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81. 发明授权

US08518654B2 Lung cancer diagnostic polypeptide, method for detecting lung cancer, and method for evaluating therapeutic effect 有权
标题翻译：肺癌诊断多肽，肺癌检测方法，治疗效果评价方法
公开(公告)号：US08518654B2
公开(公告)日：2013-08-27
申请号：US13197849
申请日：2011-08-04
申请人： Koji Ueda , Hidewaki Nakagawa , Atsuhiko Toyama , Taka-Aki Sato
发明人： Koji Ueda , Hidewaki Nakagawa , Atsuhiko Toyama , Taka-Aki Sato
IPC分类号： G01N33/53 , C12N5/00
CPC分类号： C07K14/4748 , G01N33/57423 , G01N33/6848 , G01N2800/52
摘要： A novel biomarker for use in lung cancer diagnosis is provided.
摘要翻译：提供了一种用于肺癌诊断的新型生物标志物。

82. 发明申请

US20120328862A1 WATER-ABSORBENT SHEET STRUCTURE 审中-公开
标题翻译：吸水片结构
公开(公告)号：US20120328862A1
公开(公告)日：2012-12-27
申请号：US13521491
申请日：2010-12-27
申请人： Shinya Fukudome , Junichi Maruo , Masayoshi Handa , Koji Ueda
发明人： Shinya Fukudome , Junichi Maruo , Masayoshi Handa , Koji Ueda
IPC分类号： A61F13/53 , B32B5/26
CPC分类号： A61F13/534 , A61F2013/530131 , A61F2013/530481 , A61F2013/530554 , A61F2013/5307 , A61F2013/530737 , A61F2013/53445 , Y10T442/659
摘要： A water-absorbent sheet structure comprises a structure in which an absorbent layer containing a water-absorbent resin and an adhesive is sandwiched with nonwoven fabrics from an upper side and a lower side of the absorbent layer, wherein the water-absorbent resin is contained in an amount of from 100 to 1,000 g/m2, and wherein the water-absorbent resin has a water-retention capacity of saline solution of from 15 to 50 g/g, and wherein the water-absorbent sheet structure has a peeling strength of from 0.05 to 3.0 N/7 cm. The water-absorbent sheet structure of the present invention exhibits some effects that a water-absorbent sheet structure has excellent shape retaining ability even when the structure is thin, so that the water-absorbent sheet structure does not undergo deformation of the form before liquid absorption or after the absorption, and is capable of sufficiently exhibiting absorbent properties.
摘要翻译：吸水性片材结构体包括将吸收性树脂和粘合剂的吸收层从吸收层的上侧和下侧夹在无纺织物之间的结构，其中吸水性树脂被包含在 100〜1000g / m 2的吸水性树脂，其中吸水性树脂的盐溶液的保水能力为15〜50g / g，吸水性片材结构的剥离强度为 0.05〜3.0N / 7cm。本发明的吸水片材结构具有吸水性片材结构即使在结构较薄时也具有优异的形状保持能力的效果，因此吸水性片材结构体不会在吸液片之前形成形状或吸收后，并且能够充分显示吸收性能。

83. 发明申请

US20120089108A1 WATER ABSORBENT SHEET 审中-公开
标题翻译：吸水片
公开(公告)号：US20120089108A1
公开(公告)日：2012-04-12
申请号：US13377432
申请日：2010-06-08
申请人： Koji Ueda , Tetsuhiro Hinayama , Syuji Tsuno , Masayoshi Handa
发明人： Koji Ueda , Tetsuhiro Hinayama , Syuji Tsuno , Masayoshi Handa
IPC分类号： A61L15/58 , A61L15/28 , A61L15/22
CPC分类号： A61F13/535 , A61F13/15699 , A61F13/15747 , A61F13/53409 , A61F13/53713 , A61F13/53752 , A61F13/539 , A61F2013/15406 , A61F2013/530554
摘要： A water-absorbent sheet comprising a structure in which an absorbent layer containing a water-absorbent resin and an adhesive is sandwiched with a hydrophilic nonwoven fabric, wherein the water-absorbent sheet has a structure in which the absorbent layer is fractionated into a primary absorbent layer and a secondary absorbent layer with a substrate layer formed by laminating two or more layers of a substrate having breathability adhered together with an adhesive, wherein the substrate layer satisfies the following requirements (1) and (2): (1) the substrate layer having a basis weight of 25 g/m2 or more; and (2) the substrates having breathability being adhered therebetween with an adhesive in an amount of from 0.1 to 50 g/m2. The water-absorbent sheet of the present invention exhibits some excellent effects that the water-absorbent sheet is capable of accomplishing thinning and avoidance of gel blocking phenomenon and liquid leakage, while obtaining basic properties as a water-absorbent sheet at a high level, even for a water-absorbent sheet containing a very small amount of pulps.
摘要翻译：一种吸水性片材，其特征在于，包括吸水性树脂和粘合剂的吸收层被亲水性无纺布夹持的结构，其中，吸水性片材具有将吸收层分级成初级吸收体层和二次吸收层，其具有通过层压具有透气性的两层或多层具有透气性的基材与粘合剂形成的基底层，其中基底层满足以下要求（1）和（2）：（1）基底层基重为25g / m 2以上; 和（2）具有0.1至50g / m 2量的粘合剂之间具有透气性的基材粘合在其间。本发明的吸水片表现出一些优异的效果，即吸收性片材能够在获得高水平的吸水片材的基本性能的同时，能够实现变薄和避免凝胶堵塞现象和液体泄漏，甚至用于含有非常少量纸浆的吸水片材。

84. 发明申请

US20120069640A1 MAGNETORESISTIVE ELEMENT AND MAGNETIC MEMORY 有权
标题翻译：磁性元件和磁记忆
公开(公告)号：US20120069640A1
公开(公告)日：2012-03-22
申请号：US13232782
申请日：2011-09-14
申请人： Toshihiko Nagase , Tadashi Kai , Makoto Nagamine , Katsuya Nishiyama , Eiji Kitagawa , Tadaomi Daibou , Koji Ueda , Hiroaki Yoda , Kay Yakushiji , Shinji Yuasa , Hitoshi Kubota , Taro Nagahama , Akio Fukushima , Koji Ando
发明人： Toshihiko Nagase , Tadashi Kai , Makoto Nagamine , Katsuya Nishiyama , Eiji Kitagawa , Tadaomi Daibou , Koji Ueda , Hiroaki Yoda , Kay Yakushiji , Shinji Yuasa , Hitoshi Kubota , Taro Nagahama , Akio Fukushima , Koji Ando
IPC分类号： G11C11/16
CPC分类号： H01L27/228 , G11C11/161 , H01L43/08 , H01L43/10
摘要： A magnetoresistive element according to an embodiment includes: a first and second magnetic layers having an easy axis of magnetization in a direction perpendicular to a film plane; and a first nonmagnetic layer interposed between the first and second magnetic layers, at least one of the first and second magnetic layers including a structure formed by stacking a first and second magnetic films, the second magnetic film being located closer to the first nonmagnetic layer, the second magnetic film including a structure formed by repeating stacking of a magnetic material layer and a nonmagnetic material layer at least twice, the nonmagnetic material layers of the second magnetic film containing at least one element selected from the group consisting of Ta, W, Hf, Zr, Nb, Mo, Ti, V, and Cr, one of the first and second magnetic layers having a magnetization direction that is changed by applying a current.
摘要翻译：根据实施例的磁阻元件包括：在垂直于膜平面的方向上具有易磁化轴的第一和第二磁性层; 以及介于所述第一和第二磁性层之间的第一非磁性层，所述第一和第二磁性层中的至少一个包括通过堆叠第一和第二磁性膜形成的结构，所述第二磁性膜位于更靠近所述第一非磁性层的位置，所述第二磁性膜包括通过将磁性材料层和非磁性材料层重复堆叠至少两次形成的结构，所述第二磁性膜的非磁性材料层含有选自Ta，W，Hf中的至少一种元素，Zr，Nb，Mo，Ti，V和Cr中的一种，所述第一和第二磁性层之一具有通过施加电流而改变的磁化方向。

85. 发明申请

US20090240087A1 Process for Producing Optically Active Fluorobenzyl Alcohol 有权
标题翻译：生产光活性氟苄醇的方法
公开(公告)号：US20090240087A1
公开(公告)日：2009-09-24
申请号：US12089882
申请日：2006-10-04
申请人： Akihiro Ishii , Koji Ueda , Manabu Yasumoto
发明人： Akihiro Ishii , Koji Ueda , Manabu Yasumoto
IPC分类号： C07C33/46
CPC分类号： C07C29/095 , C07B57/00 , C07B2200/07 , C07C67/08 , C07C67/60 , C07C33/40 , C07C33/22 , C07C69/80
摘要： A fluorine-containing benzaldehyde is reacted with an alkyl Grignard reagent to convert it to a magnesium alkoxide of racemic, fluorine-containing, benzyl alcohol, and subsequently the magnesium alkoxide is reacted with phthalic anhydride to obtain a phthalate half ester of racemic, fluorine-containing, benzyl alcohol, and the half ester is optically resolved by optically active 1-phenylethylamine, and then the ester group is hydrolyzed, thereby producing an optically active, fluorine-containing, benzyl alcohol.
摘要翻译：将含氟苯甲醛与烷基格氏试剂反应，将其转化成外消旋，含氟苄基醇的烷氧基镁，随后将烷氧基镁与邻苯二甲酸酐反应，得到外消旋，通过光学活性1-苯基乙胺光学拆分半酯，然后将酯基水解，从而制备光学活性的含氟苄基醇。

86. 发明授权

US07462734B2 Process for production of optically active α-fluoro-carboxylic ester derivatives 失效
标题翻译：光学活性α-氟 - 羧酸酯衍生物的制备方法
公开(公告)号：US07462734B2
公开(公告)日：2008-12-09
申请号：US11597105
申请日：2005-08-05
申请人： Akihiro Ishii , Hideyuki Tsuruta , Takashi Ootsuka , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Koji Ueda
发明人： Akihiro Ishii , Hideyuki Tsuruta , Takashi Ootsuka , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Koji Ueda
IPC分类号： C07C69/76 , C07C69/63 , C07C33/46 , C07C31/34
CPC分类号： C07C67/307 , C07B2200/07 , C07C29/147 , C07C69/65 , C07C69/63 , C07C31/38
摘要： The present invention relates to a process for producing an optically active α-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active α-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.
摘要翻译：本发明涉及式（2）表示的光学活性α-氟代羧酸酯衍生物的制备方法，该方法通过在有机碱存在下使光学活性的α-羟基羧酸酯衍生物与三氟甲磺酰氟（CF 3 SO 2 F）在式 [2]中，R表示碳数为1〜12的直链或支链烷基; 碳数为1至6的芳族烃基，不饱和烃基，直链或支链烷氧基，芳氧基，卤素原子（氟，氯，溴和碘）的任意组合中的一个或两个，被保护的羧基被保护的氨基或被保护的羟基可以在烷基的任何碳原子上被取代; R1表示碳数为1〜8的直链或支链烷基; R和R 1的烷基的任何碳原子可以形成共价键; 和*表示不对称碳。

87. 发明授权

US07459586B2 Optically active 1-aryl-2-fluoro-substituted ethylamine and method for producing same 有权
标题翻译：光活性1-芳基-2-氟取代的乙胺及其制备方法
公开(公告)号：US07459586B2
公开(公告)日：2008-12-02
申请号：US10591669
申请日：2005-02-21
申请人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Katsuhide Suto , Koji Ueda
发明人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Katsuhide Suto , Koji Ueda
IPC分类号： C07C209/62 , C07C211/00 , C07C251/00
CPC分类号： C07C251/24 , C07C209/52 , C07C209/62 , C07C211/29 , C07C249/02
摘要： The present invention relates to a method of producing an optically active 1-aryl-2-fluoro-substituted ethylamine compound of the formula [2] or a salt thereof by hydrogenolysis of an optically active secondary amine compound of the formula [1] or a salt thereof in the presence of a transition metal catalyst of Group VIII[Chem. 59] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] [Chem. 60] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon].
摘要翻译：本发明涉及通过氢解式[1]的光学活性仲胺化合物或式[1]的光学活性的1-芳基-2-氟取代的乙胺化合物或其盐，其盐在第VIII族的过渡金属催化剂存在下[Chem。 59]其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳] 60] [其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳]。

88. 发明授权

US07368609B2 Optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy- substituted phenyl)alkylamine N-monoalkyl derivatives and process for producing same 有权
标题翻译：光学活性1-（氟，三氟甲基或三氟甲氧基取代的苯基）烷基胺N-单烷基衍生物及其制备方法
公开(公告)号：US07368609B2
公开(公告)日：2008-05-06
申请号：US11705089
申请日：2007-02-12
申请人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
发明人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
IPC分类号： C07C211/00
CPC分类号： C07C209/62 , C07B2200/07 , C07C211/29 , C07C217/58 , C07C249/02 , C07C251/24
摘要： An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4 is produced by a process including (a) reacting an optically active secondary amine, represented by the formula 1, with an alkylation agent R2—X, in the presence of a base, thereby converting the secondary amine into an optically active tertiary amine represented by the formula 3; and (b) subjecting the tertiary amine to a hydrogenolysis, thereby producing the N-monoalkyl derivative, wherein R represents a fluorine atom, trifluoromethyl group or trifluoromethoxy group, n represents an integer of from 1 to 5, each of R1 and R2 independently represents an alkyl group having a carbon atom number of from 1 to 6, Me represents a methyl group, Ar represents a phenyl group or 1- or 2-naphthyl group, * represents a chiral carbon, and X represents a leaving group.
摘要翻译：由式4表示的光学活性1-（氟 - ，三氟甲基 - 或三氟甲氧基取代的苯基）烷基胺N-单烷基衍生物通过以下方法制备，该方法包括：（a）使由式1表示的光学活性仲胺与式烷基化剂R 2 -X在碱的存在下，由此将仲胺转化成由式3表示的光学活性叔胺; 和（b）使叔胺进行氢解，从而制备N-单烷基衍生物，其中R表示氟原子，三氟甲基或三氟甲氧基，n表示1〜5的整数，R 1 独立地表示碳原子数1〜6的烷基，Me表示甲基，Ar表示苯基或1-或2-萘基， *表示手性碳，X表示离去基团。

89. 发明授权

US07189863B2 Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives 失效
标题翻译：制备三氟甲基取代的2-烷氧基苯乙酮衍生物的方法
公开(公告)号：US07189863B2
公开(公告)日：2007-03-13
申请号：US11347390
申请日：2006-02-06
申请人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
发明人： Akihiro Ishii , Masatomi Kanai , Yokusu Kuriyama , Manabu Yasumoto , Kenjin Inomiya , Takashi Ootsuka , Koji Ueda
IPC分类号： C07D319/06
CPC分类号： C07D317/22 , C07C43/315 , C07C45/57 , C07C45/59 , C07C45/60 , C07C49/84 , C07D317/16 , C07C49/80
摘要： A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether
摘要翻译：制备溴化缩醛的方法（由式3表示）包括（a）在亚烷基二醇的存在下用Br 2 H 3溴化三氟甲基取代的苯乙酮。（b）使溴化缩醛与金属醇盐反应，从而将溴化缩醛转化成醚，任选地制备三氟甲基取代的2-烷氧基苯乙酮衍生物（由式9表示）和（c）在酸催化剂的存在下水解醚，以从乙醚中除去缩醛基，从而制备2-烷氧基苯乙酮衍生物。或者，2-烷氧基苯乙酮可以通过以下方法制备：（a）使三氟甲基取代的苯甲酰甲基卤化物与缩醛化剂反应，从而将苯甲酰甲酰卤转化成缩醛; （b）使缩醛与金属醇盐反应，从而将缩醛转化成醚; 和（c）在酸催化剂存在下水解该醚，以从乙醚中除去缩醛基

90. 发明申请

US20060250951A1 Path switching system for network 审中-公开
标题翻译：网路路径切换系统
公开(公告)号：US20060250951A1
公开(公告)日：2006-11-09
申请号：US11449038
申请日：2006-06-07
申请人： Koji Ueda , Kazuhiro Nakashima , Hirofumi Mitome , Tetsuya Uehori , Masayoshi Nakano
发明人： Koji Ueda , Kazuhiro Nakashima , Hirofumi Mitome , Tetsuya Uehori , Masayoshi Nakano
IPC分类号： H04J3/14
CPC分类号： H04L45/28 , H04L43/0817 , H04L45/00 , H04L45/22 , H04L45/50
摘要： A path switching system can dramatically decrease time required until a transfer path of user data is switched to a detour path when a failure occurred to a system/line constituting the network. In the path switching system, a path is set by a switch device and a plurality of relay devices adjacent to the switch device, and the switch device has a notification processing section notifying information to specify a corresponding relay device to the plurality of other relay devices when a failure of an adjacent relay device or a line failure between adjacent relay devices is detected, and the relay device has a path change processing section canceling information on the path that passes through the relay device detected to have a failure, from the information notified by the notification processing section of the relay device.
摘要翻译：当构成网络的系统/线路发生故障时，路径切换系统可以显着减少所需时间，直到用户数据的传输路径切换到迂回路径。在路径切换系统中，由开关装置和与开关装置相邻的多个中继装置设定路径，并且交换装置具有通知处理部，通知信息以向多个其他中继装置指定对应的中继装置当检测到相邻中继设备的故障或相邻中继设备之间的线路故障时，中继设备具有路径改变处理部分从通知的信息中取消通过检测到故障的中继设备的路径的信息由中继装置的通知处理部。

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