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81. 发明申请

US20150320525A1 METHODS FOR FABRICATING DENTAL PROSTHESES 审中-公开
标题翻译：用于制造牙齿前体的方法
公开(公告)号：US20150320525A1
公开(公告)日：2015-11-12
申请号：US14421188
申请日：2013-08-13
申请人： University of Louisville Research Foundation, Inc.
发明人： Wei-Shao LIN , Amirali ZANDINEJAD , Dean Morton
IPC分类号： A61C13/00 , A61K6/04 , B23K26/00 , C22C14/00 , A61C8/00 , B23K26/34
CPC分类号： A61C13/0018 , A61C8/0012 , A61C13/0019 , A61K6/04 , B22F3/1055 , B22F2207/00 , B33Y10/00 , B33Y50/00 , B33Y80/00 , C22C14/00
摘要： Methods of fabricating dental prostheses are provided that include the steps of providing a powder of a dental material, and then selectively melting the powder of the dental material to produce a functionally graded layer of the dental material. Additional layers of functionally graded dental material are then built on top of the initial layer of dental material to thereby produce a three-dimensional dental prosthesis having a functionally graded structure and a desired physical geometry. Dental prostheses produced by the foregoing methods are also provided.
摘要翻译：提供了制造牙科假体的方法，其包括以下步骤：提供牙科材料的粉末，然后选择性地熔化牙科材料的粉末以产生牙科材料的功能梯度层。然后在牙科材料的初始层的顶部上建立功能分级牙科材料的附加层，从而产生具有功能梯度结构和所需物理几何形状的三维牙科假体。还提供了通过上述方法生产的牙科假体。

82. 发明申请

US20150250482A1 ATRIAL APPENDAGE CLOSURE DEVICE AND RELATED METHODS 审中-公开
标题翻译： ATRIAL附件封闭装置及相关方法
公开(公告)号：US20150250482A1
公开(公告)日：2015-09-10
申请号：US14417536
申请日：2013-07-26
申请人： University of Louisville Research Foundation, Inc.
发明人： Mark S. Slaughter , Guruprasad A. Giridharan , Steven C. Koenig , Michael A. Sobieski , Kevin Soucy
IPC分类号： A61B17/12
CPC分类号： A61B17/12122 , A61B17/12036 , A61B17/12172 , A61B17/12177 , A61B17/122 , A61B2017/00247 , A61B2017/1205 , A61B2217/005
摘要： An atrial appendage closure device is provided that includes an insertion rod having a first end and a second end. An occluding member having an outer surface and an inner surface is connected to the first end of the insertion rod. The occluding member is moveable between a retracted position and a deployed position such that, in the deployed position, the occluding member is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring member is further connected to the insertion rod and is configured to slide along the insertion rod to secure the device to a wall of a left atrial appendage. Methods for occluding a left atrial appendage that make use of the closure devices are also provided.
摘要翻译：提供了一种包括具有第一端和第二端的插入杆的心耳封闭装置。具有外表面和内表面的阻塞构件连接到插入杆的第一端。闭塞构件可在缩回位置和展开位置之间移动，使得在展开位置，闭塞构件构造成在心脏的左心耳和左心房之间提供密封。锚定构件进一步连接到插入杆并且构造成沿着插入杆滑动以将装置固定到左心耳的壁上。还提供了用于闭塞使用闭合装置的左心耳的方法。

83. 发明申请

US20150190379A1 BAX-Activating Cancer Therapeutics 有权
标题翻译： BAX激活癌症治疗
公开(公告)号：US20150190379A1
公开(公告)日：2015-07-09
申请号：US14589050
申请日：2015-01-05
申请人： The University of Louisville Research Foundation Inc.
发明人： Chi Li , John O. Trent
IPC分类号： A61K31/437 , A61K31/495 , A61K31/282
CPC分类号： A61K31/437 , A61K31/282 , A61K31/495 , A61K31/496 , A61K31/53
摘要： The pro-apoptotic Bcl-2 protein Bax initiates apoptosis in almost all apoptotic paradigms. Agents facilitating disruptive Bax insertion into mitochondrial membranes have potential as cancer therapeutics. Small molecule compounds associating with the hydrophobic groove of the pro-apoptotic Bcl-2 protein Bax have been identified and found to promote Bax-dependent, but not Bak-dependent, apoptosis. The compounds alter Bax protein stability in vitro and promote Bax insertion into mitochondria, leading to Bax-dependent mitochondrial outer membrane permeabilization and apoptosis. The compounds activating the pro-apoptotic Bcl-2 protein Bax inhibit the growth of tumors by inducing apoptosis. Pharmaceutical compositions comprising the compounds that activate Bax and induce Bax-dependent apoptosis are useful as anti-cancer therapeutic agents alone or with other anti-cancer agents. Methods for inducing apoptosis and for treating cancer involve administering the compounds to a patient in need thereof.
摘要翻译：促细胞凋亡的Bcl-2蛋白Bax在几乎所有的凋亡模式中启动细胞凋亡。将破坏性Bax插入线粒体膜的药物具有作为癌症治疗剂的潜力。已经鉴定了与促凋亡Bcl-2蛋白Bax的疏水沟相关的小分子化合物，以促进Bax依赖性，但不促进Bak依赖性凋亡。该化合物在体外改变Bax蛋白稳定性，促进Bax插入线粒体，导致Bax依赖性线粒体外膜透化和凋亡。激活促凋亡Bcl-2蛋白Bax的化合物通过诱导凋亡来抑制肿瘤的生长。包含活化Bax并诱导Bax依赖性细胞凋亡的化合物的药物组合物可用作单独的抗癌治疗剂或与其它抗癌剂一起使用。用于诱导细胞凋亡和治疗癌症的方法包括将化合物给予有需要的患者。

84. 发明申请

US20150177264A1 METHODS AND KITS FOR DIAGNOSING OBSTRUCTIVE SLEEP APNEA 有权
标题翻译：用于诊断阻塞性睡眠APNEA的方法和工具
公开(公告)号：US20150177264A1
公开(公告)日：2015-06-25
申请号：US14641006
申请日：2015-03-06
申请人： University of Louisville Research Foundation, Inc.
发明人： David Gozal , Saeed A. Jortani , Roland Valdes, JR. , Leila Kheirandish-Gozal
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/2864
摘要： The presently-disclosed subject matter provides methods and kits for diagnosing obstructive sleep apnea (OSA) in a subject, such as a human child, wherein a biological sample is provided from the subject and the amount of a Urocortin III peptide is determined from the sample. Further provided are methods for diagnosing OSA in a subject wherein the amount of a Urocortin III peptide and one or more peptides selected from a Uromodulin peptide, an Orosomucoid 1 peptide, and a Kallikrein 1 peptide are determined in a biological sample from a subject.
摘要翻译：目前公开的主题提供了用于诊断受试者例如人类小孩的阻塞性睡眠呼吸暂停（OSA）的方法和试剂盒，其中从受试者提供生物样品，并从样品中确定Urocortin III肽的量。还提供了用于诊断受试者中的OSA的方法，其中在来自受试者的生物样品中测定Urocortin III肽和选自Uromodulin肽，Orosomuroid 1肽和激肽释放酶1肽的一种或多种肽的量。

85. 发明授权

US09061050B2 Repairing Bruch's membrane with hydrogels 有权
标题翻译：用水凝胶修复布鲁赫膜
公开(公告)号：US09061050B2
公开(公告)日：2015-06-23
申请号：US14045626
申请日：2013-10-03
申请人： University of Louisville Research Foundation, Inc.
发明人： Andrea S. Gobin , Tongalp H. Tezel
IPC分类号： A61K47/48 , A61K9/00 , A61K45/06 , A61K38/07 , A61K38/08 , A61K31/78 , A61K9/06 , A61K38/18 , A61L27/18 , A61L27/22 , A61L27/52 , A61L27/54 , A61K38/30
CPC分类号： A61K31/78 , A61K9/0048 , A61K9/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/30 , A61K45/06 , A61K47/60 , A61K47/6903 , A61L27/18 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/16 , C08L71/02 , A61K2300/00
摘要： The invention provides hydrogels and methods for their use in treating disorders of the retina such as age-related macular degeneration (AMD).
摘要翻译：本发明提供水凝胶及其用于治疗视网膜病变的方法，例如年龄相关性黄斑变性（AMD）。

86. 发明申请

US20150064796A1 NONINVASIVE DETECTION OF LUNG CANCER USING EXHALED BREATH 有权
标题翻译：使用呼吸道阻塞肺癌的非侵入性检测
公开(公告)号：US20150064796A1
公开(公告)日：2015-03-05
申请号：US14471793
申请日：2014-08-28
申请人： University of Louisville Research Foundation, Inc.
发明人： Xiaoan Fu , Michael Nantz , Michael Bousamra
IPC分类号： G01N33/574 , G01N1/40
CPC分类号： G01N33/57423 , G01N1/405 , G01N33/543 , G01N33/57484 , G01N33/64 , G01N2033/4975 , G01N2033/57453
摘要： A non-invasive method of detecting or screening for lung cancer in a subject specimen is provided. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (VOCs) that are biomarkers for lung cancer in exhaled breath from the subject specimen. The method may further include obtaining exhaled breath from the subject specimen; forming adducts of the carbonyl-containing VOCs with a reactive chemical compound; quantifying the adducts of the carbonyl-containing VOCs to establish a subject value for each of the adducts; and comparing each subject value to a threshold healthy specimen value for each of the adducts of the carbonyl-containing VOCs. One or more subject values at quantities greater than threshold healthy specimen values are also useful for screening for lung cancer in the subject specimen.
摘要翻译：提供了一种在受试者标本中检测或筛选肺癌的非侵入性方法。该方法包括检测作为来自受试者标本的呼出气中肺癌生物标志物的一种或多种含羰基挥发性有机化合物（VOC）的升高水平。该方法可以进一步包括从主体样本获得呼出的呼吸; 形成含羰基VOCs与反应性化合物的加成物; 量化含羰基VOC的加合物以建立每种加合物的主题值; 并将每个受试者值与含羰基VOC的加合物的阈值健康标本值进行比较。一个或多个数量大于阈值健康标本值的受试者值也可用于筛选受检标本中的肺癌。

87. 发明申请

US20150025129A1 COMPOUNDS, COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE 有权
标题翻译：化合物，组合物，药物组合物和使用方法
公开(公告)号：US20150025129A1
公开(公告)日：2015-01-22
申请号：US14358731
申请日：2012-11-16
申请人： University of Louisville Research Foundation, Inc , Laboratorios de Investigacion y Desarrollo: Facult de Ciencias y Filosofia
发明人： Gerald B. Hammond , Zhuang Jin , Paula J. Bates , Elsa Merit Reyes-Reyes , Abraham Vaisberg
IPC分类号： A61K31/366 , A61K36/81
CPC分类号： A61K31/366 , A61K36/81
摘要： Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
摘要翻译：本发明的某些实施方案包括包含式（I）化合物及其盐，异构体及其衍生物的组合物。本发明一些实施方案的药物组合物包含式（I）化合物及其盐，异构体及其衍生物。本发明的其它实施方案包括治疗疾病（例如癌症）的方法和给予式（I）化合物及其盐，异构体及其衍生物的方法。

88. 发明申请

US20140364866A1 ENDOSCOPIC SNARE DEVICE 审中-公开
标题翻译：内窥镜检查装置
公开(公告)号：US20140364866A1
公开(公告)日：2014-12-11
申请号：US14370617
申请日：2013-01-07
申请人： University of Louisville Research Foundation, Inc.
发明人： Gerald W. Dryden , Joseph Watson Vicars, III , Guruprasad A. Giridharan , Lauren Elizabeth Allen , Megan C. Mann , John F. Naber
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B17/32056 , A61B18/148 , A61B2017/00358 , A61B2017/00477 , A61B2017/2212 , A61B2018/00494 , A61B2018/00595 , A61B2018/00607 , A61B2018/141
摘要： Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop snare device including a means for securely closing the loop. In some embodiments, a snare device comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the device along an arcuate path curving back toward the capture mechanism such that, after the snare wire is advanced, activation of the capture mechanism captures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue.
摘要翻译：本发明的实施例涉及内窥镜和腹腔镜手术器械。更具体地，本发明的实施例涉及一种开环圈套装置，其包括用于牢固地闭合回路的装置。在一些实施例中，圈套装置包括圈套线和捕获机构，其中当所述圈套线前进时，所述圈套线沿着所述装置的远侧部分沿着沿着弯曲回向所述捕获机构的弧形路径延伸，使得在圈套线先进，捕获机构的激活捕获圈套线，在目标组织周围形成形成的环。所述圈套线和捕获机构中的至少一个的缩回使所形成的环收缩，切除所述目标组织。

89. 发明授权

US08868907B2 Device, method, and system for processing communications for secure operation of industrial control system field devices 有权
标题翻译：用于处理通信以用于工业控制系统现场设备的安全操作的装置，方法和系统
公开(公告)号：US08868907B2
公开(公告)日：2014-10-21
申请号：US13758548
申请日：2013-02-04
申请人： University of Louisville Research Foundation, Inc.
发明人： James H. Graham , Jeffrey L. Hieb
IPC分类号： H04L29/06 , H04L9/32 , G06F21/00 , G06F21/31 , G06F21/85 , H04L9/00 , G06F15/173 , G06F15/16
CPC分类号： H04L9/32 , G06F21/00 , G06F21/31 , G06F21/85
摘要： A device, method, and system for processing communications for secure operation of industrial control system field devices, includes: a processing device to be placed in-line between a Master Telemetry Unit (MTU) and a field device. A software verified microkernel includes instructions for the processing device to provide a secure partitioning of memory between a communication network interface address space, a security cell address space, and a field device interface address space. The security cell address space includes instructions to: receive communication messages from the MTU via the communication network interface address space; authenticate a user identification of each communication message; verify that an operation requested in each message is authorized for the user identification; and send each communication message having an authenticated user identification and a verified operation to the field network interface address space for communication with the field device.
摘要翻译：一种用于处理通信以用于工业控制系统现场设备的安全操作的设备，方法和系统，包括：在主遥测单元（MTU）和现场设备之间在线放置的处理设备。软件验证的微内核包括用于处理设备在通信网络接口地址空间，安全小区地址空间和现场设备接口地址空间之间提供存储器的安全分区的指令。安全小区地址空间包括：经由通信网络接口地址空间从MTU接收通信消息的指令; 验证每个通信消息的用户标识; 验证每个消息中请求的操作是否被授权用于用户标识; 并将具有认证用户标识和验证操作的每个通信消息发送到现场网络接口地址空间以与现场设备进行通信。

90. 发明申请

US20140242143A1 ADIPOSE STROMAL VASCULAR FRACTION CELL CONSTRUCTS 有权
公开(公告)号：US20140242143A1
公开(公告)日：2014-08-28
申请号：US14348584
申请日：2012-10-01
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： Amanda J. LeBlanc , James B. Hoying , Stuart K. Williams
IPC分类号： C12N5/071 , A61K35/34
CPC分类号： C12N5/069 , A61K35/34 , A61K35/35
摘要： Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of DMEM with approximately 10% FBS.
摘要翻译：描述了三维组织构建体，其可以通过分离脂肪来源的基质血管级分（SVF）细胞，将细胞电镀到聚合物支架上，并在具有约10％FBS的DMEM培养物中培养所述铺板的支架来产生。

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