专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20120283699A1 APPARATUS AND METHODS FOR CLOT DISSOLUTION 有权
标题翻译：装置解决方案的装置和方法
公开(公告)号：US20120283699A1
公开(公告)日：2012-11-08
申请号：US13548338
申请日：2012-07-13
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61M25/00 , A61M1/00 , A61M25/10
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

82. 发明授权

US07763010B2 Apparatus and methods for clot dissolution 有权
标题翻译：用于凝块溶解的装置和方法
公开(公告)号：US07763010B2
公开(公告)日：2010-07-27
申请号：US10142005
申请日：2002-05-08
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61M31/00
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

83. 发明授权

US06929633B2 Apparatus and methods for clot dissolution 有权
标题翻译：用于凝块溶解的装置和方法
公开(公告)号：US06929633B2
公开(公告)日：2005-08-16
申请号：US10278735
申请日：2002-10-21
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang , Jody Maria Cimbalo , Stephen Leeflang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang , Jody Maria Cimbalo , Stephen Leeflang
IPC分类号： A61B17/22 , A61M25/00 , A61M25/01 , A61M39/22 , A61M31/00
CPC分类号： A61B17/320758 , A61B17/22 , A61B17/22004 , A61B2017/00685 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084 , A61B2017/320716 , A61B2017/320766 , A61M25/0021 , A61M25/007 , A61M25/0075 , A61M25/0105 , A61M39/22 , A61M2025/1052
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, agitate the clot and agent, and aspirate broken-up clot from the blood vessel. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.
摘要翻译：使用具有注入溶栓剂，搅动凝块和药剂的能力的导管，以及从血管中抽出破碎的凝块来实现凝块破裂和溶解。导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。在一些实施例中，输注，抽吸和导丝通过共同内腔。血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

84. 发明授权

US08486132B2 Devices and methods for controlling expandable prostheses during deployment 有权
标题翻译：在展开期间控制可扩张假体的装置和方法
公开(公告)号：US08486132B2
公开(公告)日：2013-07-16
申请号：US11689927
申请日：2007-03-22
申请人： David W. Snow , Denise Demarais , Stuart Lin
发明人： David W. Snow , Denise Demarais , Stuart Lin
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/826 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2002/9517
摘要： A catheter for delivering a prosthesis to a treatment site in a body lumen comprises an elongate flexible member and a sheath slidably disposed thereover. A plurality of self-expanding tubular prostheses are carried in axially spaced apart locations along the elongate member, within the sheath. The prostheses may be selectively interlocked with one another and are constrained by the sheath in a radially contracted configuration. The prostheses are separately releasable from the sheath when the sheath is retracted relative to the elongate member. The catheter also has a pusher member slidably disposed along the elongate member within the sheath. The pusher is adapted to move past the prostheses in a first direction without displacing the prostheses, while in a second direction the pusher engages a selected prosthesis so as to move the prosthesis with the pusher to interlock the selected prosthesis with a second prosthesis.
摘要翻译：用于将假体递送到体腔内的治疗部位的导管包括细长的柔性构件和可滑动地设置在其上的护套。多个自膨胀管状假体在护套内沿着细长构件在轴向间隔开的位置被承载。假体可以选择性地互锁地互锁并且以径向收缩的构造被护套约束。当护套相对于细长构件缩回时，假体分开地从护套释放。该导管还具有推动器构件，该推动构件沿着护套内的细长构件可滑动地设置。推动器适于在第一方向上移动经过假体而不移动假体，而在第二方向上，推动器接合所选择的假体，以便借助于推动器移动假体以使所选择的假体与第二假体互锁。

85. 发明授权

US07517352B2 Devices for percutaneous remote endarterectomy 有权
标题翻译：用于经皮远端内膜切除术的装置
公开(公告)号：US07517352B2
公开(公告)日：2009-04-14
申请号：US09820084
申请日：2001-03-27
申请人： Michael Evans , Denise Demarais , Gwendolyn Watanabe , Stephen Leeflang
发明人： Michael Evans , Denise Demarais , Gwendolyn Watanabe , Stephen Leeflang
IPC分类号： A61M29/00
CPC分类号： A61B17/3207 , A61B17/22 , A61B17/221 , A61B17/32002 , A61B17/320725 , A61B17/32075 , A61B17/320783 , A61B2017/00287 , A61B2017/00362 , A61B2017/320004 , A61B2017/320044 , A61B2017/320741 , A61M25/1002 , A61M25/1027 , A61M29/02 , A61M2025/1015 , A61M2025/1088 , A61M2025/109
摘要： The present invention provides devices, systems, methods and kits for the percutaneous removal of unwanted tissue or obstructive matter from body cavities or lumens, particularly from the vasculature. Blood vessels, including the coronary, peripheral and neurovascular circulation, which are narrowed or blocked by atheromatous material or plaque are often treated with traditional endarterectomy procedures. The present invention allows the benefits of such a procedure with an intraluminal approach, particularly a percutaneous approach. Generally, the present invention provides a set of catheters or tools which are percutaneously introduceable to the site of the blockage or occlusion. The tools dissect or cut through the innermost tissue layer of the lumen to an underlying tissue layer. The innermost tissue layer is then stripped away from the underlying layer with the occlusive material thereattached. The detached tissue layer and occlusive material is then removed from the lumen; this may include additional cutting, maceration and removal through mechanical aspiration. In any case, the resulting lumen is free of obstruction.
摘要翻译：本发明提供用于经皮去除不想要的组织或阻塞物质的装置，系统，方法和试剂盒，所述装置，系统，方法和试剂盒用于从体腔或腔，特别是脉管系统中去除。通常使用传统的内膜切除手术治疗包括动脉粥样硬化材料或斑块变窄或阻塞的冠状动脉，周围和神经血管循环的血管。本发明允许使用腔内方法，特别是经皮方法的这种手术的益处。通常，本发明提供一组导管或工具，其经皮可引入阻塞部位或闭塞部位。该工具将内腔的最内层组织切割或切割到下面的组织层。然后将最内侧的组织层从附近的闭塞材料剥离下来的层。然后从管腔移除脱离的组织层和封闭材料; 这可能包括通过机械抽吸进行额外的切割，浸渍和去除。在任何情况下，所得到的内腔没有阻塞。

86. 发明申请

US20070208360A1 Methods and devices for reducing hollow organ volume 有权
标题翻译：减少空心器官体积的方法和装置
公开(公告)号：US20070208360A1
公开(公告)日：2007-09-06
申请号：US11799560
申请日：2007-05-02
申请人： Denise Demarais , James Gannoe , Craig Gerbi
发明人： Denise Demarais , James Gannoe , Craig Gerbi
IPC分类号： A61B17/08
CPC分类号： A61B17/12022 , A61B17/0057 , A61B17/0643 , A61B17/12099 , A61B17/12136 , A61B17/122 , A61B2017/00243 , A61B2017/081 , A61B2017/1205 , A61F5/0086
摘要： Methods and devices for providing a minimally-invasive placement of a mechanical structure for reducing the volume of a hollow body organ. Anchors may be secured within the hollow body organ and then cinched together using a tensioning member to form a stricture within the hollow body organ. In another embodiment a tensioning member may be threaded along the hollow body organ and then cinched to reduce the volume. The strictures may be placed anywhere within the hollow body organ, and more than one stricture may be formed within the hollow body organ.
摘要翻译：用于提供用于减小中空身体器官的体积的机械结构的微创放置的方法和装置。锚固件可以固定在中空身体器官内，然后使用张紧构件夹紧在一起，以在中空身体器官内形成狭窄。在另一个实施例中，张紧构件可以沿着中空身体器官进行螺纹，然后固定以减小体积。狭缝可以放置在空心体器官内的任何位置，并且可以在中空体器官内形成多于一个的狭窄。

87. 发明申请

US20060235474A1 Methods and apparatus for multi-vessel renal neuromodulation 有权
公开(公告)号：US20060235474A1
公开(公告)日：2006-10-19
申请号：US11451728
申请日：2006-06-12
申请人： Denise Demarais
发明人： Denise Demarais
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61B18/1206 , A61B18/1492 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61F7/10 , A61F2007/126 , A61N1/05 , A61N1/0507 , A61N1/0551 , A61N1/0558 , A61N1/205 , A61N1/323 , A61N1/326 , A61N1/327 , A61N1/3605 , A61N1/36114 , A61N1/36117
摘要： Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally.

88. 发明授权

US06660014B2 Systems and methods for clot disruption and retrieval 有权
公开(公告)号：US06660014B2
公开(公告)日：2003-12-09
申请号：US10162276
申请日：2002-06-03
申请人： Denise Demarais , Michael A. Evans , Stephen A. Leeflang , Christian S. Eversull
发明人： Denise Demarais , Michael A. Evans , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61B1722
CPC分类号： A61B17/320725 , A61B2017/00685 , A61B2017/2212 , A61B2017/320775 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0067 , A61F2230/0076 , A61F2230/0093 , A61M25/0023 , A61M29/02
摘要： Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to disrupt thrombus, clot, or other occlusive materials at the treatment site, and the catheter is used to collect and remove the disruptive materials from the body lumen. In particular examples, the macerator may be radially expansible and optionally rotated and/or axially translated within the positioning cage to effect disruption of the occlusive material.

89. 发明授权

US06454775B1 Systems and methods for clot disruption and retrieval 有权
标题翻译：凝块破裂和检索的系统和方法
公开(公告)号：US06454775B1
公开(公告)日：2002-09-24
申请号：US09454517
申请日：1999-12-06
申请人： Denise Demarais , Michael A. Evans , Stephen A. Leeflang , Christian S. Eversull
发明人： Denise Demarais , Michael A. Evans , Stephen A. Leeflang , Christian S. Eversull
IPC分类号： A61B1722
CPC分类号： A61B17/320725 , A61B2017/00685 , A61B2017/2212 , A61B2017/320775 , A61F2/013 , A61F2002/016 , A61F2002/018 , A61F2230/0067 , A61F2230/0076 , A61F2230/0093 , A61M25/0023 , A61M29/02
摘要： Thrombectomy and other treatments are achieved using a catheter having a positioning cage and a macerator within the positioning cage. The catheter is introduced to a target body lumen, typically a blood vessel, and a positioning cage deployed at a treatment site. The macerator is then operated to disrupt thrombus, clot, or other occlusive materials at the treatment site, and the catheter is used to collect and remove the disruptive materials from the body lumen. In particular examples, the macerator may be radially expansible and optionally rotated and/or axially translated within the positioning cage to effect disruption of the occlusive material.
摘要翻译：使用具有定位保持架内的定位保持架和剥离器的导管来实现血栓切除术和其它治疗。将导管引入目标体腔，通常为血管，以及部署在治疗部位的定位笼。然后操作浸渍器以在治疗部位破坏血栓，凝块或其它闭塞性材料，并且使用导管收集并从体腔中去除破坏性材料。在具体实例中，浸渍器可以在定位笼内径向可膨胀并任选地旋转和/或轴向平移以实现封闭材料的破坏。

90. 发明授权

US08535290B2 Apparatus and methods for clot dissolution 有权
公开(公告)号：US08535290B2
公开(公告)日：2013-09-17
申请号：US13548338
申请日：2012-07-13
申请人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
发明人： Michael A. Evans , Denise Demarais , Dino De Cicco , Kelvin Ning , Alexander Khairkhahan , Tyler Jon Strang
IPC分类号： A61M31/00
CPC分类号： A61M25/0021 , A61B17/22 , A61B17/320725 , A61B17/320758 , A61B2017/22067 , A61B2017/22084 , A61M25/007 , A61M25/0105
摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式