会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 83. 发明授权
    • Mouse MTSI gene
    • 小鼠MTSI基因
    • US5843756A
    • 1998-12-01
    • US508735
    • 1995-07-28
    • Steven StonePing JiangAlexander Kamb
    • Steven StonePing JiangAlexander Kamb
    • C07H21/04C12N1/20C12N1/21C12N15/63C12N15/85
    • C12Q1/6886C12Q2600/136C12Q2600/156C12Q2600/172
    • The present invention relates to the Multiple Tumor Suppressor (MTS) genes in mice, their expression products, and their homology to the human MTS genes. The human MTS genes are involved in human cancers. The invention is further related to the use of the MTS genes in the therapy, diagnosis and prognosis of human cancer. The invention further relates to mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
    • 本发明涉及小鼠中的多重肿瘤抑制因子(MTS)基因,其表达产物及其与人MTS基因的同源性。 人类MTS基因涉及人类癌症。 本发明进一步涉及MTS基因在人类癌症的治疗,诊断和预后中的应用。 本发明还涉及MTS基因中的突变及其在诊断黑素瘤,白血病,星形细胞瘤,成胶质细胞瘤,淋巴瘤,神经胶质瘤,霍奇金淋巴瘤,CLL和胰腺,乳腺,甲状腺,卵巢,子宫, 睾丸,肾,胃和直肠。 本发明还涉及在MTS基因中具有突变的人类癌症的治疗,包括基因治疗,蛋白质替代疗法和蛋白质模拟物。 最后,本发明涉及用于癌症治疗的药物的筛选。
    • 86. 发明授权
    • Stochastic Time-Digital Converter
    • 随机时间数字转换器
    • US08810440B2
    • 2014-08-19
    • US13983297
    • 2012-05-29
    • Jianhui WuZixuan WangXiao ShiMeng ZhangCheng HuangChao ChenFuqing HuangXincun JiPing Jiang
    • Jianhui WuZixuan WangXiao ShiMeng ZhangCheng HuangChao ChenFuqing HuangXincun JiPing Jiang
    • H03M1/04G04F10/00
    • H03M1/04G04F10/005
    • A stochastic time-digital converter (STDC) including an input switching circuit, an STDC array, and an encoder. A clock circuit inputs two clock signals into two input terminals of the input switching circuit; the input switching circuit transmits the two clock signals in a cyclic cross-transposition form to two input terminals of the STDC array, and simultaneously outputs a trigger control signal to the encoder; each comparator in the STDC array independently judges the speeds of the two clock signals and sends the judgement results to the encoder for collection and processing; and the encoder outputs the size and positivity or negativity of the phase difference of the two clock signals. The technical solution utilizes the stochastic characteristic of the STDC to double the number of the equivalent comparators in the STDC array, eliminating the effects on the circuitry of device mismatching and processes, power supply voltage, and temperature.
    • 包括输入切换电路,STDC阵列和编码器的随机时间数字转换器(STDC)。 时钟电路将两个时钟信号输入到输入开关电路的两个输入端; 输入切换电路以循环交叉形式将两个时钟信号发送到STDC阵列的两个输入端,同时向编码器输出触发控制信号; STDC阵列中的每个比较器独立地判断两个时钟信号的速度,并将判断结果发送到编码器进行采集和处理; 并且编码器输出两个时钟信号的相位差的大小和积极性或消极性。 该技术解决方案利用STDC的随机特性将STDC阵列中的等效比较器的数量加倍,从而消除了器件不匹配和处理电路,电源电压和温度的影响。