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81. 发明授权

US06846928B2 Compositions useful as inhibitors of protein kinases 失效
标题翻译：可用作蛋白激酶抑制剂的组合物
公开(公告)号：US06846928B2
公开(公告)日：2005-01-25
申请号：US10389707
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard , Albert C. Pierce
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard , Albert C. Pierce
IPC分类号： A61P35/00 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D239/28
CPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

82. 发明申请

US20050004110A1 Pyrazole compounds useful as protein kinase inhibitors 有权
标题翻译：用作蛋白激酶抑制剂的吡唑化合物
公开(公告)号：US20050004110A1
公开(公告)日：2005-01-06
申请号：US09952878
申请日：2001-09-14
申请人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian Golec , Sanjay Patel , Jean- Damien Charrier , David Kay , Robert Davies
发明人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian Golec , Sanjay Patel , Jean- Damien Charrier , David Kay , Robert Davies
IPC分类号： C07D403/12 , A61K31/415 , A61K31/437 , A61K31/4709 , A61K31/4725 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/00 , A61P1/16 , A61P3/08 , A61P3/10 , A61P3/14 , A61P5/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/10 , A61P25/18 , A61P25/28 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D239/26 , C07D239/36 , C07D239/70 , C07D239/88 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D475/10 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D491/052 , C07D491/107 , C07D491/113 , C07D491/20 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered carbocyclo ring; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译：本发明描述了式III的新型吡唑化合物：其中环D是选自芳基，杂芳基，杂环基或碳环基的5-7元单环或8-10元双环; R x和R y与它们的插入原子一起形成稠合的，不饱和的或部分不饱和的5-8元碳环; 和R 2和R 2'如说明书中所述。这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。

83. 发明授权

US06653301B2 Pyrazole compounds useful as protein kinase inhibitors 失效
标题翻译：用作蛋白激酶抑制剂的吡唑化合物
公开(公告)号：US06653301B2
公开(公告)日：2003-11-25
申请号：US10027001
申请日：2001-12-19
申请人： David Bebbington , Jean-Damien Charrier , Robert Davies , Julian M. C. Golec , David Kay , Ronald Knegtel , Sanjay Patel
发明人： David Bebbington , Jean-Damien Charrier , Robert Davies , Julian M. C. Golec , David Kay , Ronald Knegtel , Sanjay Patel
IPC分类号： A61K3133
CPC分类号： C07D403/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula IIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译：本发明描述了式IIa的新型吡唑化合物：其中R 1是T环D，其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R x和R y与它们的插入原子一起形成具有0-3个杂原子的稠合的，不饱和的或部分不饱和的5-7元环; R 2和R 2如说明书中所述。这些化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病。

84. 外观设计

USD258536S Wooden panel for tiles, building panels, furniture and the like 失效
公开(公告)号：USD258536S
公开(公告)日：1981-03-10
申请号：US907260
申请日：1978-05-18
申请人： David Kay
设计人： David Kay

85. 发明授权

US4084442A Control of processes 失效
标题翻译：流程控制
公开(公告)号：US4084442A
公开(公告)日：1978-04-18
申请号：US744895
申请日：1976-11-24
申请人： David Kay
发明人： David Kay
IPC分类号： B01F15/00 , G01N11/00 , G01N33/00 , G01N15/00
CPC分类号： B01F15/00207 , G01N11/00 , G01N2033/0091
摘要： The end-point of an operation in which the flow properties of particulate material are altered during agitation is determined using a probe inserted into the vessel in which agitation occurs and which deflects when hit by material being agitated and detecting when the amplitude and/or frequency of the deflections of the probe changes to a given level.
摘要翻译：搅拌期间颗粒材料的流动性质改变的操作的终点是使用插入到容器中的探针来确定的，其中发生搅动，当被搅拌的材料撞击时偏转，并且检测何时振幅和/或频率探头的偏转变化到给定的水平。

86. 发明授权

US09104312B2 Multimodal text input system, such as for use with touch screens on mobile phones 有权
标题翻译：多模式文本输入系统，如用于手机上的触摸屏
公开(公告)号：US09104312B2
公开(公告)日：2015-08-11
申请号：US13583840
申请日：2011-03-14
申请人： David Kay , Pim van Meurs , Erland Unruh , Santosh Sharan , Gordon Kessler , Mayank Agarwal , Greg Sigel
发明人： David Kay , Pim van Meurs , Erland Unruh , Santosh Sharan , Gordon Kessler , Mayank Agarwal , Greg Sigel
IPC分类号： G06F3/0488 , G06F17/27
CPC分类号： G06F3/023 , G06F3/0237 , G06F3/0481 , G06F3/04883 , G06F3/04886 , G06F17/2735 , G06F17/276 , G06F17/3064 , G06F2203/0381
摘要： A system and method for entering text from a user includes a programmed processor that receives inputs from the user and disambiguates the inputs to present word choices corresponding to the text. In one embodiment, inputs are received in two or more modalities and are analyzed to present the word choices. In another embodiment, a keyboard is divided into zones each of which represents two more input characters. A sequence of zones selected by the user is analyzed to present word choices corresponding to the zone selected.
摘要翻译：用于从用户输入文本的系统和方法包括编程的处理器，其接收来自用户的输入并消除输入以呈现对应于文本的单词选择。在一个实施例中，输入以两种或更多种方式被接收，并被分析以呈现单词选择。在另一个实施例中，键盘被分成区域，每个区域代表另外两个输入字符。分析由用户选择的区域序列，以呈现对应于所选区域的单词选择。

87. 发明授权

US08779127B2 Processes for preparing substituted pyrimidines 失效
标题翻译：制备取代嘧啶的方法
公开(公告)号：US08779127B2
公开(公告)日：2014-07-15
申请号：US13585861
申请日：2012-08-15
申请人： Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
发明人： Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
IPC分类号： C07D403/14 , C07D403/12 , C07D417/14
CPC分类号： C07D403/14 , C07D239/34 , C07D401/14 , C07D403/12 , C07D453/02
摘要： The present invention provides a facile process for the preparation of tri- and tetra—substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora—mediated diseases or conditions.
摘要翻译：本发明提供了制备三取代和四取代嘧啶的简便方法。该方法可用于制备蛋白激酶抑制剂，特别是Aurora激酶。这些抑制剂可用于治疗或减轻Aurora介导的疾病或病症的严重性。

88. 发明授权

US08672295B2 Gate valve 有权
标题翻译：闸阀
公开(公告)号：US08672295B2
公开(公告)日：2014-03-18
申请号：US12900682
申请日：2010-10-08
申请人： Samir Dhawan , Jason Neal Whaley , David Kay , Randall Ferrain Weaver , Neil Colin Kennedy
发明人： Samir Dhawan , Jason Neal Whaley , David Kay , Randall Ferrain Weaver , Neil Colin Kennedy
IPC分类号： F16K3/00 , F16K25/00
CPC分类号： F16K3/0236 , F16K3/0209 , F16K3/20
摘要： A gate valve comprises a valve body having an internal working fluid passage and an internal gate chamber extending transverse to the working fluid passage. In addition, the gate valve comprises a gate disposed in the internal gate chamber and movable within the gate chamber between a closed position obstructing fluid flow through the working fluid passage and an open position allowing fluid flow through the working fluid passage. Further, the gate valve comprises an internal sealing arrangement coaxially disposed in the working fluid passage and extending between the valve body and the gate to form a barrier between the internal working fluid passage and the gate chamber. The internal sealing arrangement includes a frustoconical metal sealing surface adapted to sealingly engage an opposed mating frustoconical metal sealing surface on the valve body to form a first tapered metal-to-metal seal between the sealing arrangement and the valve body.
摘要翻译：闸阀包括具有内部工作流体通道的阀体和横向于工作流体通道延伸的内部门室。此外，闸阀包括设置在内部门室中的门，并且可在门室内在阻塞流过工作流体通道的流体的关闭位置和允许流体流过工作流体通道的打开位置之间移动。此外，闸阀包括同轴地设置在工作流体通道中并在阀体和门之间延伸的内部密封装置，以在内部工作流体通道和门室之间形成阻挡层。内部密封装置包括截头圆锥形金属密封表面，其适于密封地接合阀体上相对的配合截头圆锥形金属密封表面，以在密封装置和阀体之间形成第一锥形金属对金属密封。

89. 发明授权

US08669081B2 Compositions useful as inhibitors of protein kinases 失效
标题翻译：可用作蛋白激酶抑制剂的组合物
公开(公告)号：US08669081B2
公开(公告)日：2014-03-11
申请号：US11786150
申请日：2007-04-11
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： C12P17/00 , C12P17/16
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

90. 发明申请

US20130066069A1 PROCESSES FOR PREPARING SUBSTITUTED PYRIMIDINES 失效
公开(公告)号：US20130066069A1
公开(公告)日：2013-03-14
申请号：US13585861
申请日：2012-08-15
申请人： Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
发明人： Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
IPC分类号： C07D403/14 , C07D403/04 , C07D403/12 , C07D417/14 , C07D453/02 , C07D239/38 , C07D413/14 , C07D401/14
CPC分类号： C07D403/14 , C07D239/34 , C07D401/14 , C07D403/12 , C07D453/02
摘要： The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.

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