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81. 发明申请

US20130005667A1 HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS 失效
标题翻译：异位蛋白的异位表达
公开(公告)号：US20130005667A1
公开(公告)日：2013-01-03
申请号：US13340549
申请日：2011-12-29
申请人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
发明人： Maria Beatrice Arico , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marizia Monica Guiliani , Mariagrazia Pizza
IPC分类号： A61K38/16
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localisation, and/or the immunological properties of the expressed protein.
摘要翻译：脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的异源表达的替代和改进的方法。这些方法通常影响表达水平，纯化的便利性，细胞定位和/或表达的蛋白质的免疫学性质。

82. 发明申请

US20120148617A1 MULTIPLE VARIANTS OF MENINGOCOCCAL PROTEIN NBM1870 有权
标题翻译：多功能蛋白质NBM1870变体
公开(公告)号：US20120148617A1
公开(公告)日：2012-06-14
申请号：US13364264
申请日：2012-02-01
申请人： Maurizio COMANDUCCI , Mariagrazia Pizza
发明人： Maurizio COMANDUCCI , Mariagrazia Pizza
IPC分类号： A61K39/095 , A61P37/02
CPC分类号： A61K39/095 , A61K39/102 , A61K39/39 , A61K2039/55505 , A61K2039/575 , C07K14/22 , C07K14/285 , C07K2319/00
摘要： Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting anti-meningococcal antibody responses, and that it is expressed across all meningococcal serogroups. Forty-two different NMB 1870 sequences have been identified, and these group into three variants. Serum raised against a given variant is bactericidal within the same variant group, but is not active against strains which express one of the other two variants i.e. there is intra-variant cross-protection, but not inter-variant cross-protection. For maximum cross-strain efficacy, therefore, the invention uses mixture comprising different variants of NMB 1870.
摘要翻译：脑膜炎球菌蛋白NMB1870已经在现有技术中描述。本发明人已经发现NMB1870是用于引发抗脑膜炎球菌抗体应答的有效抗原，并且其在所有脑膜炎球菌血清群中表达。已经确定了42种不同的NMB 1870序列，并且这些序列分为三个变体。针对给定变体产生的血清在同一变体组内是杀菌的，但对于表达其它两种变体之一的菌株不具有活性，即存在变异体内的交叉保护，而不是变异体间交叉保护。因此，为了获得最大的交叉应变效能，本发明使用包含NMB1870不同变体的混合物。

83. 发明申请

US20090298099A1 Gonococcal Proteins and Nucleic Acids 有权
标题翻译：淋球菌蛋白和核酸
公开(公告)号：US20090298099A1
公开(公告)日：2009-12-03
申请号：US12371691
申请日：2009-02-16
申请人： Maria Rita FONTANA , Mariagrazia Pizza , Vega Masignani , Elisabetta Monaci
发明人： Maria Rita FONTANA , Mariagrazia Pizza , Vega Masignani , Elisabetta Monaci
IPC分类号： G01N33/571 , C07K14/00 , C07K16/18 , C12N15/11
CPC分类号： C07K14/22 , A61K38/00
摘要： The invention provides proteins from gonococcus (Neisseria gonorrhoeae), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. They are also useful for distinguishing between gonococcus and meningococcus and, in particular, between gonococcus and serogroup B meningococcus.
摘要翻译：本发明提供来自淋球菌（Neisseria gonorrhoeae）的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。它们也可用于区分淋球菌和脑膜炎球菌，特别是在淋球菌和血清群B脑膜炎球菌之间。

84. 发明授权

US07504111B2 Gonococcal proteins and nucleic acids 有权
标题翻译：淋球菌蛋白质和核酸
公开(公告)号：US07504111B2
公开(公告)日：2009-03-17
申请号：US10467657
申请日：2002-02-12
申请人： Maria Rita Fontana , Mariagrazia Pizza , Vega Masiganani , Elisabetta Monaci
发明人： Maria Rita Fontana , Mariagrazia Pizza , Vega Masiganani , Elisabetta Monaci
IPC分类号： A61K39/095 , A61K39/00 , C12P21/04 , C07H21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/00
摘要： The invention provides proteins from gonococcus (Neisseria gonorrhoeae), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. They are also useful for distinguishing between gonococcus and meningococcus and, in particular, between gonococcus and serogroup B meningococcus.
摘要翻译：本发明提供来自淋球菌（Neisseria gonorrhoeae）的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。它们也可用于区分淋球菌和脑膜炎球菌，特别是在淋球菌和血清群B脑膜炎球菌之间。

85. 发明申请

US20060008476A1 Adjuvanted antigenic meningococcal compositions 审中-公开
标题翻译：佐剂抗原性脑膜炎球菌组合物
公开(公告)号：US20060008476A1
公开(公告)日：2006-01-12
申请号：US10497709
申请日：2002-12-04
申请人： Mariagrazia Pizza , Marzia Guiliani
发明人： Mariagrazia Pizza , Marzia Guiliani
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/55544 , Y02A50/466
摘要： A composition comprising a Neisserial antigen and a detoxified ADP-ribosylating toxin. These compositions have been found to be useful for mucosal immunisation, particularly nasal immunisation against Neisseria meningitidis.
摘要翻译：包含奈索氏菌抗原和解毒的ADP-核糖基化毒素的组合物。已经发现这些组合物可用于粘膜免疫，特别是针对脑膜炎奈瑟氏球菌的鼻部免疫。

86. 发明授权

US09267163B2 Hybrid expression of neisserial proteins 有权
标题翻译： neisserial蛋白的杂交表达
公开(公告)号：US09267163B2
公开(公告)日：2016-02-23
申请号：US11067260
申请日：2005-02-25
申请人： Maria Aricò , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Giuliani , Mariagrazia Pizza
发明人： Maria Aricò , Maurizio Comanducci , Cesira Galeotti , Vega Masignani , Marzia Monica Giuliani , Mariagrazia Pizza
IPC分类号： A61K39/00 , C12P21/02 , C07K14/22 , C12Q1/68 , C12P21/00 , A61K39/095 , A61K38/00
CPC分类号： A61K39/095 , A61K38/00 , A61K2039/545 , A61K2039/55505 , A61K2039/572 , A61K2039/575 , C07K14/22 , C07K2319/00 , C12P21/00 , C12P21/02 , C12Q1/689 , C12Q2600/156
摘要： Two or more Neisserial proteins (e.g. A and B) are expressed as a single hybrid protein which can be represented simply by the formula NH2-A-B—COOH.
摘要翻译：两个或更多个奈赛尔蛋白（例如A和B）被表达为可以简单地用式NH 2 -A-B-COOH表示的单一杂合蛋白。

87. 发明授权

US09206399B2 Immunogenic bacterial vesicles with outer membrane proteins 有权
标题翻译：具有外膜蛋白的免疫原性细胞囊泡
公开(公告)号：US09206399B2
公开(公告)日：2015-12-08
申请号：US11666786
申请日：2005-10-28
申请人： Jeannette Adu-Bobie , Mariagrazia Pizza , Nathalie Norais , Germano Ferrari , Guido Grandi
发明人： Jeannette Adu-Bobie , Mariagrazia Pizza , Nathalie Norais , Germano Ferrari , Guido Grandi
IPC分类号： A61K39/095 , C12N9/10 , A61K39/108
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K39/095 , C07K14/22 , C12N9/1051 , Y02A50/474
摘要： Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
摘要翻译：脑膜炎球菌mltA同系物的敲除使细菌自发释放富含免疫原性外膜蛋白的囊泡，并且能够以比正常生产过程制备的OMV更高的杀菌滴度引发交叉保护性抗体应答。因此，本发明提供了具有其mltA基因的敲除突变的细菌。本发明还提供了一种细菌，其中所述细菌：（i）具有包含肽聚糖的细胞壁; 和（ii）不表达具有MltA蛋白的裂解转糖苷酶活性的蛋白质。本发明还提供包含囊泡的组合物，其在本发明的细菌培养期间释放到培养基中。

88. 发明申请

US20150209419A1 ADJUVANTED COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEINS 审中-公开
标题翻译：肉毒杆菌因子H结合蛋白的调节组合
公开(公告)号：US20150209419A1
公开(公告)日：2015-07-30
申请号：US14368957
申请日：2011-12-29
申请人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
发明人： Beatrice Maria Arico , Brunella Brunelli , Maurizio Comanducci , Mariagrazia Pizza , Silvana Savino , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/09 , A61K47/48 , A61K39/39
CPC分类号： A61K39/095 , A61K39/092 , A61K39/39 , A61K47/646 , A61K2039/55505
摘要： The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.
摘要翻译：脑膜炎球菌fHbp的M01573序列在疫苗中的覆盖范围较差。本发明以两种方式解决了这种差的覆盖面。在第一方面，基于fHbp的疫苗包括两个家族I fHbp序列，一个与MC58比M01573更密切相关的序列，反之亦然。在第二方面，多家fHbp基疫苗使用与MC58比M01573更紧密相关的家族I fHbp序列，与III族fHbp序列组合。用磷酸铝佐剂佐剂组合物。

89. 发明申请

US20150118261A1 ESCHERICHIA COLI VACCINE COMBINATION 有权
标题翻译： ESCHERICHIA COLI VACCINE组合
公开(公告)号：US20150118261A1
公开(公告)日：2015-04-30
申请号：US14344892
申请日：2012-09-14
申请人： Laura Serino , Mariagrazia Pizza
发明人： Laura Serino , Mariagrazia Pizza
IPC分类号： A61K39/108 , C07K14/245
CPC分类号： A61K39/0258 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55516 , A61K2039/55544 , A61K2039/70 , C07K14/245 , Y02A50/474
摘要： The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid sequence set forth in SEQ ID NO:2 or a protein having at least 80% similarity thereto, and (ii) putative Lipoprotein (orf3526) having the amino acid sequence set forth in SEQ ID NO:8 or a protein having at least 80% similarity thereto.
摘要翻译：本发明提供了包含以下组合的免疫原性组合物：（i）具有SEQ ID NO：2所示氨基酸序列的细菌Ig样结构域蛋白片段（orf405B）或与其具有至少80％相似性的蛋白质，和）推定的具有SEQ ID NO：8所示氨基酸序列的脂蛋白（orf3526）或与其具有至少80％相似性的蛋白质。

90. 发明授权

US08808711B2 Meningococcal outer membrane vesicles 有权
标题翻译：脑膜炎球菌外膜囊泡
公开(公告)号：US08808711B2
公开(公告)日：2014-08-19
申请号：US11661996
申请日：2005-09-05
申请人： Philipp Oster , Mariagrazia Pizza , Rino Rappouli
发明人： Philipp Oster , Mariagrazia Pizza , Rino Rappouli
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/545 , A61K2039/55555
摘要： OMVs targeted against specific epidemic strains can be highly effective in controlling localized outbreaks of disease. In combination with large-scale and reproducible manufacturing techniques, a vaccine can be rapidly produced after an outbreak. The invention provides a method for preparing a meningococcal outer membrane vesicle (OMV) vaccine, comprising the steps of: (i) identifying the serosubtype of a meningococcal strain associated with an outbreak of meningococcal meningitis; (ii) preparing OMVs from a meningococcal strain having the serosubtype identified in step (i) for use in vaccine manufacture. The method may comprise one or both of the further steps of (iii) formulating said OMVs as a vaccine; and (iv) distributing said vaccine in a geographical area affected by or likely to be affected by said outbreak. The meningococcal strain will typically be in serogroup B, but may be instead by in serogroup A, C, W135, Y, etc.
摘要翻译：针对特定流行株的OMV可以有效控制局部的疾病暴发。结合大规模和可重现的制造技术，疫苗可以在爆发后迅速生产。本发明提供了一种制备脑膜炎球菌外膜囊泡（OMV）疫苗的方法，包括以下步骤：（i）鉴定与脑膜炎球菌脑膜炎爆发相关的脑膜炎球菌菌株的血清型; （ii）从具有步骤（i）中鉴定的血清型的脑膜炎球菌菌株制备用于疫苗制造的OMV。该方法可以包括以下一个或两个步骤：（iii）将所述OMV配制为疫苗; 和（iv）在受该疫情影响或受其影响的地理区域内分发疫苗。脑膜炎球菌病毒株通常在血清组B中，但可以代之以血清群A，C，W135，Y等。

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