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81. 发明申请

US20060145397A1 Method and tool for molding 审中-公开
标题翻译：成型方法和工具
公开(公告)号：US20060145397A1
公开(公告)日：2006-07-06
申请号：US11029432
申请日：2005-01-05
申请人： Frederick Steil , Lawrence Navarre , Ying Huang , Charles Azzopardi
发明人： Frederick Steil , Lawrence Navarre , Ying Huang , Charles Azzopardi
IPC分类号： B29C45/73 , B29C45/40
CPC分类号： B29C33/04 , B22D17/2218 , B29C45/7312 , B29C49/4823 , B29C2045/7362
摘要： A molding tool comprises a mold component having a body, a molding surface thereon, and at least one passage internal to the body for conducting a heat transfer fluid from an inlet thereto to an outlet therefrom, the passage comprising a roof spaced from and located proximate the molding surface, a floor spaced from the roof and located farther from the molding surface than the roof, the roof and floor being joined to define a passage cross section, wherein the roof extends within the tooling body so as to substantially conform in size and shape to one or more contours of the molding surface and at least one of the area of the passage cross section and the offset distance of the passage from the molding surface varies between the inlet and outlet. Advantageously, the passage comprises at least one support pillar to constrain deflection of the molding surface during molding.
摘要翻译：模制工具包括具有主体的模具部件，其上的模制表面以及在主体内部的至少一个通道，用于将传热流体从入口传导到其出口，该通道包括与顶部间隔开并位于其中的顶部模制表面，与屋顶间隔开并且与模制表面比屋顶更远的地板，屋顶和地板被连接以限定通道横截面，其中屋顶在工具主体内延伸以便基本上符合尺寸和形状与模制表面的一个或多个轮廓，并且通道横截面的区域中的至少一个和通道与模制表面的偏移距离在入口和出口之间变化。有利地，通道包括至少一个支撑柱，以在模制期间约束模制表面的偏转。

82. 发明授权

US06399983B1 Reduction of shorts among electrical cells formed on a semiconductor substrate 有权
标题翻译：减少在半导体衬底上形成的电池之间的短路
公开(公告)号：US06399983B1
公开(公告)日：2002-06-04
申请号：US09389294
申请日：1999-09-02
申请人： Er-Xuan Ping , Ying Huang
发明人： Er-Xuan Ping , Ying Huang
IPC分类号： H01L218242
CPC分类号： H01L28/91 , H01L28/84
摘要： An integrated circuit, such as a DRAM circuit, having a plurality of cells is formed in containers formed an isolation layer positioned on an first surface of a semiconductor substrate. The containers have a first region located proximal the first surface of the semiconductor substrate that has a first cross-sectional area and a second region located distal from the first surface of the semiconductor substrate that has a second cross-sectional area that is less than the first cross-sectional area. Cells, such as capacitors, are formed in the containers and the isolation material positioned between adjacent cells is removed so that a generally horizontal surface is formed. The horizontal surface is located closer to the first surface of the substrate than the transition between the first region and the second region of the container so that substantially vertical surfaces are formed in the isolation region linking the cells to the horizontal surface of the isolation layer. The addition of the vertical surfaces on the isolation region increases the surface path upon which leakage current will flow between adjacent cells thereby decreasing the likelihood of leakage currents travelling from one cell to an adjacent cell.
摘要翻译：具有多个单电池的诸如DRAM电路的集成电路形成在形成在半导体衬底的第一表面上的隔离层的容器中。这些容器具有位于半导体衬底的第一表面附近的第一区域，该第一区域具有第一横截面区域和位于远离半导体衬底的第一表面的第二区域，第二区域的第二横截面积小于第一个横截面积。在容器中形成诸如电容器的电池，并且移除位于相邻电池之间的隔离材料，从而形成大致水平的表面。水平表面比容器的第一区域和第二区域之间的过渡位置更靠近基板的第一表面，使得在将单元连接到隔离层的水平表面的隔离区域中形成基本垂直的表面。在隔离区域上添加垂直表面增加了在相邻单元之间泄漏电流将流过的表面路径，从而降低了漏电流从一个单元行进到相邻单元的可能性。

83. 发明授权

US5993632A Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation 有权
$Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation$
标题翻译：使用广义介电电泳和场流分馏法进行分馏的方法和装置
公开(公告)号：US5993632A
公开(公告)日：1999-11-30
申请号：US243348
申请日：1999-02-01
申请人： Frederick F. Becker , Peter R. C. Gascoyne , Ying Huang , Xiao-Bo Wang
发明人： Frederick F. Becker , Peter R. C. Gascoyne , Ying Huang , Xiao-Bo Wang
IPC分类号： B03C5/02 , G01N30/00 , G01N27/26
CPC分类号： G01N30/0005 , B03C5/028 , G01N2030/0035 , G01N2030/0065
摘要： The present disclosure is directed to a novel apparatus and novel methods for the separation, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transitted through the chamber, it exists at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixture of cells, such as cancer cells, separation of parasitized erythrocytes from normal erthrocytes, separation of nucleic acids, and others.
摘要翻译：本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。在物体通过腔室转运之后，它在特定位置处存在于腔室的相对端。根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。这种方法的实例可以包括细胞混合物的分离，例如癌细胞，寄生的红细胞与正常红细胞的分离，核酸的分离等。

84. 发明申请

US20220273617A1 ANTI-CANCER, ANTI-INFLAMMATORY AND IMMUNOMODULATORY ACTIVITY OF R-CARVEDILOL AND METHODS OF USE 有权
公开(公告)号：US20220273617A1
公开(公告)日：2022-09-01
申请号：US17676684
申请日：2022-02-21
申请人： Ying Huang , Bradley Tram Andresen , Jinghua Jeffrey Wang , Vijay Kumar Nekkanti , Ayaz Shahid
发明人： Ying Huang , Bradley Tram Andresen , Jinghua Jeffrey Wang , Vijay Kumar Nekkanti , Ayaz Shahid
IPC分类号： A61K31/403 , A61P9/10 , A61P9/12 , A61P9/04 , A61P35/00
摘要： A novel prophylactic therapy for cancer, as well as therapy against DNA damage, inflammation and immunosuppression involves the β-blocker carvedilol, which is a racemic mixture consisting of two enantiomers, S- and R-carvedilol, in 1:1 ratio. S-carvedilol is a β-blocker, with a highly potent antagonizing activity against the β-adrenergic receptors, which is the main mechanism for the drug's pharmacological activity in treatment of high blood pressure and heart failure. Carvedilol—the racemic mixture—prevents ultraviolet radiation induced skin cancer by attenuating DNA damage, reducing inflammation and reversing immunosuppression. The non-β-blocking enantiomer R-carvedilol exhibits the same cancer preventive efficacy as the racemic carvedilol, without disturbing the cardiovascular system. Both carvedilol and R-carvedilol prevent chemical carcinogen-induced lung cancer development and lung inflammation.

85. 发明授权

US09191598B2 Front-end pixel fixed pattern noise correction in imaging arrays having wide dynamic range 有权
标题翻译：具有宽动态范围的成像阵列中的前端像素固定图案噪声校正
公开(公告)号：US09191598B2
公开(公告)日：2015-11-17
申请号：US13206175
申请日：2011-08-09
申请人： Laurent Blanquart , Ying Huang , Joey Shah , David Lawrence Standley
发明人： Laurent Blanquart , Ying Huang , Joey Shah , David Lawrence Standley
IPC分类号： H04N5/217 , H04N5/378 , H04N5/365
CPC分类号： H04N5/378 , H04N5/365
摘要： Aspects describe front-end pixel fixed pattern noise correction in imaging arrays having wide dynamic range. A photosensor of a first pixel in a first row of an array is reset and a first reset level of the first pixel is measured. The array comprises a plurality of pixels arranged in rows and columns. In response to a result of the first reset level, a reset bus is altered. A feed-forward adjustment of the photosensor of the first pixel is performed to substantially remove fixed-pattern noise. An external readout from the photosensor can occur with substantially all the fixed-pattern noise removed. In some aspects, the adjustment is performed by a switched capacitor block.
摘要翻译：方面描述了具有宽动态范围的成像阵列中的前端像素固定图案噪声校正。阵列的第一行中的第一像素的光电传感器被复位，并且测量第一像素的第一复位电平。阵列包括以行和列排列的多个像素。响应于第一复位电平的结果，复位总线被改变。执行第一像素的光传感器的前馈调整以基本上去除固定图案噪声。可以发生来自光电传感器的外部读出，其中消除了基本上所有的固定图案噪声。在一些方面，调节由开关电容器块执行。

86. 发明授权

US09014139B2 Method and eNodeB for forwarding downlink and uplink packets based on S1 handover 有权
标题翻译：用于基于S1切换转发下行链路和上行链路分组的方法和eNodeB
公开(公告)号：US09014139B2
公开(公告)日：2015-04-21
申请号：US13276782
申请日：2011-10-19
申请人： Ying Huang
发明人： Ying Huang
IPC分类号： H04W36/02 , H04W72/12 , H04W80/02 , H04W88/04
CPC分类号： H04W36/02 , H04W36/0011 , H04W72/12 , H04W80/02 , H04W88/04
摘要： A method for forwarding downlink packets based on S1 handover is disclosed. The method includes: numbering a packet not processed by using PDCP according to a message that comprises PDCP Serial Number (SN) information if downlink packets to be forwarded include the packet not processed by using PDCP; and sending the downlink packets to the UE according to the PDCP SN corresponding to the packet included in the downlink packets. A method for forwarding uplink packets based on S1 handover is disclosed. The method includes: receiving state report information of the packet sent by the target eNodeB; and sending the packet according to the state report information of the packet. Another method for forwarding downlink packets based on S1 handover and an eNodeB are disclosed. Through the embodiments of the present disclosure, the packets are forwarded without loss in the case of S1 handover.
摘要翻译：公开了一种基于S1切换转发下行分组的方法。该方法包括：如果要转发的下行链路分组包括不使用PDCP处理的分组，则根据包括PDCP序列号（SN）信息的消息，对未被使用PDCP的分组进行编号; 根据与下行分组中包含的分组对应的PDCP SN向UE发送下行报文。公开了一种基于S1切换转发上行链路分组的方法。该方法包括：接收由目标eNodeB发送的分组的状态报告信息; 并根据报文的状态报告信息发送报文。公开了一种基于S1切换和eNodeB转发下行分组的方法。通过本公开的实施例，在S1切换的情况下，分组被转发而不丢失。

87. 发明授权

US08889683B2 Substituted quinoxalines as inhibitors of fatty acid binding protein 有权
标题翻译：取代喹喔啉作为脂肪酸结合蛋白的抑制剂
公开(公告)号：US08889683B2
公开(公告)日：2014-11-18
申请号：US13242426
申请日：2011-09-23
申请人： Clifford Cheng , Gerald W. Shipps, Jr. , Xiaohua Huang , Ying Huang , Ning Shao , Ashwin Rao , Anandan Palani , Peter Orth , Johannes H. Voigt , Robert J. Herr , Lana Michele Rossiter , Qi Zeng , Xianfeng Sun
发明人： Clifford Cheng , Gerald W. Shipps, Jr. , Xiaohua Huang , Ying Huang , Ning Shao , Ashwin Rao , Anandan Palani , Peter Orth , Johannes H. Voigt , Robert J. Herr , Lana Michele Rossiter , Qi Zeng , Xianfeng Sun
IPC分类号： A61K31/498 , C07D241/44 , C07D401/14 , C07D403/14 , C07D413/06 , C07D401/06 , C07D403/12 , C07D403/06
CPC分类号： C07D403/06 , C07D241/44 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/06
摘要： The present invention relates to novel quinoxaline compounds of Formula I: as Fatty Acid Binding Protein (“FABP”) inhibitors, pharmaceutical compositions comprising the quinoxaline compounds and the use of the quinoxaline compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.
摘要翻译：本发明涉及式I的新型喹喔啉化合物：作为脂肪酸结合蛋白（“FABP”）抑制剂，包含喹喔啉化合物的药物组合物和喹喔啉化合物用于治疗或预防心血管疾病，代谢紊乱，肥胖症或肥胖相关疾病，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。

88. 发明授权

US08623867B2 Cyclic amine BACE-1 inhibitors having a benzamide substituent 有权
标题翻译：具有苯甲酰胺取代基的环胺BACE-1抑制剂
公开(公告)号：US08623867B2
公开(公告)日：2014-01-07
申请号：US13610162
申请日：2012-09-11
申请人： Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voight , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey H. Lowrie , Kurt W. Saionz , Suresh D. Babu
发明人： Jared N. Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes H. Voight , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas W. Hobbs , Thuy X. H. Le , Jeffrey H. Lowrie , Kurt W. Saionz , Suresh D. Babu
IPC分类号： A61K31/445 , A61K31/4458 , A61K31/454 , A61K31/4545 , A61K31/5377 , C07D295/027 , C07D401/06 , C07D401/12 , C07D413/12
CPC分类号： C07D243/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/26 , C07D209/52 , C07D211/26 , C07D211/46 , C07D217/18 , C07D233/32 , C07D241/04 , C07D241/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/12 , C07D413/06
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I.Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease.Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中R1是R是-C（O）-N（R27）（R28），或其余的变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的药物组合物和方法，其包含式I化合物与除式I以外的β-分泌酶抑制剂，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，甾族抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂或抗淀粉样蛋白抗体。

89. 发明授权

US08548458B2 Method, device, and system for measuring and reporting automatic neighbour relation 有权
标题翻译：用于测量和报告自动邻居关系的方法，设备和系统
公开(公告)号：US08548458B2
公开(公告)日：2013-10-01
申请号：US13234645
申请日：2011-09-16
申请人： Ying Huang , Ping Song
发明人： Ying Huang , Ping Song
IPC分类号： H04W24/00 , H04W36/00 , H04W4/00 , H04M1/00 , H04M3/00 , H04L12/26
CPC分类号： H04W36/0083 , H04W76/19
摘要： The present invention relates to the communications field and discloses a method, a device, and a system for measuring and reporting an automatic neighbor relation (ANR), which are capable of completing an ANR function during a radio link failure (RLF), therefore saving measurement time and improving network performance. The solution is: when an RLF occurs, receiving a radio resource control (RRC) link reestablishment failure message, where the RRC link reestablishment failure message carries control information instructing a user equipment (UE) to perform an ANR measurement; performing the ANR measurement according to the control information in the RRC link reestablishment failure message to obtain an ANR measurement result; and after receiving an RRC link establishment response message, reporting the ANR measurement result by using an RRC link establishment complete message.
摘要翻译：本发明涉及通信领域，并且公开了一种能够在无线电链路故障（RLF）期间完成ANR功能的自动相邻关系（ANR）的测量和报告的方法，设备和系统，因此节省测量时间，提高网络性能。解决的办法是：当发生RLF时，接收无线电资源控制（RRC）链路重建失败消息，无线链路重建失败消息携带指示用户设备（UE）执行ANR测量的控制信息; 根据RRC链路重建失败消息中的控制信息进行ANR测量，得到ANR测量结果; 并且在接收到RRC链路建立响应消息之后，通过使用RRC链路建立完成消息来报告ANR测量结果。

90. 发明申请

US20120329743A1 CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS 有权
标题翻译：作为CRTH2受体调节剂的环丙基二烯丙基四氢喹啉
公开(公告)号：US20120329743A1
公开(公告)日：2012-12-27
申请号：US13523354
申请日：2012-06-14
申请人： Xianhai Huang , Jason Brubaker , Scott L. Peterson , John W. Butcher , Joshua T. Close , Michelle Martinez , Rachel Nicola MacCoss , Joon O. Jung , Phieng Siliphaivanh , Hongjun Zhang , Robert G. Aslanian , Purakkattle Johny Biju , Li Dong , Ying Huang , Kevin D. McCormick , Anandan Palani , Ning Shao , Wei Zhou
发明人： Xianhai Huang , Jason Brubaker , Scott L. Peterson , John W. Butcher , Joshua T. Close , Michelle Martinez , Rachel Nicola MacCoss , Joon O. Jung , Phieng Siliphaivanh , Hongjun Zhang , Robert G. Aslanian , Purakkattle Johny Biju , Li Dong , Ying Huang , Kevin D. McCormick , Anandan Palani , Ning Shao , Wei Zhou
IPC分类号： C07D221/16 , C07D413/10 , A61K31/5377 , C07D401/10 , A61P11/00 , A61K31/501 , C07H15/26 , A61K31/706 , A61P11/06 , A61P37/08 , A61K31/473 , A61K31/506
CPC分类号： C07D221/16 , A61K31/473 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
摘要翻译：本发明提供一些式（I）的环烷基稠合的四氢喹啉及其药学上可接受的盐和酯，其中R1，R2，R7，R8，R8a，E，Y，Z，n，u和t如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗与不受控制或不适当刺激CRTH2功能相关的疾病或病症的方法。

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