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81. 发明授权

US5945303A Human hematopoietic-specific protein 失效
公开(公告)号：US5945303A
公开(公告)日：1999-08-31
申请号：US837029
申请日：1997-04-11
申请人： Ying-Fei Wei , Haodong Li
发明人： Ying-Fei Wei , Haodong Li
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to hHSP polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

82. 发明授权

US5641657A DNA encoding an interleukin-6 splice variant 失效
标题翻译：编码白细胞介素-6剪接变体的DNA
公开(公告)号：US5641657A
公开(公告)日：1997-06-24
申请号：US246427
申请日：1994-05-19
申请人： Steven Ruben , Haodong Li , Mark D. Adams
发明人： Steven Ruben , Haodong Li , Mark D. Adams
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P3/10 , A61P7/00 , A61P7/04 , A61P9/00 , A61P29/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C07H21/04 , C07K14/54 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/566 , C12N15/24
CPC分类号： C07K14/5412 , A61K38/00 , A61K48/00
摘要： Polynucleotides which encode the polypeptide IL-6SV, as well as such polypeptides, antibodies and antagonist inhibitors against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cancer, auto-immune diseases, platelet reducing conditions, anemias, bone marrow and organ transplantation.
摘要翻译：编码多肽IL-6SV的多核苷酸，以及针对多肽的多肽，抗体和拮抗剂抑制剂以及多肽作为治疗癌症的药物，自身免疫疾病，血小板减少病症，贫血，骨髓和器官的用途移植。

83. 发明授权

US5504003A Macrophage inflammatory protein-3 and -4 失效
标题翻译：巨噬细胞炎症蛋白-3和-4
公开(公告)号：US5504003A
公开(公告)日：1996-04-02
申请号：US208339
申请日：1994-03-08
申请人： Haodong Li , Steven Ruben
发明人： Haodong Li , Steven Ruben
IPC分类号： A61K38/00 , C07K14/52 , C07K16/24 , C12N5/10 , C12N15/12 , C12P21/06
CPC分类号： C07K14/523 , C07K16/24 , A61K38/00
摘要： There is disclosed a human macrophage inflammatory protein-3 (MIP-3) and a human macrophage inflammatory protein-4 (MIP-4) polypeptides and DNA (RNA) encoding such polypeptides. There is also provided a procedure for producing such polypeptides by recombinant techniques and for producing antibodies against such polypeptides. In the invention there is also provided antagonist/inhibitors against such polypeptides which inhibit the functioning of such polypeptides. Another aspect of the invention provides a combination of the polypeptides of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptides for the treatment of various associated diseases.
摘要翻译：公开了人巨噬细胞炎症蛋白-3（MIP-3）和人巨噬细胞炎症蛋白-4（MIP-4）多肽和编码这种多肽的DNA（RNA）。还提供了通过重组技术产生这种多肽并产生针对这种多肽的抗体的方法。在本发明中，还提供了抑制这种多肽功能的这种多肽的拮抗剂/抑制剂。本发明的另一方面提供了本发明的多肽和合适的药物载体的组合，用于提供治疗有效量的多肽用于治疗各种相关疾病。

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