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81. 发明授权

US5866717A Metalloproteinase inhibitors 失效
标题翻译：金属蛋白酶抑制剂
公开(公告)号：US5866717A
公开(公告)日：1999-02-02
申请号：US836839
申请日：1997-05-21
申请人： Raymond Paul Beckett , Mark Whittaker , Andrew Miller , Fionna Mitchell Martin
发明人： Raymond Paul Beckett , Mark Whittaker , Andrew Miller , Fionna Mitchell Martin
IPC分类号： A61K31/16 , A61K31/165 , A61K31/38 , A61K31/381 , A61P1/02 , A61P9/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C237/22 , C07C259/06 , C07C259/14 , C07D333/34 , C07C235/70 , C07D333/32
CPC分类号： C07C237/22 , C07C259/06 , C07D333/34
摘要： Compounds of general formula (I), principally characterized in that R4 is a polyether group, are water soluble matrix metalloproteinase inhibitors. ##STR1##
摘要翻译： PCT No.PCT / GB95 / 02770 Sec。 371日期1997年5月21日 102（e）日期1997年5月21日PCT 1995年11月27日PCT PCT。 WO96 / 16931 PCT出版物日期1996年6月6日通式（I）的化合物，其主要特征在于R4为聚醚基，为水溶性基质金属蛋白酶抑制剂。（一）

82. 发明授权

US5859253A Metalloproteinase inhibitors 失效
标题翻译：金属蛋白酶抑制剂
公开(公告)号：US5859253A
公开(公告)日：1999-01-12
申请号：US25943
申请日：1998-02-19
申请人： Raymond Paul Beckett , Mark Whittaker , Andrew Miller , Fionna Mitchell Martin
发明人： Raymond Paul Beckett , Mark Whittaker , Andrew Miller , Fionna Mitchell Martin
IPC分类号： C07D249/18 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/395 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4427 , A61K31/4433 , A61K31/495 , A61K31/496 , A61P1/02 , A61P9/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P29/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07C237/22 , C07C259/06 , C07C317/44 , C07C323/50 , C07D213/75 , C07D213/89 , C07D233/88 , C07D261/14 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/56 , C07D277/82 , C07D285/08 , C07D285/12 , C07D285/135 , C07D295/22 , C07D307/52 , C07D333/34 , C07D401/12 , C07D409/12 , C07D417/12
CPC分类号： C07D213/75 , C07C237/22 , C07C259/06 , C07D213/89 , C07D277/46 , C07D285/135 , C07D333/34 , C07D401/12 , C07D409/12 , C07D417/12
摘要： L-tert-leucine-2-pyridylamide or an acid addition salt thereof.
摘要翻译： L-叔亮氨酸-2-吡啶酰胺或其酸加成盐。

83. 发明授权

US5637595A Cyclic ether acetal PAF antagonists 失效
公开(公告)号：US5637595A
公开(公告)日：1997-06-10
申请号：US175411
申请日：1993-12-30
申请人： Mark Whittaker , Andrew Miller , Stephen A. Bowles
发明人： Mark Whittaker , Andrew Miller , Stephen A. Bowles
IPC分类号： C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04 , A61K31/425 , A61K31/44
CPC分类号： C07D403/12 , C07D405/12 , C07D417/12 , C07D471/04
摘要： Compounds of general formula (I), wherein W represents a 5- or 6-membered aromatic heterocyclic ring containing one or more non-quaternised sp2 nitrogen atoms in its ring, which heterocyclic ring may be optionally fused to a benzene ring or to a further 5- or 6-membered aromatic heterocyclic ring containing one or more nitrogen atoms, wherein at least one of the said heterocyclic rings may also contain an oxygen or sulphur atom, and wherein any of the rings may be optionally substituted with one or more substituents selected from --C.sub.1 -C.sub.6 alkyl, --OC.sub.1 -C.sub.6 alkyl, halo, --CF.sub.3 and --CN; Z represents a) a divalent alkanediyl group from 1 to 8 carbon atoms which may be a straight or branched-chain, wherein the said group is either unsubstituted or substituted by one or more substituents selected from hydroxy, --OC.sub.1 -C.sub.6 alkyl, --SC.sub.1 -C.sub.6 alkyl and halo; or b) a divalent alkenediyl or alkynediyl group from 2 to 8 carbon atoms which may be a straight or branched-chain, wherein the said group is either unsubstituted or subtituted by one or more substituents selected from hydroxy, --OC.sub.1 -C.sub.6 alkyl, --SC.sub.1 -C.sub.6 alkyl and halo; R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 each represents a hydrogen atom, a --C.sub.1 -C.sub.18 alkyl or a --C.sub.2 -C.sub.18 alkenyl group; or R.sup.3 and R.sup.5 together with the carbon atoms to which they are attached can form a five to ten membered monocycycloalkyl or bicycloalkyl ring which may be optionally substituted with one or more substituents selected from --C.sub.1 -C.sub.6 alkyl, --OC.sub.1 -C.sub.6 alkyl, halo, --CF.sub.3 and --CN; or R.sup.3, R.sup.4 and R.sup.5, R.sup.6 and the carbon atoms to which they are attached form a phenyl ring which may be optionally substituted with one or more substituents selected from --C.sub.1 -C.sub.6 alkyl, --OC.sub.1 -C.sub.6 alkyl, halo, --CF.sub.3 and --CN; X represents a bond, an oxygen atom, a sulphur atom, a --NH-- group, a --N(C.sub.1 -C.sub.6 alkyl)-- group, a --(CH.sub.2).sub.n -- group or a --CR.sup.7 R.sup.8 -- group; n represents an integer of 1, 2 or 3; R.sup.7 and R.sup.8 each represents a --C.sub.1 -C.sub.18 alkyl or a --C.sub.2 -C.sub.18 alkenyl group; or R.sup.3 and R.sup.7 together with the carbon atoms to which they are attached can form a five to ten membered monocycloalkyl or bicycloalkyl ring which may be optionally substituted with one or more substituents selected from --C.sub.1 -C.sub.6 alkyl, --OC.sub.1 -C.sub.6 alkyl, halo, --CF.sub.3 and --CN; or R.sup.3, R.sup.4 and R.sup.7, R.sup.8 and the carbon atoms to which they are attached form a phenyl ring which may be optionally substituted with one or more substituents selected from --C.sub.1 -C.sub.6 alkyl, --OC.sub.1 -C.sub.6 alkyl, halo, --CF.sub.3 and --CN; and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or conditions mediated by PAF.

84. 发明授权

US5274094A Production of heterobicyclic containing benzene sulfonamides 失效
标题翻译：含杂环的苯磺酰胺的生产
公开(公告)号：US5274094A
公开(公告)日：1993-12-28
申请号：US992269
申请日：1992-12-14
申请人： Mark Whittaker , Andrew Miller , Stephen A. Bowles
发明人： Mark Whittaker , Andrew Miller , Stephen A. Bowles
IPC分类号： A61K31/415 , C07D235/08 , C07D401/12 , C07D403/12 , C07D471/04 , C07F7/18
CPC分类号： C07D401/12 , A61K31/415 , C07D235/08 , C07D403/12 , C07D471/04 , C07F7/1856
摘要： Compounds of general formula I; ##STR1## wherein: A.sup.1 is .dbd.N--, .dbd.CH-- or .dbd.CR.sup.1 --;A.sup.2 is --N.dbd., --CH.dbd. or --CR.sup.2 .dbd.;provided that, when one of A.sup.1 and A.sup.2 is a nitrogen atom, the other of A.sup.1 and A.sup.2 is other than a nitrogen atom; wherein the rest of the variables are defined in the specification; and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment of amelioration of various diseases or disorders mediated by PAF.
摘要翻译：通式I的化合物; 其中：A1为= N-，= CH-或CR1-; A2是-N =，-CH =或-CR2 = 条件是当A1和A2之一是氮原子时，A1和A2中的另一个不是氮原子; 其中所述变量的其余部分在说明书中定义; 其药学和兽医学上可接受的酸加成盐和水合物是血小板活化因子（PAF）的拮抗剂，因此可用于治疗由PAF介导的各种疾病或病症的改善。

85. 发明授权

US5180724A Carboxamide amino acid heterobicyclic PAF antagonists 失效
标题翻译：羧酰胺氨基酸酸性偶联PAF拮抗剂
公开(公告)号：US5180724A
公开(公告)日：1993-01-19
申请号：US760174
申请日：1991-09-16
申请人： Stephen A. Bowles , Mark Whittaker , Andrew Miller
发明人： Stephen A. Bowles , Mark Whittaker , Andrew Miller
IPC分类号： C07C233/83 , C07C309/65 , C07C309/66 , C07C309/73 , C07D213/74 , C07D471/04
CPC分类号： C07D213/74 , C07C233/83 , C07C309/65 , C07C309/66 , C07C309/73 , C07D471/04
摘要： Compounds of general formula I; ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, A.sup.1, A.sup.2, B, and X are variables.These compounds are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.
摘要翻译：通式I的化合物; 其中R1，R2，R3，R4，R5，R6，R7，R8，A1，A2，B和X是变量。这些化合物是血小板活化因子（PAF）的拮抗剂，因此可用于治疗或改善由PAF介导的各种疾病或病症。

86. 发明公开

US20230292929A1 APPARATUS FOR USE WITH PORTABLE HEAD SUPPORT 审中-公开
公开(公告)号：US20230292929A1
公开(公告)日：2023-09-21
申请号：US18324956
申请日：2023-05-27
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： A47C16/00 , A47C7/38
CPC分类号： A47C16/00 , A47C7/383
摘要： An accessory for use with a backpack or other carry-on item having a front side with one or more arm loops and a back side featuring a pocket for holding a portable head support. The accessory may be in the form of a slipcover that fits over the carry-on item. Other embodiments in which the arm loops and the pocket attach to the carry-on item using pre-existing attachment mechanisms that are built into the carry-on item are contemplated.

87. 发明授权

US11659935B2 Portable head support 有权
公开(公告)号：US11659935B2
公开(公告)日：2023-05-30
申请号：US17826337
申请日：2022-05-27
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： A47C16/00 , A47C7/38
CPC分类号： A47C16/00 , A47C7/383
摘要： The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.

88. 发明授权

US10548790B2 Post-surgical support member for surgical site 有权
公开(公告)号：US10548790B2
公开(公告)日：2020-02-04
申请号：US15140867
申请日：2016-04-28
申请人： Andrew Miller , Alexander R. Vaccaro
发明人： Andrew Miller , Alexander R. Vaccaro
IPC分类号： A61G7/057 , A61G7/07 , A61G13/12 , A61M1/00
摘要： A post-surgical support member is configured to be placed a post-surgically between a supine patient and a support surface so as to isolate an anatomical load from a post-surgical wound against the support surface, the anatomical load produced by the weight of the supine patient.

89. 发明授权

US10029059B2 Breathing systems 有权
公开(公告)号：US10029059B2
公开(公告)日：2018-07-24
申请号：US13991265
申请日：2011-11-01
申请人： Andrew Miller , Marc Berrow Gibbons
发明人： Andrew Miller , Marc Berrow Gibbons
IPC分类号： A61M16/10 , A61M16/00 , A61M16/08 , A61M16/20 , A61M16/04
摘要： Disclosed is an apparatus for condensing water from respiratory gases. The apparatus has a heat exchange component having an inlet, an outlet and a condensation chamber, the inlet and outlet being connectable to a breathing system, such that respiratory gases are conveyed through the condensation chamber, in use, and a base unit adapted to aid removal of heat from the walls of the heat exchange component. The heat exchange component is releasably engageable with the base unit, such that the heat exchange component is replaceable.

90. 发明申请

US20170340125A1 PORTABLE HEAD SUPPORT 审中-公开
公开(公告)号：US20170340125A1
公开(公告)日：2017-11-30
申请号：US15656455
申请日：2017-07-21
申请人： Andrew Miller
发明人： Andrew Miller
IPC分类号： A47C16/00
CPC分类号： A47C16/00 , A47C7/383
摘要： The invention is directed to a portable head support designed to fit in the interior of a carry-on article carried by a passenger. The device provides head support for those who prefer sleeping in a face-down position and comprises a base and a head support connected along at least one of their abutting edges by a mechanism which permits the angle between the base and head support to be adjusted by the user.

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