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81. 发明申请

US20130274211A1 BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS 有权
标题翻译：生物易燃，非生物降解，非毒性聚合物用于纳米脂肪药物组合物
公开(公告)号：US20130274211A1
公开(公告)日：2013-10-17
申请号：US13633638
申请日：2012-10-02
申请人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
发明人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , C08F220/56 , C08F222/12 , C08F222/385 , C08F226/10
摘要： The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.
摘要翻译：本发明涉及式（I）的生物相容性，不可生物降解的和无毒的聚合物，其包含三种单体单元，其选自1-乙烯基吡咯烷酮（VP），N-异丙基丙烯酰胺（NIPAM）和马来酸酐的酯和与双官能乙烯基衍生物交联的聚乙二醇（MPEG），其纯度高，基本上不含有毒的单体污染物及其制备方法。本发明还涉及难溶于水的药物或包含本发明聚合物的化合物的纳米颗粒药物组合物，其对于有需要的患者的床边给药是安全的，毒性较小且方便的。此外，本发明涉及用于制备难溶于水的药物或化合物的纳米颗粒药物组合物的高选择性方法。

82. 发明申请

US20130096602A1 IMPLANTABLE SUBCUTANEOUS ELECTRICAL SOCKET AND PERCUTANEOUS PLUG 有权
标题翻译：可插拔的电源插座和电脑插头
公开(公告)号：US20130096602A1
公开(公告)日：2013-04-18
申请号：US13274300
申请日：2011-10-14
申请人： Mukesh Kumar
发明人： Mukesh Kumar
IPC分类号： A61M29/00 , H01R13/52 , H01R24/00
CPC分类号： H01R13/5219 , A61B17/7216 , A61B2017/681 , A61N1/3787 , H01R4/2445 , H01R13/5224 , H01R2201/12
摘要： An implantable subcutaneous electrical socket and corresponding percutaneous plug are disclosed for controlling and/or energizing an implanted medical device, such as a bone distraction motor, within a patient. The subcutaneous electrical socket is accessed percutaneously by the plug, to connect data and power electrodes deployed from the plug into the socket to conduct control signals and electrical power from an external source to an implanted medical device within the patient. The socket and plug include insulating materials to prevent electrical shock to the patient.
摘要翻译：一种可植入的皮下电插座和相应的经皮插头公开了用于控制和/或赋能植入的医疗设备，诸如骨牵引马达，在患者体内。皮下电插座由插件经皮访问，到从插头部署数据和电源连接电极到插座以从外部源进行控制信号和电功率，以在患者体内植入的医疗器械。的插座和插头包括绝缘材料以防止触电给患者。

83. 发明申请

US20130092364A1 AIRFLOW CONTROL IN FLOOR MODE FOR VEHICLE WITH MULTIPLE SEATING ROWS 有权
标题翻译：具有多个座椅的车辆的地面模式中的气流控制
公开(公告)号：US20130092364A1
公开(公告)日：2013-04-18
申请号：US13274729
申请日：2011-10-17
申请人： Mukesh Kumar , Paul B. Hoke , Martha E. Nefcy , David Wong
发明人： Mukesh Kumar , Paul B. Hoke , Martha E. Nefcy , David Wong
IPC分类号： F28F27/00
CPC分类号： B60H1/00842 , B60H1/00021 , B60H1/00735 , B60H1/00742 , B60H2001/002 , F24F11/30 , F24F2110/00 , F24F2110/10 , F24F2120/10
摘要： A comfort system is provided for a motor vehicle. A seat occupancy sensor determines whether a third row zone is occupied. At least one flow controller is provided in the floor duct for controllably supplying the conditioned airflow to at least the third row outlet. If the third row zone is occupied, then a second row outlet and the third row outlet are turned on to supply a conditioned airflow to a front seat zone, a second row zone, and the third row zone. If the third row zone is not occupied, then the third row outlet is closed off. If the second row zone is not occupied, then the second and third row outlets are closed off. If occupied, then the second row outlet is turned on until a desired comfort level is achieved in the second row zone.
摘要翻译：为汽车提供舒适系统。座椅占用传感器确定第三行区域是否被占用。至少一个流量控制器设置在地板管道中，用于可控地将经调节的气流提供给至少第三排出口。如果第三排区域被占用，则第二排出口和第三排出口被打开以向前排座位区域，第二排区域和第三行区域提供经调节的气流。如果第三排区域未被占用，则第三行出口被关闭。如果第二行区域未被占用，则第二和第三行出口被关闭。如果被占用，则第二排出口被打开，直到在第二行区域中达到期望的舒适度。

85. 发明授权

US07740794B1 Methods of making a polymer and ceramic composite 有权
标题翻译：制造聚合物和陶瓷复合材料的方法
公开(公告)号：US07740794B1
公开(公告)日：2010-06-22
申请号：US11108657
申请日：2005-04-18
申请人： Mukesh Kumar
发明人： Mukesh Kumar
IPC分类号： C04B33/32
CPC分类号： A61L27/446 , A61F2210/0004 , A61F2310/00179 , A61L27/427 , A61L2430/02 , A61L2430/38
摘要： A method of forming a polymer/ceramic composite for use in various purposes. For example, the polymer/ceramic composite may be used in orthopedic procedures for replacing bone material, forming an implant, providing an anchor or other appropriate uses. The polymer/ceramic composite may also include selected characteristics such as a hardness, a strength, a bioabsorbability, a biocompatibility or other appropriate characteristics.
摘要翻译：形成用于各种目的的聚合物/陶瓷复合材料的方法。例如，聚合物/陶瓷复合材料可以用于矫形手术中以替代骨材料，形成植入物，提供锚固剂或其它合适的用途。聚合物/陶瓷复合材料还可以包括选定的特性，例如硬度，强度，生物吸收性，生物相容性或其它合适的特性。

86. 发明申请

US20100136214A1 Acetabular Shell System and Method for Making 审中-公开
标题翻译：髋臼壳系统及制作方法
公开(公告)号：US20100136214A1
公开(公告)日：2010-06-03
申请号：US12697847
申请日：2010-02-01
申请人： Mukesh Kumar
发明人： Mukesh Kumar
IPC分类号： A61L27/32
CPC分类号： A61L27/306
摘要： A method for forming an acetabular shell includes providing a working surface such as a mandrel, and spraying the working surface with a first layer of material having a first composition such as aluminum oxide. After a suitable thickness is generated, the spray composition is gradually changed to other compositions having desired particle sizes and distribution. In one example, the composition is changed to a mixture of aluminum oxide and titanium oxide and/or titanium. As thickness builds up, the relative amount of aluminum oxide is decreased such that the composition is all titanium and titanium oxide. After a desired thickness is generated, the acetabular shell is extracted off the mandrel.
摘要翻译：用于形成髋臼壳的方法包括提供诸如心轴的工作表面，以及用第一组合物如氧化铝的第一层材料喷涂工作表面。在产生合适的厚度之后，将喷雾组合物逐渐变为具有所需粒度和分布的其它组合物。在一个实例中，将组合物改变为氧化铝和氧化钛和/或钛的混合物。随着厚度的增加，氧化铝的相对量降低，使得组合物全部为钛和氧化钛。在产生期望的厚度之后，将髋臼壳从芯轴上取出。

87. 发明申请

US20100076909A1 SYSTEM AND METHOD FOR PROVIDING INTERACTIVE TROUBLESHOOTING 有权
标题翻译：提供交互式故障排除的系统和方法
公开(公告)号：US20100076909A1
公开(公告)日：2010-03-25
申请号：US12233637
申请日：2008-09-19
申请人： Syam S. Suri , Mukesh Kumar , Ravi S. Guduru
发明人： Syam S. Suri , Mukesh Kumar , Ravi S. Guduru
IPC分类号： G06N5/02 , G06F15/16
CPC分类号： H04L41/5061 , G06Q10/10 , H04L41/5074
摘要： An approach provides interactive troubleshooting. A robotic chat application receives a service inquiry over a chat session from a chat-enabled device, wherein the service inquiry is associated with a service provider network. A troubleshooting engine collects information from a user of the chat-enabled device regarding the service inquiry. The robotic chat application retrieves a flow definition and an associated query corresponding to the service inquiry based upon the collected information. The troubleshooting engine generates a command, based on the query, for resolving the service inquiry.
摘要翻译：一种方法提供交互式故障排除。机器人聊天应用程序通过来自启用聊天的设备的聊天会话接收服务查询，其中服务询问与服务提供商网络相关联。故障排除引擎从具有聊天功能的设备的用户收集有关服务查询的信息。机器人聊天应用程序基于所收集的信息检索对应于服务询问的流定义和相关联的查询。故障排除引擎根据查询生成一个用于解析服务查询的命令。

88. 发明授权

US07670384B2 Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone 有权
标题翻译：骨移植组合物，其包含骨材料和包含变性脱矿质骨的载体
公开(公告)号：US07670384B2
公开(公告)日：2010-03-02
申请号：US11407409
申请日：2006-04-19
申请人： Mukesh Kumar , Ned M. Hamman , Michael D. Leach , John Manocchio , Paul D'Antonio , Daryl L. Carter
发明人： Mukesh Kumar , Ned M. Hamman , Michael D. Leach , John Manocchio , Paul D'Antonio , Daryl L. Carter
IPC分类号： A61F2/28 , A61K35/32
CPC分类号： A61L27/365 , A61L27/3608 , A61L27/3683 , A61L27/3691 , A61L2430/02 , A61M5/204 , A61M5/3129
摘要： Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.
摘要翻译：用于施用于人或动物受试者的骨表面的成形组合物，包括：骨材料; 以及包含变性软化骨的载体，其中所述组合物形成适于施用于骨的形状。提供用于制备用于施用于人或动物对象的骨表面的成形组合物的方法包括混合脱矿质骨和水; 加热混合物形成载体; 将载体与骨混合以形成可成型组合物; 并模塑可模制组合物以产生形成的组合物。提供了几种用于水合形成的骨组合物的装置。还提供了水合形成的骨组合物的方法。

89. 发明申请

US20100003155A1 METHOD AND APPARATUS FOR FORMING POROUS METAL IMPLANTS 有权
标题翻译：用于形成多孔金属植入物的方法和装置
公开(公告)号：US20100003155A1
公开(公告)日：2010-01-07
申请号：US12558300
申请日：2009-09-11
申请人： Ned M. Hamman , J. Fleming , Elizabeth A. Schlueter , Isaac Janson , Jason D. Meridew , Mukesh Kumar
发明人： Ned M. Hamman , J. Fleming , Elizabeth A. Schlueter , Isaac Janson , Jason D. Meridew , Mukesh Kumar
IPC分类号： B22F3/11 , B22F1/00
CPC分类号： C09C1/00 , A61F2/30767 , A61F2/30907 , A61F2/34 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2002/30011 , A61F2002/30064 , A61F2002/30166 , A61F2002/30169 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30383 , A61F2002/30451 , A61F2002/30454 , A61F2002/30604 , A61F2002/30736 , A61F2002/30827 , A61F2002/30878 , A61F2002/3092 , A61F2002/30968 , A61F2002/3411 , A61F2220/0025 , A61F2220/0058 , A61F2230/0028 , A61F2230/0047 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2250/0023 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00131 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097 , A61F2310/00976 , A61K35/12 , A61L27/04 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/406 , A61L2300/414 , A61L2300/428 , A61L2300/606 , A61L2300/64 , B22F3/1125 , B22F2001/0066 , B22F2998/10 , C01P2004/61 , B22F1/0059 , B22F3/04 , B22F3/02 , B22F3/1021 , B22F3/1216
摘要： A method for providing a porous metal implant. A mixture of a biocompatible metal, a spacing agent, and a binder is provided. The mixture is formed into a shaped the spacing agent is removed to form a plurality of pores in the implant. A shaped porous metal implant is also provided.
摘要翻译：一种用于提供多孔金属植入物的方法。提供生物相容性金属，间隔剂和粘合剂的混合物。将混合物形成为成形物，去除间隔剂以在植入物中形成多个孔。还提供了一种成形的多孔金属植入物。

90. 发明授权

US07595303B1 Genetic adjuvants for immunotherapy 失效
标题翻译：用于免疫治疗的遗传佐剂
公开(公告)号：US07595303B1
公开(公告)日：2009-09-29
申请号：US10655873
申请日：2003-09-05
申请人： Shyam S. Mohapatra , Mukesh Kumar
发明人： Shyam S. Mohapatra , Mukesh Kumar
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： A61K38/217 , A61K38/208 , A61K39/35 , A61K39/36 , A61K39/39 , A61K2039/53 , A61K2039/55522 , A61K2039/55538
摘要： The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of nucleic acid molecules encoding interleukin-12 (IL-12), interferon-gamma (IFN-γ), or a combination thereof, to a patient in need of such treatment. The pharmaceutical compositions of the invention contain nucleic acid molecules encoding IL-12 and/or IFN-γ and an operably-linked promoter sequence. In another aspect, the present invention concerns expression vectors containing a nucleotide sequence encoding IL-12 and IFN-γ, and an operably-linked promoter sequence. In another aspect, the present invention concerns cells generally modified with a nucleotide sequence encoding IL-12 and IFN-γ.
摘要翻译：本发明涉及用于调节免疫应答的方法和药物组合物。本发明的方法涉及向需要这种治疗的患者施用有效量的编码白细胞介素-12（IL-12），干扰素-γ（IFN-γ）或其组合的核酸分子。本发明的药物组合物含有编码IL-12和/或IFN-γ的核酸分子和可操作地连接的启动子序列。另一方面，本发明涉及含有编码IL-12和IFN-γ的核苷酸序列和可操作地连接的启动子序列的表达载体。另一方面，本发明涉及用编码IL-12和IFN-γ的核苷酸序列遗传修饰的细胞。

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