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81. 发明授权

US5554182A Method for preventing restenosis 失效
标题翻译：预防再狭窄的方法
公开(公告)号：US5554182A
公开(公告)日：1996-09-10
申请号：US429444
申请日：1995-04-27
申请人： Thomas Q. Dinh , Michael Dror , Robert S. Schwartz
发明人： Thomas Q. Dinh , Michael Dror , Robert S. Schwartz
IPC分类号： A61F2/00 , A61F2/82 , A61L31/04 , A61L31/10 , A61L31/12 , A61L31/16 , A61F2/06 , A61F2/04 , A61M29/02
CPC分类号： A61L31/041 , A61F2/82 , A61L31/046 , A61L31/047 , A61L31/10 , A61L31/128 , A61L31/16 , A61F2/0077 , A61F2240/001 , A61F2250/0067 , A61L2300/252 , A61L2300/416 , A61L2300/42 , A61L2300/45 , A61L2300/622 , Y10S623/921
摘要： An intraluminal stent comprising fibrin and heparin is capable of providing a treatment of restenosis.
摘要翻译：包含纤维蛋白和肝素的管腔内支架能够提供再狭窄的治疗。

82. 发明授权

US5443496A Intravascular radially expandable stent 失效
标题翻译：血管内径向可扩张支架
公开(公告)号：US5443496A
公开(公告)日：1995-08-22
申请号：US138041
申请日：1993-10-15
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
IPC分类号： A61F2/00 , A61F2/82 , A61F2/88 , A61F2/06
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
摘要翻译：一种用于植入体腔内的径向可扩张的支架，其具有开放的近端和远端的大致圆柱体，所述圆柱形主体包括多个金属元件，所述多个金属元件连接以允许圆柱形主体沿着身体的纵向轴线弯曲，由此支架可符合弯曲体腔和在支架的金属元件之间延伸的聚合物膜。支架提供生物相容的聚合物表面以接触和支撑体腔以及柔性结构，以允许支架紧密地符合体腔内的弯曲。支架对于修复血管成形术过程中引起的血管损伤特别有用。

83. 发明授权

US5437288A Flexible catheter guidewire 失效
标题翻译：柔性导管导丝
公开(公告)号：US5437288A
公开(公告)日：1995-08-01
申请号：US940523
申请日：1992-09-04
申请人： Robert S. Schwartz , David Berry , Frederick S. Halverson , James V. Donadio, III
发明人： Robert S. Schwartz , David Berry , Frederick S. Halverson , James V. Donadio, III
IPC分类号： A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09075 , A61M2025/09133
摘要： An apparatus for use as a catheter guidewire and a method for making a catheter guidewire. The apparatus comprises an elongate non-coiled wire having a proximal portion, a distal tip and a flexible portion located between the proximal portion and the distal tip having axially spaced grooves cut therein. The method for making the guidewire includes burnishing one end of a wire to create a rounded distal tip and cutting a predetermined pattern of axially spaced grooves in a length of wire adjacent to the distal tip to create a flexible portion.
摘要翻译：用作导管导丝的装置和制造导管导丝的方法。该装置包括细长的非卷绕的线，其具有近端部分，远端部和位于近端部分和远端部之间的柔性部分，其中在其中切割有轴向间隔开的沟槽。用于制造导丝的方法包括抛光线的一端以产生圆形的远侧末端，并且切割与远侧末端相邻的线的长度方向上的轴向间隔开的凹槽的预定图案以形成柔性部分。

84. 发明授权

US5324261A Drug delivery balloon catheter with line of weakness 失效
标题翻译：药物输送气球导管有弱点
公开(公告)号：US5324261A
公开(公告)日：1994-06-28
申请号：US989412
申请日：1992-12-11
申请人： Rodney R. Amundson , Vincent W. Hull , Michael Dror , Robert S. Schwartz
发明人： Rodney R. Amundson , Vincent W. Hull , Michael Dror , Robert S. Schwartz
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/10 , A61M29/00 , A61M29/02
CPC分类号： A61M25/104 , A61F2/958 , A61L29/16 , A61F2250/0067 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/622 , A61M2025/105 , A61M2025/1081 , A61M2025/1086 , A61M25/1002
摘要： A balloon catheter includes a sheath surrounding the balloon, the sheath having a longitudinal line of weakness and a drug-containing viscous matrix material intermediate between the balloon and the sheath such that when the balloon is positioned and inflated in the body lumen it causes the sheath to burst at the line of weakness and release viscous matrix material onto said body lumen. The device provides accurate placement of the dosage required at the location in need of treatment. The catheter is especially useful in balloon angioplasty procedures.
摘要翻译：球囊导管包括围绕球囊的护套，护套具有纵向弱线线和中间在球囊和护套之间的药物粘性基质材料，使得当球囊定位并在体腔内充气时，其导致鞘在弱点处爆裂，并将粘性基质材料释放到所述体腔上。该装置提供了在需要治疗的位置所需的剂量的准确放置。导管在球囊血管成形术中特别有用。

85. 发明授权

US5163910A Intracatheter perfusion pump apparatus and method 失效
公开(公告)号：US5163910A
公开(公告)日：1992-11-17
申请号：US845170
申请日：1992-03-03
申请人： Robert S. Schwartz , Joseph G. Murphy
发明人： Robert S. Schwartz , Joseph G. Murphy
IPC分类号： A61M1/10 , A61M1/12 , A61M25/00 , A61M29/02
CPC分类号： A61M1/1081 , A61M1/1005 , A61M1/101 , A61M1/1034 , A61M1/125 , A61M2025/1095 , A61M25/00
摘要： An intracatheter pump apparatus and method is described for infusing fluids through a lumen of a catheter. The intracatheter pump includes a motor or power source on the outside of the catheter which causes movement of a fluid moving mechanism positioned in the lumen of the catheter, the fluid moving mechanism being attached to the distal end of an elongated member which in turn is attached to the motor.

86. 发明申请

US20210366620A1 MICROFLUIDIC CORONARY CIRCULATORY MODEL 有权
公开(公告)号：US20210366620A1
公开(公告)日：2021-11-25
申请号：US17059190
申请日：2019-05-31
申请人： Andre BERNARD , Peter HEEB , Cornelia NEF , Dominik OBRIST , Francesco CLAVICA , Sabrina FREY , Robert S. SCHWARTZ , Jon Helge HOEM , Oliver BLUDAU
发明人： Andre BERNARD , Peter HEEB , Cornelia NEF , Dominik OBRIST , Francesco CLAVICA , Sabrina FREY , Robert S. SCHWARTZ , Jon Helge HOEM , Oliver BLUDAU
IPC分类号： G16H50/50 , G06F30/20
摘要： Systems, methods and apparatus are included that are configured to model microvascular obstruction (MVO) in patients. According to one aspect of the present disclosure, a multi-scale model is configured to mimic myocardial microcirculation of coronary vessels. The model includes collaterals configured to provide alternative pathways possibly bypassing the MVO, and configured to model coronary artery compliance for spatially resolved fluid transport through the coronary vessels. The model is configured to simulate the MVO by increasing flow resistance in at least one of the modelled coronary vessels, or by blocking the at least one of the modelled coronary vessels completely. The model is also configured to mimic behavior of fluid transport in the coronary vessels during diagnostics or treatment, to design and optimize therapy protocols for the MVO.

87. 发明授权

US08428729B2 Cardiac stimulation apparatus and method for the control of hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US08428729B2
公开(公告)日：2013-04-23
申请号：US13281742
申请日：2011-10-26
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

88. 发明授权

US08323913B2 Marker for inflammatory conditions 有权
标题翻译：炎症症状的标记
公开(公告)号：US08323913B2
公开(公告)日：2012-12-04
申请号：US13103889
申请日：2011-05-09
申请人： Cheryl A. Conover , Antonio Bayes-Genis , David R. Holmes , Robert S. Schwartz
发明人： Cheryl A. Conover , Antonio Bayes-Genis , David R. Holmes , Robert S. Schwartz
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译：描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。

89. 发明申请

US20120041502A1 Cardiac Stimulation Apparatus And Method For The Control Of Hypertension 有权
标题翻译：心脏刺激装置及控制高血压的方法
公开(公告)号：US20120041502A1
公开(公告)日：2012-02-16
申请号：US13281742
申请日：2011-10-26
申请人： Robert S. Schwartz , Robert A. Van Tassel
发明人： Robert S. Schwartz , Robert A. Van Tassel
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.
摘要翻译：一种电刺激心肌以改变心脏的射血分布，控制心脏的机械功能并降低观察到的患者血压的方法。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。在一些情况下，在测量的预处理血压超过治疗阈值的情况下，可以以相对于患者的心脏射血周期计时的电刺激来刺激患者的心脏。这是为了在至少两个心室之间或在心室内引起不同步，其改变患者的心脏射血分布从预处理的心脏射血分布。这具有从测量的预处理血压降低患者的血压的效果。

90. 发明申请

US20090018608A1 CARDIAC STIMULATION APPARATUS AND METHOD FOR THE CONTROL OF HYPERTENSION 有权
标题翻译： CARDIAC刺激装置和控制高血压的方法
公开(公告)号：US20090018608A1
公开(公告)日：2009-01-15
申请号：US12157435
申请日：2008-06-10
申请人： Robert S. Schwartz , Robert van Tassel , Benjamin Pless
发明人： Robert S. Schwartz , Robert van Tassel , Benjamin Pless
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36564
摘要： The method calls for the periodic electrical stimulation of the heart muscle to alter the ejection profile of the heart thus reducing the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device.
摘要翻译：该方法需要对心肌的周期性电刺激以改变心脏的射血分布，从而降低观察到的患者的血压。该治疗可以由与起搏器相似的装置相关联的可植入血压传感器来调用。

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