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81. 发明授权

US07797046B2 Percutaneous neurostimulator for modulating cardiovascular function 有权
标题翻译：用于调节心血管功能的经皮神经刺激器
公开(公告)号：US07797046B2
公开(公告)日：2010-09-14
申请号：US11548348
申请日：2006-10-11
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/36014 , A61N1/36017 , A61N1/36114 , A61N1/365 , A61N1/37211 , A61N1/37252 , A61N1/37288
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers neurostimulation percutaneously to a stimulation target in the patient's body using at least one percutaneous stimulation electrode having a distal end lodged on or near the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器使用至少一个经皮刺激电极将刺激神经刺激经皮刺激到患者体内的刺激目标，所述经皮刺激电极具有放置在刺激靶上或附近的远端。

82. 发明申请

US20100211148A1 IMPLANTABLE NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 审中-公开
标题翻译：用于调节心脏功能的可植入神经细胞
公开(公告)号：US20100211148A1
公开(公告)日：2010-08-19
申请号：US12770465
申请日：2010-04-29
申请人： Anthony V. Caparso , Imad Libbus , Andrew P. Kramer
发明人： Anthony V. Caparso , Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/05 , H01R43/20
CPC分类号： A61N1/36114 , Y10T29/49204
摘要： An implantable medical device includes an implantable capsule housing a circuit that delivers neurostimulation to modulate one or more cardiovascular functions. To limit displacement after implantation, a fixation device is coupled to the implantable capsule to fix the miniature implantable medical device to a position in the body of a patient. In various embodiments, the fixation device include one or more of a suture loop, a cuff to wrap around a cylindrical structure such as a nerve of a vessel, and a transmural fixation device anchoring on the interior surface of a wall defining a cavity in the body.
摘要翻译：可植入医疗装置包括可植入的胶囊，其包含输送神经刺激以调节一种或多种心血管功能的电路。为了在植入之后限制位移，将固定装置联接到可植入胶囊以将微型可植入医疗装置固定到患者体内的位置。在各种实施例中，固定装置包括一个或多个缝合线环，围绕诸如血管的神经的圆柱形结构的袖带以及锚固在壁的内表面上的壁透视固定装置，身体。

83. 发明授权

US07551958B2 Safety control system for implantable neural stimulator 有权
标题翻译：植入式神经刺激器安全控制系统
公开(公告)号：US07551958B2
公开(公告)日：2009-06-23
申请号：US11135883
申请日：2005-05-24
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/08
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.
摘要翻译：神经刺激系统包括防止神经刺激脉冲传递引起潜在有害影响的安全控制系统。将神经刺激脉冲输送到一个或多个神经以控制由一个或多个神经调节的生理功能。这种有害影响的实例包括与神经刺激脉冲的过度递送引起的自主神经刺激和神经损伤相关的生理功能中的意想不到的影响。

84. 发明申请

US20080091248A1 PERCUTANEOUS NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 有权
标题翻译：用于调节心脏功能的PERCUTANEOUS神经调节器
公开(公告)号：US20080091248A1
公开(公告)日：2008-04-17
申请号：US11548348
申请日：2006-10-11
申请人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
发明人： Imad Libbus , Anthony V. Caparso , Andrew P. Kramer
IPC分类号： A61N1/18
CPC分类号： A61N1/05 , A61N1/36014 , A61N1/36017 , A61N1/36114 , A61N1/365 , A61N1/37211 , A61N1/37252 , A61N1/37288
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers neurostimulation percutaneously to a stimulation target in the patient's body using at least one percutaneous stimulation electrode having a distal end lodged on or near the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器使用至少一个经皮刺激电极将刺激神经刺激经皮刺激到患者体内的刺激目标，所述经皮刺激电极具有放置在刺激靶上或附近的远端。

85. 发明授权

US09409025B2 Cardiac rhythm management device with neural sensor 有权
公开(公告)号：US09409025B2
公开(公告)日：2016-08-09
申请号：US12840449
申请日：2010-07-21
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36117
摘要： Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

86. 发明申请

US20130165998A1 SYSTEM AND METHOD FOR CLOSED-LOOP NEURAL STIMULATION 审中-公开
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US20130165998A1
公开(公告)日：2013-06-27
申请号：US13709271
申请日：2012-12-10
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/36117
摘要： Various device embodiments comprise a pulse generator, a signal processing module and a controller. The pulse generator is adapted to provide a neural stimulation signal to be applied at a neural simulation site within an autonomic nervous system (ANS). The signal processing module is adapted to receive and process sensed neural traffic at a neural sensing site within the ANS. The controller is connected to the pulse generator and adapted to provide a neural stimulation control signal to the pulse generator to generate the neural stimulation signal, and to the signal processing module to receive a feedback control signal indicative of the sensed neural traffic. The controller is adapted to adjust the neural stimulation control signal to adjust at least one parameter of the neural stimulation signal to converge on desired sensed neural traffic at the neural sensing site. Other aspects and embodiments are provided herein.
摘要翻译：各种装置实施例包括脉冲发生器，信号处理模块和控制器。脉冲发生器适于提供在自主神经系统（ANS）内的神经模拟部位应用的神经刺激信号。信号处理模块适于在ANS内的神经感测部位接收和处理感测到的神经流量。控制器连接到脉冲发生器并且适于向脉冲发生器提供神经刺激控制信号以产生神经刺激信号，并且向信号处理模块接收指示所感测的神经流量的反馈控制信号。控制器适于调整神经刺激控制信号以调整神经刺激信号的至少一个参数以收敛于神经感测位置处的期望感测的神经交通。本文提供了其它方面和实施例。

87. 发明授权

US08457734B2 System and method for neural stimulation 有权
公开(公告)号：US08457734B2
公开(公告)日：2013-06-04
申请号：US11468135
申请日：2006-08-29
申请人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
发明人： Imad Libbus , Andrew P. Kramer , Anthony V. Caparso , Kristofer J. James , Stephen Ruble , Weiying Zhao
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/36053 , A61N1/36114
摘要： Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

88. 发明授权

US08452401B2 Method and device for comprehensive anti-tachyarrhythmia therapy 有权
标题翻译：综合性抗心律失常治疗方法和装置
公开(公告)号：US08452401B2
公开(公告)日：2013-05-28
申请号：US13287842
申请日：2011-11-02
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/36114 , A61N1/3962
摘要： A method and apparatus for delivering therapy to treat ventricular tachyarrhythmias is described. In one embodiment, neural stimulation, anti-tachycardia pacing, and shock therapy are employed in a progressive sequence upon detection of a ventricular tachycardia.
摘要翻译：描述了用于递送治疗以治疗室性快速性心律失常的方法和装置。在一个实施例中，在检测到室性心动过速时，采用进行性顺序的神经刺激，抗心动过速起搏和休克疗法。

89. 发明授权

US08396560B2 System and method for closed-loop neural stimulation 有权
标题翻译：闭环神经刺激的系统和方法
公开(公告)号：US08396560B2
公开(公告)日：2013-03-12
申请号：US10992319
申请日：2004-11-18
申请人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
发明人： Imad Libbus , Andrew P. Kramer , Julia Moffitt
IPC分类号： A61N1/18
CPC分类号： A61N1/36117 , A61N1/08 , A61N1/36171
摘要： Various aspects of the present subject matter provide a device. In various embodiments, the device comprises a port adapted to connect a lead, a pulse generator connected to the port and adapted to provide a neural stimulation signal to the lead, and a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The device includes a controller connected to the pulse generator and the signal processing module. The controller is adapted to implement a stimulation protocol to provide the neural stimulation signal with desired neural stimulation parameters based on the signal indicative of the nerve traffic. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供了一种装置。在各种实施例中，该装置包括适于连接引线的端口，连接到端口的脉冲发生器，并适于向引线提供神经刺激信号，以及信号处理模块，连接到端口并且适于接收和处理神经交通信号从引导到指示神经交通的信号。该装置包括连接到脉冲发生器和信号处理模块的控制器。控制器适于实现刺激方案，以基于指示神经交通的信号向神经刺激信号提供期望的神经刺激参数。本文提供了其他方面。

90. 发明授权

US08041423B2 System and method for testing neural stimulation threshold 有权
标题翻译：神经刺激阈值检测系统及方法
公开(公告)号：US08041423B2
公开(公告)日：2011-10-18
申请号：US13024120
申请日：2011-02-09
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，早产性心室收缩（PVC）事件检测器，心率检测器，分析器和控制器。神经刺激器适于产生适于刺激自主神经靶标的刺激信号。分析器适于响应来自PVC事件检测器的PVC事件信号，产生作为PVC前心率数据和PVC后心率数据的函数的自主平衡指示器（ABI）。本文提供了其它方面和实施例。

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