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81. 发明申请

US20080039375A1 Phosphorus-containing hepatitis C serine protease inhibitors 有权
标题翻译：含磷的丙型肝炎丝氨酸蛋白酶抑制剂
公开(公告)号：US20080039375A1
公开(公告)日：2008-02-14
申请号：US11503407
申请日：2006-08-11
申请人： Joel D. Moore , Deqiang Niu , Guoyou Xu , Dong Liu , Yat Sun Or , Zhe Waug
发明人： Joel D. Moore , Deqiang Niu , Guoyou Xu , Dong Liu , Yat Sun Or , Zhe Waug
IPC分类号： A61K38/12 , A61K38/05 , C07K5/12 , C07K5/08
CPC分类号： A61K38/21 , C07K5/06191 , C07K5/0804 , A61K2300/00
摘要： The present invention relates to phosphorus-derived compounds of Formula I or Formula II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof, which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶活性的式I或式II的磷衍生化合物或其药学上可接受的盐，酯或前药。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

82. 发明申请

US20070281884A1 Macrocyclic oximyl hepatitis C protease inhibitors 审中-公开
标题翻译：大环肟基丙型肝炎蛋白酶抑制剂
公开(公告)号：US20070281884A1
公开(公告)日：2007-12-06
申请号：US11502740
申请日：2006-08-11
申请人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
发明人： Ying Sun , Deqiang Niu , Guoyou Xu , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/12 , A61K31/395 , C07K5/12
CPC分类号： A61K38/212 , A61K38/12 , A61K38/215 , C07K5/0804 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

83. 发明申请

US20070244160A1 6-11 Bicyclic Ketolide Derivatives 审中-公开
标题翻译： 6-11双环酮内酯衍生物
公开(公告)号：US20070244160A1
公开(公告)日：2007-10-18
申请号：US11758225
申请日：2007-06-05
申请人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
发明人： Yat Sun Or , Wang Guoqiang , Ly Tam Phan , Deqiang Niu , Nha Huu Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Judson Farmer , Guoyou Xu
IPC分类号： A61K31/44 , A61P31/04
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

84. 发明申请

US20070232554A1 3,6-Bridged 9,12-oxolides 失效
标题翻译： 3,6桥9,12-草甘膦
公开(公告)号：US20070232554A1
公开(公告)日：2007-10-04
申请号：US11435401
申请日：2006-05-16
申请人： Yat Or , Deqiang Niu , Zhe Wang
发明人： Yat Or , Deqiang Niu , Zhe Wang
IPC分类号： A61K31/7052 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了具有抗菌性质的式（I）化合物或其药学上可接受的盐，酯或前药。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

85. 发明申请

US20060252710A1 6-11 Bridged oxime erythromycin derivatives 审中-公开
标题翻译： 6-11桥接肟红霉素衍生物
公开(公告)号：US20060252710A1
公开(公告)日：2006-11-09
申请号：US11122251
申请日：2005-05-04
申请人： Guoqiang Wang , Ly Phan , Yat Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
发明人： Guoqiang Wang , Ly Phan , Yat Or , Yao-Ling Qiu , Deqiang Niu , Yulin Peng , Marina Busuyek , Yanchun Wang , Suanne Nakajima
IPC分类号： C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes processes by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

86. 发明授权

US07049417B2 6,11-4-Carbon bridged ketolides 失效
标题翻译： 6,11-4-碳桥式酮内酯
公开(公告)号：US07049417B2
公开(公告)日：2006-05-23
申请号：US10841206
申请日：2004-05-07
申请人： Yat Sun Or , Guoqiang Wang , Deqiang Niu , Ly Tam Phan
发明人： Yat Sun Or , Guoqiang Wang , Deqiang Niu , Ly Tam Phan
IPC分类号： C07H1/00
CPC分类号： C07H17/08
摘要： Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.
摘要翻译：描述了包含治疗有效量的本发明化合物与药学上可接受的载体的新颖的6,11-4-碳桥连酮内酯，药学上可接受的组合物。还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。

87. 发明申请

US20050171033A1 9N-substituted 6-11 bicyclic erythromycin derivatives 失效
标题翻译： 9N-取代的6-11双环红霉素衍生物
公开(公告)号：US20050171033A1
公开(公告)日：2005-08-04
申请号：US11031465
申请日：2005-01-07
申请人： Yao-Ling Qiu , Deqiang Niu , Zhe Wang , Ly Phan , Yat Or
发明人： Yao-Ling Qiu , Deqiang Niu , Zhe Wang , Ly Phan , Yat Or
IPC分类号： A01N43/04 , A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formula I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译：本发明公开了式I，II，III或IV的化合物或其外消旋物，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。

88. 发明申请

US20050159370A1 6-11 Bicyclic ketolide derivatives 有权
公开(公告)号：US20050159370A1
公开(公告)日：2005-07-21
申请号：US11042720
申请日：2005-01-25
申请人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
发明人： Yat Or , Guoqiang Wang , Ly Phan , Deqiang Niu , Nha Vo , Yao-Ling Qiu , Yanchun Wang , Marina Busuyek , Ying Hou , Yulin Peng , Heejin Kim , Tongzhu Liu , Jay Farmer , Guoyou Xu
IPC分类号： A61K31/7052 , A61K45/06 , C07H17/08
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

89. 发明申请

US20050009763A1 6,11-4-Carbon bridged erythromycin derivatives 审中-公开
标题翻译： 6,11-4-碳桥红霉素衍生物
公开(公告)号：US20050009763A1
公开(公告)日：2005-01-13
申请号：US10841249
申请日：2004-05-07
申请人： Yat Or , Guoqiang Wang , Deqiang Niu , Ly Phan
发明人： Yat Or , Guoqiang Wang , Deqiang Niu , Ly Phan
IPC分类号： C07H17/08 , A61K31/7048
CPC分类号： C07H17/08
摘要： Novel 6, 11-4-carbon bridged erythromycin derivatives and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are methods for treating bacterial infections by administering to an animal a pharmaceutical composition containing a therapeutically effective amount of a compound of the invention and processes for the preparation of such compounds.
摘要翻译：描述了新颖的6,11-碳桥连红霉素衍生物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。还描述了通过向动物施用含有治疗有效量的本发明化合物和制备这些化合物的方法的药物组合物来治疗细菌感染的方法。

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