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    • 81. 发明授权
    • Multiple unit oral pharmaceutical formulations
    • 多单位口服药物制剂
    • US5955104A
    • 1999-09-21
    • US896629
    • 1997-07-18
    • Helmut MombergerMarc RaberDieter KuhnWolfgang Schmid
    • Helmut MombergerMarc RaberDieter KuhnWolfgang Schmid
    • A61P25/04A61K9/22A61K9/50A61K9/52A61K9/54A61K9/60A61K9/62A61K31/135A61K31/137A61P29/00
    • A61K31/137A61K9/5078Y10S514/951
    • A multiple unit oral pharmaceutical dosage form having a plurality of pellets in a water soluble capsule or in a tablet compressed from the pellets, wherein each pellet contains (a) a substantially inert core, (b) an active ingredient layer over the inert core, and containing (i) a pharmacologically active particulate active ingredient, (ii) a nonembedding amount of a binder for adhering the active ingredient over the inert core, and optionally (iii) a pharmaceutically acceptable, inert adjuvant, such as colloidal silica, and (c) a coating over the active ingredient layer for retarding the release of the active ingredient from the active ingredient layer into an aqueous body fluid solvent in situ, the nonembedding amount of the binder is suitably from about 1% wt. to about 10% wt. based on the active ingredient layer, the binder in the active ingredient layer is suitably a mixture of ethylcellulose and shellac, in a weight proportion suitably of from about 1:9 to about 9:1, the coating for retarding the release suitably contains from about 70% wt. to about 95% wt. based on the coating, of a substantially water-insoluble, pharmacologically inert, particulate material, and a binder; the pharmacologically inert, particulate material is suitably talcum, and the binder in the active ingredient layer is suitably identical to the binder in the coating.
    • 一种多单位口服药物剂型,其在水溶性胶囊中或在片剂中压制的片剂中具有多个丸粒,其中每个丸粒包含(a)基本上惰性的核心,(b)惰性核心上的活性成分层, 并且包含(i)药理学活性的颗粒活性成分,(ii)非固定量的用于将活性成分粘附在惰性核上的粘合剂,以及任选地(iii)药学上可接受的惰性佐剂,例如胶体二氧化硅和( c)活性成分层上的涂层,用于阻止活性成分从活性成分层原位释放到体液溶剂中,非粘合剂量的粘合剂适宜为约1重量% 至约10重量% 基于活性成分层,活性成分层中的粘合剂适当地为乙基纤维素和虫胶的混合物,其重量比适当地为约1:9至约9:1,用于延缓释放的涂层适当地含有约 70%wt 至约95重量% 基于涂层,基本上不溶于水的,药理惰性的颗粒材料和粘合剂; 药理学惰性的颗粒材料适当地是滑石粉,并且活性成分层中的粘合剂适当地与涂层中的粘合剂相同。
    • 85. 发明授权
    • Protective circuit for a semiconductor laser
    • 半导体激光器的保护电路
    • US4872080A
    • 1989-10-03
    • US638095
    • 1984-08-06
    • Christian HentschelWolfgang Schmid
    • Christian HentschelWolfgang Schmid
    • H01S5/042H01S5/068
    • H01S5/06825H01S5/042
    • A protective circuit for a semiconductor laser supplied with an excitation current by a current generator circuit is created using a transducer, whose output is controlled by the laser light, a limit circuit cooperating with the transducer and a current shunt circuit energized by the limit circuit and switched in parallel with the semiconductor laser. Once the permissible emitted light power is reached, excessive excitation current is diverted to the shunt circuit. Exemplary embodiments of the invention are found to achieve response times below 20 ns and are able to protect the semiconductor laser from overload currents even during power-on and power off.
    • 通过使用由激光控制输出的传感器,与换能器配合的限制电路和由限位电路供电的电流分流电路,产生由电流发生器电路提供励磁电流的半导体激光器的保护电路,以及 与半导体激光器并联切换。 一旦达到允许的发射光功率,则过大的励磁电流被转移到分流电路。 发现本发明的示例性实施例实现低于20ns的响应时间,并且即使在上电和断电期间也能够保护半导体激光器免受过载电流的影响。
    • 86. 发明授权
    • Multi-cylinder internal-combustion engine control device
    • 多缸内燃机控制装置
    • US4637363A
    • 1987-01-20
    • US706449
    • 1985-02-27
    • Wolfgang Schmid
    • Wolfgang Schmid
    • F02D9/02F02D17/02
    • F02D9/02F02D17/02F02D2009/0261F02D2009/0279
    • An internal-combustion engine which includes two cylinder groups, of which one cylinder group operates constantly, whereas the second cylinder group is inactive in a part-load operation for better fuel economy. However, during forward or reverse operation of the vehicle and during the warm-up phase of the internal-combustion engine, the second cylinder group is provided with a reduced fuel-air mixture to prevent the engine from dying. An actuating device is provided which responds to certain parameters such as engine temperature and gear position. This actuating device controls a radial cam which interacts with the throttle valve for the second set of cylinders during these conditions to supply the required fuel-air mixture.
    • 一种内燃机,其包括两个气缸组,其中一个气缸组一直运行,而第二气缸组在部分负载运行中不起作用以获得更好的燃油经济性。 然而,在车辆的正向或反向操作期间和内燃机的预热阶段期间,第二气缸组设置有减少的燃料 - 空气混合物,以防止发动机死亡。 提供致动装置,其响应于诸如发动机温度和档位的某些参数。 该致动装置在这些条件期间控制径向凸轮,该径向凸轮与用于第二组气缸的节流阀相互作用以供应所需的燃料 - 空气混合物。
    • 87. 发明授权
    • Lower pressure fractionation of waste gas from ammonia synthesis
    • 从氨合成中降低废气分馏
    • US4473385A
    • 1984-09-25
    • US449794
    • 1982-12-14
    • Rainer FabianWolfgang SchmidHerwig Landes
    • Rainer FabianWolfgang SchmidHerwig Landes
    • F25J3/02F25J3/04
    • F25J3/0285F25J3/0219F25J3/0233F25J3/0252F25J3/0257F25J2200/02F25J2200/30F25J2200/74F25J2200/76F25J2205/04F25J2210/20F25J2270/02F25J2270/04F25J2270/42F25J2270/90Y10S62/934
    • In a low temperature process for the fractionation of ammonia synthesis waste gas (N.sub.2, H.sub.2, Ar, CH.sub.4) comprising two successive separating stages and a nitrogen refrigeration cycle for supplying reboiler heat to each of the stages and also liquid nitrogen, wherein nitrogen is compressed in a compressor to a final pressure, cooled, expanded, and partially liquefied, gaseous and revaporized liquid nitrogen being recompressed, the improvement comprising compressing the nitrogen to a medium pressure, e.g., 6-20 bar, withdrawing a portion of resultant medium-pressure nitrogen from the compressor, compressing remaining medium-pressure nitrogen to the final pressure, e.g., 30-50 bar, cooling resultant medium-pressure nitrogen in parallel with resultant final-pressure nitrogen, further cooling the medium-pressure nitrogen by supplying reboiler heat to the two separating columns, expanding resultant cooled medium-pressure nitrogen to at least partially liquefy the same, expanding resultant cooled final-pressure nitrogen to at least partially liquefy the same, and combining both resultant at least partially liquefied nitrogen streams in a phase separator.
    • 在用于分馏氨合成废气(N 2,H 2,Ar,CH 4)的低温方法中,包括两个连续的分离阶段和用于向每个阶段供应再沸器热的氮气制冷循环以及氮气被压缩 在压缩机中至最终压力,冷却,膨胀和部分液化的气态和再蒸发的液氮被再压缩,改进包括将氮气压缩至中压,例如6-20巴,取出一部分所得中压 压缩机中的氮气,将剩余的中压氮气压缩至最终压力,例如30-50巴,与所得到的最终压力氮气平行冷却所得的中压氮气,通过将再沸器热量供给到另外的方式进一步冷却中压氮气 两个分离柱,使所得到的冷却的中压氮膨胀至少部分地液化,使得冷却 最终压力的氮气至少部分地使其液化,并将所得到的至少部分液化的氮气流合并在相分离器中。