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81. 发明授权

US07078014B2 Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals 失效
标题翻译：使用二氢卟酚和细菌氯胺基氨基苯基DTPA和N2S2共轭物用于MR造影剂和放射性药物的方法
公开(公告)号：US07078014B2
公开(公告)日：2006-07-18
申请号：US10390438
申请日：2003-03-17
申请人： Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
发明人： Ravindra K. Pandey , Zachary Grossman , Peter Kanter , Thomas J. Dougherty
IPC分类号： A61B5/055
CPC分类号： C07D487/22 , A61K49/085 , A61K49/103 , A61K51/0478 , A61K51/0485 , C07D471/22
摘要： A method for MR imaging that comprises conducting the MR imaging after injecting compositions that are chemical combination of porphyrins, chlorins, bacteriochlorins, and related tetra-pyrrolic compounds with radioactive elements such as Technetium99, Gadolinium, Indium111 and radioactive iodine. When the element can form cations, the compound is usually a chelate with the porphyrin or chlorin structure. When the element forms anions, the compound is usually a direct chemical combination of the radioactive element into the porphyrin or chlorin structure. The method uses the compounds of the invention for diagnostic imaging of hyperproliferative tissue such as tumors and new blood vessel growth as is associated with the wet form of age related macular degeneration and methods of making the compounds. Compounds for MRI contrast imaging of the invention are usually Tc99, In111 or Gd(III) complexes of compounds of the formula:
摘要翻译：一种用于MR成像的方法，其包括在注入组合物之后进行MR成像，所述组合物是卟啉，二氢卟酚，细菌二氢卟酚和相关的四吡咯化合物与放射性元素如锝99，钆， SUP> 111和放射性碘。当元素可以形成阳离子时，化合物通常是具有卟啉或二氢卟酚结构的螯合物。当元素形成阴离子时，化合物通常是放射性元素与卟啉或二氢卟酚结构的直接化学组合。该方法使用本发明的化合物用于与增殖性组织例如肿瘤和新血管生长的诊断成像，其与湿性形式的年龄相关性黄斑变性相关联，以及制备该化合物的方法。本发明的MRI造影成像的化合物通常为下式化合物的Tc 99，III 111或Gd（III）络合物：

82. 发明授权

US07053210B2 Efficient synthesis of pyropheophorbide a and its derivatives 失效
标题翻译：高效合成焦脱镁叶绿酸a及其衍生物
公开(公告)号：US07053210B2
公开(公告)日：2006-05-30
申请号：US10613474
申请日：2003-07-02
申请人： Ravindra K. Pandey , Thomas J. Dougherty , Alexander J. Pallenberg
发明人： Ravindra K. Pandey , Thomas J. Dougherty , Alexander J. Pallenberg
IPC分类号： A61B5/055 , A61B10/00 , C07B47/00 , C07F5/10 , A61K31/555
CPC分类号： C07D471/22 , C07D487/22 , C07D491/22
摘要： A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, with a base, followed by heating to give pyropheophorbide a, which is converted to HPPH by treatment with acid, followed by hexyl alcohol under basic conditions.
摘要翻译：提供了制备焦脱镁叶绿酸a及其衍生物的方法，包括3-脱乙烯基-3-（1'-己氧基）乙基 - 焦脱镁叶绿酸a，也称为HPPH。该方法包括用碱处理其三甲酯形式的二氢卟酚，然后加热得到焦脱镁叶绿酸a，其通过用酸处理转化成HPPH，随后用己醇转化为HPPH 基本条件

83. 发明授权

US07045236B1 Heat and gas exchange system for battery 有权
标题翻译：蓄电池热交换系统
公开(公告)号：US07045236B1
公开(公告)日：2006-05-16
申请号：US10216060
申请日：2002-08-09
申请人： Michael G. Andrew , Gary P. Houchin-Miller , William P. Segall, Jr. , Thomas J. Dougherty , William J. Wruck
发明人： Michael G. Andrew , Gary P. Houchin-Miller , William P. Segall, Jr. , Thomas J. Dougherty , William J. Wruck
IPC分类号： H01M8/12 , H01M2/00
CPC分类号： H01M2/1077 , H01M2/1083 , H01M10/486 , H01M10/613 , H01M10/625 , H01M10/643 , H01M10/6557 , H01M10/6563 , H01M10/6565
摘要： A heat and gas exchange system for a battery is disclosed. The batter includes a plurality of cells and at least one space between the cells. The system includes a base configured to support the battery. The system also includes a plurality of members coupled to the base. Each of the members is configured to extend at least partially within at least one space between the cells of the battery. A heat and gas exchange system for a battery is also disclosed. A module for a battery for a vehicle is also disclosed. The battery includes a plurality of cells and at least one space between the cells. The module includes a base for supporting the battery. The module also includes a plurality of members coupled to the base. The module also includes a control system configured to provide air through the plurality of members from the space between the cells.
摘要翻译：公开了一种用于电池的热交换系统。面糊包括多个单元和单元之间的至少一个空间。该系统包括被配置为支撑电池的基座。该系统还包括耦合到基座的多个构件。每个构件被构造成至少部分地延伸在电池单体之间的至少一个空间内。还公开了一种用于电池的热交换系统。还公开了一种用于车辆的电池的模块。电池包括多个电池和电池之间的至少一个空间。该模块包括用于支撑电池的基座。模块还包括耦合到基座的多个构件。该模块还包括一个控制系统，该控制系统配置成从单元之间的空间提供通过多个构件的空气。

84. 发明授权

US06849607B2 Galectin recognized photosensitizers for photodynamic therapy 失效
标题翻译： Galectin认可光敏剂用于光动力疗法
公开(公告)号：US06849607B2
公开(公告)日：2005-02-01
申请号：US10141241
申请日：2002-05-07
申请人： Ravindra K. Pandey , Thomas J. Dougherty
发明人： Ravindra K. Pandey , Thomas J. Dougherty
IPC分类号： A61P35/00 , C07H15/18 , C07H15/26 , C07H23/00 , A01N43/04 , A61B5/055 , C07H15/00
CPC分类号： C07H15/18 , C07H15/26 , C07H23/00
摘要： Purpurin-carbohydrate conjugates and their method of preparation and use for treatment of cancer cells. The conjugates have the general formula: wherein R6 and R7 taken together are ═NR11 or are independently —OR11, where at least one R11 is preferably a mono or polysaccharide moiety and R1-R8 are various groups formed from carbon and hydrogen and optionally oxygen and nitrogen where R3 and R4 may together from a covalent bond.
摘要翻译：紫杉醇 - 碳水化合物缀合物及其制备和用于治疗癌细胞的方法。缀合物具有以下通式：其中R 6和R 7一起为= NR 11或独立地为-OR 11，其中至少一个R 11优选为单糖或多糖部分，并且R 1 -R 8为由碳和氢以及任选的氧形成的各种基团，氮，其中R3和R4可以共价键。

85. 发明授权

US06624187B1 Long wave length absorbing bacteriochlorin alkyl ether analogs 有权
标题翻译：长波长吸收菌二氯酚烷基醚类似物
公开(公告)号：US06624187B1
公开(公告)日：2003-09-23
申请号：US09592150
申请日：2000-06-12
申请人： Ravindra K. Pandey , Thomas J. Dougherty , William R. Potter
发明人： Ravindra K. Pandey , Thomas J. Dougherty , William R. Potter
IPC分类号： C07D48722
CPC分类号： C07D471/22 , C07D487/22 , C07D491/22
摘要： Novel compounds that either preferentially absorb into hyperproliferative tissue and absorb light efficiently at a wavelength of between about 700 and about 850 nm or act as intermediates for such absorbing compounds. More particularly, the compounds of the invention have the formula: where R1, R5, R9, and R10 are independently lower alkyl of 1 to 3 carbon atoms provided that at least three of R1, R5, R9, and R10 are methyl; R2 is —OH, —OR11, —NHR11, aryl, or -aminoacid; R3 and R4 are independently —COR11 or taken together are R6 and R7 are independently lower alkyl of 1 to 3 carbon atoms; R8 is O-alkyl of 1 to about 12 carbon atoms, S-alkyl of 1 to about 12 carbon atoms, —O-aryl, or —O-heterocyclic ring of 5 or 6 carbon atoms; R11 is alkyl of 1 to 6 carbon atoms; and R12 is lower alkyl of 1 to about 12 carbon atoms, aryl, or aminoalkyl of 1 to 8 carbon atoms; provided that at least one of R8, R11, and R12 is hydrophobic and together contain at least 10 carbon atoms. The invention also includes method of making and using the compounds.
摘要翻译：优先吸收过度增生组织并在约700至约850nm波长处有效吸收光的新型化合物或作为这种吸收化合物的中间体。更具体地，本发明的化合物具有下式：其中R 1，R 5，R 9和R 10独立地为1至3个碳原子的低级烷基，条件是R R 1，R 5，R 9和R 10是甲基; R 2是-OH，-OR 11，-NHR 11，芳基或 - 氨基酸; R 3和R 4独立地为-COR 11或一起为R 6和R 7独立地为1至3个碳原子的低级烷基; R 8是1至约12个碳原子的O-烷基，1至约12个碳原子的S-烷基，具有5或6个碳原子的-O-芳基或-O-杂环; R 11是1至6个碳原子的烷基; 且R 12为1至约12个碳原子的低级烷基，1至8个碳原子的芳基或氨基烷基; 条件是R 8，R 11和R 12中的至少一个是疏水性的并且一起含有至少10个碳原子。本发明还包括制备和使用该化合物的方法。

86. 发明授权

US06587859B2 Printable interfaces and digital linkmarks 有权
标题翻译：可打印的界面和数字链接
公开(公告)号：US06587859B2
公开(公告)日：2003-07-01
申请号：US09841796
申请日：2001-04-24
申请人： Thomas J. Dougherty , S. Joy Mountford , Daniel Cummings , Allison De Fren
发明人： Thomas J. Dougherty , S. Joy Mountford , Daniel Cummings , Allison De Fren
IPC分类号： G06C1730
CPC分类号： G06K7/10861 , G06K17/0022 , G06K19/06037 , G06K2019/06225 , G06K2019/06253 , Y10S707/99945 , Y10S707/99948
摘要： The present invention improves the human/computer interface by providing printable interfaces that enable a user to invoke and control computer processes. The present invention teaches an encoded physical medium suitable for use in interfacing a computer user and a computer system such that the user can control and/or access a plurality of computer implemented processes such computer applications and web pages. The encoded physical medium has a Linkmark and an instruction mark. Encoded within the Linkmark is machine readable linking information directing to a computer implemented process. Encoded within the instruction mark is a machine readable operating instruction that, when decoded, may be executed by the computer implemented process. The present invention also teaches that the marks can present human readable information related to the nature of the machine readable information stored therein. For example, the Linkmark may have graphical illustrations indicating content found at the web page, media format of the content, user designation, payment and membership requirements, communication speed, duration of content, etc. The present invention further teaches a two-dimensional bar code with a plurality of colored glyphs formed such that the average color of the two-dimensional bar code represents encoded information. The colored glyphs are also arranged such that digital information is encoded within the two-dimensional bar code.
摘要翻译：本发明通过提供能够使用户调用和控制计算机进程的可打印接口来改进人机/计算机接口。本发明教导了一种适用于连接计算机用户和计算机系统的编码物理介质，使得用户可以控制和/或访问多个计算机实现的过程，例如计算机应用程序和网页。编码的物理介质具有Linkmark和指令标记。在Linkmark中编码的是机器可读链接信息，指向计算机实现的过程。在指令标记内编码的是机器可读操作指令，当被解码时，可以由计算机实现的过程执行。本发明还教导了标记可以呈现与其中存储的机器可读信息的性质相关的人类可读信息。例如，Linkmark可以具有指示在网页上找到的内容，内容的媒体格式，用户指定，支付和成员资格要求，通信速度，内容持续时间等的图示。本发明进一步教导了二维条具有形成为使得二维条形码的平均颜色表示编码信息的多个彩色字形的代码。彩色字形也被布置成使得数字信息被编码在二维条形码中。

87. 发明授权

US06518950B1 Methods and systems for providing human/computer interfaces 失效
标题翻译：提供人机界面的方法和系统
公开(公告)号：US06518950B1
公开(公告)日：2003-02-11
申请号：US08946327
申请日：1997-10-07
申请人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Brygg A. Ullmer
发明人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Brygg A. Ullmer
IPC分类号： G06K710
CPC分类号： G06F17/30876 , G06K7/0008 , G06K7/12 , G06K7/1443 , G06K19/06037
摘要： The present invention teaches a variety of methods and systems for providing computer/human interfaces. According to one method, the user interfaces with an electronic device such as a computer system by engaging a sensor with desired regions of an encoded physical medium. The encoded physical medium is preferably chosen to provide intuitive meaning to the user, and is thus an improved metaphor for interfacing with the computer system. Suitable examples of the encoded physical medium include a data-linked book, magazine, globe, or article of clothing. Some or all of the selected regions have had certain information encoded therein, information suitable for interfacing and controlling the computer system. When the user engages the sensor with a region having certain encoded information, the certain encoded information is interpreted and an appropriate action taken. For example, the sensor or the computer system may provide suitable feedback to the user. The encoded physical medium may have text and/or graphic illustrations that draw the user in or provide meaningful clues or instructions perhaps related to the encoded information. One scheme for storing the certain encoded data is a spectral encoding scheme. In a preferred embodiment, the spectral encoding scheme uses red, green, blue (RGB). The content is encoded according to the intensities of the RGB colors within the hot spot. In another embodiment, a marker color is inserted into the hot spot to indicate that content is encoded therein.
摘要翻译：本发明教导了用于提供计算机/人类接口的各种方法和系统。根据一种方法，用户通过将传感器与编码的物理介质的期望区域接合而与诸如计算机系统的电子设备接口。编码的物理介质优选地被选择以向用户提供直观的含义，因此是用于与计算机系统接口的改进的比喻。编码物理介质的合适实例包括数据链接的书籍，杂志，地球仪或服装。部分或全部所选择的区域已经在其中编码了某些信息，适合于连接和控制计算机系统的信息。当用户使用具有特定编码信息的区域接合传感器时，解释特定编码信息并采取适当的动作。例如，传感器或计算机系统可以向用户提供合适的反馈。编码的物理介质可以具有绘制用户的文本和/或图示，或提供可能与编码信息相关的有意义的线索或指令。用于存储某些编码数据的一种方案是频谱编码方案。在优选实施例中，频谱编码方案使用红色，绿色，蓝色（RGB）。内容根据热点内的RGB颜色的强度进行编码。在另一个实施例中，将标记颜色插入到热点中以指示内容在其中被编码。

88. 发明授权

US06439459B1 Methods and systems for providing human/computer interfaces 有权
标题翻译：提供人机界面的方法和系统
公开(公告)号：US06439459B1
公开(公告)日：2002-08-27
申请号：US09721032
申请日：2000-11-24
申请人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Philip A. van Allen , Daniel E. Cummings , Brygg A. Ullmer
发明人： Thomas J. Dougherty , S. Joy Mountford , Jesse L. Dorogusker , James H. Boyden , Philip A. van Allen , Daniel E. Cummings , Brygg A. Ullmer
IPC分类号： G06K710
CPC分类号： G06F17/30876 , G06K7/0008 , G06K7/12 , G06K7/1443 , G06K19/06037
摘要： The present invention teaches a variety of methods and systems for providing computer/human interfaces. According to one method, the user interfaces with an electronic device such as a computer system by engaging a sensor with desired regions of an encoded physical medium. The encoded physical medium is preferably chosen to provide intuitive meaning to the user, and is thus an improved metaphor for interfacing with the computer system. Suitable examples of the encoded physical medium include a data-linked book, magazine, globe, or article of clothing. Some or all of the selected regions have had certain information encoded therein, information suitable for interfacing and controlling the computer system. When the user engages the sensor with a region having certain encoded information, the certain encoded information is interpreted and an appropriate action taken. For example, the sensor or the computer system may provide suitable feedback to the user. The encoded physical medium may have text and/or graphic illustrations that draw the user in or provide meaningful clues or instructions perhaps related to the encoded information. The sensor may have at least one identification number (ID) providing information such as user identity, sensor type, access type, or language type. The sensor can transmit the certain decoded information together with the at least one ID to the computer system.
摘要翻译：本发明教导了用于提供计算机/人类接口的各种方法和系统。根据一种方法，用户通过将传感器与编码的物理介质的期望区域接合而与诸如计算机系统的电子设备接口。编码的物理介质优选地被选择以向用户提供直观的含义，因此是用于与计算机系统接口的改进的比喻。编码物理介质的合适实例包括数据链接的书籍，杂志，地球仪或服装。部分或全部所选择的区域已经在其中编码了某些信息，适合于连接和控制计算机系统的信息。当用户使用具有特定编码信息的区域接合传感器时，解释特定编码信息并采取适当的动作。例如，传感器或计算机系统可以向用户提供合适的反馈。编码的物理介质可以具有绘制用户的文本和/或图示，或提供可能与编码信息相关的有意义的线索或指令。传感器可以具有提供诸如用户身份，传感器类型，访问类型或语言类型之类的信息的至少一个标识号（ID）。该传感器可以将该解码信息与该至少一个ID一起发送到该计算机系统。

89. 外观设计

USD442542S1 Case for battery cells 失效
标题翻译：电池的情况
公开(公告)号：USD442542S1
公开(公告)日：2001-05-22
申请号：US29114072
申请日：1999-11-17
申请人： Thomas J. Dougherty , Michael G. Andrew , Gerald K. Bowen , Jeffrey P. Zagrodnik
设计人： Thomas J. Dougherty , Michael G. Andrew , Gerald K. Bowen , Jeffrey P. Zagrodnik

90. 发明授权

US06222341B1 Dual battery charge maintenance system and method 失效
标题翻译：双电池充电维护系统及方法
公开(公告)号：US06222341B1
公开(公告)日：2001-04-24
申请号：US08932950
申请日：1997-09-17
申请人： Thomas J. Dougherty , William P. Segall , Michael E. Iverson
发明人： Thomas J. Dougherty , William P. Segall , Michael E. Iverson
IPC分类号： H02J700
CPC分类号： H02J7/1423 , F02N11/0866 , F02N11/087 , F02N2200/061 , H02J7/0054 , Y02T10/7005
摘要： An electrical system of a vehicle has a starting battery and a reserve battery. The charge of the starting battery is maintained by a charge maintenance device under control of a controller which couples energy from the reserve battery to the starting battery during periods when the vehicle is not being used or during periods of operation where the starting battery voltage requires additional charge.
摘要翻译：车辆的电气系统具有起动电池和备用电池。起动电池的充电由控制器控制的充电维护装置维持，该控制器在车辆未被使用的时段期间或在起动电池电压需要额外的操作期间将来自备用电池的能量耦合到起动电池收费。

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