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81. 发明申请

US20130194688A1 THREE DIMENSIONAL ANGULAR ADJUSTABLE OPTICAL MOUNT 有权
标题翻译：三维角度可调光学安装
公开(公告)号：US20130194688A1
公开(公告)日：2013-08-01
申请号：US13806766
申请日：2011-06-28
申请人： Jianqiang Zhu , Fang Liu , Hongbiao Huang , Gengxiu Tang
发明人： Jianqiang Zhu , Fang Liu , Hongbiao Huang , Gengxiu Tang
IPC分类号： G02B7/00
CPC分类号： G02B7/00 , G02B7/004
摘要： A compact optical mount for adjust optical component in 3 dimensions. Based on the traditional 2D adjustable optical mount, its inner space is utilized for installing the third dimension angular adjustment. By virtue of its compact structure, convenient adjustment, high precision and good stability, the invention is suitable for adjusting small optics in 3 dimensions, by which the real optical axel can agree with the idea optical axel well to fast adjust the whole optical system.
摘要翻译：一种紧凑型光学座架，用于调整三维光学部件。基于传统的2D可调光学安装座，其内部空间用于安装第三维角度调节。本发明结构紧凑，调节方便，精度高，稳定性好，适用于三维尺寸小光学调整，真正的光轴可以与光轴一致，快速调整整个光学系统。

82. 发明申请

US20130157005A1 Method for Wafer-Level Surface Micromachining to Reduce Stiction 有权
标题翻译：晶圆表面微机械加工技术降低线性度的方法
公开(公告)号：US20130157005A1
公开(公告)日：2013-06-20
申请号：US13331582
申请日：2011-12-20
申请人： Fang Liu , Kuang Yang
发明人： Fang Liu , Kuang Yang
IPC分类号： B32B3/30 , B05D3/10
CPC分类号： B81B3/001 , B81B3/0005 , B81B3/0018 , B81C2201/112 , Y10T428/24355 , Y10T428/24521
摘要： An array of microbumps with a layer or coating of non-superhydrophobic material yields a superhydrophobic surface, and may also have a contact angle hysteresis of 15 degrees or less. A surface with such an array may therefore be rendered superhydrophobic even though the surface structure and materials are not, by themselves, superhydrophobic.
摘要翻译：具有非超疏水材料层或涂层的微丸阵列产生超疏水表面，并且还可具有15度或更小的接触角滞后。因此，即使表面结构和材料本身不是超疏水的，具有这种阵列的表面也可能变得超疏水。

83. 发明授权

US08449891B2 Recombinant flagellin protein and preparation and use thereof 有权
标题翻译：重组鞭毛蛋白及其制备及应用
公开(公告)号：US08449891B2
公开(公告)日：2013-05-28
申请号：US13122409
申请日：2010-08-09
申请人： Huimin Yan , Fang Liu , Jingyi Yang
发明人： Huimin Yan , Fang Liu , Jingyi Yang
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , A61K39/00 , A61K39/02 , A61K39/112 , A61K39/38
CPC分类号： C07K14/255 , A61K39/39 , A61K2039/55594
摘要： The present invention provides an optimized recombinant flagellin protein and preparation and use thereof. The protein is with a deletion in the hypervariable region, said hypervariable region is the region from 180 to 400 amino acid of the flagellin protein, and the proteins include FliCΔ190-278, FliCΔ220-320 or FliCΔ180-400. The method of preparing said protein, comprising introducing a deletion into the hypervariable region of the flagellin protein. First constructed the flagellin protein recombinant plasmid, and then used it as template to construct the flagellin deletion cloning, and expressed and purified. The present invention also provides the use of the recombinant flagellin protein as adjuvant. The recombinant flagellin protein in present invention decreases the potential risks it may have, and decreases its antigenicity and immunogenicity and the inflammatory response induced by it, through deleting its main areas of immunogenicity and antigen activity.
摘要翻译：本发明提供优化的重组鞭毛蛋白及其制备和应用。该蛋白质在高变区具有缺失，所述高变区是鞭毛蛋白的180至400个氨基酸的区域，蛋白质包括FliCDelta190-278，FliCDelta220-320或FliCDelta180-400。制备所述蛋白质的方法，包括向鞭毛蛋白的高变区引入缺失。首先构建鞭毛蛋白重组质粒，然后用它作为模板构建鞭毛蛋白缺失克隆，并进行表达纯化。本发明还提供了重组鞭毛蛋白作为佐剂的用途。本发明的重组鞭毛蛋白降低其可能存在的潜在风险，并通过缺失其主要免疫原性和抗原活性区域降低其抗原性和免疫原性及其诱导的炎性反应。

84. 发明授权

US08420775B2 Polypeptides and methods for modulating D1-D2 dopamine receptor interaction and function 有权
标题翻译：多肽和调节D1-D2多巴胺受体相互作用和功能的方法
公开(公告)号：US08420775B2
公开(公告)日：2013-04-16
申请号：US12997813
申请日：2009-06-12
申请人： Fang Liu
发明人： Fang Liu
IPC分类号： A61K38/00 , A61K38/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K14/575 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/47 , C07K16/286 , C07K2319/10
摘要： The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.
摘要翻译：本发明提供预防和/或治疗涉及D1-D2多巴胺受体偶联和/或活化异常的神经或神经精神障碍。提供了用于调节由D1-D2偶联和/或激活产生的多巴胺受体功能的方法和试剂。本发明的药剂包括可以破坏D1-D2偶联的D2受体或D1受体的片段。

85. 发明申请

US20130007080A1 MULTI-MODE COMBINED ROTATOR 有权
标题翻译：多模式组合式旋转机
公开(公告)号：US20130007080A1
公开(公告)日：2013-01-03
申请号：US13174151
申请日：2011-06-30
申请人： Fang Liu , Honkai (John) Tam
发明人： Fang Liu , Honkai (John) Tam
IPC分类号： G06F5/01
CPC分类号： G06F5/01 , G06F7/76 , G06F9/30032 , G06F2207/382
摘要： A system and method for efficiently rotating data in a processor for multiple operand sizes. A processor comprises a rotator configured to support multiple operand sizes. The rotator receives a rotate amount and an input operand with a size less than a maximum operand size supported by the processor. The rotator generates a mask with a same size as the received input operand. The mask comprises a number of asserted most-significant bits equal to the rotate amount. The remaining bits in the mask are deasserted. For a given rotation result bit position with an associated asserted mask bit, the rotator selects a value in the input operand at a bit position with a distance from the given result bit position equal to the rotate amount plus a difference between the maximum operand size supported by the processor and the input operand size.
摘要翻译：一种用于在处理器中有效旋转数据以用于多个操作数大小的系统和方法。处理器包括配置成支持多个操作数大小的旋转器。旋转器接收一个小于处理器支持的最大操作数大小的旋转量和一个输入操作数。旋转器产生与接收的输入操作数相同大小的掩码。掩模包括等于旋转量的多个断言的最高有效位。掩码中的其余位被取消置位。对于具有相关联的有效屏蔽位的给定旋转结果位位置，旋转器在比特位置选择输入操作数中的值，距离给定结果位位置的距离等于旋转量加上支持的最大操作数大小之间的差由处理器和输入操作数大小。

86. 发明授权

US08304519B2 Compositions and methods for modulating dopamine neurotransmission 失效
标题翻译：用于调节多巴胺神经传递的组合物和方法
公开(公告)号：US08304519B2
公开(公告)日：2012-11-06
申请号：US12904834
申请日：2010-10-14
申请人： Fang Liu
发明人： Fang Liu
IPC分类号： C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , A61K38/00
CPC分类号： C07K14/001 , A61K31/7088 , C07K14/705 , G01N33/9413 , G01N2800/044 , G01N2800/2835 , G01N2800/2864 , G01N2800/304
摘要： The present invention provides for diagnosis or treatment of neurological or neuropsychiatric disorders involving abnormal dopamine neurotransmission. Methods and agents are provided for modulating dopamine transporter activity and modulating dopaminergic neurotransmission. Agents of the present invention include fragments of D2 receptor or dopamine transporter (DAT) that can disrupt D2-DAT coupling.
摘要翻译：本发明提供诊断或治疗涉及异常多巴胺神经传递的神经或神经精神障碍。提供了调节多巴胺转运蛋白活性和调节多巴胺能神经传递的方法和试剂。本发明的试剂包括可以破坏D2-DAT偶联的D2受体或多巴胺转运蛋白（DAT）的片段。

87. 发明申请

US20120134991A1 COMPOSITIONS AND METHODS FOR MODULATING D1-D2 DOPAMINE RECEPTOR INTERACTION AND FUNCTION 有权
标题翻译：用于调节D1-D2多巴胺受体相互作用和功能的组合物和方法
公开(公告)号：US20120134991A1
公开(公告)日：2012-05-31
申请号：US12997813
申请日：2009-06-12
申请人： Fang Liu
发明人： Fang Liu
IPC分类号： A61K39/395 , A61K38/17 , A61K38/10 , A61P25/24 , C07H21/04 , A61P25/18 , A61P25/22 , C07K4/12 , C07K14/435 , C07K7/08 , A61K31/7088 , A61P25/00
CPC分类号： C07K14/70571 , A61K38/00 , C07K14/47 , C07K16/286 , C07K2319/10
摘要： The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.
摘要翻译：本发明提供预防和/或治疗涉及D1-D2多巴胺受体偶联和/或活化异常的神经或神经精神障碍。提供了用于调节由D1-D2偶联和/或激活产生的多巴胺受体功能的方法和试剂。本发明的药剂包括可以破坏D1-D2偶联的D2受体或D1受体的片段。

88. 发明授权

US08108391B1 Identifying non-compositional compounds 有权
标题翻译：鉴定非成分化合物
公开(公告)号：US08108391B1
公开(公告)日：2012-01-31
申请号：US12403328
申请日：2009-03-12
申请人： Stewart Yang , Fang Liu , Pei Cao
发明人： Stewart Yang , Fang Liu , Pei Cao
IPC分类号： G06F17/30
CPC分类号： G06F17/2775
摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for identifying non-compositional compounds. In one aspect, a method includes the actions of receiving a collection of phrases, each phrase including two or more words; for each phrase, determining if the phrase is a non-compositional compound, a non-compositional compound being a phrase of two or more words where the words composing the phrase have different meanings in a compound than their conventional meanings individual, the determining including: identifying a similar term for a term of the phrase, substituting the similar term for the term of the phrase to generate a substitute phrase, calculating a similarity between the phrase and the substitute phrase, and identifying the phrase as a non-compositional compound when the calculated similarity is less than a specified threshold value.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于识别非组成化合物。一方面，一种方法包括接收短语集合的动作，每个短语包括两个或多个单词; 对于每个短语，确定短语是否是非组合化合物，非组合化合物是两个或更多个词的短语，其中组合该短语的词在化合物中具有与其常规含义个体不同的含义，所述确定包括：识别该短语的术语的类似术语，将该短语的术语的类似术语替换为产生替代短语，计算短语和替代短语之间的相似性，以及当短语和替代短语之间将该短语识别为非组合化合物时计算的相似度小于指定的阈值。

89. 发明申请

US20100210521A1 Compositions and methods for modulating ampa receptor-mediated excitotoxicity 有权
标题翻译：调节AMPA受体介导的兴奋性毒性的组合物和方法
公开(公告)号：US20100210521A1
公开(公告)日：2010-08-19
申请号：US12310558
申请日：2007-08-31
申请人： Fang Liu
发明人： Fang Liu
IPC分类号： A61K38/16 , C07K14/00 , C07H21/04 , A61P25/00 , A61P25/08
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention provides AMPAR excitotoxicity mediating polypeptides comprising the GluR2 NT1-3-2 (Y142-K172) amino acid sequence (SEQ ID NO:1) or the GAPDH(2-2-1-1) (I221-E250) amino acid sequence (SEQ ID NO:2). Also disclosed are nucleotide sequences encoding the polypeptides, methods of inhibiting GAPDH association with the GluR2 subunit or p53. Methods of inhibiting AMPA receptor mediated excitotoxicity using the polypeptides and nucleic acids are also disclosed.
摘要翻译：本发明提供AMPAR兴奋性毒性介导包含GluR2 NT1-3-2（Y142-K172）氨基酸序列（SEQ ID NO：1）或GAPDH（2-2-1-1）（I221-E250）氨基酸的多肽序列（SEQ ID NO：2）。还公开了编码多肽的核苷酸序列，抑制与GluR2亚基或p53的GAPDH结合的方法。还公开了使用多肽和核酸抑制AMPA受体介导的兴奋性毒性的方法。

90. 发明授权

US07627301B2 Spatial diversity receiving device and input channel switching method 有权
标题翻译：空间分集接收设备和输入通道切换方法
公开(公告)号：US07627301B2
公开(公告)日：2009-12-01
申请号：US11636084
申请日：2006-12-08
申请人： Saixin Zhou , Liusi Ye , Hong Chen , Yunhui She , Fang Liu , Yueping Zuo
发明人： Saixin Zhou , Liusi Ye , Hong Chen , Yunhui She , Fang Liu , Yueping Zuo
IPC分类号： H04B1/06 , H04Q7/20
CPC分类号： H04B7/082 , H04B7/0814 , H04B17/318 , H04M1/576
摘要： The invention relates to a spatial diversity receiving device and an input channel switching method. The device comprises a main control circuit and at least one receiving channel including a RF selective switch, wherein the circuit controls the switch, so as to select one of the plurality of input signals from the plurality of antennae and send that signal to a receiving module. The module comprises a RSSI unit for outputting a RSSI value and sends the value to the circuit. On basis of a real time analysis to the receiving signal, the circuit selects a predetermined occasion to perform a compulsive switching and dynamically selects the antenna with a stronger signal so that the generation of error code due to transient interference may be reduced. The system exhibits an excellent resistance to wireless signal fading, and has a simple structure as well as a low cost and power consumption.
摘要翻译：本发明涉及空间分集接收装置和输入信道切换方法。该装置包括主控制电路和至少一个包括RF选择开关的接收通道，其中电路控制开关，以从多个天线中选择多个输入信号中的一个，并将该信号发送到接收模块。该模块包括用于输出RSSI值并将该值发送到电路的RSSI单元。基于对接收信号的实时分析，电路选择预定的时机进行强迫切换，并且动态地选择具有较强信号的天线，从而可以减少由于瞬时干扰引起的错误码的产生。该系统具有优异的抗无线信号衰落性，结构简单，成本低，功耗低。

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