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81. 发明授权

US07407476B2 Tissue irradiation with shielding 有权
标题翻译：组织照射与屏蔽
公开(公告)号：US07407476B2
公开(公告)日：2008-08-05
申请号：US11593952
申请日：2006-11-06
申请人： Paul Lubock , Michael L. Jones
发明人： Paul Lubock , Michael L. Jones
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.
摘要翻译：公开了用于治疗围绕体腔或其他体内部位的组织的装置和方法，例如在去除组织后，例如，癌症。这种装置包括在装置的远端部分上的处理位置，其中一个或多个辐射屏蔽部件在处理位置部分地环绕辐射源以控制来自辐射源的辐射。该装置最小化对体腔或其他部位周围的健康组织的辐射损伤，同时辐射未被辐射屏蔽部件屏蔽的组织。体现本发明特征的装置可包括密封构件，该密封构件位于靠近处理位置的装置的轴上的位置处，以密封通向体腔的通道。

82. 发明申请

US20080139925A1 MRI detectable obturator 审中-公开
标题翻译： MRI可检测的闭孔器
公开(公告)号：US20080139925A1
公开(公告)日：2008-06-12
申请号：US11985989
申请日：2007-11-19
申请人： Paul Lubock , Michael L. Jones , Ethan Broadaway , Frank R. Louw
发明人： Paul Lubock , Michael L. Jones , Ethan Broadaway , Frank R. Louw
IPC分类号： A61B5/055
CPC分类号： G01R33/286 , A61B5/055 , A61B90/39 , A61B2090/3954 , A61B2090/3987
摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.
摘要翻译：具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。

83. 发明申请

US20070167666A1 Asymmetrical irradiation of a body cavity 有权
标题翻译：体腔不对称照射
公开(公告)号：US20070167666A1
公开(公告)日：2007-07-19
申请号：US11593784
申请日：2006-11-06
申请人： Paul Lubock , Michael L. Jones , Frank R. Louw
发明人： Paul Lubock , Michael L. Jones , Frank R. Louw
IPC分类号： A61N5/00
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如，活检或癌症。一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射（例如健康组织）。

84. 发明授权

US07024952B2 Automated method and system to assemble and inspect tubing assemblies 失效
标题翻译：自动化方法和系统组装和检查管道组件
公开(公告)号：US07024952B2
公开(公告)日：2006-04-11
申请号：US10684983
申请日：2003-10-14
申请人： Dan N. Huynh , David K. Vogt , Stephen J. Morgan , Christopher C. Calkin , Kyle G. Dalton , Michael L. Jones , William S. Carnegie , Yong C. Joo
发明人： Dan N. Huynh , David K. Vogt , Stephen J. Morgan , Christopher C. Calkin , Kyle G. Dalton , Michael L. Jones , William S. Carnegie , Yong C. Joo
IPC分类号： G01M19/00
CPC分类号： G01M99/00 , B23P19/04 , B23Q1/5462 , B25J17/0216 , B25J19/0075 , F16L1/10 , G01B5/0004 , Y10T29/49826
摘要： An automated method and system to assemble and inspect tubing assemblies includes one or more coordinate tables with each table having a plurality of robotic fixtures mounted for movement on the table. The robotic fixtures are controlled by a computerized control system to move to predetermined positions on the table surface, and tubing holders on the robotic fixtures are controlled to receive portions of a bent length of metal tubing to inspect and assemble the portions of tubing.
摘要翻译：用于组装和检查管道组件的自动化方法和系统包括一个或多个坐标表，其中每个工作台具有安装用于在工作台上移动的多个机器人固定装置。机器人固定装置由计算机控制系统控制以移动到工作台表面上的预定位置，并且控制机器人固定装置上的管道保持器以接收弯曲长度的金属管的部分以检查和组装管道的部分。

85. 发明授权

US06712775B2 Tissue acquisition system and method of use 失效
标题翻译：组织采集系统及使用方法
公开(公告)号：US06712775B2
公开(公告)日：2004-03-30
申请号：US10202547
申请日：2002-07-23
申请人： Fred Burbank , Paul Lubock , Michael L. Jones , Martin V. Shabaz
发明人： Fred Burbank , Paul Lubock , Michael L. Jones , Martin V. Shabaz
IPC分类号： A61B1000
CPC分类号： A61B10/0233 , A61B10/02 , A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B17/00491 , A61B17/32056 , A61B17/320725 , A61B17/3417 , A61B18/14 , A61B18/1482 , A61B18/1487 , A61B18/1492 , A61B90/17 , A61B90/37 , A61B2010/0225 , A61B2017/3488 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00333 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/144 , A61B2018/1475 , A61B2018/162 , A61B2090/3908
摘要： A tissue acquisition system includes radio frequency (RF) cutter loops which are extendable out a cannula to cut cylindrical tissue samples from a tissue of interest in a patient. The cannula includes inner and outer cannulae which are mutually rotatable and include cutouts through which the cutting loop can be rotated and longitudinally extended to perform the cuts. The tissue samples are then aspirated proximally through the cannula for collection.
摘要翻译：组织采集系统包括射频（RF）切割器回路，其可伸出套管以从病人的感兴趣的组织切割圆柱形组织样本。套管包括内部和外部套管，其可相互旋转并且包括切口，切割环可以通过切口旋转并纵向延伸以执行切割。然后将组织样品通过套管向近侧吸出以进行收集。

86. 发明授权

US5851508A Compositions for use in embolizing blood vessels 失效
标题翻译：用于栓塞血管的组合物
公开(公告)号：US5851508A
公开(公告)日：1998-12-22
申请号：US800677
申请日：1997-02-14
申请人： Richard J. Greff , Michael L. Jones , Scott Evans
发明人： Richard J. Greff , Michael L. Jones , Scott Evans
IPC分类号： A61K47/48 , A61K49/04 , A61L24/00 , A61L24/04 , A61L24/06 , A61L24/08 , C08K3/08 , C08K3/22 , C08K3/30 , C08L23/08 , C08L29/04 , A61K31/765 , A61F5/00 , G01N31/00 , G21F1/10
CPC分类号： A61L24/08 , A61K49/0404 , A61K49/0414 , A61L24/001 , A61L24/046 , A61L24/06 , A61L2430/36
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise an ethylene vinyl alcohol copolymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
摘要翻译：公开了适用于栓塞血管的组合物，其组合物包含乙烯乙烯醇共聚物，生物相容性溶剂和选自钽，氧化钽和硫酸钡的水不溶性对比剂。还公开了使用本文所述的组合物栓塞血管的方法。

87. 发明授权

US5580568A Cellulose diacetate compositions for use in embolizing blood vessels 失效
标题翻译：用于栓塞血管的纤维素二乙酸酯组合物
公开(公告)号：US5580568A
公开(公告)日：1996-12-03
申请号：US508248
申请日：1995-07-27
申请人： Richard J. Greff , Michael L. Jones , Scott Evans
发明人： Richard J. Greff , Michael L. Jones , Scott Evans
IPC分类号： A61K47/38 , A61K47/48 , A61K49/04 , A61L24/00 , A61L24/04 , A61L24/06 , A61L24/08 , A61K49/00 , G01N31/00 , G01N33/48
CPC分类号： A61L24/06 , A61K49/0414 , A61L24/001 , A61L24/046 , A61L24/08 , A61L2430/36
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise a cellulose diacetate polymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
摘要翻译：公开了适合用于栓塞血管的组合物，该组合物包含纤维素二乙酸酯聚合物，生物相容性溶剂和选自钽，氧化钽和硫酸钡的水不溶性对比剂。还公开了使用本文所述的组合物栓塞血管的方法。

88. 发明授权

US5496333A Laparoscopic surgical clamp 失效
标题翻译：腹腔镜手术夹
公开(公告)号：US5496333A
公开(公告)日：1996-03-05
申请号：US139919
申请日：1993-10-20
申请人： Jonathan M. Sackier , Michael L. Jones , Edward E. Dolendo
发明人： Jonathan M. Sackier , Michael L. Jones , Edward E. Dolendo
IPC分类号： A61B17/00 , A61B17/122 , A61B17/128 , A61B17/28 , A61B17/04
CPC分类号： A61B17/1285 , A61B17/122 , A61B2017/2837 , Y10S227/901 , Y10S227/902
摘要： A surgical clamp combination includes a clamp movable between a free state and operable state, the clamp including a pair of jaws which can be operated to occlude a body conduit. A clamp applier is adapted to releasibly engage the clamp in the free state and to operate the clamp in the operable state to close the jaws. The applier has a housing disposed at a proximal end and a tube extending distally and configured to receive the clamp in the operable state. A shaft is disposed within the tube and movable between an extended position to engage the clamp in the free state and a retracted position to releasibly hold the clamp in the operable state. With the clamp in the operable state, the shaft is rotatable by operation of a handle and aladdin screw, to alternatively rotate in opposite directions to open and close the jaws of the clamp.
摘要翻译：手术夹具组合包括可在自由状态和可操作状态之间移动的夹具，所述夹具包括一对钳口，所述钳口可操作以阻塞身体导管。夹具施加器适于将夹具可释放地接合在自由状态，并且将夹具操作在可操作状态以闭合夹爪。施放器具有设置在近端处的壳体和向远侧延伸并且构造成在可操作状态下接收夹具。轴设置在管内并且可在伸出位置之间移动，以在夹紧件接合自由状态和缩回位置以可释放地将夹具保持在可操作状态。当夹具处于可操作状态时，轴可通过手柄和阿拉丁螺丝的操作而旋转，以可选地沿相反的方向旋转以打开和关闭夹具的钳口。

89. 发明授权

US08740873B2 Soft body catheter with low friction lumen 有权
标题翻译：软体导管低摩擦腔
公开(公告)号：US08740873B2
公开(公告)日：2014-06-03
申请号：US11724578
申请日：2007-03-15
申请人： Michael L. Jones , Frank R. Louw
发明人： Michael L. Jones , Frank R. Louw
IPC分类号： A61M25/00
CPC分类号： A61N5/1015 , A61L29/085 , A61M2025/0047
摘要： The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.
摘要翻译：本公开涉及辐射导管装置，用于受控地应用照射到身体部位的组织的方法，例如在去除组织之后形成的空腔，例如，癌症，使用这种辐射导管装置，用于形成更加光滑的腔表面的解决方案以及用于衬里这些装置的流明以提高其摩擦特性的方法。导管装置包括柔性细长轴，其由低硬度聚合物材料形成，其可以容易地折叠或卷绕以将轴固定到患者的皮肤上或皮下，以及衬有高硬度聚合物材料的辐射腔，以改善摩擦特点细长轴具有用于接收辐射源的至少一个内腔，辐射源具有提供较低表面摩擦以便促进其中的辐射源的高硬度聚合材料层。

90. 发明授权

US08361082B2 Marker delivery device with releasable plug 有权
标题翻译：带可释放插头的标记输送装置
公开(公告)号：US08361082B2
公开(公告)日：2013-01-29
申请号：US13037971
申请日：2011-03-01
申请人： Michael L. Jones , Paul Lubock , John Merritt
发明人： Michael L. Jones , Paul Lubock , John Merritt
IPC分类号： A61B17/00
CPC分类号： A61B5/064 , A61B5/055 , A61B5/062 , A61B6/12 , A61B8/0833 , A61B10/02 , A61B17/0057 , A61B90/39 , A61B2017/00637 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966 , A61B2090/3987 , A61K49/12 , A61K49/18 , A61K2123/00 , A61M5/007 , A61M37/0069
摘要： A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.
摘要翻译：标记输送装置包括细长的输送套管，其具有与内腔连通的远端部分中的远端部分，内腔和排出口。至少一个细长的纤维标记物体可滑动地设置在细长的输送套管的内腔内。所述至少一个细长的纤维标记物主体包括多个生物可吸收的聚合物链。股线被压缩成压缩构型并且在插入细长的输送套管之前用压缩构型与聚合物粘合剂结合在一起。可释放插塞设置在内腔的远侧部分内并且远离至少一个细长纤维标记体，以至少部分地封闭远端部分中的排出口。

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