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81. 发明授权

US09493539B2 Peptides associated with HLA-DR MHC class II molecules involved in autoimmune diseases 有权
标题翻译：与涉及自身免疫疾病的HLA-DR MHC II类分子相关的肽
公开(公告)号：US09493539B2
公开(公告)日：2016-11-15
申请号：US10548258
申请日：2004-03-05
申请人： Jonathan Hill , Ewa Cairns , David Bell
发明人： Jonathan Hill , Ewa Cairns , David Bell
IPC分类号： C07K14/74 , C07K14/47 , A61K38/00
CPC分类号： C07K14/70539 , A61K38/00 , C07K14/4713 , Y10S435/81
摘要： Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an increased affinity for HLA-DR molecules and associated with Rheumatoid arthritis. These novel peptides provide the basis for new methods of diagnosis and treatment of Rheumatoid arthritis.
摘要翻译：公开了与称为HLA-DR分子的共享表位结合MHC II类分子的抗原肽。更具体地，是具有增加的对HLA-DR分子的亲和力并与类风湿性关节炎相关的瓜氨酸化抗原肽。这些新型肽为新型风湿性关节炎的诊断和治疗方法提供了依据。

82. 发明授权

US09279396B2 Boost air management for improved engine performance 有权
标题翻译：提升空气管理，提高发动机性能
公开(公告)号：US09279396B2
公开(公告)日：2016-03-08
申请号：US13474434
申请日：2012-05-17
申请人： John Eric Rollinger , Adam J. Richards , David Bell , Robert Andrew Wade
发明人： John Eric Rollinger , Adam J. Richards , David Bell , Robert Andrew Wade
IPC分类号： F02B33/44 , F01N3/00 , F02M25/07 , F02D41/10 , F02D41/00 , F02D23/02 , F02B37/14
CPC分类号： F02M26/05 , F02B37/14 , F02D23/02 , F02D41/0007 , F02D41/10 , F02M26/04 , F02M26/09 , F02M26/34 , F02M26/37 , Y02T10/144
摘要： Methods and systems are provided for reducing turbo lag in a boosted engine. A boost reservoir coupled to the engine may be charged with compressed intake air and/or combusted exhaust gas. The pressurized charge may then be discharged during a tip-in to either the intake or the exhaust manifold.
摘要翻译：提供的方法和系统用于减少增压发动机中的涡轮迟滞。联接到发动机的增压储存器可以装有压缩的进气和/或燃烧的废气。然后，可以在进入或排气歧管的尖端期间将加压的电荷排出。

83. 发明授权

US08647312B2 Injection site for male luer or other tubular connector 有权
标题翻译：男性鲁尔或其他管状连接器的注射部位
公开(公告)号：US08647312B2
公开(公告)日：2014-02-11
申请号：US13738842
申请日：2013-01-10
申请人： David S. Utterberg , William J. Schnell , David Bell
发明人： David S. Utterberg , William J. Schnell , David Bell
IPC分类号： A61M5/00
CPC分类号： A61M5/16813 , A61M39/02 , A61M39/045 , A61M39/26
摘要： A medical device has an interior for containment of fluids; an opening into the interior, an elastomeric wall comprising a fixedly placed, flexible barrier across the opening; and a retention wall positioned adjacent to a peripheral portion of the elastomeric wall. The retention wall defines a central opening and has a generally rigid retention zone surrounding the central opening, to engage and retain a connector tube which is advanced into the central opening to open a flow aperture through the elastomeric wall, for flow through the wall and connector tube. One of the retention zone and connector tube may be made of a material of sufficient hardness that material of the other engaging member is deformed by engagement therewith, which increases the strength of retention between the retention wall and the connector tube.
摘要翻译：医疗装置具有用于容纳流体的内部; 通向内部的开口，弹性体壁，其包括穿过开口的固定放置的柔性屏障; 以及邻近弹性体壁的周边部分定位的保持壁。保持壁限定了中心开口，并且具有围绕中心开口的大致刚性的保持区域，以接合并保持连接管，该连接器管进入中心开口以打开穿过弹性体壁的流动孔，以流过壁和连接器管。保持区域和连接管中的一个可以由足够硬度的材料制成，另一个接合构件的材料通过与其接合而变形，这增加了保持壁和连接器管之间的保持力。

84. 发明申请

US20130311068A1 COORDINATION OF CAM TIMING AND BLOW-THROUGH AIR DELIVERY 有权
标题翻译：凸轮定时和透气空气交付协调
公开(公告)号：US20130311068A1
公开(公告)日：2013-11-21
申请号：US13474540
申请日：2012-05-17
申请人： John Eric Rollinger , Adam J. Richards , Robert Andrew Wade , David Bell
发明人： John Eric Rollinger , Adam J. Richards , Robert Andrew Wade , David Bell
IPC分类号： F02D9/02 , F02D41/30
CPC分类号： F02B37/20 , F02B37/12 , F02B37/168 , F02D13/0215 , F02D13/0261 , F02D23/02 , F02D41/0007 , F02D41/005 , F02D41/0065 , F02D41/0077 , F02D41/38 , F02D2041/001 , F02D2041/389 , F02M26/05 , Y02T10/144 , Y02T10/18 , Y02T10/47
摘要： Methods and systems are provided for reducing turbo lag by directing intake air from an intake manifold to an exhaust manifold. The intake air may be directed via an EGR passage by opening an EGR valve or by may be directed via engine cylinders by increasing positive valve overlap. Amounts of air directed via external EGR and air directed via positive valve overlap are based on engine operating conditions.
摘要翻译：提供了通过将进气从进气歧管引导到排气歧管来减少涡轮滞后的方法和系统。吸入空气可以通过打开EGR阀通过EGR通道引导，或者可以通过增加正的阀重叠来引导通过发动机气缸。通过外部EGR引导的空气量和通过正阀重叠引导的空气量是基于发动机的运行条件。

85. 发明申请

US20120236940A1 Method for Efficient Parallel Processing for Real-Time Video Coding 审中-公开
标题翻译：用于实时视频编码的高效并行处理方法
公开(公告)号：US20120236940A1
公开(公告)日：2012-09-20
申请号：US13049298
申请日：2011-03-16
申请人： Ran Katzur , David Bell
发明人： Ran Katzur , David Bell
IPC分类号： H04N7/32
CPC分类号： H04N19/40 , H04N19/43 , H04N19/436 , H04N19/61
摘要： Embodiments of the invention include a parallel method for real-time video encoding in a multicore processor system. A first frame of video data is divided into groups. Each group has one or more rows of a plurality of macroblocks. Motion estimation is performed on a second group following a first group by a first core of said multicore system. While said motion estimation is being performed by said first core, compression-and-reconstruction is performed on said first group by a second core.
摘要翻译：本发明的实施例包括用于多核处理器系统中的实时视频编码的并行方法。视频数据的第一帧被分成组。每个组具有多个宏块的一行或多行。通过所述多核系统的第一核心在第一组之后的第二组上执行运动估计。当由所述第一核心执行所述运动估计时，通过第二核心对所述第一组进行压缩和重建。

86. 发明申请

US20120213732A1 TARGETED DELIVERY OF ANTIVIRAL COMPOUNDS THROUGH HEMOGLOBIN BIOCONJUGATES 审中-公开
标题翻译：通过HEMOGLOBIN BIOCONJUGATES有针对性地提供抗病毒化合物
公开(公告)号：US20120213732A1
公开(公告)日：2012-08-23
申请号：US13399046
申请日：2012-02-17
申请人： J. Gordon Adamson , David Bell , Nancy Ng , Petrus Biessels
发明人： J. Gordon Adamson , David Bell , Nancy Ng , Petrus Biessels
IPC分类号： A61K47/48 , A61P7/06 , A61P31/18 , C07K14/805 , A61P31/14
CPC分类号： A61K31/7056 , A61K47/62 , A61K47/6445
摘要： This invention relates to targeted delivery of anti-viral compounds through protein bioconjugation. More particularly, it relates to an anti-viral compound conjugated to a protein, such as hemoglobin and to a method of treating a viral infection using said conjugate. The invention also provides a method of targeted drug delivery of an anti-viral nucleoside analogue to macrophages, cells comprising a hemoglobin receptor and to CD163 bearing cells.
摘要翻译：本发明涉及通过蛋白质生物共轭靶向递送抗病毒化合物。更具体地说，本发明涉及与蛋白质（例如血红蛋白）缀合的抗病毒化合物以及使用所述缀合物治疗病毒感染的方法。本发明还提供了将抗病毒核苷类似物靶向药物递送至巨噬细胞，包含血红蛋白受体的细胞和携带CD163的细胞的方法。

87. 发明授权

US08229666B2 Generating and using pattern keys in navigation systems to predict user destinations 有权
标题翻译：在导航系统中生成和使用模式键来预测用户目的地
公开(公告)号：US08229666B2
公开(公告)日：2012-07-24
申请号：US12355901
申请日：2009-01-19
申请人： David Bell , Chris Bygrave , Oliver Dineen , Philip Norton
发明人： David Bell , Chris Bygrave , Oliver Dineen , Philip Norton
IPC分类号： G01C21/34
CPC分类号： G01C21/3617 , G01C21/36
摘要： Systems and methods for automatically generating pattern keys based on models of user travel patterns and behavior, wherein the pattern keys may be used in automated navigation systems for fast and efficient prediction of user destinations.
摘要翻译：基于用户行进模式和行为模型自动生成模式键的系统和方法，其中模式键可用于自动导航系统中，用于快速和有效地预测用户目的地。

88. 发明申请

US20120156466A1 FIBRE MATRIX AND A METHOD OF MAKING A FIBRE MATRIX 有权
标题翻译：纤维矩阵和制作纤维矩阵的方法
公开(公告)号：US20120156466A1
公开(公告)日：2012-06-21
申请号：US13384487
申请日：2010-07-19
申请人： David Bell , Roy George Price
发明人： David Bell , Roy George Price
IPC分类号： B29B11/16 , B29C39/38 , B29C39/42 , B32B27/04 , B29C39/00
CPC分类号： D04H1/64 , B01J6/008 , B29B11/16 , B29C41/02 , B33Y10/00 , B33Y70/00 , C04B35/62204 , C04B35/6263 , C04B35/62685 , C04B35/6269 , C04B35/6316 , C04B35/63416 , C04B35/63424 , C04B35/63436 , C04B35/63444 , C04B35/63452 , C04B35/63456 , C04B35/6346 , C04B35/63488 , C04B35/803 , C04B35/83 , C04B2235/3418 , C04B2235/422 , C04B2235/5248 , C04B2235/5264 , C04B2235/5268 , C04B2235/5272 , C04B2235/5436 , C04B2235/604 , C04B2235/608 , C04B2235/614 , C04B2235/95 , D21H13/50 , F16D69/023 , F16D69/026 , F41H5/0471 , F41H5/0485 , Y10T428/1362 , Y10T428/24994 , Y10T442/60
摘要： A method of forming a three dimensional fibre structure is disclosed which comprises the steps of a) providing a starting material which comprises liquid carrier, fibres and binder; b) passing the starting material over a substrate so as to deposit fibres onto the substrate; c) forming a three dimensional fibre matrix; and d) curing the binder. The flow of material onto the substrate may be controlled such that the flow of a starting material over the substrate is chaotic and fibres are laid down in a three dimensional structure containing a high proportion of voids. The preform may be pressurised while moist and is cured under pressure. The fibres may comprise carbon fibres; recycled carbon fibre has been found to be particularly useful. The resulting preform may be stochastic and is suitable for use in ablative and braking applications.
摘要翻译：公开了形成三维纤维结构的方法，其包括以下步骤：a）提供包含液体载体，纤维和粘合剂的原料; b）将原料通过基片，以将纤维沉积到基底上; c）形成三维纤维基质; 和d）固化粘合剂。可以控制衬底上的材料流动，使得起始材料在衬底上的流动是混沌的，并且将纤维放置在含有高比例空隙的三维结构中。预制件可以在潮湿的同时被加压并在压力下固化。纤维可以包含碳纤维; 已经发现再循环碳纤维特别有用。所得到的预制件可以是随机的，并且适用于烧蚀和制动应用。

89. 发明申请

US20120034351A1 CARBONATED JELLY BEVERAGE WITH INCLUSIONS 审中-公开
标题翻译：含糖的珍珠啤酒
公开(公告)号：US20120034351A1
公开(公告)日：2012-02-09
申请号：US13179708
申请日：2011-07-11
申请人： Vidya Sridhar , David Bell , Casey McCormick , Manisha Lokre , Mohamed Zaki Badaoui Najjar
发明人： Vidya Sridhar , David Bell , Casey McCormick , Manisha Lokre , Mohamed Zaki Badaoui Najjar
IPC分类号： A23L1/052 , A23L1/0524 , A23L2/58 , A23L1/0534 , A23L2/54 , A23L2/68 , A23L1/0526 , A23L1/054 , A23L1/0532 , A23L2/56
CPC分类号： A23L2/52 , A23L2/54 , A23L29/206 , A23L29/269 , A23L29/272
摘要： A carbonated gelatinous beverage containing inclusions and methods for making same.
摘要翻译：含有夹杂物的碳酸化凝胶状饮料及其制造方法。

90. 发明授权

US08092414B2 Diaphragm pressure pod for medical fluids 有权
标题翻译：医用液体隔膜压力舱
公开(公告)号：US08092414B2
公开(公告)日：2012-01-10
申请号：US11270080
申请日：2005-11-09
申请人： William J. Schnell , David Bell , Karen Wilson , David S. Utterberg
发明人： William J. Schnell , David Bell , Karen Wilson , David S. Utterberg
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3641 , A61M1/16 , A61M1/3627 , A61M1/3639 , A61M1/3655 , A61M39/00 , F16L29/005 , Y10T137/85978
摘要： A tubular medical fluid flow set comprises a pressure sensing chamber connected in flow-through relation to fluid flow tubing of the set. The pressure sensing chamber defines a movable, flexible, impermeable diaphragm dividing the chamber into two separate compartments. The fluid flow tubing communicates with one of the compartments and is isolated from the other of the compartments. A port is carried on the chamber, the port having a seal therein, and communicating with the other of the compartments. Thus, the other of the compartments is hermetically sealed until the port is opened for connection with a pressure measuring device, to keep the flexible diaphragm in a desired, initial position prior to opening of the seal.
摘要翻译：管状医疗流体流动装置包括与组件的流体流管连通的压力感测室。压力传感室限定了一个可移动的，柔性的，不可渗透的隔膜，将隔室分隔成两个独立的隔间。流体流动管道与隔室中的一个连通，并且与隔室中的另一个隔离。端口被承载在腔室上，该端口在其中具有密封，并且与另一个隔间连通。因此，隔室中的另一个被气密地密封，直到端口打开以与压力测量装置连接，以便在打开密封件之前将柔性隔膜保持在期望的初始位置。

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