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81. 发明授权

US4608048A Dispensing device with drug delivery patterns 失效
标题翻译：配药装置配药方式
公开(公告)号：US4608048A
公开(公告)日：1986-08-26
申请号：US678744
申请日：1984-12-06
申请人： Richard Cortese , Felix Theeuwes
发明人： Richard Cortese , Felix Theeuwes
IPC分类号： A61K9/00 , A61M7/00
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering an agent to a selected environment. The device comprises a semipermeable wall surrounding a first and second compartment for containing the agent, and the device is provided with means for delivering the agent from both compartments through a single osmotic passageway.
摘要翻译：公开了用于将试剂递送到所选择的环境的渗透装置。该装置包括围绕用于容纳试剂的第一和第二隔室的半透壁，并且该装置设置有用于通过单个渗透通道从两个隔室输送试剂的装置。

82. 发明授权

US4586922A Intravenous system for delivering a beneficial agent 失效
公开(公告)号：US4586922A
公开(公告)日：1986-05-06
申请号：US702273
申请日：1985-02-15
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.

83. 发明授权

US4576604A Osmotic system with instant drug availability 失效
标题翻译：渗透系统具有即时药物可用性
公开(公告)号：US4576604A
公开(公告)日：1986-03-18
申请号：US472333
申请日：1983-03-04
申请人： George V. Guittard , Joseph C. Deters , Felix Theeuwes , Richard Cortese
发明人： George V. Guittard , Joseph C. Deters , Felix Theeuwes , Richard Cortese
IPC分类号： A61K9/00 , A61K9/22 , A61K9/58
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing an agent, a passageway in the wall connecting the exterior of the device with the compartment, and (a) an agent in the wall or (b) an agent carried on the wall in the wall. The device delivers the agent from the compartment and the wall.
摘要翻译：公开了用于递送有益剂的渗透装置。该装置包括围绕包含试剂的隔室的壁，连接装置外部与隔室的通道，和（a）壁中的试剂或（b）承载在墙壁上的试剂。该设备从隔室和墙壁传送代理。

84. 发明授权

US4521211A Parenteral agent dispensing equipment 失效
标题翻译：肠胃外给药设备
公开(公告)号：US4521211A
公开(公告)日：1985-06-04
申请号：US576572
申请日：1984-02-03
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A parenteral delivery system and a formulation chamber are disclosed for administering a beneficial agent. The parenteral delivery system comprises a drip chamber and a formulation chamber. The formulation chamber comprises a wall surrounding an internal space and it has an inlet for admitting a liquid into the formulation chamber and an outlet for letting an agent formulation leave the formulation chamber. The chamber houses an agent delivery system for releasing a beneficial agent into a liquid that enters the chamber.
摘要翻译：公开了胃肠外递送系统和制剂室，用于施用有益剂。胃肠外输送系统包括滴注室和制剂室。制剂室包括围绕内部空间的壁，并且其具有用于将液体进入制剂室的入口和用于使制剂制剂离开制剂室的出口。该室容纳用于将有益剂释放到进入室的液体中的药剂递送系统。

85. 发明授权

US4455143A Osmotic device for dispensing two different medications 失效
标题翻译：渗透装置用于分配两种不同的药物
公开(公告)号：US4455143A
公开(公告)日：1984-06-19
申请号：US360396
申请日：1982-03-22
申请人： Felix Theeuwes , Brian Barclay , Richard Cortese
发明人： Felix Theeuwes , Brian Barclay , Richard Cortese
IPC分类号： A61M31/00 , A61K9/00 , A61K9/22 , A61K9/52
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering two beneficial drugs to an environment of use. The device comprises a semipermeable wall surrounding a lumen divided into a first compartment containing a drug that is separated from a second compartment containing a different drug. An orifice through the wall communicates with the first compartment for delivering drug from the first compartment, and another orifice through the wall communicates with the second compartment for delivering drug from the second compartment. In operation, drug is dispensed separately from each compartment by fluid being imbibed through the wall into each compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall against the drug in each compartment thereby producing in each compartment a solution containing drug that is dispensed through their orifices at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了用于将两种有益药物递送到使用环境的渗透装置。该装置包括围绕分隔成包含药物的内腔的半透壁，所述第一隔室含有与含有不同药物的第二隔室分离的药物。通过该壁的孔与第一隔室连通，用于从第一隔室输送药物，另一个穿过该壁的孔与第二隔室连通，用于从第二隔室输送药物。在操作中，药物从每个隔室分开分配，流体通过壁被吸入每个隔室中，其速率由壁的渗透性和穿过壁的渗透压梯度相对于每个隔室中的药物控制，从而在每个隔室中产生含有药物的溶液在长时间内以受控和连续的速率通过其孔口分配。

86. 发明授权

US4410328A Dispensing device with internal drive 失效
标题翻译：带内部驱动器的点胶装置
公开(公告)号：US4410328A
公开(公告)日：1983-10-18
申请号：US281952
申请日：1981-07-10
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61K9/00 , A61M5/145 , B65D83/00 , A61M7/00
CPC分类号： A61K9/0004 , B65D83/00 , A61M2005/14513
摘要： A device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space (2) a piston in the housing separating the space into an agent compartment and a power compartment, or a flexible container in the space, (3) an opening in the housing connecting the agent compartment or the container with the exterior of the housng, and (4) an osmotic device in the power compartment or beneath the container.
摘要翻译：公开了用于递送有益剂的装置。该装置包括（1）壳体，其限定内部空间（2）壳体中的活塞，该空间将空间分隔成空间中的空间，动力隔室或柔性容器;（3）壳体中的开口，代理舱或带有外部外壳的容器，以及（4）电源舱或集装箱下方的渗透装置。

87. 发明授权

US4331728A Laminate made of a cellulose acetate layer and an elastomeric material layer 失效
标题翻译：由乙酸纤维素层和弹性体材料层制成的层压板
公开(公告)号：US4331728A
公开(公告)日：1982-05-25
申请号：US101870
申请日：1979-12-10
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A01N25/10 , A01N25/34 , A61K9/00 , A61K9/22 , B32B23/08 , B01D39/18 , B32B5/22 , B32B23/14 , B32B23/20
CPC分类号： A61K9/0004 , A01N25/10 , A01N25/34 , B32B23/08 , Y10T428/24967 , Y10T428/24975 , Y10T428/31841 , Y10T428/31884 , Y10T428/31888 , Y10T428/31891
摘要： An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains (1) an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or (2) the compartment contains an agent having limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains along with (1) or (2) a volume amplifier for increasing the amount of agent delivered from the system. The amplifier comprises a membrane surrounding a gas generating couple with the membrane formed of an expandable material permeable to fluid and impermeable to the couple. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution of (1), or a suspension of (2), and for imbibition by the amplifier causing the couple to generate gas and continuously fill the amplifier thereby urging it to increase in volume and fill the compartment whereby agent (1) or (2) is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the rate of imbibition and increase in volume of the amplifier over a prolonged period of time.
摘要翻译：公开了用于递送有益剂的渗透系统。该系统包括围绕隔室的壁，并且具有通过该壁的通道，用于从隔间输送药剂。该壁由对外部流体的通道可渗透并且不能透过试剂通过的材料形成。隔室包含（1）可溶于流体并且穿过壁表现出渗透压梯度相对于流体的试剂，或（2）隔室含有在流体中溶解度有限的试剂，并显示出有限的渗透压梯度墙壁对着流体。隔间还包含（1）或（2）个放大器，用于增加从系统传递的代理量。放大器包括围绕气体发生耦合的膜，膜由可渗透流体并且不可渗透的可膨胀材料形成。在操作中，通过流体通过壁被吸入到隔室中，通过通道以受控的速率从系统输送试剂，以产生（1）或（2）的悬浮液并由放大器吸收的溶液该对以产生气体并连续地填充放大器，从而促使其增加体积并填充隔室，由此药剂（1）或（2）以由壁的渗透性控制的速率释放，穿过壁的渗透压梯度，以及放大器的吸入速率和放大器的体积增加。

88. 发明授权

US4320759A Dispenser with diffuser 失效
标题翻译：分配器与扩散器
公开(公告)号：US4320759A
公开(公告)日：1982-03-23
申请号：US268046
申请日：1981-05-28
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M31/00 , A61M7/00
CPC分类号： A61M31/002
摘要： A system is disclosed for delivering a beneficial agent at a substantially constant rate over time. The system comprises (1) a wall formed of a microporous polymer, or (2) a wall formed in part of a microporous polymer with the remaining part of the wall formed of a semipermeable polymer. The wall in (1) surrounds a compartment comprising a flexible partition that separates the compartment into a first space containing the beneficial agent and a second space containing a swellable polymer. The wall in (2) surrounds a compartment comprising a flexible partition that separates the compartment into a first space in contact with the microporous wall and containing the beneficial agent, and a second space in contact with the semipermeable polymer containing an osmotically effective solute, or a swellable polymer. In operation, agent is delivered from the system by (a) fluid diffusing through the microporous wall into the second space causing the polymer to swell, or by (b) fluid being imbibed through the semipermeable wall into the second space causing the solute to dissolve and form a solution, or causing the polymer to swell, wherein in (a) or (b), the second space expands against the partition urging it to move into the first space and maintain the agent in a saturated state at the microporous wall, with the agent diffusing from the first space through fluid filled micropaths in the wall from the system at a substantially zero order rate over a prolonged period of time.
摘要翻译：公开了一种随时间以基本上恒定的速率递送有益试剂的系统。该系统包括（1）由微孔聚合物形成的壁，或（2）部分由微孔聚合物形成的壁，其余部分壁由半透性聚合物形成。（1）中的壁围绕包括柔性隔板的隔间，该隔板将隔室分隔成含有有益剂的第一空间和含有可溶胀聚合物的第二空间。（2）中的壁围绕包括柔性隔板的隔室，该柔性隔板将隔室分隔成与微孔壁接触并包含有益剂的第一空间，以及与含有渗透性有效溶质的半透性聚合物接触的第二空间，或可溶胀聚合物。在操作中，通过（a）流体通过微孔壁流体扩散到第二空间中使得聚合物膨胀，或者（b）流体通过半透壁吸入第二空间中，使溶质溶解并且形成溶液，或使聚合物膨胀，其中在（a）或（b）中，第二空间相对于分隔壁膨胀，促使其移动到第一空间中并将试剂维持在微孔壁处于饱和状态，其中所述试剂在长时间段内以基本上零级的速率从所述系统从所述第一空间扩散通过所述壁中的流体填充的微通道。

89. 发明授权

US4235236A Device for dispensing drug by combined diffusional and osmotic operations 失效
标题翻译：通过组合扩散和渗透操作分配药物的装置
公开(公告)号：US4235236A
公开(公告)日：1980-11-25
申请号：US011121
申请日：1979-02-12
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22 , A61M7/00
CPC分类号： A61K9/0004
摘要： A device is disclosed for delivering an agent to an environment of use at a substantially constant rate over time. The device comprises a wall formed of a microporous material surrounding a compartment housing the agent and a thermodynamic member. The member comprises a film formed of an expandable, semipermeable material surrounding a means for expanding the member. The member can occupy any space-position in the compartment, and it also can be in contact with the wall. In operation, when the device is in the environment, agent is delivered from the device by diffusion through fluid-filled paths in the microporous wall, with external fluid simultaneously entering the compartment through the paths, also, fluid is imbibed by the member from fluid present in the compartment or directly across the wall causing it to expand, fill the compartment and continuously maintain agent in a substantially saturated state at the wall, thereby delivering agent at a substantially zero order rate of release from the device over a prolonged period of time.
摘要翻译：公开了一种用于随着时间以基本上恒定的速率将试剂递送到使用环境的装置。该装置包括由围绕容纳所述试剂的隔室和热力学构件的微孔材料形成的壁。该构件包括由围绕用于使构件膨胀的装置的可膨胀的半渗透材料形成的膜。该构件可以占据隔间中的任何空间位置，并且它也可以与墙壁接触。在操作中，当设备处于环境中时，通过扩散通过在微孔壁中的流体填充路径从设备传送代理，外部流体同时通过路径进入隔室，流体也被流体从流体中吸收存在于隔室中或直接穿过壁，导致其膨胀，填充隔室并且在壁处连续地将基本饱和状态的药剂维持在该壁上，由此以较短的时间段从该装置释放基本上零级的释放速率。

90. 发明授权

US4203439A Osmotic system with volume amplifier for increasing amount of agent delivered therefrom 失效
标题翻译：具有体积放大器的渗透系统，用于增加从其传送的剂量
公开(公告)号：US4203439A
公开(公告)日：1980-05-20
申请号：US950515
申请日：1978-10-11
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61K9/0004
摘要： An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains (1) an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or (2) the compartment contains an agent having limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains along with (1) or (2) a volume amplifier for increasing the amount of agent delivered from the system. The amplifier comprises a membrane surrounding a gas generating couple with the membrane formed of an expandable material permeable to fluid and impermeable to the couple. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution of (1), or a suspension of (2), and for imbibition by the amplifier causing the couple to generate gas and continuously fill the amplifier thereby urging it to increase in volume and fill the compartment whereby agent (1) or (2) is released at a rate controlled by the permeability of the wall, the osmotic pressure gradient across the wall, and the rate of imbibition and increase in volume of the amplifier over a prolonged period of time.
摘要翻译：公开了用于递送有益剂的渗透系统。该系统包括围绕隔室的壁，并且具有通过该壁的通道，用于从隔间输送药剂。该壁由对外部流体的通道可渗透并且不能透过试剂通过的材料形成。隔室包含（1）可溶于流体并且穿过壁表现出渗透压梯度相对于流体的试剂，或（2）隔室含有在流体中溶解度有限的试剂，并显示出有限的渗透压梯度墙壁对着流体。隔间还包含（1）或（2）个放大器，用于增加从系统传递的代理量。放大器包括围绕气体发生耦合的膜，膜由可渗透流体并且不可渗透的可膨胀材料形成。在操作中，通过流体通过壁被吸入到隔室中，通过通道以受控的速率从系统输送试剂，以产生（1）或（2）的悬浮液并由放大器吸收的溶液该对以产生气体并连续地填充放大器，从而促使其增加体积并填充隔室，由此药剂（1）或（2）以由壁的渗透性控制的速率释放，穿过壁的渗透压梯度，以及放大器的吸入速率和放大器的体积增加。

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