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81. 发明授权

US08168418B2 Expression of HIV polypeptides and production of virus-like particles 有权
标题翻译： HIV多肽的表达和病毒样颗粒的产生
公开(公告)号：US08168418B2
公开(公告)日：2012-05-01
申请号：US12770905
申请日：2010-04-30
申请人： Susan W Barnett , Jan Zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W Barnett , Jan Zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12N7/00 , A61K39/21
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译：本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。

82. 发明申请

US20120051412A1 SYMMETRICAL DATA SIGNAL PROCESSING 有权
标题翻译：对称数据信号处理
公开(公告)号：US20120051412A1
公开(公告)日：2012-03-01
申请号：US13290256
申请日：2011-11-07
申请人： Hong Liu , Raul A. Casas , Haosong Fu
发明人： Hong Liu , Raul A. Casas , Haosong Fu
IPC分类号： H04L27/01 , H04B17/00
CPC分类号： H04L25/03171 , H04L25/0212 , H04L27/04 , H04L2025/03382 , H04L2025/03522
摘要： A digital communications receiver includes an input configured to receive, via a communications channel, a received first signal representing a sequence of symbols, each symbol being encoded to be representative of a plurality of data bits. A processor adjusts a magnitude and filters the received signal. An equalizer applies a cyclic prefix restoration to the adjusted and filtered signal, producing a second signal, converts the second signal from time domain to frequency domain to produce a frequency domain signal, and determines a first quantity of values representing a first portion of the symbols by evaluating a relationship of channel values representing characteristics of the communications channel and a second quantity of values representing a portion of the frequency domain signal, the first quantity being smaller than the second quantity.
摘要翻译：数字通信接收机包括被配置为经由通信信道接收表示符号序列的接收的第一信号的输入，每个符号被编码为表示多个数据比特。处理器调整幅度并对接收到的信号进行滤波。均衡器对经调整和滤波的信号应用循环前缀恢复，产生第二信号，将第二信号从时域转换到频域以产生频域信号，并且确定表示符号的第一部分的第一数量的值通过评估表示通信信道的特性的信道值的关系和表示频域信号的一部分的第二数量的值，第一数量小于第二数量。

83. 发明授权

US08098425B2 Fiber communication system, fiber amplifier, and method for fabricating fiber amplifier 有权
标题翻译：光纤通信系统，光纤放大器及制造光纤放大器的方法
公开(公告)号：US08098425B2
公开(公告)日：2012-01-17
申请号：US12417947
申请日：2009-04-03
申请人： Wendou Zhang , Dongming Li , Hong Liu
发明人： Wendou Zhang , Dongming Li , Hong Liu
IPC分类号： H01S3/00
CPC分类号： H01S3/06754 , G02B6/12
摘要： The present invention discloses a fiber amplifier, a fabricating method thereof, and a fiber communication system. The fiber amplifier includes at least a pump laser, at least a gain medium and at least an integrated optical component. The integrated optical component includes multiple optical input/output ports, and the optical input/output ports are connected to the pump laser or gain medium directly or indirectly. The present invention may better address problems of unstable performance and difficulty in reducing the size of components in the prior art where fiber amplifiers are formed by a number of discrete components with many fiber fusion splices. In addition, the present invention may reduce the production complexity and costs of fiber amplifiers, and improve the productivity of fiber amplifiers.
摘要翻译：本发明公开了一种光纤放大器及其制造方法以及光纤通信系统。光纤放大器至少包括泵浦激光器，至少增益介质和至少一个集成的光学部件。集成光学部件包括多个光输入/输出端口，光输入/输出端口直接或间接连接到泵浦激光器或增益介质。本发明可以更好地解决现有技术中不稳定性能和难以减小元件尺寸的问题，其中光纤放大器由许多具有许多光纤熔接的分立元件形成。此外，本发明可以降低光纤放大器的生产复杂度和成本，并且提高光纤放大器的生产率。

84. 发明申请

US20110293279A1 Tunable Multi-Wavelength Optical Transmitter and Transceiver for Optical Communications Based on Wavelength Division Multiplexing 有权
标题翻译：基于波分复用的光通信可调多波长光发射机和收发器
公开(公告)号：US20110293279A1
公开(公告)日：2011-12-01
申请号：US12788204
申请日：2010-05-26
申请人： Cedric F. Lam , Hong Liu
发明人： Cedric F. Lam , Hong Liu
IPC分类号： H04J14/02
CPC分类号： H04J14/02 , H01S5/0265 , H01S5/06256 , H01S5/4031 , H01S5/4087 , H04J14/0279
摘要： Techniques, devices and systems for optical communications based on wavelength division multiplexing (WDM) that use tunable multi-wavelength laser transmitter modules.
摘要翻译：基于使用可调谐多波长激光发射器模块的波分复用（WDM）的光通信技术，设备和系统。

85. 发明申请

US20110263624A1 BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF 有权
标题翻译：双相异构体衍生物及其使用方法
公开(公告)号：US20110263624A1
公开(公告)日：2011-10-27
申请号：US13141344
申请日：2009-12-21
申请人： Joel M. Harris , Bernard R. Neustadt , Andrew Stamford , Hong Liu
发明人： Joel M. Harris , Bernard R. Neustadt , Andrew Stamford , Hong Liu
IPC分类号： A61K31/506 , A61P3/00 , A61P3/10 , A61P3/04 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a GPCR in a patient.
摘要翻译：本发明涉及双环杂环衍生物，包含双环杂环衍生物的组合物，以及使用双环杂环衍生物治疗或预防肥胖，糖尿病，代谢紊乱，心血管疾病或与GPCR活性有关的障碍的方法病人。

86. 发明申请

US20110152256A1 1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE AND PYRAZOLO[4,3-e]-1,2,4-TRIAZOLO[4,3-c]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 有权
标题翻译： 1,2,4-三唑[4,3-c]嘧啶-3-酮和吡唑并[4,3-e] -1,2,4-三唑[4,3-c]吡啶-3-酮化合物用作腺苷A2a受体拮抗剂
公开(公告)号：US20110152256A1
公开(公告)日：2011-06-23
申请号：US12920924
申请日：2009-03-03
申请人： Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
发明人： Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
IPC分类号： A61K31/5377 , C07D487/14 , A61K31/519 , C07D413/14 , A61K31/497 , C07D487/04 , A61P25/16 , A61P25/28
CPC分类号： C07D487/14 , C07D487/04
摘要： Compounds of the Formula I wherein R1 and R2 together with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.
摘要翻译：其中R1和R2与它们所键合的碳原子一起形成式（II）的另外的杂芳环以及其药学上可接受的盐，溶剂合物，酯和前药的式I化合物是腺苷A 2a受体拮抗剂和因此，可用于治疗中枢神经系统疾病，特别是帕金森病。

87. 发明申请

US20110105513A1 AMINO-QUINOXALINE AND AMINO-QUINOLINE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS 有权
标题翻译：氨基喹啉和氨基喹啉化合物用作腺苷A2a受体拮抗剂
公开(公告)号：US20110105513A1
公开(公告)日：2011-05-05
申请号：US12920928
申请日：2009-03-03
申请人： Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
发明人： Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
IPC分类号： A61K31/498 , C07D241/44 , C07D417/12 , C07D405/12 , C07D401/12 , C07D413/04 , C07D215/38 , A61K31/47 , A61P25/00 , A61P25/24 , A61P25/28 , A61P25/16 , A61P25/18
CPC分类号： C07D241/44 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D417/12
摘要： Compounds of the Formula (I), where W represents CH or N; and Q represents —CN, —C(═NOH)NH2, —CONHR1 or various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof. Care adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.
摘要翻译：式（I）的化合物，其中W表示CH或N; 和Q表示-CN，-C（= NOOH）NH 2，-CONHR1或本文所述的各种杂环基; 以及其药学上可接受的盐，溶剂合物，酯和前药。护理腺苷A2a受体拮抗剂，因此可用于治疗中枢神经系统疾病，特别是帕金森病。

88. 发明申请

US20110065146A1 Expression of HIV polypeptides and production of virus-like particles 有权
标题翻译： HIV多肽的表达和病毒样颗粒的产生
公开(公告)号：US20110065146A1
公开(公告)日：2011-03-17
申请号：US12770905
申请日：2010-04-30
申请人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
发明人： Susan W. Barnett , Jan zur Megede , Indresh Srivastava , Ying Lian , Karin Hartog , Hong Liu , Catherine Greer , Mark Selby , Christopher Walker
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译：本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。

89. 发明授权

US07732449B2 Inhibitors of cathepsin S 失效
标题翻译：组织蛋白酶S抑制剂
公开(公告)号：US07732449B2
公开(公告)日：2010-06-08
申请号：US12361287
申请日：2009-01-28
申请人： Hong Liu , Arnab K. Chatterjee , David C. Tully , Phillip B. Alper , David H. Woodmansee
发明人： Hong Liu , Arnab K. Chatterjee , David C. Tully , Phillip B. Alper , David H. Woodmansee
IPC分类号： C07D295/145 , C07D403/12 , A61K31/496
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: wherein Q is an optionally substituted piperazinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译：本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供具有式1的化合物：其中Q是任选取代的哌嗪基; A，R5，R6，R7，R8，R9和Ar为取代基。

90. 发明申请

US20100120870A1 Dispersible pesticidal compositions 有权
标题翻译：分散农药组合物
公开(公告)号：US20100120870A1
公开(公告)日：2010-05-13
申请号：US11578005
申请日：2005-04-13
申请人： Hong Liu
发明人： Hong Liu
IPC分类号： A01N43/40
CPC分类号： A01N43/40 , A01N25/30 , A01N25/14 , A01N25/12 , A01N2300/00
摘要： Soluble granule pesticidal compositions comprise Flonicamid, a dispersant, and a wetting agent are disclosed.
摘要翻译：可溶性颗粒杀虫组合物包括Flonicamid，分散剂和润湿剂。

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