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    • 86. 发明授权
    • Quinoline compound composing 1,2,4-triazine-dione and use thereof
    • 组合1,2,4-三嗪 - 二酮的喹啉化合物及其用途
    • US08822465B2
    • 2014-09-02
    • US13828615
    • 2013-03-14
    • Hua Xu
    • Hua Xu
    • A61K31/5377A61K31/53C07D401/14C07D401/12
    • C07D401/12C07D401/14
    • The present invention relates to a quinoline derivative represented by general formula (I) or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof, wherein Ar, R1, R2, R3, X, Y and n have the meanings given in the description. The present invention also relates to the comparatively strong effect of the compound represented by general formula (I) on inhibiting c-Met kinase. The present invention further relates to the use of this compound or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof in the manufacturing of a medicament for treating the disease caused by abnormally over-expressing c-Met kinase, in particular, for treating or preventing cancer.
    • 本发明涉及由通式(I)表示的喹啉衍生物或其药学上可接受的盐,水合物,溶剂合物或前药,其中Ar,R 1,R 2,R 3,X,Y和n具有说​​明书中给出的含义。 本发明还涉及由通式(I)表示的化合物对抑制c-Met激酶的相对较强的作用。 本发明还涉及该化合物或其药学上可接受的盐,水合物,溶剂化物或前药在制备用于治疗由异常过表达c-Met激酶引起的疾病的药物中的用途,特别是用于治疗或 预防癌症。