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81. 发明申请

US20070134221A1 Stabilizing peptides 审中-公开
标题翻译：稳定肽
公开(公告)号：US20070134221A1
公开(公告)日：2007-06-14
申请号：US11285794
申请日：2005-11-22
申请人： Min Lu
发明人： Min Lu
IPC分类号： A61K38/54 , C12N9/99
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0815 , C07K7/08 , C07K14/005 , C12N2740/16122
摘要： The invention provides peptide inhibitors of HIV infection and methods for stabilizing those peptides.
摘要翻译：本发明提供了HIV感染的肽抑制剂和稳定这些肽的方法。

82. 发明授权

US07179468B1 Antigen for developing neutralizing antibodies to human immunodeficiency virus 失效
标题翻译：用于发展针对人类免疫缺陷病毒的中和抗体的抗原
公开(公告)号：US07179468B1
公开(公告)日：2007-02-20
申请号：US09877606
申请日：2001-06-08
申请人： Min Lu , Hong Ji
发明人： Min Lu , Hong Ji
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/545 , A61K2039/55566 , C07K14/005 , C07K2319/73 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides polypeptides comprising a stabilized trimer of the carboxyl-terminal core region of the ectodomain of an enveloped virus, such as HIV. A subject polypeptide comprises three monomers that form a trimeric coiled coil in a prefusogenic conformation of an enveloped virus such as HIV. The subject polypeptides are useful as vacciness against enveloped virus, such as HIV, which vaccines are also provided. The present invention also provides methods of vaccinating an individual to prevent or treat HIV infection or prevent or treat infection by another enveloped virus, using a subject vaccine. Antibodies or binding portions thereof raised against a C-terminus trimeric coiled coil motif of an HIV gp41 ectodomain, or carboxyl-terminal core region of the ectodomain of another enveloped virus, are also provided as are methods of making such antibodies. Methods for detecting HIV or other enveloped viruses in a sample, as well as methods of screening for drugs which can inhibit HIV infection or other enveloped virus infection, are also provided by the present invention.
摘要翻译：本发明提供了包含例如HIV的包膜病毒的胞外域的羧基末端核心区的稳定化三聚体的多肽。主题多肽包含在包膜病毒如HIV的前引发构象中形成三聚螺旋卷曲的三种单体。本发明的多肽可用作针对包膜病毒（例如HIV）的疫苗，其还提供疫苗。本发明还提供使用本发明的疫苗接种个体以预防或治疗HIV感染或预防或治疗由另一包膜病毒感染的方法。作为制备这种抗体的方法，还提供抗HIV gp41胞外域的C末端三聚体卷曲基序或另一包膜病毒的胞外域的羧基末端核心区域的抗体或其结合部分。检测样品中HIV或其他包膜病毒的方法以及筛选可抑制HIV感染或其他包膜病毒感染的药物的方法也由本发明提供。

83. 发明申请

US20050089526A1 Human immunodeficiency virus envelope clycoprotein mutants and uses thereof 审中-公开
标题翻译：人类免疫缺陷病毒包膜clycoprotein突变体及其用途
公开(公告)号：US20050089526A1
公开(公告)日：2005-04-28
申请号：US10489040
申请日：2002-09-06
申请人： John Moore , James Binley , Min Lu , William Olson , Norbert Schulke , Jason Gardner , Paul Maddon , Rogier Sanders
发明人： John Moore , James Binley , Min Lu , William Olson , Norbert Schulke , Jason Gardner , Paul Maddon , Rogier Sanders
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/39 , A61K47/48 , A61P31/18 , C07K20060101 , C07K14/16 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/48 , C12P21/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/505 , A61K2039/545 , A61K2039/55522 , A61K2039/55555 , A61K2039/55577 , A61K2039/60 , A61K2039/6056 , A61K2039/622 , A61K2039/64 , C12N2740/16122 , C12N2740/16134
摘要： This invention provides stable HIV-1 pre-fusion envelope glycoprotein trimeric complexes. This invention also provides related polypeptides and compositions comprising pharmaceutically acceptable particles and the trimeric complexes operably affixed thereto. This invention further provides related nucleic acids, vectors, host cells, compositions, production methods, and prophylactic and therapeutic methods.
摘要翻译：本发明提供稳定的HIV-1预融合包膜糖蛋白三聚体复合物。本发明还提供了相关多肽和包含药学上可接受的颗粒的组合物和可操作地固定于其上的三聚体复合物。本发明还提供了相关的核酸，载体，宿主细胞，组合物，生产方法以及预防和治疗方法。

84. 发明授权

US06506554B1 Core structure of gp41 from the HIV envelope glycoprotein 有权
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US06506554B1
公开(公告)日：2003-01-14
申请号：US09484925
申请日：2000-01-18
申请人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
发明人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the &agr;-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

85. 发明授权

US6150088A Core structure of gp41 from the HIV envelope glycoprotein 失效
标题翻译：来自HIV包膜糖蛋白的gp41的核心结构
公开(公告)号：US6150088A
公开(公告)日：2000-11-21
申请号：US62241
申请日：1998-04-17
申请人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
发明人： David C. Chan , Deborah Fass , Min Lu , James M. Berger , Peter S. Kim
IPC分类号： A61K38/00 , C07K14/16 , C12Q1/70 , C07K5/00 , C12P21/06
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Described are the crystal structure of the .alpha.-helical domain of the gp41 component of HIV-1 envelope glycoprotein which represents the core of fusion-active gp41, methods of identifying and designing drugs which inhibit gp41 function and drugs which do so.
摘要翻译：描述了代表融合活性gp41核心的HIV-1包膜糖蛋白的gp41组分的α-螺旋结构域的晶体结构，鉴定和设计抑制gp41功能的药物的方法和这样做的药物的方法。

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