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81. 发明申请

US20110244037A1 PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND 审中-公开
公开(公告)号：US20110244037A1
公开(公告)日：2011-10-06
申请号：US13161107
申请日：2011-06-15
申请人： Ryu HIRATA , Yasuhiro HARADA , Ryuji UENO
发明人： Ryu HIRATA , Yasuhiro HARADA , Ryuji UENO
IPC分类号： A61K9/64 , A61K31/352
CPC分类号： A61K9/4858 , A61K9/08 , A61K31/352 , A61K31/353 , A61K31/382 , A61K31/4741 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/36
摘要： Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.

82. 发明授权

US08026393B2 Soft-gelatin capsule formulation 有权
标题翻译：软明胶胶囊制剂
公开(公告)号：US08026393B2
公开(公告)日：2011-09-27
申请号：US11656476
申请日：2007-01-23
申请人： Yukiko Hashitera , Ryu Hirata , Yasuhiro Harada , Ryuji Ueno
发明人： Yukiko Hashitera , Ryu Hirata , Yasuhiro Harada , Ryuji Ueno
IPC分类号： C07C61/06 , C07C61/20
CPC分类号： A61K31/352 , A61K9/4816 , A61K9/4825 , A61K9/4858 , A61K31/557 , A61K31/5575
摘要： The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
摘要翻译：本发明公开了一种15-酮 - 前列腺素化合物的软明胶胶囊制剂，其包含：包含明胶和糖醇作为增塑剂的软明胶胶囊壳，以及包含15-酮前列腺素化合物和药学上可接受的混合物装在壳中的车辆。通过将15-酮 - 前列腺素化合物包封在指定的软明胶胶囊壳中，化合物的稳定性显着提高。

83. 发明申请

US20110065784A1 METHOD FOR PROMOTING GASTROINTESTINAL BICARBONATE SECRETION 有权
标题翻译：促进胃肠双歧杆菌分泌的方法
公开(公告)号：US20110065784A1
公开(公告)日：2011-03-17
申请号：US12952626
申请日：2010-11-23
申请人： Ryuji UENO
发明人： Ryuji UENO
IPC分类号： A61K31/352 , A61P1/04
CPC分类号： A61K31/557 , A61K31/558
摘要： Provided is a method for promoting gastrointestinal bicarbonate secretion in a mammalian subject, which comprises administering an effective amount of a compound of Formula (I): to a subject in need thereof. The compound is also useful for protecting the gastrointestinal tract of a mammal from mucosal damage.
摘要翻译：提供一种用于促进哺乳动物受试者中胃肠道碳酸氢盐分泌的方法，其包括向有需要的受试者施用有效量的式（I）化合物。该化合物也可用于保护哺乳动物的胃肠道免受粘膜损伤。

84. 发明申请

US20110054016A1 METHOD FOR MODULATING CLAUDIN MEDIATED FUNCTIONS 失效
标题翻译：用于调节CLAUDIN介质功能的方法
公开(公告)号：US20110054016A1
公开(公告)日：2011-03-03
申请号：US12853692
申请日：2010-08-10
申请人： Ryuji UENO , Sachiko TSUKITA
发明人： Ryuji UENO , Sachiko TSUKITA
IPC分类号： A61K31/343 , A61P17/00
CPC分类号： A61K31/352 , A61K31/5575 , A61K31/558
摘要： Disclosed is a method for modulating a claudin-mediated function in a mammalian subject which comprises administering to a subject in need thereof an effective amount of a specific fatty acid derivative. The application also discloses a method for treating a dermatological disease and a method for modulating an expression of a claudin in a mammalian subject using the same fatty acid derivative as above.
摘要翻译：公开了一种用于调节哺乳动物受试者的紧密连接蛋白介导的功能的方法，其包括向有需要的受试者施用有效量的特定脂肪酸衍生物。本申请还公开了一种用于使用与上述相同的脂肪酸衍生物在哺乳动物受试者中治疗皮肤病的方法和调节紧密连蛋白的表达的方法。

85. 发明授权

US07812182B2 Method for preparing prostaglandin derivative 有权
标题翻译：前列腺素衍生物的制备方法
公开(公告)号：US07812182B2
公开(公告)日：2010-10-12
申请号：US11703138
申请日：2007-02-07
申请人： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
发明人： Ryu Hirata , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC分类号： C07D311/94 , C07C69/608
CPC分类号： C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
摘要： Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
摘要翻译：公开了一种制备式（A）的前列腺素衍生物的方法：其包括在碱性氢氧化物作为唯一碱的存在下，在反应溶剂中使由式（1）表示的醛与2-氧代烷基膦酸酯反应。通过在反应体系中使用碱金属氢氧化物作为底物进行反应，可以通过简单的方法和高收率获得所需的前列腺素衍生物。

86. 发明申请

US20100204489A1 METHOD FOR PREPARING PROSTAGLANDIN DERIVATIVE 有权
公开(公告)号：US20100204489A1
公开(公告)日：2010-08-12
申请号：US12762917
申请日：2010-04-19
申请人： Ryu HIRATA , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
发明人： Ryu HIRATA , Tatsuya Matsukawa , Kazuhiro Masuzaki , Ryuji Ueno
IPC分类号： C07D307/935 , C07D309/12
CPC分类号： C07D307/93 , C07C405/0025 , C07D307/935 , C07D309/12 , C07D311/94
摘要： Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.

87. 发明申请

US20090281711A1 ENERGY-EFFICIENT AUTOMOBILE 失效
标题翻译：能源效率高的汽车
公开(公告)号：US20090281711A1
公开(公告)日：2009-11-12
申请号：US12463660
申请日：2009-05-11
申请人： Ryuji Ueno
发明人： Ryuji Ueno
IPC分类号： F02D41/30
CPC分类号： F02D11/106 , B60L15/2045 , B60L2240/441 , B60L2240/445 , B60W2510/0638 , B60W2510/0676 , B60W2510/244 , B60W2540/10 , B60W2710/0605 , B60W2710/0616 , F02D41/107 , F02D2041/2027 , F02D2200/701 , F02D2200/702 , Y02T10/645 , Y02T10/72 , Y02T10/7283
摘要： Disclosed is an automobile equipped with an engine having an electronically-controlled throttle valve adapted to have an opening angle which is controlled according to an accelerator-pedal depression amount. The engine further includes an accelerator pedal sensor, an actuator adapted to selectively open and close the throttle valve, and a controller. The controller is adapted to calculate a target throttle opening angle corresponding to the accelerator-pedal depression amount, and output a continuous control signal corresponding to the target throttle opening angle, to the actuator. The controller is operable, in a traveling environment of the automobile or an operating condition of the engine where a required engine power is less than an engine power corresponding to the target throttle opening angle, to convert the continuous control signal into a pulsed control signal, and output the pulsed control signal to the actuator.
摘要翻译：本发明公开了一种具有发动机的汽车，该发动机具有电子控制节流阀，其适于具有根据加速器踏板下压量来控制的开启角度。发动机还包括加速踏板传感器，适于选择性地打开和关闭节流阀的致动器以及控制器。控制器适于计算对应于加速器踏板下压量的目标节气门开度角，并将与目标节气门开度相对应的连续控制信号输出到致动器。控制器可操作在汽车的行驶环境或发动机的运转状态，其中所需的发动机功率小于对应于目标节气门开度角的发动机功率，以将连续控制信号转换成脉冲控制信号，并将脉冲控制信号输出到致动器。

88. 发明申请

US20080033036A1 Composition and Method for Promoting Hair Growth 失效
标题翻译：促进头发生长的组成和方法
公开(公告)号：US20080033036A1
公开(公告)日：2008-02-07
申请号：US10567462
申请日：2004-08-12
申请人： Ryuji Ueno , Tsuyoshi Habe , Takashi Sekida
发明人： Ryuji Ueno , Tsuyoshi Habe , Takashi Sekida
IPC分类号： A61K31/215 , A61K31/357 , A61P17/14 , A61Q7/00 , C07C69/734 , C07D317/30 , C07D319/06
CPC分类号： A61K8/4973 , A61K8/37 , A61K8/498 , A61K31/22 , A61K31/357 , A61Q7/00 , C07C405/00 , C07D317/30 , C07D319/06
摘要： The present invention provides a method and composition for promoting hair growth in a mammal which comprises a prostaglandin compound having two hetero atoms at the 15 position as an active ingredient thereof.
摘要翻译：本发明提供一种用于促进哺乳动物毛发生长的方法和组合物，其包含在15位具有两个杂原子的前列腺素化合物作为其活性成分。

89. 发明申请

US20070208068A1 Aqueous Composition Comprising Thiazole Derivative 审中-公开
标题翻译：包含噻唑衍生物的水性组合物
公开(公告)号：US20070208068A1
公开(公告)日：2007-09-06
申请号：US10591986
申请日：2005-03-18
申请人： Ryuji Ueno , Ryu Hirata , Yasuhiro Harada
发明人： Ryuji Ueno , Ryu Hirata , Yasuhiro Harada
IPC分类号： A61K31/426
CPC分类号： C07D417/12 , A61K31/426 , C07D277/46 , C07D277/56 , C07D417/06
摘要： The present invention provides an aqueous composition comprising a thiazole derivative of the formula (I): R1—NH—X—Y-Z (I) wherein each symbol is as defined above, or a pharmaceutically acceptable salt thereof, and an additive selected from the group consisting of polyol, sugar, sugar alcohol, boric acid or its salt, and water. The aqueous composition is very stable and can be stored for a long time.
摘要翻译：本发明提供一种水性组合物，其包含式（I）的噻唑衍生物：其中每个符号如上所定义的R 1 -NH-XYZ（I）或其药学上可接受的盐，以及选自多元醇，糖，糖醇，硼酸或其盐和水的添加剂。水性组合物非常稳定，可以长时间储存。

90. 发明授权

US07063857B1 Use of macrolide compounds for the treatment of dry eye 失效
公开(公告)号：US07063857B1
公开(公告)日：2006-06-20
申请号：US09926411
申请日：2000-04-26
申请人： Ryuji Ueno
发明人： Ryuji Ueno
IPC分类号： A61F2/02 , A61K31/74 , A61K9/20 , A61K9/48
CPC分类号： A61K31/4745 , A61K31/407 , A61K31/436
摘要： The present invention provides an agent for treating a dry eye, which contains a macrolide compound such as FK506.

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