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    • 88. 发明申请
    • Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof
    • 昆虫或83b气味受体基因的核酸和蛋白质及其用途
    • US20050053933A1
    • 2005-03-10
    • US10486781
    • 2002-08-14
    • Kevin LeeThuy-Ai NguyenBrian Kloss
    • Kevin LeeThuy-Ai NguyenBrian Kloss
    • C12N15/09A01N63/02C07K14/435C12N1/15C12N1/19C12N1/21C12N5/10C12Q1/02C12Q1/04C12Q1/68A01N25/00C07H21/04C12N5/06
    • C07K14/43563
    • The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an Or83b odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an Or83b odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these Or83b odorant receptor genes are provided. Molecules found to bind or modulate the activity of Or83b genes may be formulated into pest control agents by providing a carrier. In a preferred embodiment, molecules that bind or modulate the activity of an Or83b gene form one species but not others is desired. Methods to modify the insect behaviour by modifying an insect Or83b odorant are also provided.
    • 本发明涉及昆虫气味受体基因和鉴别加味剂受体基因的方法。 本发明提供昆虫气味受体基因Or83b,其编码蛋白质(包括肽或多肽)的氨基酸序列以及相关产物和方法的核苷酸序列。 本发明的核酸可以可操作地连接到启动子序列并转化到宿主细胞中。 提供了Or83b气味受体蛋白质的生产方法(例如,通过重组方法)及其衍生物和类似物。 提供了对Or83b加味剂受体蛋白质的抗体及其衍生物和类似物。 提供了用于鉴定结合或调节这些Or83b加味剂受体基因的活性的分子的方法。 发现结合或调节Or83b基因活性的分子可以通过提供载体来配制成害虫防治剂。 在优选的实施方案中,期望结合或调节Or83b基因的活性形成一种但不是其它物质的分子。 还提供了通过修改昆虫Or83b气味来改变昆虫行为的方法。