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81. 发明申请

US20100298901A1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC ELECTRICAL STIMULATION 审中-公开
标题翻译：用于心脏电刺激的可植入医疗装置
公开(公告)号：US20100298901A1
公开(公告)日：2010-11-25
申请号：US12771217
申请日：2010-04-30
申请人： John Louis Sommer , Scott J. Brabec , Jon Frederic Urban , Yong-Fu Xiao , Xiaohong Zhou
发明人： John Louis Sommer , Scott J. Brabec , Jon Frederic Urban , Yong-Fu Xiao , Xiaohong Zhou
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/3621 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/0452 , A61B5/0456 , A61N1/3627 , A61N1/3702
摘要： A method and apparatus for reducing a patient's heart rate or blood pressure. The apparatus provides stimulation to the patient's atrial and/or nodal tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial an/or nodal tissue, responsive to detecting an occurrence of a ventricular depolarization following a preceding atrial depolarization.The apparatus may define a time window following the ventricular depolarization, following the atrial depolarization or determined based upon the timing of both the atrial and ventricular depolarizations. The stimulus may be delivered during or on expiration of the defined time window. The duration of the time window may be pre-set or determined based upon measurements of the patient's refractory periods.
摘要翻译：一种减轻患者心率或血压的方法和装置。该装置响应于检测在前面的心室去极化的发生之后，在心室的相关不应期内但在受刺激的心房和/或淋巴结组织的相关不应期之外对患者的心房和/或淋巴结组织提供刺激。心房去极化。该装置可以在心房去极化之后定义心室去极化之后的时间窗口，或者基于心房和心室去极化的时间确定。刺激可以在定义的时间窗口期间或期满时传送。时间窗口的持续时间可以基于患者的不应期的测量来预先确定或确定。

82. 发明申请

US20100114200A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114200A1
公开(公告)日：2010-05-06
申请号：US12362814
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

83. 发明申请

US20100114199A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114199A1
公开(公告)日：2010-05-06
申请号：US12362809
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/3688
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

84. 发明申请

US20100114197A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114197A1
公开(公告)日：2010-05-06
申请号：US12362773
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , James D. Reinke , Timothy Davis
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3605 , A61N1/36114 , A61N1/36521 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

85. 发明申请

US20100114196A1 IMPLANTABLE MEDICAL DEVICE CROSSTALK EVALUATION AND MITIGATION 有权
公开(公告)号：US20100114196A1
公开(公告)日：2010-05-06
申请号：US12362768
申请日：2009-01-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio , James D. Reinke , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , Timothy Davis
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio , James D. Reinke , Gerald P. Arne , David J. Peichel , Xiaohong Zhou , Timothy Davis
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/3622 , A61N1/37247 , A61N1/37258 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

86. 发明申请

US20100114195A1 IMPLANTABLE MEDICAL DEVICE INCLUDING EXTRAVASCULAR CARDIAC STIMULATION AND NEUROSTIMULATION CAPABILITIES 审中-公开
标题翻译：包括超声心动图刺激和神经细胞功能的可植入医疗装置
公开(公告)号：US20100114195A1
公开(公告)日：2010-05-06
申请号：US12362662
申请日：2009-01-30
申请人： John E. Burnes , Chris Zillmer , Paul G. Krause , Gerald P. Arne , Timothy Davis , David J. Peichel , James D. Reinke , William T. Donofrio , Xiaohong Zhou
发明人： John E. Burnes , Chris Zillmer , Paul G. Krause , Gerald P. Arne , Timothy Davis , David J. Peichel , James D. Reinke , William T. Donofrio , Xiaohong Zhou
IPC分类号： A61N1/39 , A61N1/36 , A61N1/362
CPC分类号： A61N1/0504 , A61B5/046 , A61N1/0587 , A61N1/36114 , A61N1/3622 , A61N1/365 , A61N1/3962
摘要： An implantable medical device may deliver pacing, cardioversion, and/or defibrillation stimulation to a heart of a patient via extravascular electrodes and delivers electrical stimulation to a nonmyocardial tissue site to modulate the autonomic nervous system of the patient. The implantable medical device may include a cardiac therapy module that generates and delivers at least one of pacing, cardioversion, or defibrillation therapy to a patient via an extravascular electrode, and a neurostimulation therapy module that generates and delivers a neurostimulation signal to the patient via a neurostimulation electrode. The cardiac therapy module and neurostimulation therapy module may be disposed in a common housing of the medical device. In some examples, at least one common lead may electrically couple the neurostimulation electrode and the extravascular electrode to the neurostimulation and cardiac therapy modules, respectively.
摘要翻译：可植入医疗装置可以通过血管外电极向患者的心脏递送起搏，心脏复律和/或除颤刺激，并将电刺激递送至非心肌组织部位以调节患者的自主神经系统。可植入医疗装置可以包括心脏治疗模块，该心脏治疗模块通过血管外电极产生并向患者提供起搏，心脏复律或除颤疗法中的至少一种，以及神经刺激治疗模块，其通过以下方式产生并递送神经刺激信号给患者神经刺激电极。心脏治疗模块和神经刺激治疗模块可以设置在医疗装置的公共壳体中。在一些示例中，至少一个共同的引线可以将神经刺激电极和血管外电极分别电耦合到神经刺激和心脏治疗模块。

87. 发明申请

US20090269410A1 Inhibition of Neovascularization by Cerium Oxide Nanoparticles 有权
标题翻译：通过氧化铈纳米颗粒抑制新血管形成
公开(公告)号：US20090269410A1
公开(公告)日：2009-10-29
申请号：US12429650
申请日：2009-04-24
申请人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou
发明人： James F. McGinnis , Lily L. Wong , Xiaohong Zhou
IPC分类号： A61K33/24 , A61K9/14 , A61P29/00 , A61P27/02 , A61P9/00 , A61P19/02 , A61P1/00 , A61P17/00
CPC分类号： A61K9/14 , A61K33/24
摘要： The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
摘要翻译：本发明提供了通过在受试者体内施用纳米颗粒（氧化铈纳米颗粒）的体内，减少，逆转或抑制具有涉及新血管形成的病理状况的哺乳动物受试者的组织中的新生血管形成的方法。本发明的方法例如用于减少，治疗，逆转或抑制眼组织如视网膜，黄斑或角膜中的新生血管形成; 在皮肤上在滑膜组织中在肠组织中或在骨头。此外，本发明的方法可用于减少或抑制肿瘤（肿瘤）中的新生血管形成，其可以是良性或恶性的，并且恶性肿瘤可以是转移性肿瘤。因此，本发明提供了含有纳米颗粒并且可用于在哺乳动物受试者中减少，治疗，逆转或抑制血管生成的组合物。

88. 发明申请

US20080269819A1 DISCRIMINATION OF SUPRAVENTRICULAR TACHYCARDIA FROM VENTRICULAR TACHYCARDIA 审中-公开
标题翻译：从室内TACHYCARDIA分离的非致病性TACHYCARDIA
公开(公告)号：US20080269819A1
公开(公告)日：2008-10-30
申请号：US11740565
申请日：2007-04-26
申请人： Xiaohong Zhou
发明人： Xiaohong Zhou
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/3962
摘要： An implantable medical device and associated method discriminate between ventricular tachycardia and supraventricular tachycardia. Cardiac signals are sensed for detecting ventricular intervals corresponding to a tachycardia. Electrical stimulation pulses are delivered to cardiac neural tissue and verified as being effective in exciting the cardiac neural tissue. If the ventricular intervals corresponding to the tachycardia are increased in response to delivering stimulation pulses to the cardiac neural tissue, the tachycardia is detected as a supraventricular tachycardia.
摘要翻译：植入式医疗装置和相关方法区分室性心动过速和室上性心动过速。感测心脏信号以检测对应于心动过速的心室间隔。电刺激脉冲被递送到心脏神经组织并被证实是有效激励心脏神经组织。如果对应于心动过速的心室间隔响应于向心脏神经组织递送刺激脉冲而增加，则将心动过速检测为室上性心动过速。

89. 发明申请

US20080082133A1 METHOD AND APPARATUS FOR INDUCED T-WAVE ALTERNANS ASSESSMENT 有权
标题翻译：用于诱导T波变换器评估的方法和装置
公开(公告)号：US20080082133A1
公开(公告)日：2008-04-03
申请号：US11536946
申请日：2006-09-29
申请人： Xiaohong Zhou
发明人： Xiaohong Zhou
IPC分类号： A61N1/00
CPC分类号： A61B5/0456 , A61B5/0452 , A61N1/365 , G16H40/63
摘要： An implantable medical device and associated method assesses T-wave alternans. The method includes sensing a cardiac signal from implanted electrodes subsequent to a premature contraction; measuring a T-wave parameter from the sensed cardiac signal for a plurality of cardiac cycles; and determining a T-wave alternans metric corresponding to the measured T-wave parameter.
摘要翻译：可植入医疗器械和相关方法评估T波交替。该方法包括在过早收缩之后感测来自植入电极的心脏信号; 从感测的心脏信号中测量多个心动周期的T波参数; 以及确定对应于所测量的T波参数的T波交替量度。

90. 发明授权

US07155278B2 Neurostimulation to treat effects of sleep apnea 有权
标题翻译：神经刺激治疗睡眠呼吸暂停的效果
公开(公告)号：US07155278B2
公开(公告)日：2006-12-26
申请号：US10419405
申请日：2003-04-21
申请人： Gary W. King , Marcus J. Mianulli , Michael R. S. Hill , Thomas J. Mullen , Roy L. Testerman , John E. Burnes , Xiaohong Zhou
发明人： Gary W. King , Marcus J. Mianulli , Michael R. S. Hill , Thomas J. Mullen , Roy L. Testerman , John E. Burnes , Xiaohong Zhou
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36017 , A61N1/36114
摘要： Neurostimulation is delivered to one or more predetermined locations on or within a patient in order to treat effects of sleep apnea by modulating autonomic nervous activity. Delivery of neurostimulation at predetermined locations can decrease sympathetic nervous activity and/or increase parasympathetic nervous activity, countering the increased intrinsic sympathetic activity associated with apnea-arousal cycles. In some embodiments, neurostimulation is delivered to the spinal cord of the patient via an implanted electrode. In other embodiments, neurostimulation is delivered transcutaneously to the spinal cord or other locations via electrodes located on the surface of the patient. In some embodiments, delivery of neurostimulation is initiated or modified in response to detection of apneas.
摘要翻译：神经刺激被递送到患者体内或患者内的一个或多个预定位置，以通过调节自主神经活动来治疗睡眠呼吸暂停的影响。在预定位置递送神经刺激可降低交感神经活动和/或增加副交感神经活动，抵抗与呼吸暂停 - 觉醒周期相关的增加的内在交感神经活动。在一些实施方案中，神经刺激经由植入的电极递送至患者的脊髓。在其他实施方案中，神经刺激通过位于患者表面上的电极经皮递送至脊髓或其它位置。在一些实施方案中，响应于呼吸暂停的检测开始或修饰神经刺激的递送。

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