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81. 发明申请

US20110250185A1 TUMOR SUPPRESSION USING PLACENTAL STEM CELLS 审中-公开
标题翻译：肿瘤抑制使用普通干细胞
公开(公告)号：US20110250185A1
公开(公告)日：2011-10-13
申请号：US13164378
申请日：2011-06-20
申请人： Casper Paludan , James W. Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri , Qian Ye
发明人： Casper Paludan , James W. Edinger , Ryhor Harbacheuski , RoseAnn Murray , Robert J. Hariri , Qian Ye
IPC分类号： A61K35/50 , C12N5/00 , C12Q1/02 , A61P35/00 , C12N5/02
CPC分类号： C12N5/0693 , A61K35/12 , A61K35/48 , C12N5/0605 , C12N5/0668 , C12N5/0694 , C12N2501/23 , C12N2501/24 , C12N2502/025 , C12N2502/1388 , C12N2510/00
摘要： The present invention provides methods of suppression of tumor cell proliferation and tumor growth using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of tumor suppression, and compositions comprising such cells and cell populations.
摘要翻译：本发明提供使用胎盘干细胞和胎盘干细胞群抑制肿瘤细胞增殖和肿瘤生长的方法。本发明还提供了基于肿瘤抑制产生和选择胎盘细胞和细胞群的方法，以及包含这种细胞和细胞群的组合物。

82. 发明申请

US20110250182A1 ANGIOGENESIS USING PLACENTAL STEM CELLS 有权
标题翻译：使用平面干细胞的血管生成
公开(公告)号：US20110250182A1
公开(公告)日：2011-10-13
申请号：US13081415
申请日：2011-04-06
申请人： Stewart ABBOT , James W. EDINGER , Aleksandar FRANCKI , Robert J. HARIRI , Vladimir JANKOVIC , Aleksandr KAPLUNOVSKY , Kristen LABAZZO , Eric LAW , Neerav D. PADLIYA , Jennifer PAREDES , Jia-Lun WANG
发明人： Stewart ABBOT , James W. EDINGER , Aleksandar FRANCKI , Robert J. HARIRI , Vladimir JANKOVIC , Aleksandr KAPLUNOVSKY , Kristen LABAZZO , Eric LAW , Neerav D. PADLIYA , Jennifer PAREDES , Jia-Lun WANG
IPC分类号： A61K35/50 , A61P9/00 , C12N5/071
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61L27/3633 , A61L27/3683 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/3895 , C12N5/0605 , A61K2300/00
摘要： Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.
摘要翻译：本文提供了使用胎盘细胞（例如本文所述的胎盘干细胞和胎盘多潜能细胞（PDAC））以及这些胎盘细胞群来治疗患有循环系统疾病或病症的个体的方法。本发明还提供了使用这种细胞或包含这种细胞的细胞群的血管生成方法。

83. 发明申请

US20110217272A1 TREATMENT OF RADIATION INJURY USING PLACENTAL STEM CELLS 有权
标题翻译：使用普通干细胞治疗辐射损伤
公开(公告)号：US20110217272A1
公开(公告)日：2011-09-08
申请号：US13108901
申请日：2011-05-16
申请人： Robert J. HARIRI
发明人： Robert J. HARIRI
IPC分类号： A61K35/50 , A61P43/00
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

84. 发明申请

US20100183571A1 TREATMENT OF MULTIPLE SCLEROSIS USING PLACENTAL STEM CELLS 有权
标题翻译：使用平面干细胞治疗多发性硬化症
公开(公告)号：US20100183571A1
公开(公告)日：2010-07-22
申请号：US12687851
申请日：2010-01-14
申请人： Casper PALUDAN , James EDINGER , Ryhor HARBACHEUSKI , RoseAnn MURRAY , Robert J. HARIRI
发明人： Casper PALUDAN , James EDINGER , Ryhor HARBACHEUSKI , RoseAnn MURRAY , Robert J. HARIRI
IPC分类号： A61K35/12 , A61P37/00 , A61P21/00
CPC分类号： A61K35/50 , C12N5/0605 , C12N5/0668 , C12N2502/11
摘要： The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
摘要翻译：本发明提供使用胎盘干细胞和胎盘干细胞群进行免疫调节的方法。本发明还提供了在免疫调节的基础上产生和选择胎盘细胞和细胞群的方法，以及包含这种细胞和细胞群的组合物。

85. 发明申请

US20100120015A1 METHOD OF COLLECTING PLACENTAL STEM CELLS 有权
标题翻译：收集普通干细胞的方法
公开(公告)号：US20100120015A1
公开(公告)日：2010-05-13
申请号：US12618664
申请日：2009-11-13
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N1/02 , C12N5/00 , C12N15/63 , C12N13/00 , C12N5/02
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.
摘要翻译：一种从胎盘收集胚胎样干细胞的方法，其已经通过用排泄的胎盘用抗凝血剂溶液灌注去除残留的脐带血来清除残留细胞，从排出的胎盘收集残留细胞和灌注液，并分离来自残留细胞和灌注液的胚胎样细胞。外源细胞可以在胎盘生物反应器中繁殖并从其中收集生物活性分子。

86. 发明申请

US20090136471A1 TREATMENT OF PREMATURE BIRTH COMPLICATIONS 审中-公开
标题翻译：治疗孕产妇出生体重
公开(公告)号：US20090136471A1
公开(公告)日：2009-05-28
申请号：US12267499
申请日：2008-11-07
申请人： Mohammad A. Heidaran , Robert J. Hariri , Kristine Erickson Johnson
发明人： Mohammad A. Heidaran , Robert J. Hariri , Kristine Erickson Johnson
IPC分类号： A61K35/12 , A61K35/14
CPC分类号： A61K35/51 , A61K31/714 , A61K33/26 , A61K35/18 , A61K35/50 , A61K38/1816 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of treating one or more complications of premature birth suffered by premature infants, comprising administering to the premature infant umbilical cord blood stem cells and, optionally, placental stem cells. The present invention also provides methods of combining and administering, and compositions comprising, umbilical cord blood stem cells, particularly autologous cord blood cells, and placental stem cells for the treatment of premature infants.
摘要翻译：本发明提供了治疗早产儿早产的一种或多种并发症的方法，包括对早产儿脐带血干细胞和任选的胎盘干细胞施用。本发明还提供组合和给药的方法，以及包含脐带血干细胞，特别是自体脐带血细胞和用于治疗早产儿胎盘干细胞的组合物。

87. 发明申请

US20080206343A1 Hepatocytes and Chondrocytes from Adherent Placental StemCells; And CD34+ ,CD45- Placental Stem Cell-Enriched Cell Populations 审中-公开
标题翻译：来自粘附胎盘干细胞的肝细胞和软骨细胞; 和CD34 +，CD45-胎盘干细胞富集细胞群体
公开(公告)号：US20080206343A1
公开(公告)日：2008-08-28
申请号：US12030170
申请日：2008-02-12
申请人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Marian Pereira , Sascha Dawn Abramson , Kristen S. Labazzo
发明人： James W. Edinger , Robert J. Hariri , Jia-Lun Wang , Qian Ye , Marian Pereira , Sascha Dawn Abramson , Kristen S. Labazzo
IPC分类号： A61K9/14 , C12N5/06 , A61K35/12 , A01K67/00 , C12Q1/70 , C12Q1/68 , C12N5/00
CPC分类号： C12N5/067 , A01K67/0271 , A01K2267/0337 , A61K2035/128 , C12N5/0605 , C12N5/0607 , C12N5/0655 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/15 , C12N2501/999 , C12N2506/02 , C12N2506/03 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34+CD45− stem cells from placenta.
摘要翻译：本文提供了用于从胎盘干细胞产生肝细胞的方法和组合物。本文进一步提供的是这种肝细胞在治疗和干预例如肝脏的创伤，炎症和退行性疾病中的用途。本文还提供了与纳米纤维支架和粘附性胎盘干细胞的组合相关的组合物和方法及其在软骨修复中的使用方法。最后，本文提供的是与来自胎盘的非粘附的CD34 + CD45 +干细胞相关的组合物和方法。

88. 发明申请

US20080131966A1 Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells 有权
标题翻译：干细胞对脱细胞组织和尸体器官的改造和再灌注
公开(公告)号：US20080131966A1
公开(公告)日：2008-06-05
申请号：US11980012
申请日：2007-10-29
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： C12N5/08
CPC分类号： A61K35/50 , A61K35/12 , A61L27/3695 , A61L27/3834 , A61L2430/34 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12N5/0068 , C12N5/0605 , C12N5/0606 , C12N5/0663 , C12N5/0678 , C12N2509/00 , C12N2513/00 , C12N2533/90
摘要： A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matrix is then implanted on or into a patient. The seeded tissue matrix made by the method of the present invention is also disclosed.
摘要翻译：公开了一种制造用于植入患者的组织基质的方法。该方法阐述了从胎盘收集胚胎干细胞，其已被处理以除去残留的脐带血，并将收集的干细胞接种到组织基质上或组织基质上。然后将接种的组织基质植入患者体内或进入患者体内。还公开了通过本发明的方法制备的接种的组织基质。

89. 发明授权

US07255879B2 Post-partum mammalian placenta, its use and placental stem cells therefrom 有权
标题翻译：产后哺乳动物胎盘，其使用和胎盘干细胞
公开(公告)号：US07255879B2
公开(公告)日：2007-08-14
申请号：US10640428
申请日：2003-08-12
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A61K34/14 , A01N63/00
CPC分类号： C12N5/0605 , A61K35/12 , A61K48/00 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12N5/0068 , C12N2500/90 , C12N2509/00 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

90. 发明授权

US4998938A Removable skull mounted work platform and method of assembling same 失效
标题翻译：可移动颅骨安装工作平台及其组装方法
公开(公告)号：US4998938A
公开(公告)日：1991-03-12
申请号：US204451
申请日：1988-06-09
申请人： Jamshid B. G. Ghajar , Fathali G. Ghadjar , Robert J. Hariri
发明人： Jamshid B. G. Ghajar , Fathali G. Ghadjar , Robert J. Hariri
IPC分类号： A61B17/34 , A61B19/00
CPC分类号： A61B90/11 , A61B2017/3484 , A61B2017/3492
摘要： A device for facilitating the insertion of an instrument such as a surgical or observational tool into a patient's cranial cavity through a previously formed aperture in the cranium. The device comprises a guide with an open elongated tubular member having a first and a second end, wherein at least a portion of the tubular member at the first and thereof is configured and adapted for passage through the aperture. An outer surface portion of the open tubular member is configured for engagement with a separate locking apparatus for securing the device to the cranial surface. The device further comprises a flanged tip on the first end of the tubular member for stabilizing it within the aperture. An alignment stand configured for the passage therethrough of at least a portion of the device is seated upon the cranium directly above the aperture. The guide is inserted therethrough and into the cranial cavity. Subsequently, an elongated tubular member is inserted into the guide, which spreads the flanged tips therof, thus creating an interference fit between the flanges and the inner surface of the cranium. A locking ring, positioned upon the guide above the alignment stand, is utilized to secure the device against the cranium by screwing the ring in the direction of the stand. A method for assembling the device within a burr hole previously prepared in the patient's cranium is additionally disclosed.
摘要翻译：一种便于将诸如手术或观察工具的器械通过颅骨中先前形成的孔插入患者颅腔中的装置。该装置包括具有开口的细长管状构件的引导件，该构件具有第一和第二端，其中在第一和第二端处的管状构件的至少一部分构造并适于通过孔。开口管状构件的外表面部分构造成用于与单独的锁定装置接合，用于将装置固定到颅面。该装置还包括在管状构件的第一端上的凸缘尖端，用于使其在孔内稳定。配置用于穿过其中至少一部分装置的对准支架直接位于颅骨上方的正上方。引导件插入其中并进入颅腔。随后，将细长的管状构件插入引导件中，该引导件扩大了带凸缘的尖端，从而在凸缘和颅骨的内表面之间形成过盈配合。位于定位架上方的引导件上的锁定环用于通过沿着支架的方向拧紧环来将装置固定在颅骨上。另外公开了一种将装置组装在预先制备在患者头颅中的钻孔内的方法。

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