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81. 发明申请

US20070125033A1 Multiple node junction structure 审中-公开
标题翻译：多节点结结构
公开(公告)号：US20070125033A1
公开(公告)日：2007-06-07
申请号：US11487113
申请日：2006-07-14
申请人： Soeren Stephan , Ian Collins
发明人： Soeren Stephan , Ian Collins
IPC分类号： E04B7/08 , E04H12/00
CPC分类号： E04B1/32 , E04B2001/3247 , E04B2001/3294
摘要： Multiple node junctions have at least two nodes sharing an axis. Each node includes a node adaptor-mounting-surface at an angle Θ relative to the axis. An adaptor mounted to each node at the angle Θ relative to the axis uses an adaptor node-mounting-surface and at least one adaptor beam-mounting-surface. A beam having one or more adaptor-mounting-surfaces is mounted to the adaptors using beam adaptor-mounting-surfaces so that the beam is mounted at the angle Θ relative to the axis. The length of each adaptor corresponds to the spacing between each adaptor node-mounting-surface and its matching adaptor beam-mounting-surface. The lengths of the first and second adaptors are selected to accommodate the angle Θ. A framework, for example a free form glass wall or the like, can be created using a plurality of multiple node junctions according to embodiments of the present invention.
摘要翻译：多个节点具有至少两个共享一个轴的节点。每个节点包括一个相对于轴的角度角的节点适配器安装表面。以相对于轴的角度的角度安装到每个节点的适配器使用适配器节点安装表面和至少一个适配器梁安装表面。具有一个或多个适配器安装表面的梁使用光束适配器安装表面安装到适配器，使得光束相对于轴以角度θta安装。每个适配器的长度对应于每个适配器节点安装表面与其匹配的适配器梁安装表面之间的间距。选择第一和第二适配器的长度以适应角度θ。可以使用根据本发明的实施例的多个多节点连接来创建框架，例如自由形式的玻璃壁等。

82. 发明申请

US20070124130A1 Systems and methods for automated diagnosis and repair of storage devices 失效
标题翻译：存储设备自动诊断和修复的系统和方法
公开(公告)号：US20070124130A1
公开(公告)日：2007-05-31
申请号：US11699877
申请日：2007-01-29
申请人： Jeffrey Brunet , Ian Collins , Yousuf Chowdhary , Eric Li
发明人： Jeffrey Brunet , Ian Collins , Yousuf Chowdhary , Eric Li
IPC分类号： G06F9/455
CPC分类号： G06F11/261
摘要： A peripheral electronic device includes a health check application configured to execute automatically upon connection of the peripheral device to a data source, such as a personal computer. The health check application can diagnose problems and if necessary, repair the problems with the peripheral device, the data source, or both. Examples of problems include corrupted data and indications of software, firmware, and hardware failures or impending failures. In some instances, the health check application can provide a warning of an impending failure. The health check application, after initially executing, can be triggered in various ways to scan again for problems. In addition to finding and repairing problems, the health check application can also attend to maintenance.
摘要翻译：外围电子设备包括健康检查应用，其配置为在外围设备连接到数据源（例如个人计算机）时自动执行。健康检查应用程序可以诊断问题，如有必要，可以修复外围设备，数据源或两者的问题。问题的例子包括损坏的数据和软件，固件，硬件故障或即将发生的故障的指示。在某些情况下，健康检查应用程序可以提供即将发生故障的警告。健康检查应用程序在初始执行后可以通过各种方式触发，以再次扫描问题。除了查找和修复问题外，健康检查应用程序也可以参加维护。

83. 发明申请

US20060166838A1 Method of preparing microparticles 审中-公开
标题翻译：微粒制备方法
公开(公告)号：US20060166838A1
公开(公告)日：2006-07-27
申请号：US10516622
申请日：2003-05-15
申请人： Ian Collins , Simon Duncum
发明人： Ian Collins , Simon Duncum
IPC分类号： C09K8/60
CPC分类号： C09K8/92 , B01J13/125 , C09K8/536 , C09K8/54
摘要： A method of preparing microparticles comprising an aqueous solution or dispersion of an oil or gas field production chemical encapsulated in a continuous polymeric phase comprising a degradable polymer, which method comprises: (a) preparing a water in oil in water double emulsion or a water in oil in oil double emulsion having an internal aqueous phase comprising an aqueous solution or dispersion of the production chemical and an internal oil phase comprising a solution of a degradable polymer dissolved in a volatile organic solvent wherein the internal aqueous phase is dispersed in the internal oil phase of the double emulsion in the form of droplets having a mean diameter of less than 10 microns; and (b) at least in part evaporating the volatile organic solvent from the double emulsion such that the degradable polymer accumulates around the droplets of the internal aqueous phase and hardens to form microparticles comprising a continuous polymeric phase encapsulating the internal aqueous phase having a mean particle diameter of less than 10 microns.
摘要翻译：一种制备微粒的方法，其包括包封在包含可降解聚合物的连续聚合物相中的油或气田生产化学品的水溶液或分散体，该方法包括：（a）在水中制备水包油双乳液或水油包水乳液，其具有包含生产化学品的水溶液或分散体的内部水相和包含溶解在挥发性有机溶剂中的可降解聚合物溶液的内部油相，其中内部水相分散在内部油相中的平均直径小于10微米的液滴形式的双重乳液; 和（b）至少部分地从双重乳液中蒸发挥发性有机溶剂，使得可降解聚合物在内部水相的液滴周围积聚并硬化以形成包含连续聚合物相的微粒，所述微粒包封具有平均粒子的内部水相直径小于10微米。

84. 发明申请

US20060162928A1 Process for treating a formation 失效
标题翻译：处理地层的方法
公开(公告)号：US20060162928A1
公开(公告)日：2006-07-27
申请号：US10524050
申请日：2003-08-06
申请人： Ian Collins , Trevor Jones , Christopher Osborne
发明人： Ian Collins , Trevor Jones , Christopher Osborne
IPC分类号： E21B43/12
CPC分类号： C09K8/706 , C09K8/512 , C09K8/514 , C09K8/516 , C09K8/52 , C09K8/54 , C09K8/601 , C09K8/887 , C09K2208/20 , Y10S507/902 , Y10S507/906
摘要： A method of introducing an oil field or gas field production chemical into a hydrocarbon-bearing porous subterranean formation penetrated by a wellbore comprising: injecting a gelling composition comprising an aqueous liquid, an oil field or gas field production chemical, and a gellable polymer through the wellbore into the porous subterranean formation wherein the gellable polymer forms a gel within the pores of the subterranean formation thereby encapsulating the production chemical in the gel; and controllably releasing the production chemical from the gel into a formation fluid.
摘要翻译：一种将油田或气田生产化学物质引入到井眼穿透的含烃多孔地下地层中的方法，包括：通过所述井眼注入包含含水液体，油田或气田生产化学品和可凝胶聚合物的胶凝组合物井眼进入多孔地层，其中可凝胶聚合物在地层的孔内形成凝胶，从而将生产化学品包封在凝胶中; 并且可控制地将生产化学品从凝胶释放到地层流体中。

85. 发明申请

US20050069552A1 Fusion antibodies 有权
标题翻译：融合抗体
公开(公告)号：US20050069552A1
公开(公告)日：2005-03-31
申请号：US10900928
申请日：2004-07-28
申请人： Gregory Bleck , Dona York , Ian Collins
发明人： Gregory Bleck , Dona York , Ian Collins
IPC分类号： C07K16/00 , G01N33/53 , A61K39/395 , C07K16/46
CPC分类号： G01N33/53 , A61K2039/505 , C07K16/00 , C07K2317/31 , C07K2319/00
摘要： The present invention provides novel antibodies. In particular, the present invention provides fusion antibodies comprising antibody heavy and light chain fusions. The present invention further provides multivalent antibodies comprising multiple fusion antibody chains. The present invention further provides methods of generating splice resistant antibody genes.
摘要翻译：本发明提供新型抗体。特别地，本发明提供了包含抗体重链和轻链融合物的融合抗体。本发明还提供了包含多个融合抗体链的多价抗体。本发明还提供了产生抗拼接抗体基因的方法。

86. 发明授权

US4154761A Pharmacologically active compounds 失效
标题翻译：药理活性化合物
公开(公告)号：US4154761A
公开(公告)日：1979-05-15
申请号：US763618
申请日：1977-01-28
申请人： Ian Collins , Philip D. Wicks
发明人： Ian Collins , Philip D. Wicks
IPC分类号： A61K31/16 , A61K31/135 , A61K31/165 , A61K31/357 , A61K31/36 , A61P11/08 , A61P25/02 , C07C67/00 , C07C213/00 , C07C215/60 , C07C215/76 , C07C217/84 , C07C227/00 , C07C229/38 , C07C233/36 , C07D317/66 , C07C91/06
CPC分类号： C07C229/38 , C07D317/66
摘要： Compounds of the general formula (I): ##STR1## in which R.sup.1 represents hydrogen or a straight or branched chain alkyl group, or an acyl group of the formula --COR.sup.5 (in which R.sup.5 represents a hydrogen atom or a straight or branched chain alkyl group);R.sup.2 represents an aryl group of the formula: ##STR2## (in which R.sup.6 represents a hydrogen atom or independently one or more of the following groups, that is, hydroxy, alkoxy, alkyl, halogen, dialkylamino and trifluoromethyl, or may represent a 3,4-methylenedioxy group ##STR3## R.sup.3 and R.sup.4 may independently represent hydrogen or a straight or branched chain alkyl group; andN represents 1, 2 or 3; and pharmaceutically acceptable salts thereof; and hydrates of said compounds or salts thereof. The invention also includes processes for the production of these compounds, compositions containing them and methods of treatment using them.
摘要翻译：通式（I）的化合物：其中R 1表示氢或直链或支链烷基或式-COR 5的酰基（其中R 5表示氢原子或直链或支链烷基）; R 2表示下式的芳基：其中R 6表示氢原子或独立地是一个或多个下列基团，即羟基，烷氧基，烷基，卤素，二烷基氨基和三氟甲基，或可以表示3 ，4-亚甲二氧基，R 3和R 4可以独立地表示氢或直链或支链烷基; N代表1,2或3;及其药学上可接受的盐;以及所述化合物或其盐的水合物本发明还包括生产这些化合物的方法，含有它们的组合物和使用它们的处理方法。

87. 发明授权

US3997535A Quinoxaline-2-carboxamidotetrazoles 失效
标题翻译：喹喔啉-2-甲酰胺基四唑
公开(公告)号：US3997535A
公开(公告)日：1976-12-14
申请号：US449992
申请日：1974-03-11
申请人： Ian Collins , Gwynn Pennant Ellis
发明人： Ian Collins , Gwynn Pennant Ellis
IPC分类号： C07D403/12 , C07D241/44 , C07D241/00
CPC分类号： C07D241/44 , Y10S514/826 , Y10S514/861
摘要： Compounds of the general formula I: ##STR1## and pharmaceutically acceptable salts thereof in which: A represents the group ##STR2## or the group ##STR3## linked to the adjacent benzene ring through the nitrogen atom, in which R.sub.1 represents a hydrogen atom, or an alkyl group which may optionally be substituted by one or more aryl, aryloxy, alkoxy, acyloxy, amino, alkylamino, dialkylamino or hydroxy groups or represents an alkenyl group;R.sub.2 represents a hydrogen atom, a halogen atom or an alkyl group or the group OR.sub.3, where R.sub.3 is a hydrogen atom or an alkyl group which may optionally be substituted by one or more aryl, aryloxy, alkoxy, acyloxy, hydroxy, amino, alkylamino or dialkylamino groups or the group NR.sub.4 R.sub.5 where R.sub.4 and R.sub.5 may be the same or different and have the meanings given for R.sub.1 or R.sub.4 and R.sub.5 together with the nitrogen atom form a 5 or 6 membered heterocyclic ring which may optionally contain additional hetero atoms;R.sub.6 and R.sub.7 which may be the same or different represent a hydrogen atom, or a halogen atom or an alkyl group or the group OR.sub.3 or the group NR.sub.4 R.sub.5 as defined above. These compounds have activity as for the treatment of conditions caused primarily by the combination of an antigen with a reaginic antibody.
摘要翻译：通式I：Ⅰ的化合物及其药学上可接受的盐，其中：

88. 发明申请

US20140135332A1 AROMATIC AMIDES AND USES THEREOF 有权
标题翻译：芳香剂及其用途
公开(公告)号：US20140135332A1
公开(公告)日：2014-05-15
申请号：US14112735
申请日：2012-04-20
申请人： David John Haydon , Lloyd George Czaplewski , Neil Robert Stokes , David Davies , Ian Collins , James T Palmer , Jeffrey Peter Mitchell , Gary Robert William Pitt , Daniel Offermann
发明人： David John Haydon , Lloyd George Czaplewski , Neil Robert Stokes , David Davies , Ian Collins , James T Palmer , Jeffrey Peter Mitchell , Gary Robert William Pitt , Daniel Offermann
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/421 , C07D513/04 , C07D413/12 , C07D285/08 , C07D277/30 , C07D263/32 , A61K31/496 , A61K31/426
CPC分类号： A61K31/5377 , A61K31/166 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/30 , C07D285/08 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D513/04
摘要： The present invention provides compounds of Formula (I): and salts, racemates, isomers, diastereoisomers, enantiomers, hydrates, solvates, N-oxides, pharmaceutically acceptable derivatives or prodrugs thereof. Also provided the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.
摘要翻译：本发明提供式（I）的化合物：及其盐，外消旋物，异构体，非对映异构体，对映异构体，水合物，溶剂化物，N-氧化物，其药学上可接受的衍生物或前药。还提供这些化合物作为抗菌剂的用途，包含它们的组合物及其制备方法。

89. 发明授权

US08530468B2 Bicyclylaryl-aryl-amine compounds and their use 有权
标题翻译：双环芳基 - 芳基胺化合物及其用途
公开(公告)号：US08530468B2
公开(公告)日：2013-09-10
申请号：US12918266
申请日：2009-02-19
申请人： Ian Collins , John Charles Reader , David Hugh Williams , Sukhbinder Singh Klair , Jane Elizabeth Scanlon , Nelly Piton , Michael Cherry
发明人： Ian Collins , John Charles Reader , David Hugh Williams , Sukhbinder Singh Klair , Jane Elizabeth Scanlon , Nelly Piton , Michael Cherry
IPC分类号： A61K31/497 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D413/14
CPC分类号： C07D471/04
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicyclylaryl-aryl-amines compounds of the following formula (referred to herein as BCAA compounds), which, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or TS inhibitor; (d) a microtubule targeted agent; and (e) ionising radiation:
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及下列通式的某些双环芳基 - 芳基胺化合物（本文称为BCAA化合物），其特别地抑制检测点激酶1（CHK1）激酶功能。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制CHK1激酶功能，以及治疗由CHK1介导的疾病和病症，即通过抑制CHK1激酶功能等改善，包括增殖条件如癌症等，任选地与另一种试剂组合，例如（a）DNA拓扑异构酶I或II抑制剂; （b）DNA损伤剂; （c）抗代谢物或TS抑制剂; （d）微管靶向剂; 和（e）电离辐射：

90. 发明授权

US08415383B2 Substituted benzamidines as antibacterial agents 有权
公开(公告)号：US08415383B2
公开(公告)日：2013-04-09
申请号：US12679334
申请日：2008-09-22
申请人： David John Haydon , Ian Collins , Lloyd George Czaplewski
发明人： David John Haydon , Ian Collins , Lloyd George Czaplewski
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： C07D277/34 , A61K31/4245 , A61K31/427 , A61K31/429 , A61K31/433 , C07D271/07 , C07D277/64 , C07D285/08 , C07D417/12
摘要： Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═C(H)— or ═N—; R3 is a radical of formula -(Alk1)m-(Z1)p-(Alk2)n-Q wherein m, p and n are independently 0 or 1, provided that at least one of m, p and n is 1, Z1 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —0—(C═O)—, —C(═O)—O—, or an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; Alk1 and Alk2 are optionally substituted C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, Or —N(CH2CH3)—; and Q is hydrogen, halogen, nitrile, or hydroxyl, or an optionally substituted monocyclic carbocyclic or heterocyclic radical having 3 to 6 ring atoms; or an optionally substituted bicyclic carbocyclic or heterocyclic radical having 5 to 10 ring atoms; R4 and R5 are optional substituents; and R2, R6 and R7 are independently hydrogen or a radical of formula -(Alk3)x-(Z2)y-(Alk4)z-H wherein x, y and z are independently 0 or 1, Z2 is —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C(—O)—, —0—(C═O)— or —C(═O)—O—; Alk3 and Alk4 are optionally substituted C1-C3 alkylene, C2-C3 alkenylene, or C2-C3 alkynylene radicals, which may optionally terminate with or be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, or —N(CH2CH3)—.

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