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81. 发明授权

US07037469B2 Method and composition for reducing contact lens swelling 失效
标题翻译：减少隐形眼镜肿胀的方法和组成
公开(公告)号：US07037469B2
公开(公告)日：2006-05-02
申请号：US10392743
申请日：2003-03-19
申请人： Zhenze Hu , Joseph C. Salamone , Dharmendra Jani
发明人： Zhenze Hu , Joseph C. Salamone , Dharmendra Jani
IPC分类号： A61L2/18 , C11D1/72 , C11D3/37
CPC分类号： C11D3/3707 , A61L12/142 , C11D3/0078 , C11D3/3773 , C11D3/3776
摘要： The present invention is directed to an ophthalmic solution for soft contact lenses for controlled release of polyethers into an eye's tear film. Polyether components of the subject solution are released from the soft contact lens material matrix over long time periods to produce longer lasting wetting performance, improved lubricity, improved end-of-the-day comfort and reduced feeling of dryness from wearing contact lenses. The present invention also includes the use of cationic polyelectrolytes for controlling the swelling of hydrogel contact lenses typically caused by the absorption of high concentrations of polyethers.
摘要翻译：本发明涉及用于将聚醚控制释放到眼睛的泪液膜中的软性隐形眼镜的眼用溶液。本发明溶液的聚醚组分长时间从软性隐形眼镜材料基质中释放出来，以产生更持久的润湿性能，改善的润滑性，改善了最终的舒适感和减少佩戴隐形眼镜的干燥感。本发明还包括使用阳离子聚电解质来控制通常由吸收高浓度聚醚引起的水凝胶隐形眼镜的溶胀。

82. 发明授权

US06906162B2 High refractive index aromatic-based siloxane monofunctional macromonomers 失效
$High refractive index aromatic-based siloxane monofunctional macromonomers$
标题翻译：高折射率芳族基硅氧烷单官能大分子单体
公开(公告)号：US06906162B2
公开(公告)日：2005-06-14
申请号：US10692378
申请日：2003-10-23
申请人： Joseph C. Salamone , Jay F. Kunzler , Richard M. Ozark , David E. Seelye
发明人： Joseph C. Salamone , Jay F. Kunzler , Richard M. Ozark , David E. Seelye
IPC分类号： G02C7/02 , A61L27/18 , C07F7/08 , C08F283/12 , C08F290/06 , C08G77/20 , C08G77/38 , G02B1/04 , C08G77/00
CPC分类号： C08G77/38 , A61L27/18 , A61L2430/16 , C07F7/0838 , C08F283/12 , C08F290/068 , G02B1/043 , Y10S623/905 , C08L51/085 , C08L83/04
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses, corneal inlays and contact lenses made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more aromatic-based siloxane macromonomers or the copolymerization of one or more aromatic-based siloxane macromonomers with one or more non-siloxy aromatic-based monomers, non-aromatic-based hydrophobic monomers or non-aromatic-based hydrophilic monomers.
摘要翻译：本文描述了光学透明，相对高折射率的聚合物组合物和眼科装置，例如眼内透镜，角膜嵌体和由其制成的隐形眼镜。优选的聚合物组合物通过一种或多种芳族基硅氧烷大分子单体的聚合或一种或多种芳族基硅氧烷大分子单体与一种或多种非甲硅烷氧基芳族基单体，非芳族基疏水单体或非芳香族亲水单体。

83. 发明授权

US06852793B2 Low water content, high refractive index, flexible, polymeric compositions 有权
$Low water content, high refractive index, flexible, polymeric compositions$
标题翻译：低含水量，高折射率，柔性聚合物组合物
公开(公告)号：US06852793B2
公开(公告)日：2005-02-08
申请号：US10175715
申请日：2002-06-19
申请人： Joseph C. Salamone , Jay F. Kunzler , Richard M. Ozark , David E. Seelye
发明人： Joseph C. Salamone , Jay F. Kunzler , Richard M. Ozark , David E. Seelye
IPC分类号： A61F2/14 , A61F2/16 , A61L27/16 , C08F2/44 , C08F4/34 , C08F212/04 , C08F220/00 , C08F220/12 , C08F122/10 , C08F212/08
CPC分类号： C08F220/12 , A61L27/16 , C08F212/04 , C08L33/06
摘要： Optically transparent, relatively high refractive index polymeric compositions and ophthalmic devices such as intraocular lenses and corneal inlays made therefrom are described herein. The preferred polymeric compositions are produced through the polymerization of one or more copolymers with one or more hydrophilic monomers and optionally one or more aromatic-based monomers, hydrophobic monomers or a combination thereof.
摘要翻译：本文描述了光学透明的相对高折射率的聚合物组合物和眼科装置，例如由其制成的眼内透镜和角膜嵌体。优选的聚合物组合物通过一种或多种共聚物与一种或多种亲水单体和任选的一种或多种芳族基单体，疏水单体或其组合的聚合来制备。

84. 发明授权

US06428839B1 Surface treatment of medical device 失效
标题翻译：医疗器械表面处理
公开(公告)号：US06428839B1
公开(公告)日：2002-08-06
申请号：US09586941
申请日：2000-06-02
申请人： Jay F. Künzler , David E. Seelye , Joseph C. Salamone
发明人： Jay F. Künzler , David E. Seelye , Joseph C. Salamone
IPC分类号： A61L3110
CPC分类号： C08J7/047 , A61L27/34 , A61L29/085 , A61L31/10 , C08J2433/00 , C08L33/02 , C08L33/26
摘要： The invention provides a method for improving the wettability of a medical device, comprising the steps of: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a silicone-containing monomer, wherein said medical device has not been subjected to a surface oxidation treatment; (b) contacting a surface of the medical device with a solution comprising a proton-donating wetting agent, whereby the wetting agent forms a complex with the hydrophilic monomer on the surface of the medical device in the absence of a surface oxidation treatment step and without the addition of a coupling agent.
摘要翻译：本发明提供了一种改善医疗装置的润湿性的方法，包括以下步骤：（a）提供由包含亲水性单体和含硅酮单体的单体混合物形成的医疗装置，其中所述医疗装置未经受进行表面氧化处理;（b）使医疗装置的表面与包含质子递送润湿剂的溶液接触，由此在不存在聚合物的情况下，润湿剂与医疗装置的表面上的亲水性单体形成络合物表面氧化处理步骤，而不加入偶联剂。

85. 发明授权

US6143028A Medicament coated refractive anterior chamber ocular implant 失效
$Medicament coated refractive anterior chamber ocular implant$
标题翻译：药物涂层折叠前房眼植入物
公开(公告)号：US6143028A
公开(公告)日：2000-11-07
申请号：US063624
申请日：1998-04-20
申请人： Miles A. Galin , Joseph C. Salamone , Stanley C. Israel
发明人： Miles A. Galin , Joseph C. Salamone , Stanley C. Israel
IPC分类号： A61F2/14 , A61L27/00 , A61L27/34 , A61L33/00 , A61F2/16
CPC分类号： A61F2/1605 , A61F2/147 , A61L27/34 , A61L33/0011 , A61L33/0094 , A61L2430/16 , Y10S623/901
摘要： A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating which comprises a compatible sulfated polysaccharide medicament coating, such as heparin, and having a structure which positions the artificial lens in the anterior chamber of the eye to prevent contact between the implant and the anatomic lens. The implant compensates for refractive errors or creates a specific refraction to assist in visual function and has increased biocompatibility in the anterior chamber of the eye, thereby preventing or mitigating detrimental effects typically associated with the implantation of an uncoated refractive anterior chamber implant in the eye. A method of preparing such a minus power anterior chamber ocular implant comprises first exposing an uncoated implant to a plasma to generate a plasma-treated implant having a surface containing amines, carboxylic acids, active free radicals or passive free radicals, and thereafter bonding the medicament to the plasma-treated implant surface. A method of treating myopia comprises surgically implanting and anchoring the implant in the phakic eye to compensate for refractive errors.
摘要翻译：用于放置在具有解剖镜片的晶状体眼的前房中的负功率前房眼植入物包括具有至少一个凹表面的负人造折射透镜，包含相容的硫酸化多糖药物涂层的表面涂层，例如肝素，并且具有将人造镜片定位在眼睛前房中以防止植入物和解剖镜片之间接触的结构。植入物补偿屈光不正或产生特定折射以辅助视觉功能，并且增加眼睛前房中的生物相容性，从而防止或减轻通常与眼睛中未涂覆的折射性前房植入物植入有关的有害影响。制备这种负电源前房眼植入物的方法包括首先将未涂覆的植入物暴露于等离子体以产生具有包含胺，羧酸，活性自由基或被动自由基的表面的等离子体处理的植入物，然后将药物到等离子体处理的植入物表面。治疗近视的方法包括将植入物手术植入和固定在晶状体眼中以补偿屈光不正。

86. 发明授权

US5965152A Controlled release of miotic and mydriatic drugs in the anterior chamber 失效
标题翻译：在前房中控制释放弥漫性和散瞳药物
公开(公告)号：US5965152A
公开(公告)日：1999-10-12
申请号：US815896
申请日：1997-03-12
申请人： Miles A. Galin , Joseph C. Salamone , Stanley C. Israel
发明人： Miles A. Galin , Joseph C. Salamone , Stanley C. Israel
IPC分类号： A61K9/107 , A61F9/00 , A61K9/00 , A61K9/50 , A61K31/137 , A61K31/165 , A61K31/221 , A61K31/415 , A61K31/4178 , A61K31/46 , A61K31/715 , A61K31/728 , A61K31/74 , A61K31/765 , A61K45/00 , A61K47/30 , A61L31/04 , A61P27/02 , A61P27/06 , A61P27/08 , A61F2/00 , A61K9/14
CPC分类号： A61L31/048 , A61K31/137 , A61K31/221 , A61K31/4178 , A61K31/46 , A61K31/728 , A61K31/765 , A61K9/0048 , A61F9/00 , Y10S514/912
摘要： The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.
摘要翻译：本发明涉及在眼科手术期间保持眼睛前房的结构完整性的组合物，从而保护形成和排出前节段的组织免受潜在的损伤并同时提供缩瞳剂或散瞳剂的持续递送。本发明提供了包含粘弹性聚合物的组合物，其中缩瞳剂或散瞳剂的持续释放是通过离子相互作用介导的，以及其中微型或散瞳剂的持续释放由微胶囊或共聚物胶束介导的组合物。

87. 发明授权

US5766580A Controlled release of miotic and mydriatic drugs in the anterior chamber 失效
公开(公告)号：US5766580A
公开(公告)日：1998-06-16
申请号：US815215
申请日：1997-03-12
申请人： Miles A. Galin , Joseph C. Salamone , Stanley C. Israel
发明人： Miles A. Galin , Joseph C. Salamone , Stanley C. Israel
IPC分类号： A61K9/107 , A61F9/00 , A61K9/00 , A61K9/50 , A61K31/137 , A61K31/165 , A61K31/221 , A61K31/415 , A61K31/4178 , A61K31/46 , A61K31/715 , A61K31/728 , A61K31/74 , A61K31/765 , A61K45/00 , A61K47/30 , A61L31/04 , A61P27/02 , A61P27/06 , A61P27/08
CPC分类号： A61L31/048 , A61K31/137 , A61K31/221 , A61K31/4178 , A61K31/46 , A61K31/728 , A61K31/765 , A61K9/0048 , A61F9/00 , Y10S514/912
摘要： The present invention relates to compositions which maintain the structural integrity of the anterior chamber of the eye during ophthalmologic surgery, thereby protecting the tissues that form and line the anterior segment from potential damage and simultaneously providing sustained delivery of a miotic or mydriatic agent. The present invention provides for compositions which comprise a viscoelastic polymer, wherein sustained release of a miotic or mydriatic agent is mediated by ionic interactions, as well as for compositions wherein sustained release of a miotic or mydriatic agent is mediated by microcapsules or copolymer micelles.

88. 发明授权

US5684059A Fluorine containing soft contact lens hydrogels 失效
标题翻译：含氟软胶囊水凝胶
公开(公告)号：US5684059A
公开(公告)日：1997-11-04
申请号：US404124
申请日：1995-03-13
申请人： Joseph C. Salamone
发明人： Joseph C. Salamone
IPC分类号： C08F20/26 , C08F26/00 , C08F220/28 , C08F226/06 , C08F290/06 , G02B1/04 , G02C7/04 , C08J3/24
CPC分类号： G02B1/043 , C08F220/28 , C08F226/06 , C08F290/062
摘要： An improved soft contact lens material, existing as a hydrogel, is formed by a polymer containing a fluorinated monomer, a hydroxyalkyl ester of acrylic or methacrylic acid, and an N-vinyl lactam. The polymer may also contain other hydrophilic and/or hard hydrophobic monomers, crosslinking agents, and uv-absorbing agents. Contact lenses made of these combinations have high water of hydrations, are highly wettable, have extremely high oxygen permeabilities and are resistant to protein deposits and other forms of attached debris.
摘要翻译：通过含有氟化单体，丙烯酸或甲基丙烯酸的羟烷基酯和N-乙烯基内酰胺的聚合物形成改进的作为水凝胶存在的软性隐形眼镜材料。聚合物还可以含有其它亲水和/或硬疏水单体，交联剂和紫外线吸收剂。由这些组合制成的隐形眼镜具有高水合水分，高度可湿润，具有极高的氧气渗透性，并且对蛋白质沉积物和其他形式的附着碎片具有抗性。

89. 发明授权

US4394179A Abrasive-containing contact lens cleaning materials 失效
公开(公告)号：US4394179A
公开(公告)日：1983-07-19
申请号：US197223
申请日：1980-10-15
申请人： Edward J. Ellis , Joseph C. Salamone
发明人： Edward J. Ellis , Joseph C. Salamone
IPC分类号： C11D1/14 , C11D1/29 , C11D3/00 , C11D17/00 , G02C13/00 , B08B11/00 , B08B7/00 , C11D3/14 , C11D17/08
CPC分类号： G02C13/008 , C11D17/0013 , C11D3/0078 , C11D1/146 , C11D1/29
摘要： New cleaning solutions for contact lens have a surface active agent, an inorganic abrasive, and a suspending agent to provide a suspension in an aqueous solution or organic liquid.

90. 发明授权

US4152508A Silicone-containing hard contact lens material 失效
标题翻译：有机硅硬质隐形眼镜材料
公开(公告)号：US4152508A
公开(公告)日：1979-05-01
申请号：US878163
申请日：1978-02-15
申请人： Edward J. Ellis , Joseph C. Salamone
发明人： Edward J. Ellis , Joseph C. Salamone
IPC分类号： G02C7/04 , C08F20/10 , C08F20/26 , C08F30/00 , C08F30/08 , C08F220/10 , C08F220/12 , C08F220/20 , C08F220/26 , C08F222/12 , C08F230/08 , C08F289/00 , C08J5/18 , G02B1/04 , B29D11/00 , C08F4/04
CPC分类号： G02B1/04 , C08F230/08 , G02B1/043 , Y10S526/923
摘要： An improved contact lens material is formed by a copolymer of a siloxanyl alkyl ester monomer, an itaconate ester and an ester of acrylic or methacrylic acid. The copolymer preferably includes a cross-linking agent and a hydrophilic monomer. Contact lenses made of the mterial can be readily machined and polished into hard contact lenses having excellent dimensional stability but also have extremely high permeability to oxygen.
摘要翻译：改进的隐形眼镜材料由硅氧烷基烷基酯单体，衣康酸酯和丙烯酸或甲基丙烯酸的酯的共聚物形成。共聚物优选包括交联剂和亲水性单体。由该制成的隐形眼镜可以容易地加工和抛光成具有优异的尺寸稳定性的硬接触镜片，但也具有极高的氧气渗透性。

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