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81. 发明申请

US20090156620A1 [4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, FORMS AND METHODS RELATED THERETO 审中-公开
公开(公告)号：US20090156620A1
公开(公告)日：2009-06-18
申请号：US12265699
申请日：2008-11-05
申请人： Emma Sharp , Louisa Jane Quegan , Anjali Pandey , Juan Wang , Matthew Nieder , Wolin Huang
发明人： Emma Sharp , Louisa Jane Quegan , Anjali Pandey , Juan Wang , Matthew Nieder , Wolin Huang
IPC分类号： C07D409/12 , A61K31/517 , C12N5/06 , A61P9/00 , A61P7/00
CPC分类号： C07D409/12
摘要： The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a salt of formula (I) or a pharmaceutically acceptable form thereof.

82. 发明申请

US20090054425A1 PROTEIN KINASE INHIBITORS 有权
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20090054425A1
公开(公告)日：2009-02-26
申请号：US12192034
申请日：2008-08-14
申请人： Yonghong Song , Qing Xu , Anjali Pandey
发明人： Yonghong Song , Qing Xu , Anjali Pandey
IPC分类号： A61K31/496 , C07D487/04 , A61K31/538 , A61P7/00 , A61P9/00 , A61P29/00 , A61P35/02 , C07D413/14
CPC分类号： C07D487/04
摘要： Compounds, particularly compounds having spleen tyrosine kinase (Syk) inhibition activity, having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 is structure (a), (b), (c) or (d): and Ra, Rb, Rc, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed, as well as uses of the same to treat a condition or disorder mediated by a Syk and/or JAK kinase.
摘要翻译：具有以下结构的化合物，特别是具有脾酪氨酸激酶（Syk）抑制活性的化合物或其药学上可接受的盐，其中R 1是结构（a），（b），（c）或（d）：和Ra，Rb ，Rc，R2，R3，R4，R5，R6和R7如本文所定义。还公开了与其制备和使用相关的方法以及含有该组合物的药物组合物，以及其用于治疗由Syk和/或JAK激酶介导的病症或病症的用途。

83. 发明授权

US07109332B2 2,4-dioxo-3-quinazolinylaryl sulfonylureas 失效
标题翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲
公开(公告)号：US07109332B2
公开(公告)日：2006-09-19
申请号：US10956004
申请日：2004-09-29
申请人： Robert M. Scarborough , Wolin Huang , Anjali Pandey , Shawn M. Bauer , Xiaoming Zhang , Zhaozhong J. Jia
发明人： Robert M. Scarborough , Wolin Huang , Anjali Pandey , Shawn M. Bauer , Xiaoming Zhang , Zhaozhong J. Jia
IPC分类号： C07D409/12 , C07D409/14 , A61K31/517 , A61P7/02
CPC分类号： C07D409/12 , C07D409/14
摘要： 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C1-6 alkyl; R1 is a member selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C3-5 cycloalkyl and C3-5 cycloalkyl-alkyl; R2 is a member selected from the group consisting of H, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, cyano and —C(O)R2a, wherein R2a is a member selected from the group consisting of C1-6 alkoxy and (C1-6 alkyl)0-2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of —CH2—, —CH(CH3)—, —CH2CH2—, —CH2CH(CH3)— and —CH2CH2CH2—; L1 is a linking group selected from the group consisting of a bond and —CH2—; L2 is a linking group selected from the group consisting of a bond, —NH— and —CH2—; and Ar1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine; are provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
摘要翻译： 2,4-二氧代-3-喹唑啉基芳基磺酰脲类化合物，其具有下式：其中R是选自H和C 1-6烷基的成员; R 1是选自H，C 1-6烷基，C 1-6卤代烷基，C 1 -C 6烷基，C 1 -C 6烷基， 3-5个环烷基和C 3-5环烷基 - 烷基; R 2是选自H，卤素，C 1-6 - 烷基，C 2-6 - 烯基，C 1 -C 6烷基， C 1-6烷基，C 1-6烷氧基，氰基和-C（O）R 2a，其中R 2a是选自C 1-6烷氧基和（C 1-6烷基）烷基的成员， 0-2氨基; L是选自-CH 2 - ， - CH（CH 3 CH 3） - ， - CH 2 - ， - CH 2 CH 2（CH 3 CH 3） - 和-CH 2 CH _{2 CH 2 - ; L 1是选自键和-CH 2 - 的连接基团。 L 2是从由-NH-和-CH 2 - 的键组成的组中的连接基团。和Ar 1是选自苯，吡啶和嘧啶的芳环; 被提供。该化合物可用于抑制ADP-血小板聚集，特别是在治疗血栓形成和血栓相关病症或病症中。}

84. 发明申请

US20220347120A1 COMPOSITIONS FOR MANAGEMENT OF POLYCYSTIC OVARY SYNDROME 有权
公开(公告)号：US20220347120A1
公开(公告)日：2022-11-03
申请号：US17732655
申请日：2022-04-29
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
IPC分类号： A61K31/12 , A61K9/00 , A61P15/08 , A61K9/20 , A61K9/16 , A61K47/26 , A61K47/42 , A61K47/12 , A61K47/10 , A61K9/48
摘要： The invention discloses compositions comprising bisdemethoxycurcumin and methods for managing polycystic ovary syndrome (PCOS) and its associated conditions which include hormonal imbalance, obesity, hypothyroidism, hyperandrogenism, oxidative stress, inflammation, gut dysbiosis, hypercholesterolemia, cardiovascular complications, hyperglycemia and insulin resistance. The invention also discloses the potential of a curcuminoid composition comprising 20-80% w/w bisdemethoxycurcumin, 10-35% w/w demethoxycurcumin and 10-50% w/w curcumin for use in the therapeutic management of PCOS.

85. 发明申请

US20210220291A1 THERAPEUTIC COMPOSITIONS AND METHODS FOR PULMONARY FIBROSIS 有权
公开(公告)号：US20210220291A1
公开(公告)日：2021-07-22
申请号：US17151172
申请日：2021-01-17
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
IPC分类号： A61K31/122 , A61K31/09 , A61P11/00
摘要： The present invention discloses a method for therapeutic management of pulmonary fibrosis in mammals using a composition comprising iso-garcinol or octahydrocurcumin or a combination of iso-garcinol and octahydrocurcumin. The composition is very suitable for treating pulmonary fibrosis due to viral infections, specifically COVID 19 and for improving lung function during prognosis.

86. 发明授权

US11052125B2 Compositions for weight loss 有权
公开(公告)号：US11052125B2
公开(公告)日：2021-07-06
申请号：US16396902
申请日：2019-04-29
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Lakshmi Mundkur , Sarang Bani , Anjali Pandey
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Lakshmi Mundkur , Sarang Bani , Anjali Pandey
IPC分类号： A61K36/8905 , A61K36/38 , A61K36/67 , A61P3/04 , A61K36/53
摘要： The present invention discloses a composition comprising extracts of Cyperus rotundus, standardized to contain 3-5% w/w total stilbenes, extracts of Garcinia sp., standardized to contain 20% w/w garcinol and extracts of Coleus forskohlii standardized to contain not less than 10% w/w forskolin for the therapeutic management of diet induced obesity and weight gain and related conditions like liver dysfunction, NASH, NAFLD, liver cirrhosis, hypercholesterolemia, hyperlipidemia, kidney dysfunction by bringing about a reduction in body weight, increasing lean body mass and by normalizing the levels of liver enzymes, kidney markers and circulating lipids.

87. 发明授权

US10864243B1 Composition for prostaglandin transporter inhibition and related therapeutic applications 有权
公开(公告)号：US10864243B1
公开(公告)日：2020-12-15
申请号：US16432950
申请日：2019-06-06
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
IPC分类号： A61K36/8962 , A61K36/88 , A61K36/21 , A61K36/71 , A61K36/185 , A61P9/12 , A61K31/122 , A61K31/704 , A61K31/192 , A61K31/197
CPC分类号： A61K36/88 , A61K31/122 , A61K31/192 , A61K31/197 , A61K31/704 , A61K36/185 , A61K36/21 , A61K36/71 , A61P9/12
摘要： The present invention discloses a composition comprising Allium sativum extract standardized to contain not less that 0.3% w/w S-allylcysteine, Beta vulgaris extract standardized to contain not less than 2% w/w nitrates, Nigella sativa extract standardized to contain 0.1%-5% w/w thymoquinone, about 0.01%-10% w/w thymohydroquinone, about 20%-95% w/w fatty acids, about 0.001%-3% w/w α-hederin or hederagenin, and Terminalia arjuna extract standardized to contain 3% w/w arjunoglucosides for use a prostaglandin transporter inhibitor. The invention also discloses the use of the aforementioned composition in the therapeutic management of hypertension and cardiovascular complications.

88. 发明授权

US10864242B2 Aphrodisiac composition and management of male sexual dysfunction 有权
公开(公告)号：US10864242B2
公开(公告)日：2020-12-15
申请号：US16386376
申请日：2019-04-17
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sarang Bani , Anjali Pandey
IPC分类号： A61K36/81 , A61K36/48 , A61P15/10 , A61K36/906 , A61K36/67 , A61K36/53
CPC分类号： A61K36/81 , A61K36/48 , A61K36/53 , A61K36/67 , A61K36/906 , A61P15/10
摘要： The present invention discloses a composition for the therapeutic management of male sexual dysfunction and related disorders. Specifically, the invention discloses a composition comprising 60-65% w/w Withania somnifera extract, 12-18% w/w Mucana pruriens extract, 5-10% w/w Coleus forskolii extract, 12-18% w/w Kaempferia parviflora extract, 0.1-2% w/w Piper nigrum extract, for use as an aphrodisiac.

89. 发明申请

US20170072003A1 COMPOSITION COMPRISING SCIRPUSIN A AND SCIRPUSIN B AND ANTI-OBESITY POTENTIAL THEREOF 审中-公开
标题翻译：包含SCIRPUSIN A和SCIRPUSIN B的组合物及其抗氧化潜能
公开(公告)号：US20170072003A1
公开(公告)日：2017-03-16
申请号：US15213655
申请日：2016-07-19
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Douglas Kalman , Beena Bhat , Priti Vaidyanathan , Sarang Bani , Anjali Pandey , Suresh Karri
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Douglas Kalman , Beena Bhat , Priti Vaidyanathan , Sarang Bani , Anjali Pandey , Suresh Karri
IPC分类号： A61K36/8905 , A61K31/343 , A61K31/015
CPC分类号： A61K36/8905 , A61K31/015 , A61K31/343
摘要： Disclosed are methods of managing hypercholesterolemia using a composition of matter comprising the ethyl acetate fraction of the extract of Cyperus rotundus rhizomes standardized to contain 5% of total stilbenes.
摘要翻译：公开了使用包含标准化为含有5％总茋的莎草莎草提取物的乙酸乙酯部分的物质组合物来控制高胆固醇血症的方法。

90. 发明授权

US08536184B2 Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof 失效
公开(公告)号：US08536184B2
公开(公告)日：2013-09-17
申请号：US12622411
申请日：2009-11-19
申请人： James Kanter , James Robinson , Anjali Pandey , Robert M. Scarborough
发明人： James Kanter , James Robinson , Anjali Pandey , Robert M. Scarborough
IPC分类号： A61K31/4965 , C07D241/04
CPC分类号： C07D239/94
摘要： The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.

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