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81. 发明申请

US20060067977A1 Pre-dried drug delivery coating for use with a stent 审中-公开
标题翻译：用于支架的预干燥药物递送涂层
公开(公告)号：US20060067977A1
公开(公告)日：2006-03-30
申请号：US11239555
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： A61F2/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A method and apparatus for the provision of a coating for application to a medical device results in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component and solvent can also be provided. The solvent is removed from the coating before the coating is applied to the medical device. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：提供用于医疗装置的涂层的方法和装置导致具有生物可吸收涂层的医疗装置。涂层包括生物吸收载体组分。除了生物吸收性载体成分之外，还可以提供治疗剂成分和溶剂。在将涂层施加到医疗装置之前，从涂层中除去溶剂。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

82. 发明申请

US20080113001A1 Tissue separating device with reinforced support for anchoring mechanisms 有权
标题翻译：组织分离装置，具有用于锚固机构的加强支撑
公开(公告)号：US20080113001A1
公开(公告)日：2008-05-15
申请号：US11980155
申请日：2007-10-30
申请人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
发明人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

83. 发明申请

US20080015500A1 Application of a therapeutic substance to a tissue location using an expandable medical device 有权
标题翻译：使用可扩张医疗装置将治疗物质施用于组织位置
公开(公告)号：US20080015500A1
公开(公告)日：2008-01-17
申请号：US11804478
申请日：2007-05-18
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton
IPC分类号： A61M29/02
CPC分类号： A61M25/1027 , A61L29/085 , A61L29/146 , A61L29/16 , A61L2300/22 , A61L2300/606 , A61M2025/1075 , A61M2025/1088 , C08L27/18
摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.
摘要翻译：应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。输送装置使用充气流体的压力膨胀。在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

84. 发明申请

US20060121081A1 Application of a coating on a medical device 有权
标题翻译：涂在医疗器械上的应用
公开(公告)号：US20060121081A1
公开(公告)日：2006-06-08
申请号：US11238554
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： A61F2/06 , A61M35/00 , B05D3/02
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译：用于在可植入医疗装置上提供涂层的方法和装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。

85. 发明申请

US20060112536A1 Method of coating a folded medical device 有权
标题翻译：折叠式医疗装置的涂敷方法
公开(公告)号：US20060112536A1
公开(公告)日：2006-06-01
申请号：US11250768
申请日：2005-10-14
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
IPC分类号： B23P17/04
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译：以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

86. 发明申请

US20060110457A1 Heat cured gel and method of making 有权
标题翻译：热固化凝胶及其制作方法
公开(公告)号：US20060110457A1
公开(公告)日：2006-05-25
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Thomas Swanick
IPC分类号： A61K9/14 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。

87. 发明申请

US20060067983A1 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US20060067983A1
公开(公告)日：2006-03-30
申请号：US11237264
申请日：2005-09-28
申请人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K31/355 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

88. 发明申请

US20060067974A1 Drug delivery coating for use with a stent 有权
标题翻译：用于支架的药物输送涂层
公开(公告)号：US20060067974A1
公开(公告)日：2006-03-30
申请号：US11236908
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck
IPC分类号： A61K35/60 , A61F2/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

89. 发明授权

US09427423B2 Fatty-acid based particles 有权
标题翻译：脂肪酸基颗粒
公开(公告)号：US09427423B2
公开(公告)日：2016-08-30
申请号：US12401243
申请日：2009-03-10
申请人： Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
发明人： Thomas M. Swanick , Joseph Ferraro , Lisa Rogers , Paul Martakos
IPC分类号： A61K31/20 , A61K31/7028 , A61K38/13 , A61K9/10 , A61K31/4353 , A61K9/70 , A61K31/00 , A61K9/14 , A61K31/4545 , A61K31/496
CPC分类号： A61K31/20 , A61K9/10 , A61K9/145 , A61K9/16 , A61K9/7007 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4545 , A61K31/496 , A61K31/7028 , A61K31/7036 , A61K35/60 , A61K38/13 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/606
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要翻译：本发明涉及脂肪酸类颗粒，以及制造这种颗粒的方法。颗粒可以与另外的治疗剂相关联。本文还提供了形成脂肪酸颗粒的方法，其包括将交联的脂肪酸衍生的生物材料与低温液体缔合; 并使生物材料/低温液体组合物分裂，从而形成脂肪酸颗粒。该颗粒可用于各种治疗应用。

90. 发明申请

US20060058737A1 Catheter treatment stylet 审中-公开
标题翻译：导管治疗探针
公开(公告)号：US20060058737A1
公开(公告)日：2006-03-16
申请号：US10944393
申请日：2004-09-16
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Joseph Ferraro
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Joseph Ferraro
IPC分类号： A61M5/178
CPC分类号： A61M25/00
摘要： A therapeutic agent-eluting stylet treats a catheter by at least temporarily locating the stylet in a lumen of an indwelling catheter placed into a patient. The therapeutic agent-carrying stylet provides a localized therapeutic effect to the catheter and patient by eluting one or more therapeutic agents directly into the lumen of the catheter, into the fluid within the catheter, into the fluid and tissue in contact with the catheter, and onto the surface of the catheter. By removal and replacement of the temporary stylet from the catheter, renewable therapeutic agent doses can be provided to a component, such as the lumen, of the catheter while the catheter remains within in a patient. One or more therapeutically effective doses of medicated agents can be tailored along the length of the stylet and controlled by the length of time by which the stylet remains installed in the catheter.
摘要翻译：治疗剂洗脱的管心针通过至少临时将探针置于置于患者体内的留置导管的内腔中来治疗导管。治疗剂携带管心针通过将一种或多种治疗剂直接洗脱到导管的内腔，导管内的流体中，与导管接触的流体和组织中，向导管和患者提供局部治疗效果，以及到导管的表面。通过从导管中移除和替换临时探针，当导管保持在患者体内时，可将可再生治疗剂剂量提供给导管的部件（例如内腔）。一个或多个治疗有效剂量的药剂可以沿着探针的长度进行调整，并由探针保持安装在导管中的时间长度来控制。

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