira Kawamura , Takeshi Matsui , Shunichi Hashimoto , Yoshinori Tanaka , Takeshiro Nakatsue
IPC分类号： G02B2714
CPC分类号： G02B27/0149 , G02B5/30 , G02B27/01 , G02B27/0101 , G02B27/225 , G02B2027/0125 , G02B2027/0138 , G02B2027/0154 , G02B2027/0156 , H04N5/7491 , H04N13/111 , H04N13/158 , H04N13/167 , H04N13/189 , H04N13/194 , H04N13/204 , H04N13/289 , H04N13/322 , H04N13/324 , H04N13/337 , H04N13/341 , H04N13/344 , H04N13/363 , H04N13/366 , H04N13/398 , H04N19/597 , Y10S248/917
摘要： A semi-spherical system holding mechanism 8 such as to cover the head portion of the user is provided in the upper portion of a user holding mechanism 9 such as chair, sofa, or the like. A display apparatus 7 is fixed in the system holding mechanism 8. In the display apparatus 7, a video image displayed on a display panel 14 is enlarged by a lens 13, so that a virtual image is formed. The virtual images which are observed by the right and left eyes of the user are arranged at the same position in a space.
摘要翻译：诸如椅子，沙发等用户保持机构9的上部设置有用于覆盖使用者头部的半球形系统保持机构8。显示装置7固定在系统保持机构8中。在显示装置7中，通过透镜13放大显示面板14上显示的视频图像，从而形成虚像。由用户的左眼和左眼观察到的虚拟图像被布置在空间中的相同位置。

88. 发明授权

US6052239A Portable display device 失效
标题翻译：便携式显示设备
公开(公告)号：US6052239A
公开(公告)日：2000-04-18
申请号：US984097
申请日：1997-12-03
申请人： Takeshi Matsui , Akira Kawamura , Shunichi Hashimoto , Yoshinori Tanaka
发明人： Takeshi Matsui , Akira Kawamura , Shunichi Hashimoto , Yoshinori Tanaka
IPC分类号： G02B27/00 , G02B27/01 , G02B27/04 , G02B27/22 , H04N13/00 , G02B27/02 , G02B3/60 , G02B7/62
CPC分类号： H04N13/0275 , G02B27/017 , G02B27/0172 , G02B27/0176 , G02B27/04 , G02B27/2228 , H04N13/0029 , H04N13/0296 , H04N13/044 , H04N13/0497 , G02B2027/0132 , H04N13/0285
摘要： In a non-use state in which a cover (2) is closed (FIG. 6A), a lens (11R) is accommodated in a housing (1) such that the lens is in a so-called laid state. In a use state in which the cover (2) is open (FIG. 6B), the lens (11R) is exposed from the housing (1) and is set in a so-called rise state. In this state, when a user looks through the lens (11R), the user can see an virtual image formed by magnifying an image displayed on a display panel (12R) with the lens (11R).
摘要翻译：在盖（2）关闭的不使用状态（图6A）中，透镜（11R）容纳在壳体（1）中，使得透镜处于所谓的放置状态。在盖（2）打开的使用状态（图6B）中，透镜（11R）从壳体（1）露出，并被设定在所谓的上升状态。在这种状态下，当用户看透镜（11R）时，用户可以看到通过用透镜（11R）放大显示在显示面板（12R）上的图像而形成的虚像。

89. 发明授权

US5486841A Glasses type display apparatus 失效
标题翻译：眼镜型显示装置
公开(公告)号：US5486841A
公开(公告)日：1996-01-23
申请号：US76953
申请日：1993-06-15
申请人： Nobuyuki Hara , Akira Kawamura , Takeshi Matsui
发明人： Nobuyuki Hara , Akira Kawamura , Takeshi Matsui
IPC分类号： G02B5/30 , G02B7/12 , G02B27/00 , G02B27/01 , H04N13/00 , G09G5/00
CPC分类号： H04N13/044 , G02B27/017 , G02B27/0172 , G02B27/0176 , G02B7/12 , H04N13/0497 , G02B2027/0132 , G02B2027/0154 , G02B2027/0156 , G02B2027/0159 , G02B2027/0178 , G02B5/30 , H04N13/0285
摘要： A glasses type head mounted display apparatus for seeing a virtual image through left and right lens systems provided with corresponding left and right display portions displaying left and right pictures, respectively. The display apparatus includes left and right slide mechanisms for moving the respectively left and right display portions on the main point axes of the lens systems and on segment lines through the central points of the left and right lens systems and focuses of the left and right lens systems so that the user sees through the left and right lens systems a virtual image synthesized with pictures of the left and right display portions.
摘要翻译：一种眼镜型头戴式显示装置，用于通过分别显示左图像和右图像的相应左和右显示部分的左右透镜系统来观看虚像。该显示装置包括用于使透镜系统的主点轴上的分别左右显示部分和通过左右透镜系统的中心点在分割线上移动的左右滑动机构，左右透镜的焦点系统，使得用户通过左右透镜系统看到与左显示部分和右显示部分的图片合成的虚拟图像。

90. 发明授权

US4996182A Heat-sensitive recording material 失效
标题翻译：热敏记录材料
公开(公告)号：US4996182A
公开(公告)日：1991-02-26
申请号：US312916
申请日：1989-02-21
申请人： Takeshi Matsui , Takehiko Watanabe , Katsunori Miyazaki , Hiroo Hayashi
发明人： Takeshi Matsui , Takehiko Watanabe , Katsunori Miyazaki , Hiroo Hayashi
IPC分类号： B41M5/28 , B41M5/30 , B41M5/41
CPC分类号： B41M5/41
摘要： A heat-sensitive recording material which comprises a heat-sensitive recording layer and a substrate, the substrate having as a constituent element a synthetic resin film layer containing minute cavities and a content of cavities in the synthetic resin film layer being 40 to 100 cc/100 g. The heat-sensitive recording material has excellent resolution and gives a clear recorded image having a high density even with low printing energy.
摘要翻译：一种热敏记录材料，其包括热敏记录层和基材，所述基材作为构成元素是合成树脂膜层，所述合成树脂膜层含有微小空穴，所述合成树脂膜层中的空腔含量为40〜100cc / 100克。热敏记录材料具有优异的分辨率，并且即使在低打印能量下也能提供高密度的清晰记录图像。

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