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81. 发明授权

US06680316B1 Pyridazin-3-one derivatives and medicines containing the same 失效
标题翻译：哒嗪-3-酮衍生物及含有其的药物
公开(公告)号：US06680316B1
公开(公告)日：2004-01-20
申请号：US09926040
申请日：2001-08-20
申请人： Masao Ohkuchi , Yoshinori Kyotani , Hiromichi Shigyo , Hideo Yoshizaki , Tomoyuki Koshi , Takahiro Kitamura , Takayuki Matsuda , Kyoko Yasuoka , Tomoko Furuyama
发明人： Masao Ohkuchi , Yoshinori Kyotani , Hiromichi Shigyo , Hideo Yoshizaki , Tomoyuki Koshi , Takahiro Kitamura , Takayuki Matsuda , Kyoko Yasuoka , Tomoko Furuyama
IPC分类号： C07D23724
CPC分类号： C07D237/24
摘要： Objects of the invention are to provide compounds having excellent activity against interleukin-1&bgr; production and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): wherein Ar1 represents a substituted or unsubstituted aromatic group, Ar2 represents a phenyl group having a substituent at least at the 4-position thereof, R1 represents a linear or branched alkyl group, an alkyl group having a cyclic structure, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenyl(lower alkyl) group, and R2 represents a cyano group, a carboxyl group, a (lower alkoxy)carbonyl group, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted carbamoyl group, or salts thereof; and medicines comprising them as effective ingredients.
摘要翻译：本发明的目的是提供对白细胞介素-1β生产具有优异活性的化合物以及包含它们作为有效成分的药物。由下式（1）表示的哒嗪-3-酮衍生物：其中Ar 1表示取代或未取代的芳基，Ar 2表示至少在其4位具有取代基的苯基，R 1表示直链或支链烷基，具有环状结构的烷基，取代或未取代的苯基或取代或未取代的苯基（低级烷基），R 2表示氰基，羧基，（低级烷氧基）羰基，取代或未取代的低级烷基或取代或未取代的氨基甲酰基，或盐的; 和包含它们作为有效成分的药物。

82. 发明授权

US06403586B1 Pyridazine derivatives and drugs containing the same as the active ingredient 有权
标题翻译：哒嗪衍生物和含有与活性成分相同的药物
公开(公告)号：US06403586B1
公开(公告)日：2002-06-11
申请号：US09622897
申请日：2000-08-31
申请人： Masao Ohkuchi , Yoshinori Kyotani , Hiromichi Shigyo , Hideo Yoshizaki , Tomoyuki Koshi , Takahiro Kitamura , Takayuki Matsuda , Soichi Oda , Yuriko Habata , Kyoko Kotaki
发明人： Masao Ohkuchi , Yoshinori Kyotani , Hiromichi Shigyo , Hideo Yoshizaki , Tomoyuki Koshi , Takahiro Kitamura , Takayuki Matsuda , Soichi Oda , Yuriko Habata , Kyoko Kotaki
IPC分类号： A61K3150
CPC分类号： C07D401/06 , C07D237/02 , C07D237/04 , C07D237/22 , C07D237/24 , C07D401/12
摘要： This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a lower alkoxyl group, a lower alkylthio group or a halogen atom; R2 represents H, a lower alkoxyl group, a lower alkylthio group or a halogen atom; R3 represents a lower alkyl or lower alkenyl group, which may be substituted by one or more OHs, CNs, lower cycloalkyl groups, (substituted) aromatic groups or (substituted) carbamoyl groups; R4 represents COOH, a lower alkoxycarbonyl group, a (substituted) carbamoyl group, a (substituted) amino group, or a (substituted) ureido group; and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1&bgr; production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.
摘要翻译：本发明涉及由式（1）表示的哒嗪衍生物：其中R1表示低级烷氧基，低级烷硫基或卤素原子; R2表示H，低级烷氧基，低级烷硫基或卤素原子; R 3表示低级烷基或低级烯基，其可以被一个或多个OH，CN，低级环烷基，（取代的）芳族基团或（取代的）氨基甲酰基取代; R4表示COOH，低级烷氧基羰基，（取代）氨基甲酰基，（取代）氨基或（取代）脲基; 虚线表示4位和5位之间的碳 - 碳键为单键或双键，或其盐; 以及含有它们作为有效成分的药物。这些化合物对白细胞介素-1β生产具有优异的抑制活性，可用作免疫系统疾病，炎性疾病，缺血性疾病等的预防药物和治疗剂。

83. 发明授权

US06348468B1 Pyridazine compounds and compositions containing the same 失效
标题翻译：哒嗪化合物及其组合物
公开(公告)号：US06348468B1
公开(公告)日：2002-02-19
申请号：US09530949
申请日：2000-05-15
申请人： Masao Ohkuchi , Yoshinori Kyotani , Hiromichi Shigyo , Tomoyuki Koshi , Takahiro Kitamura , Tadaaki Ohgiya , Takayuki Matsuda , Yukiyoshi Yamazaki , Natsuyo Kumai , Kyoko Kotaki , Hideo Yoshizaki , Yuriko Habata
发明人： Masao Ohkuchi , Yoshinori Kyotani , Hiromichi Shigyo , Tomoyuki Koshi , Takahiro Kitamura , Tadaaki Ohgiya , Takayuki Matsuda , Yukiyoshi Yamazaki , Natsuyo Kumai , Kyoko Kotaki , Hideo Yoshizaki , Yuriko Habata
IPC分类号： A61K31501
CPC分类号： C07D401/04 , C07D237/02 , C07D237/04 , C07D237/14 , C07D237/18 , C07D401/06 , C07D401/14 , C07D413/04
摘要： This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower alkoxyl group or a lower alkylthio group, R3 represents a lower alkoxyl group, a halogenated lower alkyl group, a lower cycloalkyl group, a (subsituted) aryl group, a (substituted) aryloxy group, a (substituted) nitrogen-containing heterocyclic ring residue, a (substituted) aminocarbonyl group or a lower alkylcarbonyl group, A represents a single bond, a lower alkylene group or a lower alkenylene group, X represents O or S, and the dashed line indicates that the carbon-carbon bond between the 4-position and the 5-position is a single bond or a double bond, or salts thereof; and also to medicines containing them as effective ingredients. These compounds have excellent inhibitory activity against interleukin-1&bgr; production, and are useful as preventives and therapeutics for immune system diseases, inflammatory diseases, ischemic diseases and the like.
摘要翻译：本发明涉及由式（1）表示的哒嗪衍生物：其中R1表示（取代的）芳基，R2表示通过低级烷氧基或低级烷硫基在4位被取代的苯基，R3表示低级烷氧基基团，卤代低级烷基，低级环烷基，（取代的）芳基，（取代的）芳氧基，（取代的）含氮杂环残基，（取代的）氨基羰基或低级烷基羰基， A表示单键，低级亚烷基或低级亚烯基，X表示O或S，虚线表示4-位和5-位之间的碳 - 碳键为单键或双键键或其盐; 以及含有它们作为有效成分的药物。这些化合物对白细胞介素-1β生产具有优异的抑制活性，可用作免疫系统疾病，炎性疾病，缺血性疾病等的预防药物和治疗剂。

84. 发明授权

US5881548A Cable drag chain 失效
标题翻译：电缆拖链
公开(公告)号：US5881548A
公开(公告)日：1999-03-16
申请号：US949231
申请日：1997-10-13
申请人： Toshio Takahashi , Katsutoshi Shibayama , Tsutomu Iwami , Takayuki Matsuda
发明人： Toshio Takahashi , Katsutoshi Shibayama , Tsutomu Iwami , Takayuki Matsuda
IPC分类号： B65H57/04 , F16G13/16 , H02G11/00
CPC分类号： F16G13/16
摘要： A cable drag chain wherein a plurality of link members each comprising a pair of right and left side plates and connecting plates connecting upper and lower edges, respectively, of the side plates are connected together contiguously in a bendable manner, the connecting plates are to be connected strongly to the side plates. A cable drag chain 10 comprises a plurality of resinous link members 12 connected together contiguously in a bendable manner. Each link member 12 has a pair of right and left side plates 14, 16 and connecting plates 18, 20 which connect transversely upper and lower edges, respectively, of the side plates. A pair of connecting arms 22, 22 are projected at both ends of the connecting plate 18. A connecting arm receptacle portion 24 for receiving the connecting arms 22, 22 therein is formed in the upper edge of each side plate 14 (16) centrally in the longitudinal direction of the cable drag chain. Engaging pins 26 are projected from abutment surfaces of the connecting arms 22, 22, while engaging pin receptacle holes 28 are formed in abutment surfaces of the connecting arm receptacle portion 24. The engaging pin receptacle hole 28 is open sideways of the side plate 14 (16), but is closed at the upper edge of the side plate 14 (16), so that the connecting plate 18 is difficult to be disconnected above the side plates 14 and 16.
摘要翻译：一种电缆牵引链，其中分别包括一对左右侧板的多个连杆构件和分别连接在侧板上的上边缘和下边缘的连接板以可弯曲的方式连接在一起，连接板应为与侧板强烈连接。电缆拖链10包括以可弯曲的方式连续地连接在一起的多个树脂连接构件12。每个连杆构件12具有分别连接侧板的横向上下边缘的一对左右侧板14,16和连接板18,20。一对连接臂22,22突出在连接板18的两端。在每个侧板14（16）的上边缘中央形成有用于接收连接臂22,22的连接臂插座部分24 电缆牵引链的纵向。接合销26从连接臂22,22的邻接表面突出，而接合销接收孔28形成在连接臂插座部分24的邻接表面中。接合销插座孔28侧向侧板14 16），但是在侧板14（16）的上边缘处封闭，使得连接板18难以在侧板14和16上方断开。

85. 发明授权

US4021205A Sintered powdered ferrous alloy article and process for producing the alloy article 失效
标题翻译：烧结粉末铁合金制品及其制造方法
公开(公告)号：US4021205A
公开(公告)日：1977-05-03
申请号：US693770
申请日：1976-06-08
申请人： Takayuki Matsuda , Yoichi Shimizu , Hiroki Shimizu , Kazushi Imazaki , Setsuo Nii
发明人： Takayuki Matsuda , Yoichi Shimizu , Hiroki Shimizu , Kazushi Imazaki , Setsuo Nii
IPC分类号： B22F1/00 , C22C19/07 , C22C33/02 , C22C38/00 , B22F3/00
CPC分类号： C22C33/0207
摘要： A sintered powdered ferrous alloy article having high heat and abrasion resistances and a high workability is produced by admixing, (1) 5 to 30% by weight of a finely divided component alloy which consists of the following composition,______________________________________ 1 to 4% by weight carbon 10 to 30% by weight chromium 2 to 15% by weight nickel 10 to 30% by weight molybdenum 20 to 40% by weight cobalt 1 to 5% by weight niobium the balance iron, ______________________________________ (2) 0.8 to 2% by weight of finely divided carbon and (3) the balance of a finely divided ferrous base metal, compression molding the admixture under a pressure of 4 to 6 metric tons/cm.sup.2 and sintering the molded admixture in a reducing atmosphere at a temperature of 1050.degree. to 1150.degree. C, the resultant alloy article comprising a matrix component formed from the finely divided carbon and ferrous base metal, numerous particles of the finely divided component alloy dispersed in the matrix and bounding phases formed, around the particles of the finely divided component alloy, from a portion of the matrix and portions of the finely divided component alloy diffused into the portions of the matrix.
摘要翻译：通过混合（1）5〜30重量％的由以下组成组成的细分成分合金，制造具有高耐热耐磨性和高加工性的烧结铁粉合金制品，1〜4重量％碳} 10〜30重量％的铬} 2〜15重量％的镍} 10〜30重量％的钼} 20〜40重量％的钴} 1〜5重量％的铌}余量的铁，}（2） 0.8至2％重量的精细分选碳和（3）精细分离的富碱基金属的平衡，压缩成型4至6公吨/ CM2压力下的粘合剂，并在A A中减少大气中的成型混合物 1050〜1150℃的温度，所得的合金制品包括由细碎的碳和铁基金属形成的基体组分，分散在基质中的细分散组分合金的许多颗粒和形成的界面相细分成分合金，从基体的一部分和细分散的组分合金的部分扩散到基体的部分。

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