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81. 发明授权

US5374662A Fumarate and fumaramide siloxane hydrogel compositions 失效
标题翻译：富马酸和富马酰胺硅氧烷水凝胶组合物
公开(公告)号：US5374662A
公开(公告)日：1994-12-20
申请号：US31428
申请日：1993-03-15
申请人： Yu-Chin Lai , Ronald E. Bambury
发明人： Yu-Chin Lai , Ronald E. Bambury
IPC分类号： C07F7/08 , C08F30/08 , C08F290/06 , G02B1/04 , C08F230/08
CPC分类号： G02B1/043 , C07F7/0818 , C07F7/0854 , C08F290/064 , C08F290/068 , C08F30/08
摘要： Novel fumarate- and fumaramide-containing monomers are disclosed which are especially useful in the preparation of biocompatible devices, especially contact lenses.
摘要翻译：公开了新型的富马酸盐和富马酰胺单体，其特别可用于制备生物相容性装置，特别是隐形眼镜。

82. 发明授权

US5158717A Method of molding shaped polymeric articles 失效
标题翻译：模塑成型聚合物制品的方法
公开(公告)号：US5158717A
公开(公告)日：1992-10-27
申请号：US618448
申请日：1990-11-27
申请人： Yu-Chin Lai
发明人： Yu-Chin Lai
IPC分类号： B29C33/38 , B29C33/40 , B29C39/26 , B29D11/00 , B29K83/00 , B29L11/00 , C08F2/02 , C08F30/08 , C08F230/08 , C08F290/00 , C08F299/08 , C08G18/61 , C08G18/67 , G02B1/04 , G02C7/04
CPC分类号： B29D11/00125 , B29C33/40 , C08G18/61 , G02B1/043 , B29K2063/00 , B29K2833/20 , B29K2995/0093 , Y10S425/808
摘要： When molding shaped articles such as contact lenses from monomeric mixtures containing silicone monomers and hydrophilic monomers, the wettability of the resulting article is improved by using a mold material produced from a resin comprising a copolymer of an alpha, beta, olefinically saturated mononitrile and at least one comonomer to enhance melt processability.
摘要翻译：当从含有硅氧烷单体和亲水单体的单体混合物成型成型物品如隐形眼镜时，通过使用由包含α，β，烯属饱和单腈的共聚物的树脂生产的模具材料和至少一种共聚单体，以增强熔体加工性能。

83. 发明授权

US08119753B2 Silicone hydrogels with amino surface groups 失效
标题翻译：具有氨基表面基团的硅氧烷水凝胶
公开(公告)号：US08119753B2
公开(公告)日：2012-02-21
申请号：US12242955
申请日：2008-10-01
申请人： Yu-Chin Lai , Weihong Lang
发明人： Yu-Chin Lai , Weihong Lang
IPC分类号： C08F30/08
CPC分类号： C08J7/047 , C08J2383/08 , C08J2400/104 , C08J2400/105 , C08J2433/24 , C08L83/10 , G02B1/043 , C08L101/14
摘要： A silicone hydrogel comprising monomeric units of one or more amino monomers, wherein the amino monomers are of formula IA, IB, IIA or IIB and monomeric units of one or more silicone monomers wherein R1, R2 and R3 are independently selected from hydrogen, C1-C6 alkyl or CH2OH; R4 is a C1-C10 alkyl optionally substituted with hydroxyl or carboxylic acid; E is a polymerizable group; X is an anion suitable for quaternary nitrogen; and n is 0, 1, 2, or 3 and m is an integer from 1 to 8.
摘要翻译：一种硅氧烷水凝胶，其包含一种或多种氨基单体的单体单元，其中所述氨基单体具有式IA，IB，IIA或IIB以及一种或多种硅氧烷单体的单体单元，其中R 1，R 2和R 3独立地选自氢，C1- C6烷基或CH2OH; R4是任选被羟基或羧酸取代的C1-C10烷基; E是可聚合基团; X是适合季氮的阴离子; n为0,1,2或3，m为1〜8的整数。

84. 发明授权

US08071660B2 Surface modified biomedical devices 失效
标题翻译：表面改性生物医学装置
公开(公告)号：US08071660B2
公开(公告)日：2011-12-06
申请号：US12329694
申请日：2008-12-08
申请人： Weihong Lang , Yu-Chin Lai
发明人： Weihong Lang , Yu-Chin Lai
IPC分类号： G02C7/02 , C08F14/18 , A61F2/16
CPC分类号： C08F220/22 , C08F220/26 , C08F230/08 , C08J7/047 , C08J2383/04
摘要： A method for making a surface modified biomedical device is disclosed, the method comprising contacting a surface of a biomedical device with a copolymer which is the reaction product of one or more polymerizable polyhydric alcohols and one or more polymerizable fluorine-containing monomers.
摘要翻译：公开了一种制备表面改性生物医学装置的方法，所述方法包括使生物医学装置的表面与作为一种或多种可聚合多元醇和一种或多种可聚合含氟单体的反应产物的共聚物接触。

85. 发明授权

US07691917B2 Silcone-containing prepolymers 失效
标题翻译：含Silcone的预聚物
公开(公告)号：US07691917B2
公开(公告)日：2010-04-06
申请号：US11762970
申请日：2007-06-14
申请人： Yu-Chin Lai , Weihong Lang , Edmond T. Quinn
发明人： Yu-Chin Lai , Weihong Lang , Edmond T. Quinn
IPC分类号： G02B1/04 , C08F290/06 , C08G77/04 , C08G77/20
CPC分类号： G02B1/043 , C07F7/0838 , C08F283/12 , C08F290/068 , C08G18/0814 , C08G18/672 , C08G77/14 , C08G77/20 , C08G77/458 , C08G2210/00 , C08L53/00 , C08L53/005 , C08L83/10 , C08L51/085 , C08G18/61 , C08L2666/02
摘要： Prepolymers comprising at least one block of Formula II and terminated with a polymerizable ethylenically unsaturated radical are useful in hydrogel materials are disclosed: wherein n, R, R1, R2 and X+ are as defined herein.
摘要翻译：包含至少一个式II的嵌段并用可聚合烯属不饱和基团封端的预聚物可用于水凝胶材料：其中n，R，R1，R2和X +如本文所定义。

86. 发明申请

US20090111942A1 Method for Making Surface Modified Biomedical Devices 审中-公开
标题翻译：制备表面改性生物医学装置的方法
公开(公告)号：US20090111942A1
公开(公告)日：2009-04-30
申请号：US11924359
申请日：2007-10-25
申请人： Weihong Lang , Yu-Chin Lai , Daniel J. Hook
发明人： Weihong Lang , Yu-Chin Lai , Daniel J. Hook
IPC分类号： C08G63/48
CPC分类号： A61L27/34 , A61L27/50 , A61L2400/18 , A61L2430/16 , C08J7/16
摘要： Disclosed are methods for making a surface modified biomedical device involving (a) exposing a biomedical device having a plurality of biomedical device surface functional groups to one or more ethylenically unsaturated-containing organic compounds having a reactive group that is co-reactive to the biomedical device surface functional groups of the biomedical device; and (b) graft polymerizing a hydrophilic reactive monomer having a complementary reactive functionality with the ethylenically unsaturated functionalities of the ethylenically unsaturated-containing organic compounds on or near the surface of the biomedical device thus forming a biocompatible surface on the biomedical device. The methods disclosed are two-step methods and do not include any additional surface treatment steps.
摘要翻译：公开了用于制备表面改性生物医学装置的方法，其涉及（a）将具有多个生物医学装置表面官能团的生物医学装置暴露于具有与生物医学装置共反应的反应性基团的一种或多种含烯属不饱和的有机化合物生物医学装置的表面官能团; 和（b）将具有互补反应性官能团的亲水性反应性单体与含烯属不饱和有机化合物的烯属不饱和官能团接枝聚合到生物医学装置的表面上或附近，从而在生物医学装置上形成生物相容性表面。所公开的方法是两步法，不包括任何额外的表面处理步骤。

87. 发明授权

US07482416B2 Prepolymers for improved surface modification of contact lenses 失效
标题翻译：用于改善隐形眼镜表面改性的预聚物
公开(公告)号：US07482416B2
公开(公告)日：2009-01-27
申请号：US11955683
申请日：2007-12-13
申请人： Yu-Chin Lai , Edmond T. Quinn
发明人： Yu-Chin Lai , Edmond T. Quinn
IPC分类号： C08F130/08
CPC分类号： A61L27/16 , A61L27/18 , C08F290/068 , G02B1/043 , C08L51/085 , C08L35/00 , C08L67/06
摘要： Provided are a novel class of fumaric- and itaconic-containing prepolymers and compositions comprising the prepolymers used in the manufacture of medical devices.
摘要翻译：提供了一类新颖的含富马酸和衣康酸的预聚物和包含用于制造医疗器械的预聚物的组合物。

88. 发明申请

US20080197324A1 OPHTHALMIC COMPOSITION CONTAINING A POLYOL-ACID COPOLYMER 审中-公开
标题翻译：含有多元醇酸共聚物的光学组合物
公开(公告)号：US20080197324A1
公开(公告)日：2008-08-21
申请号：US11751806
申请日：2007-05-22
申请人： Fang Zhao , Vicki L. Barniak , Weihong Lang , Kimberly Millard , Yu-Chin Lai
发明人： Fang Zhao , Vicki L. Barniak , Weihong Lang , Kimberly Millard , Yu-Chin Lai
IPC分类号： C08L101/06 , C09K3/00
CPC分类号： C08K5/0058 , C08L39/06
摘要： An ophthalmic composition comprising a copolymer and one or more cationic antimicrobial components. The copolymer comprises monomeric units of one or more polymerizable alcohols or polymerizable polyols, and monomeric units of one or more polymerizable carboxylic acids. Also, the composition has an osmolality from 200 mOsmol/kg to 400 mOsmol/kg.
摘要翻译：一种眼用组合物，其包含共聚物和一种或多种阳离子抗微生物组分。共聚物包含一种或多种可聚合醇或可聚合多元醇的单体单元和一种或多种可聚合羧酸的单体单元。此外，组合物的重量摩尔渗透压浓度为200mOsmol / kg至400mOsmol / kg。

89. 发明授权

US07399795B2 Surface modification of contact lenses 失效
标题翻译：隐形眼镜的表面改性
公开(公告)号：US07399795B2
公开(公告)日：2008-07-15
申请号：US11442826
申请日：2006-05-30
申请人： Yu-Chin Lai , Edmond T. Quinn
发明人： Yu-Chin Lai , Edmond T. Quinn
IPC分类号： C08F290/96 , G02C7/04
CPC分类号： C08G77/38 , A61L27/34 , G02B1/043 , C08L51/085 , C08L83/04
摘要： Provided are surface modified contact lenses formed from one or more fumaric- or itaconic-containing prepolymers having reactive functionality that is complimentary to reactive hydrophilic polymers.
摘要翻译：提供由具有与反应性亲水聚合物互补的反应性官能度的一种或多种富马酸或含衣康酸的预聚物形成的表面改性隐形眼镜。

90. 发明申请

US20080141628A1 Packaging Solutions 审中-公开
标题翻译：包装解决方案
公开(公告)号：US20080141628A1
公开(公告)日：2008-06-19
申请号：US11611307
申请日：2006-12-15
申请人： Weihong Lang , Yu-Chin Lai
发明人： Weihong Lang , Yu-Chin Lai
IPC分类号： B65B55/22 , B65B55/12 , B65B55/14 , B65D85/00
CPC分类号： A61L12/04 , B65B25/008 , C11D3/0078 , C11D3/227
摘要： The present invention is directed to new and improved packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to a packaging system for storing an ophthalmic device in an aqueous packaging solution comprising hyaluronic acid or a salt thereof. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, thereby preventing dryness and improving lubricity.
摘要翻译：本发明涉及用于存储诸如隐形眼镜的眼科装置的新的和改进的包装系统，以及用于包装这些眼科装置的方法，以提高穿戴期间镜片的舒适度。特别地，本发明涉及用于将眼科装置储存在包含透明质酸或其盐的含水包装溶液中的包装系统。这种溶液长时间保留在未使用的镜片的表面上，导致眼睛中持续存在的表面改性，这可以显着改善首次使用的新鲜隐形眼镜的润湿性能，此外甚至镜片插入后数小时，从而防止干燥，提高润滑性。

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